KEGG   DRUG: D00336Help
Entry
D00336                      Drug                                   

Name
Glibenclamide (JP16/INN);
Glyburide (USP);
Diabeta (TN);
Glynase (TN);
Micronase (TN)
Product
  Generic
GLYBURIDE (Aidarex Pharmaceuticals LLC), GLYBURIDE (Aphena Pharma Solutions - Tennessee), GLYBURIDE (Aurobindo Pharma Limited), GLYBURIDE (Bryant Ranch Prepack), GLYBURIDE (Bryant Ranch Prepack), GLYBURIDE (Cardinal Health), GLYBURIDE (Cardinal Health), GLYBURIDE (Citron Pharma LLC), GLYBURIDE (Clinical Solutions Wholesale), GLYBURIDE (Clinical Solutions Wholesale), GLYBURIDE (Contract Pharmacy Services-PA), GLYBURIDE (CorePharma), GLYBURIDE (DAVA Pharmaceuticals), GLYBURIDE (Dispensing Solutions), GLYBURIDE (Dispensing Solutions), GLYBURIDE (Greenstone LLC), GLYBURIDE (Heritage Pharmaceuticals), GLYBURIDE (Lake Erie Medical DBA Quality Care Products LLC), GLYBURIDE (Lake Erie Medical DBA Quality Care Products LLC), GLYBURIDE (Lake Erie Medical DBA Quality Care Products LLC), GLYBURIDE (Legacy Pharmaceutical Packaging), GLYBURIDE (Major Pharmaceuticals), GLYBURIDE (McKesson Contract Packaging), GLYBURIDE (McKesson Packaging Services a business unit of McKesson Corporation), GLYBURIDE (MedVantx), GLYBURIDE (Mylan Pharmaceuticals), GLYBURIDE (NCS HealthCare of KY), GLYBURIDE (NCS HealthCare of KY), GLYBURIDE (PD-Rx Pharmaceuticals), GLYBURIDE (PD-Rx Pharmaceuticals), GLYBURIDE (PD-Rx Pharmaceuticals), GLYBURIDE (PD-Rx Pharmaceuticals), GLYBURIDE (PD-Rx Pharmaceuticals), GLYBURIDE (Physicians Total Care), GLYBURIDE (Physicians Total Care), GLYBURIDE (Preferred Pharmaceuticals), GLYBURIDE (REMEDYREPACK), GLYBURIDE (REMEDYREPACK), GLYBURIDE (REMEDYREPACK), GLYBURIDE (REMEDYREPACK), GLYBURIDE (REMEDYREPACK), GLYBURIDE (REMEDYREPACK), GLYBURIDE (Rebel Distributors Corp), GLYBURIDE (Rebel Distributors Corp), GLYBURIDE (Rebel Distributors Corp), GLYBURIDE (TEVA Pharmaceuticals USA), GLYBURIDE (Teva Pharmaceuticals USA), GLYBURIDE (Teva Pharmaceuticals USA), GLYBURIDE (UDL Laboratories), GLYBURIDE (Unit Dose Services), GLYBURIDE (Unit Dose Services), GLYBURIDE (West-Ward Pharmaceutical Corp)
Formula
C23H28ClN3O5S
Exact mass
493.1438
Mol weight
494.0035
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antidiabetic [DS:H00409]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Comment
The effects of the sulfonylureas are initiated by binding to and blocking an ATP-sensitive K+ channel, which has been cloned.
Target
ATP-sensitive potassium channel (SUR1/Kir6.2) brocker [HSA:6833 3767] [KO:K05032 K05004]
  Pathway
hsa02010  ABC transporters
hsa04911  Insulin secretion
hsa04930  Type II diabetes mellitus  
 
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Transporter: SLCO2B1 [HSA:11309], ABCB1 [HSA:5243]
Interaction
Genomic biomarker: G6PD [HSA:2539]
Transporter inhibition: ABCB1 [HSA:5243], ABCB11 (BSEP) [HSA:8647], OAT2 [HSA:10864], MRP2 [HSA:1244]
Drug interaction
Structure map
Sulfonamide derivatives - hypoglycemic agents
Antidiabetics
Potassium channel blocking and opening drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BB Sulfonamides, urea derivatives
     A10BB01 Glibenclamide
      D00336  Glibenclamide (JP16/INN); Glyburide (USP)
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Antidiabetic Agents
   Glyburide
    D00336  Glibenclamide (JP16/INN); Glyburide (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   396  Antidiabetic agents
    3961  Sulfonylureas
     D00336  Glibenclamide (JP16/INN); Glyburide (USP)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Related to voltage-gated cation channels
   Inward rectifier channel (Kir)
    ATP-sensitive potassium channel (SUR1/Kir6.2)
     Glibenclamide
      D00336  Glibenclamide (JP16/INN); Glyburide (USP)
 Transporters
  ABC transporters
   ABCC (CFTR/MRP) subfamily
    ABCC8 (sulfonylurea receptor 1)
     Glibenclamide
      D00336  Glibenclamide (JP16/INN); Glyburide (USP)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2C9
   Glibenclamide
    D00336  Glibenclamide (JP16/INN); Glyburide (USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00336  Glibenclamide
BRITE hierarchy
Other DBs
CAS: 
10238-21-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        33
            1   C8y C    26.8252  -19.4896
            2   C8y C    26.8192  -18.0900
            3   C8x C    28.0263  -20.1953
            4   C5a C    25.6122  -20.1836
            5   C8x C    28.0322  -17.3962
            6   O2a O    25.6122  -17.3905
            7   C8y C    29.2393  -19.5012
            8   N1b N    24.4051  -19.4896
            9   O5a O    25.6122  -21.5831
            10  C8x C    29.2451  -18.1017
            11  C1a C    25.6181  -15.9967
            12  X   Cl   30.4405  -20.2010
            13  C1b C    23.1982  -20.1836
            14  C1b C    21.9911  -19.4838
            15  C8y C    20.7840  -20.1836
            16  C8x C    20.7840  -21.5772
            17  C8x C    19.5769  -19.4838
            18  C8x C    19.5710  -22.2770
            19  C8x C    18.3639  -20.1836
            20  C8y C    18.3698  -21.5772
            21  S4a S    17.1628  -22.2712
            22  N1b N    15.9557  -21.5772
            23  O3c O    17.1628  -23.6707
            24  O3c O    17.1802  -20.7200
            25  C5a C    14.7428  -22.2712
            26  N1b N    13.5358  -21.5714
            27  O5a O    14.7428  -23.6648
            28  C1y C    12.3287  -22.2712
            29  C1x C    12.3287  -23.6648
            30  C1x C    11.1216  -21.5714
            31  C1x C    11.1216  -24.3646
            32  C1x C     9.9145  -22.2712
            33  C1x C     9.9145  -23.6648
BOND        35
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     4   8 1
            8     4   9 2
            9     5  10 1
            10    6  11 1
            11    7  12 1
            12    8  13 1
            13   13  14 1
            14   14  15 1
            15   15  16 2
            16   15  17 1
            17   16  18 1
            18   17  19 2
            19   18  20 2
            20   20  21 1
            21   21  22 1
            22   21  23 2
            23   21  24 2
            24   22  25 1
            25   25  26 1
            26   25  27 2
            27   26  28 1
            28   28  29 1
            29   28  30 1
            30   29  31 1
            31   30  32 1
            32   31  33 1
            33    7  10 2
            34   19  20 1
            35   32  33 1

» Japanese version   » Back

DBGET integrated database retrieval system