| Entry |
|
|---|
| Name |
Darotropium bromide (USAN/INN) |
|---|
| Formula |
C24H29N2. Br
|
|---|
| Exact mass |
424.1514
|
|---|
| Mol weight |
425.4045
|
|---|
| Structure |
|
|---|
| Class |
Neuropsychiatric agent
DG01491 Muscarinic cholinergic receptor antagonist
|
|---|
| Efficacy |
Bronchodilator, Muscarinic acetylcholine receptor antagonist |
|---|
| Comment |
long-acting muscarinic acetylcholine antagonist (LAMA)
Atropine [CPD: C01479] derivative
Treatment of COPD
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
|
|---|
| Brite |
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01491 Muscarinic cholinergic receptor antagonist
D09402 Darotropium bromide
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Acetylcholine (muscarinic)
CHRM
D09402 Darotropium bromide (USAN/INN)
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 27
1 C1x C 18.7600 -23.7300
2 C1x C 19.1100 -22.5400
3 C1y C 19.9500 -23.4500
4 C1y C 20.3000 -22.2600
5 N2y N 19.0400 -20.9300 #+
6 C1x C 21.8400 -23.4500
7 C1x C 21.5600 -22.2600
8 C1y C 22.8900 -24.0100
9 C1b C 23.9400 -24.8500
10 C1a C 18.2700 -19.7400
11 C1a C 17.7800 -21.5600
12 C1d C 25.0340 -24.1305
13 C8y C 26.3837 -24.7731
14 C8y C 25.0942 -22.7540
15 C3b C 26.2517 -23.4153
16 C8x C 26.3105 -22.1205
17 C8x C 26.3013 -20.7218
18 C8x C 25.1904 -19.9699
19 C8x C 23.9741 -20.6034
20 C8x C 23.9133 -22.0020
21 C8x C 26.3955 -26.1780
22 C8x C 27.6466 -26.8063
23 C8x C 28.8163 -26.0369
24 C8x C 28.8744 -24.7021
25 C8x C 27.4833 -24.0038
26 N3a N 27.4642 -22.7153
27 X Br 20.7200 -19.3900 #-
BOND 29
1 1 2 1
2 1 3 1
3 2 4 1
4 3 5 1
5 3 6 1
6 4 7 1
7 6 8 1
8 8 9 1 #Down
9 4 5 1
10 7 8 1
11 5 10 1
12 5 11 1
13 9 12 1
14 12 13 1
15 12 14 1
16 12 15 1
17 14 16 2
18 16 17 1
19 17 18 2
20 18 19 1
21 19 20 2
22 14 20 1
23 13 21 2
24 21 22 1
25 22 23 2
26 23 24 1
27 24 25 2
28 13 25 1
29 15 26 3
|
|---|
