KEGG   DRUG: GlyburideHelp
Entry
D00336                      Drug                                   

Name
Glyburide (USP);
Glibenclamide (JP17/INN);
Diabeta (TN);
Glynase (TN);
Micronase (TN)
Product
  Generic
GLYBURIDE (A-S Medication Solutions), GLYBURIDE (Aidarex Pharmaceuticals LLC), GLYBURIDE (American Health Packaging), GLYBURIDE (Aphena Pharma Solutions - Tennessee), GLYBURIDE (Aurobindo Pharma Limited), GLYBURIDE (AvKARE), GLYBURIDE (Avera McKennan Hospital), GLYBURIDE (Blenheim Pharmacal), GLYBURIDE (Bryant Ranch Prepack), GLYBURIDE (Bryant Ranch Prepack), GLYBURIDE (Bryant Ranch Prepack), GLYBURIDE (Cadila Healthcare Limited), GLYBURIDE (Cardinal Health), GLYBURIDE (Cardinal Health), GLYBURIDE (Citron Pharma LLC), GLYBURIDE (Clinical Solutions Wholesale), GLYBURIDE (Clinical Solutions Wholesale), GLYBURIDE (Contract Pharmacy Services-PA), GLYBURIDE (CorePharma), GLYBURIDE (DAVA Pharmaceuticals), GLYBURIDE (DirectRX), GLYBURIDE (DirectRX), GLYBURIDE (Dispensing Solutions), GLYBURIDE (Dispensing Solutions), GLYBURIDE (Heritage Pharmaceuticals), GLYBURIDE (Hikma Pharmaceutical), GLYBURIDE (Lake Erie Medical DBA Quality Care Products LLC), GLYBURIDE (Lake Erie Medical DBA Quality Care Products LLC), GLYBURIDE (Lake Erie Medical DBA Quality Care Products LLC), GLYBURIDE (Legacy Pharmaceutical Packaging), GLYBURIDE (Major Pharmaceuticals), GLYBURIDE (McKesson Contract Packaging), GLYBURIDE (McKesson Packaging Services a business unit of McKesson Corporation), GLYBURIDE (MedVantx), GLYBURIDE (Medsource Pharmaceuticals), GLYBURIDE (Mylan Institutional), GLYBURIDE (Mylan Pharmaceuticals), GLYBURIDE (NCS HealthCare of KY), GLYBURIDE (NCS HealthCare of KY), GLYBURIDE (PD-Rx Pharmaceuticals), GLYBURIDE (PD-Rx Pharmaceuticals), GLYBURIDE (PD-Rx Pharmaceuticals), GLYBURIDE (PD-Rx Pharmaceuticals), GLYBURIDE (PD-Rx Pharmaceuticals), GLYBURIDE (Physicians Total Care), GLYBURIDE (Physicians Total Care), GLYBURIDE (Preferred Pharmaceuticals), GLYBURIDE (Preferred Pharmaceuticals), GLYBURIDE (Proficient Rx LP), GLYBURIDE (Proficient Rx LP), GLYBURIDE (REMEDYREPACK), GLYBURIDE (REMEDYREPACK), GLYBURIDE (REMEDYREPACK), GLYBURIDE (REMEDYREPACK), GLYBURIDE (REMEDYREPACK), GLYBURIDE (REMEDYREPACK), GLYBURIDE (REMEDYREPACK), GLYBURIDE (Rebel Distributors Corp), GLYBURIDE (Rebel Distributors Corp), GLYBURIDE (Rebel Distributors Corp), GLYBURIDE (TEVA Pharmaceuticals USA), GLYBURIDE (TYA Pharmaceuticals), GLYBURIDE (Teva Pharmaceuticals USA), GLYBURIDE (Teva Pharmaceuticals USA), GLYBURIDE (TruPharma), GLYBURIDE (Unit Dose Services), GLYBURIDE (Unit Dose Services), GLYBURIDE (West-Ward Pharmaceuticals Corp), GLYBURIDE (Zydus Pharmaceuticals (USA))
Formula
C23H28ClN3O5S
Exact mass
493.1438
Mol weight
494.0035
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antidiabetic agent
 DG01790  Sulfonamide hypoglycemic
  DG01734  Sulfonamide type sulfonylurea receptor agonist
 DG01508  Sulfonylurea receptor agonist
Transporter substrate
 DG01665  P-glycoprotein substrate
Remark
Same as: 
Therapeutic category: 
ATC code: 
Activity
Antidiabetic
  Disease
Type 2 diabetes mellitus [DS:H00409]
Comment
The effects of the sulfonylureas are initiated by binding to and blocking an ATP-sensitive K+ channel, which has been cloned.
Target
ATP-sensitive potassium channel (SUR1/Kir6.2) brocker [HSA:6833 3767] [KO:K05032 K05004]
  Pathway
ABC transporters
Insulin secretion
Type II diabetes mellitus
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Transporter: SLCO2B1 [HSA:11309], ABCB1 [HSA:5243]
Interaction
Genomic biomarker: G6PD [HSA:2539]
Transporter inhibition: ABCB1 [HSA:5243], ABCB11 [HSA:8647], OAT2 [HSA:10864], MRP2 [HSA:1244]
Drug interaction
Structure map
Sulfonamide derivatives - hypoglycemic agents
Antidiabetics
Potassium channel blocking and opening drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BB Sulfonylureas
     A10BB01 Glibenclamide
      D00336  Glyburide (USP)
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Antidiabetic Agents
   Glyburide
    D00336  Glyburide (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   396  Antidiabetic agents
    3961  Sulfonylureas
     D00336  Glyburide (USP); Glibenclamide (JP17/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Related to voltage-gated cation channels
   Inward rectifier channel (Kir)
    ATP-sensitive potassium channel (SUR1/Kir6.2)
     Glibenclamide
      D00336  Glyburide (USP)
 Transporters
  ABC transporters
   ABCC (CFTR/MRP) subfamily
    ABCC8 (sulfonylurea receptor 1)
     Glibenclamide
      D00336  Glyburide (USP)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP2C9
   Glibenclamide
    D00336  Glyburide (USP)
 Transporter inhibitors
  ABCB1
   Glibenclamide
    D00336  Glyburide (USP)
  ABCB11
   Glibenclamide
    D00336  Glyburide (USP)
  ABCC2
   Glibenclamide
    D00336  Glyburide (USP)
  OAT2
   Glibenclamide
    D00336  Glyburide (USP)
 Transporter substrates
  ABCB1
   Glyburide
    D00336  Glyburide (USP)
  SLCO1B1
   Glyburide
    D00336  Glyburide (USP)
  SLCO1B3
   Glyburide
    D00336  Glyburide (USP)
  SLCO2B1
   Glyburide
    D00336  Glyburide (USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00336  Glibenclamide
Antidiabetics [br08361.html]
 D00336
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Polymorphisms and germline mutations
  D00336
BRITE hierarchy
Other DBs
CAS: 
10238-21-8
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        33
            1   C8y C     7.5600  -22.0500
            2   C8y C     7.5600  -23.4500
            3   C8x C     6.3700  -21.2800
            4   C5a C     8.7500  -21.3500
            5   C8x C     6.3700  -24.0800
            6   O2a O     8.7500  -24.1500
            7   C8y C     5.1100  -21.9800
            8   N1b N     9.9400  -22.0500
            9   O5a O     8.7500  -19.9500
            10  C8x C     5.1100  -23.3800
            11  C1a C     8.7500  -25.4800
            12  X   Cl    3.9200  -21.2800
            13  C1b C    11.2000  -21.3500
            14  C1b C    12.3900  -22.0500
            15  C8y C    13.5800  -21.3500
            16  C8x C    13.5800  -19.9500
            17  C8x C    14.7700  -22.0500
            18  C8x C    14.7700  -19.2500
            19  C8x C    16.0300  -21.3500
            20  C8y C    16.0300  -19.9500
            21  S4a S    17.2200  -19.2500
            22  N1b N    18.4100  -19.9500
            23  C5a C    19.6000  -19.2500
            24  N1b N    20.8600  -19.9500
            25  O5a O    19.6000  -17.8500
            26  C1y C    22.0500  -19.2500
            27  C1x C    22.0500  -17.8500
            28  C1x C    23.2400  -19.9500
            29  C1x C    23.2400  -17.1500
            30  C1x C    24.4300  -19.2500
            31  C1x C    24.4300  -17.8500
            32  O3c O    17.9200  -18.0376
            33  O3c O    16.5200  -18.0376
BOND        35
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     4   8 1
            8     4   9 2
            9     5  10 1
            10    6  11 1
            11    7  12 1
            12    8  13 1
            13   13  14 1
            14   14  15 1
            15   15  16 2
            16   15  17 1
            17   16  18 1
            18   17  19 2
            19   18  20 2
            20   20  21 1
            21   21  22 1
            22   22  23 1
            23   23  24 1
            24   23  25 2
            25   24  26 1
            26   26  27 1
            27   26  28 1
            28   27  29 1
            29   28  30 1
            30   29  31 1
            31    7  10 2
            32   19  20 1
            33   30  31 1
            34   21  32 2
            35   21  33 2

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