| Entry |
|
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| Name |
Metoprolol fumarate (USP);
Lopressor (TN) |
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| Formula |
(C15H25NO3)2. C4H4O4
|
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| Exact mass |
650.3778
|
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| Mol weight |
650.8
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG01461 beta1-Adrenergic receptor antagonist
DG01653 Antiarrhythmics
DG01806 Class II antiarrhythmic agent
DG03231 Antihypertensive
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
|
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| Remark |
| Product (DG00313): | D00601<JP/US> D00635<US> |
|
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| Efficacy |
Antihypertensive, beta1-Adrenergic receptor antagonist |
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| Comment |
Propranolol derivative
|
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| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
|
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| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]
|
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| Interaction |
|
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| Structure map |
| map07214 | beta-Adrenergic receptor agonists/antagonists |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C07 BETA BLOCKING AGENTS
C07A BETA BLOCKING AGENTS
C07AB Beta blocking agents, selective
C07AB02 Metoprolol
D05011 Metoprolol fumarate (USP)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG01461 beta1-Adrenergic receptor antagonist
DG00313 Metoprolol
D05011 Metoprolol fumarate
DG01653 Antiarrhythmics
DG01806 Class II antiarrhythmic agent
DG00313 Metoprolol
D05011 Metoprolol fumarate
DG03231 Antihypertensive
DG00313 Metoprolol
D05011 Metoprolol fumarate
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00313 Metoprolol
D05011 Metoprolol fumarate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRB1
D05011 Metoprolol fumarate (USP)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D05011
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG01461 beta1-Adrenergic receptor antagonist
DG00313 Metoprolol
DG01653 Antiarrhythmics
DG01806 Class II antiarrhythmic agent
DG00313 Metoprolol
DG03231 Antihypertensive
DG00313 Metoprolol
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00313 Metoprolol
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 46
1 C6a C 31.1975 -34.7892
2 C2b C 32.4086 -35.4912
3 O6a O 29.9865 -35.4912
4 O6a O 31.1975 -33.3911
5 C2b C 33.6253 -34.7892
6 C6a C 34.8363 -35.4912
7 O6a O 36.0473 -34.7892
8 O6a O 34.8363 -36.8893
9 C1c C 24.3600 -31.9900
10 C1a C 25.5724 -32.6900
11 N1b N 23.1476 -32.6900
12 C1a C 24.3600 -30.5900
13 C1b C 21.9521 -31.9996
14 C1c C 20.7647 -32.6851
15 C1b C 19.5735 -31.9971
16 O1a O 20.7645 -34.0898
17 O2a O 18.3840 -32.6838
18 C8y C 18.3840 -34.0838
19 C8x C 17.1886 -34.7742
20 C8x C 17.1889 -36.1742
21 C8y C 18.4014 -36.8740
22 C8x C 19.5968 -36.1836
23 C8x C 19.5966 -34.7836
24 C1b C 18.4016 -38.2900
25 C1b C 17.1955 -38.9865
26 O2a O 16.0030 -38.2980
27 C1a C 14.8144 -38.9844
28 C1c C 24.3600 -31.9900
29 C1a C 25.5724 -32.6900
30 N1b N 23.1476 -32.6900
31 C1b C 21.9521 -31.9996
32 C1c C 20.7647 -32.6851
33 C1b C 19.5735 -31.9971
34 O2a O 18.3840 -32.6838
35 C8y C 18.3840 -34.0838
36 C8x C 17.1886 -34.7742
37 C8x C 17.1889 -36.1742
38 C8y C 18.4014 -36.8740
39 C8x C 19.5968 -36.1836
40 C8x C 19.5966 -34.7836
41 C1b C 18.4016 -38.2900
42 C1b C 17.1955 -38.9865
43 O2a O 16.0030 -38.2980
44 C1a C 14.8144 -38.9844
45 O1a O 20.7645 -34.0898
46 C1a C 24.3600 -30.5900
BOND 45
1 1 2 1
2 1 3 1
3 1 4 2
4 2 5 2
5 5 6 1
6 6 7 1
7 6 8 2
8 9 10 1
9 9 11 1
10 9 12 1
11 11 13 1
12 13 14 1
13 14 15 1
14 14 16 1
15 15 17 1
16 17 18 1
17 18 19 2
18 19 20 1
19 20 21 2
20 21 22 1
21 22 23 2
22 18 23 1
23 21 24 1
24 24 25 1
25 25 26 1
26 26 27 1
27 28 29 1
28 28 30 1
29 28 46 1
30 30 31 1
31 31 32 1
32 32 33 1
33 32 45 1
34 33 34 1
35 34 35 1
36 35 36 2
37 36 37 1
38 37 38 2
39 38 39 1
40 39 40 2
41 35 40 1
42 38 41 1
43 41 42 1
44 42 43 1
45 43 44 1
BRACKET 1 12.0400 -39.8300 12.0400 -29.5400
1 27.4400 -29.5400 27.4400 -39.8300
1 2
ORIGINAL 1 9 10 11 13 14 15 17 18 19 20 21 22 23 24 25 26
1 27 16 12
REPEAT 1 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43
1 44 45 46
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