KEGG   DRUG: D00710Help
Entry
D00710                      Drug                                   

Name
Sodium valproate (JP16);
Valproate sodium (USAN);
Depakene (TN);
Selenica (TN)
Product
  Generic
Formula
C8H15O2. Na
Exact mass
166.097
Mol weight
166.1933
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anticonvulsant
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Valproic acid is contraindicated in patients with known urea cycle disorders [DS:H00164 H00185 H00186 H00187 H01028 H01032]
Target
GABA transaminase inhibitor [HSA:18] [KO:K13524];
calcium channel T type blocker [HSA:8911 8912 8913] [KO:K04856 K04855 K04854];
histone acetyltransferase inhibitor [HSA:203611 253175 9085 9426] [KO:K00653];
histone deacetylases (HDACs) inhibitor [HSA:3065 3066 8841 9759 10014 10013 51564 55869 9734 83933] [KO:K06067 K11404 K11406 K11407 K11408 K11405 K11409 K18671]
  Pathway
hsa00250  Alanine, aspartate and glutamate metabolism
hsa00280  Valine, leucine and isoleucine degradation
hsa00410  beta-Alanine metabolism
hsa00640  Propanoate metabolism
hsa00650  Butanoate metabolism
hsa04010  MAPK signaling pathway
hsa04020  Calcium signaling pathway
hsa04727  GABAergic synapse  
 
Metabolism
Enzyme: CYP2C9 [HSA:1559], CYP3A4 [HSA:1576]
Interaction
Genomic biomarker: (1) NAGS [HSA:162417], CPS [HSA:1373], ASS [HSA:445], OTC [HSA:5009], ASL [HSA:435], ARG [HSA:383 384], (2) POLG [HSA:5428]
Drug interaction
Structure map
Anticonvulsants
Calcium channel blocking drugs
Antimigraines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AG Fatty acid derivatives
     N03AG01 Valproic acid
      D00710  Sodium valproate (JP16); Valproate sodium (USAN)
USP drug classification [BR:br08302]
 Anticonvulsants
  Gamma-aminobutyric Acid (GABA) Augmenting Agents
   Valproate
    D00710  Sodium valproate (JP16); Valproate sodium (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   113  Antiepileptics
    1139  Others
     D00710  Sodium valproate (JP16); Valproate sodium (USAN)
   117  Psychotropics
    1179  Others
     D00710  Sodium valproate (JP16); Valproate sodium (USAN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Ca2+ channel, CACN alpha-1, CaVx.x
    calcium channel T type
     Valproic acid
      D00710  Valproate sodium (USAN)
 Enzymes
  Transferases
   histone acetyltransferase
    Valproic acid
     D00710  Valproate sodium (USAN)
   GABA transaminase
    Valproic acid
     D00710  Valproate sodium (USAN)
  Hydrolases
   histone deacetylase
    Valproic acid
     D00710  Sodium valproate (JP16); Valproate sodium (USAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2C9
   Valproic acid
    D00710  Sodium valproate (JP16); Valproate sodium (USAN)
  CYP3A4
   Valproic acid
    D00710  Sodium valproate (JP16); Valproate sodium (USAN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00710  Sodium valproate
  D00710  Sodium valproate tablets
  D00710  Sodium valproate syrup
BRITE hierarchy
Other DBs
CAS: 
1069-66-5
PubChem: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        11
            1   C1c C    24.8619  -18.6957
            2   C1b C    24.8619  -17.3175
            3   C1b C    23.6530  -19.4139
            4   C6a C    26.0650  -19.4139
            5   C1b C    23.6472  -16.6109
            6   C1b C    22.4441  -18.6957
            7   O6a O    27.2738  -18.6957
            8   O6a O    26.0650  -20.8098 #-
            9   C1a C    22.4384  -17.3175
            10  C1a C    21.2412  -19.4139
            11  Z   Na   28.5001  -20.7280 #+
BOND        9
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     4   7 2
            7     4   8 1
            8     5   9 1
            9     6  10 1

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