KEGG ORTHOLOGY: K04363

ORTHOLOGY: K04363

Entry

K04363                      KO

Symbol

PDGFRA, CD140A

Name

platelet-derived growth factor receptor alpha [EC:2.7.10.1]

Pathway

map01521

EGFR tyrosine kinase inhibitor resistance

map04010

MAPK signaling pathway

map04014

Ras signaling pathway

map04015

Rap1 signaling pathway

map04020

Calcium signaling pathway

map04072

Phospholipase D signaling pathway

map04144

Endocytosis

map04151

PI3K-Akt signaling pathway

map04510

Focal adhesion

map04540

Gap junction

map04630

JAK-STAT signaling pathway

map04810

Regulation of actin cytoskeleton

map05163

Human cytomegalovirus infection

map05200

Pathways in cancer

map05206

MicroRNAs in cancer

map05214

Glioma

map05215

Prostate cancer

map05218

Melanoma

map05230

Central carbon metabolism in cancer

map05231

Choline metabolism in cancer

Disease

H00042

Glioma

H01590

Chronic eosinophilic leukemia

H01591

Gastrotintestinal stromal tumor

H01599

Hypereosinophilic syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04014 Ras signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04015 Rap1 signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04630 JAK-STAT signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04020 Calcium signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04072 Phospholipase D signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04151 PI3K-Akt signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04540 Gap junction
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05206 MicroRNAs in cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05230 Central carbon metabolism in cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05231 Choline metabolism in cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  09162 Cancer: specific types
   05214 Glioma
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05218 Melanoma
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05215 Prostate cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
Protein kinases [BR:ko01001]
Receptor tyrosine kinases (RTK)
  PDGFR family [OT]
   K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
CD molecules [BR:ko04090]
Proteins
  K04363  CD140a, PDGFRA; platelet-derived growth factor receptor, alpha polypeptide

Other DBs

GO:

0005018

Genes

HSA:	5156(PDGFRA)

PTR:	461318(PDGFRA)

PPS:	100982337(PDGFRA)

GGO:	101124928(PDGFRA)

PON:	100431735(PDGFRA)

NLE:	100603207(PDGFRA)

HMH:	116467343(PDGFRA)

MCC:	697002(PDGFRA)

MCF:	102138392(PDGFRA)

MTHB:

126954734

MNI:	105463522(PDGFRA)

CSAB:

103235675(PDGFRA)

CATY:

105592013(PDGFRA)

PANU:

101022081(PDGFRA)

TGE:	112625154(PDGFRA)

MLEU:

105529382(PDGFRA)

RRO:	104658857(PDGFRA)

RBB:	108533750(PDGFRA)

TFN:	117085606(PDGFRA)

PTEH:

111520430(PDGFRA)

CANG:

105523780(PDGFRA)

CJC:	100412331(PDGFRA)

SBQ:	101040156(PDGFRA)

CIMI:

108312367(PDGFRA)

CSYR:

103249185(PDGFRA)

MMUR:

105867837(PDGFRA)

LCAT:

123624835(PDGFRA)

PCOQ:

105807665(PDGFRA)

OGA:	100961338(PDGFRA)

MMU:	18595(Pdgfra)

MCAL:

110295292(Pdgfra)

MPAH:

110331028(Pdgfra)

RNO:	25267(Pdgfra)

MCOC:

116071260(Pdgfra)

ANU:	117712829(Pdgfra)

MUN:	110558105(Pdgfra)

CGE:	100760258(Pdgfra)

MAUA:

101822506(Pdgfra)

PROB:

127232306(Pdgfra)

PLEU:

114683759(Pdgfra)

MORG:

121460639(Pdgfra)

MFOT:

126506425

AAMP:

119807129(Pdgfra)

NGI:	103734393(Pdgfra)

HGL:	101697360(Pdgfra)

CPOC:

100726209(Pdgfra)

CCAN:

109685094(Pdgfra) 109702274

DORD:

105980318(Pdgfra)

DSP:	122106871(Pdgfra)

PLOP:

125364960(Pdgfra)

NCAR:

124995024

MMMA:

107139238(Pdgfra)

OCU:

100343006

OPI:	101516125(PDGFRA)

TUP:	102488187(PDGFRA)

GVR:	103589787(PDGFRA)

CFA:	442860(PDGFRA)

CLUD:

112652233(PDGFRA)

VVP:	112933353(PDGFRA)

VLG:	121472891(PDGFRA)

NPO:	129520020(PDGFRA)

AML:	100464991(PDGFRA)

UMR:	103672737(PDGFRA)

UAH:	113262493(PDGFRA)

UAR:	123804080(PDGFRA)

ELK:

111148924

LLV:

125093724

MPUF:

101684479(PDGFRA)

MNP:	132006175(PDGFRA)

MLK:	131824031(PDGFRA)

NVS:	122919222(PDGFRA)

ORO:	101372359(PDGFRA)

EJU:	114206758(PDGFRA)

ZCA:	113925340(PDGFRA)

MLX:	118010522(PDGFRA)

NSU:	110590873(PDGFRA)

LWW:	102746830(PDGFRA)

FCA:	101090765(PDGFRA)

PYU:	121035565(PDGFRA)

PCOO:

112858116(PDGFRA)

PBG:	122478872(PDGFRA)

PVIV:

125163328(PDGFRA)

LRUF:

124520247

PTG:	102955481(PDGFRA)

PPAD:

109278988(PDGFRA)

PUC:

125923629

AJU:

106983998

HHV:	120222584(PDGFRA)

BTA:	282301(PDGFRA)

BOM:	102282598(PDGFRA)

BIU:	109560475(PDGFRA)

BBUB:

102409620(PDGFRA)

BBIS:

105002851(PDGFRA)

CHX:	102174007(PDGFRA)

OAS:	101106012(PDGFRA)

BTAX:

128049579(PDGFRA)

ODA:	120862113(PDGFRA)

CCAD:

122427991(PDGFRA)

MBEZ:

129562088(PDGFRA)

SSC:	100627123(PDGFRA)

CFR:	102512589(PDGFRA)

CBAI:

105077672(PDGFRA)

CDK:	105103397(PDGFRA)

VPC:	102528303(PDGFRA)

BACU:

102998016(PDGFRA)

BMUS:

118895166(PDGFRA)

LVE:	103071473(PDGFRA)

OOR:	101269459(PDGFRA)

DLE:	111169692(PDGFRA)

PCAD:

102994349(PDGFRA)

PSIU:

116754045(PDGFRA)

NASI:

112400744(PDGFRA)

ECB:	100059815(PDGFRA)

EPZ:	103552305(PDGFRA)

EAI:	106839051(PDGFRA)

MYB:	102255326(PDGFRA)

MYD:	102761943(PDGFRA)

MMYO:

118668634(PDGFRA)

MLF:	102417415(PDGFRA)

PKL:	118706667(PDGFRA)

EFUS:

103284970(PDGFRA)

MNA:	107532710(PDGFRA)

DRO:	112316918(PDGFRA)

SHON:

118978642(PDGFRA)

AJM:	119054288(PDGFRA)

PDIC:

114493180(PDGFRA)

PHAS:

123815579(PDGFRA)

MMF:	118624129(PDGFRA)

PPAM:

129077631(PDGFRA)

HAI:	109381815(PDGFRA)

RFQ:	117022011(PDGFRA)

PALE:

102895362(PDGFRA)

PGIG:

120588066(PDGFRA)

PVP:	105293808(PDGFRA)

RAY:	107499793(PDGFRA)

MJV:	108385741(PDGFRA)

TOD:	119261223(PDGFRA)

SARA:

101539850(PDGFRA)

SETR:

126032431(PDGFRA)

LAV:	100670735(PDGFRA)

TMU:

101348884

ETF:	101663213(PDGFRA)

DNM:	101428297(PDGFRA)

MDO:	100013088(PDGFRA)

GAS:	123252399(PDGFRA)

SHR:	100925116(PDGFRA)

AFZ:

127539873

PCW:	110200158(PDGFRA)

OAA:	100084432(PDGFRA)

GGA:	395509(PDGFRA)

PCOC:

116225916(PDGFRA)

MGP:	100542010(PDGFRA)

CJO:	107313741(PDGFRA)

TPAI:

128080542(PDGFRA)

LMUT:

125692539(PDGFRA)

NMEL:

110397725(PDGFRA)

APLA:

101797285(PDGFRA)

ACYG:

106030788(PDGFRA)

CATA:

118248600(PDGFRA)

AFUL:

116488453(PDGFRA)

TGU:	100218386(PDGFRA)

LSR:	110469831(PDGFRA)

SCAN:

103825217(PDGFRA)

PMOA:

120497403(PDGFRA)

OTC:	121334956(PDGFRA)

PRUF:

121349389(PDGFRA)

GFR:	102044274(PDGFRA)

FAB:	101820996(PDGFRA)

OMA:	130252678(PDGFRA)

PHI:	102113476(PDGFRA)

PMAJ:

107203533(PDGFRA)

CCAE:

111928019(PDGFRA)

CCW:	104690630(PDGFRA)

CBRC:

103622463(PDGFRA)

ETL:	114058301(PDGFRA)

ZAB:	102070900 102075453(PDGFRA)

ACHL:

103803982(PDGFRA)

SVG:	106851489(PDGFRA)

MMEA:

130573943(PDGFRA)

HRT:	120753384(PDGFRA)

FPG:	101913531(PDGFRA)

FCH:	102054310(PDGFRA)

CLV:	102087625(PDGFRA)

EGZ:	104129386(PDGFRA)

NNI:	104020776(PDGFRA)

PCRI:

104033607(PDGFRA)

PLET:

104623117(PDGFRA)

EHS:	104509161(PDGFRA)

PCAO:

104042646(PDGFRA)

ACUN:

113479434(PDGFRA)

TALA:

104362833(PDGFRA)

PADL:

103926287(PDGFRA)

AFOR:

103897403(PDGFRA)

ACHC:

115341064(PDGFRA)

HALD:

104323103(PDGFRA)

HLE:	104836128(PDGFRA)

AGEN:

126051775

GCL:

127015473

CCRI:

104158694(PDGFRA)

CSTI:

104563475(PDGFRA)

CMAC:

104485376(PDGFRA)

MUI:	104544483(PDGFRA)

BREG:

104639315(PDGFRA)

FGA:	104075470(PDGFRA)

GSTE:

104264045(PDGFRA)

LDI:	104352929(PDGFRA)

MNB:	103778913(PDGFRA)

OHA:	104334893(PDGFRA)

NNT:	104404822(PDGFRA)

SHAB:

115611017(PDGFRA)

DPUB:

104299132(PDGFRA)

PGUU:

104462640(PDGFRA)

ACAR:

104526681(PDGFRA)

CPEA:

104393038(PDGFRA)

AVIT:

104273942(PDGFRA)

CVF:	104286392(PDGFRA)

RTD:	128910230(PDGFRA)

CUCA:

104067138(PDGFRA)

TEO:	104374063(PDGFRA)

BRHI:

104498042(PDGFRA)

AAM:	106490172(PDGFRA)

AROW:

112974613(PDGFRA)

NPD:	112942568(PDGFRA)

DNE:	112979490(PDGFRA)

SCAM:

104139531(PDGFRA)

ASN:	102378120(PDGFRA)

AMJ:	102575338(PDGFRA)

CPOO:

109322084(PDGFRA)

GGN:	109303887(PDGFRA)

PSS:	102443708(PDGFRA)

CMY:	102935642(PDGFRA)

CCAY:

125635912(PDGFRA)

DCC:	119854364(PDGFRA)

CPIC:

101935558(PDGFRA)

TST:	117878037(PDGFRA)

CABI:

116821225(PDGFRA)

MRV:	120407146(PDGFRA)

ACS:	100565834(pdgfra)

ASAO:

132776647(PDGFRA)

PVT:	110078407(PDGFRA)

SUND:

121930753(PDGFRA)

PBI:	103067713(PDGFRA)

PMUR:

107298631(PDGFRA)

CTIG:

120316828(PDGFRA)

PGUT:

117662144(PDGFRA)

APRI:

131202829(PDGFRA)

PTEX:

113435807(PDGFRA)

NSS:	113422760(PDGFRA)

VKO:	123016964(PDGFRA)

PMUA:

114604335(PDGFRA)

PRAF:

128421512(PDGFRA)

ZVI:	118083576(PDGFRA)

HCG:	128328379(PDGFRA)

GJA:	107106036(PDGFRA)

STOW:

125440368(PDGFRA)

EMC:	129336443(PDGFRA)

XLA:	108706592(pdgfra.S) 380245(pdgfra.L)

XTR:	100124862(pdgfra)

NPR:	108804111(PDGFRA)

RTEM:

120922903(PDGFRA)

BBUF:

120990209(PDGFRA)

BGAR:

122941740(PDGFRA)

MUO:	115461528(PDGFRA)

GSH:	117360846(PDGFRA)

DRE:	386856(pdgfra)

SRX:	107718396 107755213

SANH:

107665286 107683957

SGH:	107597438 107601905

CCAR:

109112741

CAUA:

113063319 113078680 113120986

CGIB:

127938096 127984263

PTET:

122325140(pdgfra) 122325223

LROH:

127183147(pdgfra)

OMC:	131527390(pdgfra)

PPRM:

120493762(pdgfra)

RKG:	130097535(pdgfra)

MAMB:

125277998(pdgfra)

CIDE:

127502375

MASI:

127410197 127416231

TROS:

130566360(pdgfra)

TDW:	130434670(pdgfra)

MANU:

129428961(pdgfra)

IPU:

108258040

IFU:	128601293(pdgfra)

PHYP:

113546841(pdgfra)

SMEO:

124377156(pdgfra)

TFD:	113642582(pdgfra)

TVC:	132843456(pdgfra)

AMEX:

103044267(pdgfra)

CMAO:

118815384(pdgfra)

EEE:	113586382(pdgfra)

CHAR:

105895070(pdgfra)

TRU:	101073543(pdgfra)

TFS:	130528831(pdgfra)

TNG:	GSTEN00032764G001

LCO:	104919088(pdgfra)

NCC:	104947073(pdgfra)

TBEN:

117495114(pdgfra)

CGOB:

115006742(pdgfra)

PGEO:

117445902(pdgfra)

GACU:

117555073(pdgfra)

EMAC:

134869964(pdgfra)

ELY:	117253552(pdgfra)

EFO:	125895404(pdgfra)

PLEP:

121940421(pdgfra)

SLUC:

116058814(pdgfra)

ECRA:

117950139(pdgfra)

ESP:	116695589(pdgfra)

PFLV:

114561192(pdgfra)

GAT:	120824143(pdgfra)

PPUG:

119216932(pdgfra)

AFB:	129094441(pdgfra)

CLUM:

117730130(pdgfra)

PSWI:

130193912(pdgfra)

MSAM:

119901064(pdgfra)

SCHU:

122877458(pdgfra)

CUD:	121512171(pdgfra)

ALAT:

119028306(pdgfra)

MZE:	101471693(pdgfra)

ONL:	100692594(pdgfra)

OAU:	116331096(pdgfra)

OLA:	100049280(pdgfra)

OML:	112137012(pdgfra)

CSAI:

133458269(pdgfra)

XMA:	102219876(pdgfra)

XCO:	114151105(pdgfra)

XHE:	116726146(pdgfra)

PRET:

103463840(pdgfra)

PFOR:

103137117(pdgfra)

PLAI:

106963502(pdgfra)

PMEI:

106924185(pdgfra)

GAF:	122838005(pdgfra)

PPRL:

129369979(pdgfra)

CVG:	107091563(pdgfra)

CTUL:

119780613(pdgfra)

GMU:	124873707(pdgfra)

NFU:	107393382(pdgfra)

KMR:	108243392(pdgfra)

ALIM:

106524096(pdgfra)

NWH:	119430861(pdgfra)

AOCE:

111569607(pdgfra)

MCEP:

125009234(pdgfra)

CSEM:

103376707(pdgfra)

POV:	109625664(pdgfra)

SSEN:

122780311(pdgfra)

HHIP:

117760248(pdgfra)

HSP:	118121006(pdgfra)

SMAU:

118317851(pdgfra)

LCF:

108879100

SDU:	111226338(pdgfra)

SLAL:

111644345(pdgfra)

XGL:	120790742(pdgfra)

HCQ:	109532287(pdgfra)

SSCV:

125976148

SBIA:

133503119(pdgfra)

PEE:	133406249(pdgfra)

PTAO:

133480405(pdgfra)

BPEC:

110154688(pdgfra)

MALB:

109962087(pdgfra)

BSPL:

114854622(pdgfra)

SJO:	128361361(pdgfra)

SASA:

106560269 106584117(pdgfra)

STRU:

115158529 115192386

OTW:	112249110(pdgfra) 112251129

OMY:	110521671(pdgfra) 110523003

OGO:	123996500 124037857(pdgfra)

ONE:	115108534 115145127(pdgfra)

OKI:	109898025(pdgfra) 109902718

OKE:	118358652(pdgfra) 118380692

SALP:

111972315(pdgfra) 111976174

SNH:	120052582(pdgfra) 120054283

CCLU:

121533963 121540157(pdgfra)

ELS:	105011836(pdgfra)

SFM:	108922803(pdgfra)

PKI:

111850064

AANG:

118225723(pdgfra)

LOC:	102682229(pdgfra)

PSPA:

121298148 121320036

ARUT:

117408343 117420605

PSEX:

120527608(pdgfra)

LCM:	102353753(PDGFRA)

CMK:	103178167(pdgfra)

RTP:	109927411(pdgfra)

CPLA:

122550155(pdgfra)

HOC:	132815312(pdgfra)

LERI:

129697462(pdgfra)

PMRN:

116939357 116942836

LRJ:	133342875 133346943 133346982

CGLO:

DMK:

PCHN:

PCLA:

DFR:

NVE:

EPA:	110240437 110244533

PDAM:

113683455

SPIS:

111322907 111344410

» show all

Reference

PMID:2544881

Authors

Claesson-Welsh L, Eriksson A, Westermark B, Heldin CH

Title

cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor.

Journal

Proc Natl Acad Sci U S A 86:4917-21 (1989)
DOI:10.1073/pnas.86.13.4917

Sequence

[hsa:5156]

Reference

PMID:8188664

Authors

Vassbotn FS, Havnen OK, Heldin CH, Holmsen H

Title

Negative feedback regulation of human platelets via autocrine activation of the platelet-derived growth factor alpha-receptor.

Journal

J Biol Chem 269:13874-9 (1994)

Sequence

[hsa:5156]

LinkDB

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