KEGG   DRUG: Flurbiprofen sodiumHelp
Entry
D02290                      Drug                                   

Name
Flurbiprofen sodium (USP);
Ocufen (TN)
Product
  Generic
Formula
C15H12FO2. 2H2O. Na
Exact mass
302.093
Mol weight
302.2733
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Anti-inflammatory
 DG01908  Antiinflammatory drug, propionic acid derivatives
 DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
Remark
ATC code: 
Chemical group: 
Activity
Anti-inflammatory, COX inhibitor, Prostaglandin synthesis inhibitor
Comment
Propionic acid derivative
Indications: Rheumatoid arthritis, Osteoarthritis
Target
cyclooxygenase-1 (COX-1) [HSA:5742] [KO:K00509];
cyclooxygenase-2 (COX-2) [HSA:5743] [KO:K11987]
  Pathway
Arachidonic acid metabolism
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Interaction
Genomic biomarker: CYP2C9 [HSA:1559]
Drug interaction
Structure map
Cyclooxygenase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AE Propionic acid derivatives
     M01AE09 Flurbiprofen
      D02290  Flurbiprofen sodium (USP)
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AA Antiinflammatory preparations, non-steroids for topical use
     M02AA19 Flurbiprofen
      D02290  Flurbiprofen sodium (USP)
 R RESPIRATORY SYSTEM
  R02 THROAT PREPARATIONS
   R02A THROAT PREPARATIONS
    R02AX Other throat preparetions
     R02AX01 Flurbiprofen
      D02290  Flurbiprofen sodium (USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BC Antiinflammatory agents, non-steroids
     S01BC04 Flurbiprofen
      D02290  Flurbiprofen sodium (USP)
USP drug classification [BR:br08302]
 Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Flurbiprofen
    D02290  Flurbiprofen sodium (USP)
 Anti-inflammatory Agents
  Nonsteroidal Anti-inflammatory Drugs
   Flurbiprofen
    D02290  Flurbiprofen sodium (USP)
 Ophthalmic Agents
  Ophthalmic Anti-inflammatories
   Flurbiprofen
    D02290  Flurbiprofen sodium (USP)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases
   cyclooxygenase-1 (COX-1)
    Flurbiprofen
     D02290  Flurbiprofen sodium (USP)
   cyclooxygenase-2 (COX-2)
    Flurbiprofen
     D02290  Flurbiprofen sodium (USP)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP2C9
   Flurbiprofen
    D02290  Flurbiprofen sodium (USP)
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Polymorphisms and germline mutations
  D02290
BRITE hierarchy
Other DBs
CAS: 
56767-76-1
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        21
            1   O0  O    38.2961  -15.7791
            2   C8x C    28.2100  -16.5900
            3   C8y C    28.2100  -15.1900
            4   C8x C    26.9500  -14.4900
            5   C8x C    25.7600  -15.1900
            6   C8x C    25.7600  -16.5900
            7   C8x C    26.9500  -17.2900
            8   C8y C    29.4000  -14.4900
            9   C8y C    30.5900  -15.1900
            10  C8x C    31.8500  -14.4900
            11  C8y C    31.8500  -13.0900
            12  C8x C    30.5900  -12.3900
            13  C8x C    29.4000  -13.0900
            14  X   F    30.5900  -16.5900
            15  C1c C    33.0400  -12.3900
            16  C6a C    34.2300  -13.0900
            17  C1a C    33.0400  -11.0600
            18  O6a O    34.2300  -14.4900
            19  O6a O    35.4900  -12.3900 #-
            20  Z   Na   37.2400  -12.4600 #+
            21  O0  O    38.2961  -15.7791
BOND        19
            1     5   6 2
            2     6   7 1
            3     8   9 2
            4     9  10 1
            5    10  11 2
            6    11  12 1
            7    12  13 2
            8    13   8 1
            9     7   2 2
            10    9  14 1
            11   11  15 1
            12    3   8 1
            13   15  16 1
            14    2   3 1
            15   15  17 1
            16    3   4 2
            17   16  18 2
            18    4   5 1
            19   16  19 1
BRACKET     1    36.4000  -16.7300   36.4000  -14.7000
            1    38.8500  -14.7000   38.8500  -16.7300
            1  2
 ORIGINAL  1    1
 REPEAT    1   21

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