KEGG   DRUG: D09394Help
Entry
D09394                      Drug                                   

Name
Fidaxomicin (USAN);
Dificid (TN);
Dificlir (TN)
Product
Formula
C52H74Cl2O18
Exact mass
1056.4252
Mol weight
1058.0392
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Treatment and prevention of Clostridium difficile Infections (CDI) or Clostridium difficile-Associated Diarrhea (CDAD)
Remark
ATC code: 
Drug group: 
Comment
macrocyclic antibiotic
Target
Clostridium difficile RNA polymerase inhibitor
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07A INTESTINAL ANTIINFECTIVES
    A07AA Antibiotics
     A07AA12 Fidaxomicin
      D09394  Fidaxomicin (USAN)
USP drug classification [BR:br08302]
 Antibacterials
  Macrolides
   Fidaxomicin
    D09394  Fidaxomicin (USAN)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   16S rRNA of 30S ribosomal subunit inhibitor
    Aminoglycosides
     Fidaxomicin
      D09394  Fidaxomicin (USAN)
BRITE hierarchy
Other DBs
CAS: 
873857-62-6
PubChem: 
LigandBox: 
LinkDB All DBs
KCF data Show

ATOM        72
            1   C1y C    19.2500  -39.1300
            2   C2x C    19.2500  -40.5300
            3   C2y C    20.4624  -41.2300
            4   C1y C    21.6749  -40.5300
            5   C2y C    21.6749  -39.1300
            6   C1y C    20.4624  -38.4300
            7   C1x C    22.8873  -41.2300
            8   C2x C    24.0997  -40.5300
            9   C2y C    24.0997  -39.1300
            10  C2x C    22.8873  -38.4300
            11  C2x C    25.3122  -41.2300
            12  C2x C    26.5246  -40.5300
            13  C1x C    26.5246  -39.1300
            14  C2x C    25.3122  -38.4300
            15  C2y C    27.7370  -41.2300
            16  C7x C    28.9495  -40.5300
            17  O7x O    28.9495  -39.1300
            18  C1y C    27.7370  -38.4300
            19  C1a C    20.4624  -42.6298
            20  C1a C    21.6851  -37.7301
            21  C1a C    24.0997  -37.7300
            22  C1c C    27.7370  -37.0300
            23  O1a O    28.9366  -36.3373
            24  C1a C    26.5119  -36.3226
            25  O6a O    30.1846  -41.2434
            26  C1b C    27.7370  -42.6300
            27  O2a O    28.9367  -43.3226
            28  C1y C    30.1491  -44.0226
            29  C1y C    30.1490  -45.4298
            30  C1y C    31.3614  -46.1299
            31  C1y C    32.5739  -45.4300
            32  C1y C    32.5740  -44.0228
            33  O2x O    31.3616  -43.3227
            34  C1a C    33.7653  -43.3350
            35  O2a O    28.9523  -46.1208
            36  C1a C    27.7647  -45.4350
            37  O1a O    31.3613  -47.5300
            38  O7a O    33.7682  -46.1199
            39  C7a C    34.9552  -45.4348
            40  C8y C    36.1465  -46.1229
            41  O6a O    34.9555  -44.0302
            42  C8y C    36.1463  -47.5298
            43  C8y C    37.3586  -48.2299
            44  C8y C    38.5712  -47.5301
            45  C8y C    38.5714  -46.1233
            46  C8y C    37.3590  -45.4231
            47  C1b C    34.9141  -48.2412
            48  C1a C    33.7089  -47.5453
            49  X   Cl   37.3584  -49.6298
            50  O1a O    39.7826  -48.2297
            51  X   Cl   39.7800  -45.4257
            52  O1a O    37.3593  -44.0302
            53  O1a O    20.6850  -39.5401
            54  C1b C    18.0376  -38.4300
            55  C1a C    16.8421  -39.1204
            56  O2a O    20.4624  -37.0302
            57  C1y C    20.4624  -35.6302
            58  O2x O    21.6580  -34.9397
            59  C1z C    21.6578  -33.5397
            60  C1y C    20.4453  -32.8398
            61  C1y C    19.2497  -33.5303
            62  C1y C    19.2499  -34.9303
            63  O1a O    18.0377  -35.6303
            64  O1a O    18.0373  -32.8305
            65  C1a C    22.8532  -32.8490
            66  C1a C    22.8453  -34.2251
            67  O7a O    20.4452  -31.4300
            68  C7a C    19.2288  -30.7279
            69  O6a O    18.0315  -31.4194
            70  C1c C    19.2287  -29.3302
            71  C1a C    18.0322  -28.6394
            72  C1a C    20.4570  -28.6207
BOND        75
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     5   6 1
            5     1   6 1
            6     4   7 1
            7     7   8 1
            8     9  10 1
            9     5  10 2
            10    8  11 2
            11   11  12 1
            12   13  14 1
            13    9  14 2
            14   12  15 2
            15   15  16 1
            16   16  17 1
            17   17  18 1
            18   13  18 1
            19    3  19 1
            20    5  20 1
            21    9  21 1
            22   18  22 1
            23   22  23 1 #Up
            24   22  24 1
            25   16  25 2
            26   15  26 1
            27   26  27 1
            28   28  27 1 #Down
            29   28  29 1
            30   29  30 1
            31   30  31 1
            32   31  32 1
            33   32  33 1
            34   28  33 1
            35   32  34 1 #Down
            36   29  35 1 #Down
            37   35  36 1
            38   30  37 1 #Down
            39   31  38 1 #Up
            40   38  39 1
            41   39  40 1
            42   39  41 2
            43   40  42 2
            44   42  43 1
            45   43  44 2
            46   44  45 1
            47   45  46 2
            48   40  46 1
            49   42  47 1
            50   47  48 1
            51   43  49 1
            52   44  50 1
            53   45  51 1
            54   46  52 1
            55    4  53 1 #Up
            56    1  54 1 #Down
            57   54  55 1
            58    6  56 1 #Up
            59   56  57 1
            60   57  58 1
            61   58  59 1
            62   59  60 1
            63   60  61 1
            64   61  62 1
            65   57  62 1
            66   62  63 1 #Up
            67   61  64 1 #Up
            68   59  65 1
            69   59  66 1
            70   60  67 1 #Down
            71   67  68 1
            72   68  69 2
            73   68  70 1
            74   70  71 1
            75   70  72 1

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