KEGG   DRUG: Dorzolamide hydrochloride and timolol maleate
Entry
D08493            Mixture   Drug                                   
Name
Dorzolamide hydrochloride and timolol maleate (JP18);
Cosopt (TN)
Product
COSOPT (Thea Pharma), COSOPT PF (Thea Pharma), DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (Akorn)
  Generic
DORZOLAMIDE AND TIMOLOL (Leading Pharma), DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (A-S Medication Solutions), DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (Aurobindo Pharma Limited), DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (Bausch & Lomb Incorporated), DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (Bryant Ranch Prepack), DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (Bryant Ranch Prepack), DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (Gland Pharma Limited), DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (Golden State Medical Supply), DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (Ingenus Pharmaceuticals), DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (Micro Labs Limited), DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (Sandoz), DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (Somerset Therapeutics), DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE OPHTHALMIC (A-S Medication Solutions), DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE OPHTHALMIC SOLUTION (Alembic Pharmaceuticals), DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE OPHTHALMIC SOLUTION (Micro Labs Limited), DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE PRESERVATIVE FREE (Aurobindo Pharma Limited), DORZOLAMIDE HYDROCHLORIDE TIMOLOL MALEATE (Biocon Pharma), DORZOLAMIDE HYDROCHLORIDE TIMOLOL MALEATE (Florida Pharmaceutical Products), DORZOLAMIDE HYDROCHLORIDE TIMOLOL MALETAE (Indoco Remedies Limited)
Component
Dorzolamide hydrochloride [DR:D00653], Timolol maleate [DR:D00603]
Class
Ophthalmic agent
 DG03201  Intraocular pressure lowering agent
  DG03030  Combination of carbonic anhydrase inhibitor and beta blocker
Metabolizing enzyme substrate
 DG01642  CYP2C9 substrate
 DG01639  CYP2C19 substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 1319
ATC code: S01ED51
Product: D08493<JP/US>
Efficacy
Antiglaucoma
  Disease
Open-angle glaucoma [DS:H00612]
Comment
carbonic anhydrase inhibitor / beta-blocker combination
Dorzolamide is primarily metabolized by CYP2C9, CYP2C19 and CYP3A4.
Timolol is primarily metabolized by CYP2D6.
Metabolism
Enzyme: CYP2C9 [HSA:1559], CYP2C19 [HSA:1557], CYP3A4 [HSA:1576], CYP2D6 [HSA:1565]
Interaction
Structure map
map07054  Antiglaucoma agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01ED Beta blocking agents
     S01ED51 Timolol, combinations
      D08493  Dorzolamide hydrochloride and timolol maleate (JP18) <JP/US>
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Ophthalmic Agents, Combinations
   Dorzolamide Hydrochloride/ Timolol Maleate
    D08493  Dorzolamide hydrochloride and timolol maleate (JP18)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D08493  Dorzolamide hydrochloride and timolol maleate (JP18)
Drug groups [BR:br08330]
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   DG03030  Combination of carbonic anhydrase inhibitor and beta blocker
    D08493  Dorzolamide hydrochloride and timolol maleate
 Metabolizing enzyme substrate
  DG01642  CYP2C9 substrate
   D08493  Dorzolamide hydrochloride and timolol maleate
  DG01639  CYP2C19 substrate
   D08493  Dorzolamide hydrochloride and timolol maleate
  DG01644  CYP2D6 substrate
   D08493  Dorzolamide hydrochloride and timolol maleate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D08493  Dorzolamide hydrochloride and timolol maleate
Drug classes [BR:br08332]
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   D08493  Dorzolamide hydrochloride and timolol maleate
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D08493  Dorzolamide hydrochloride and timolol maleate ophthalmic solution
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D08493
Other DBs
PubChem: 124490301
LinkDB

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