KEGG ORTHOLOGY: K05725

ORTHOLOGY: K05725

Entry

K05725                      KO

Symbol

PTK2, FAK

Name

focal adhesion kinase 1 [EC:2.7.10.2]

Pathway

map01522

Endocrine resistance

map04012

ErbB signaling pathway

map04062

Chemokine signaling pathway

map04148

Efferocytosis

map04151

PI3K-Akt signaling pathway

map04360

Axon guidance

map04370

VEGF signaling pathway

map04510

Focal adhesion

map04670

Leukocyte transendothelial migration

map04810

Regulation of actin cytoskeleton

map04935

Growth hormone synthesis, secretion and action

map05100

Bacterial invasion of epithelial cells

map05131

Shigellosis

map05135

Yersinia infection

map05146

Amoebiasis

map05163

Human cytomegalovirus infection

map05165

Human papillomavirus infection

map05170

Human immunodeficiency virus 1 infection

map05200

Pathways in cancer

map05202

Transcriptional misregulation in cancer

map05205

Proteoglycans in cancer

map05208

Chemical carcinogenesis - reactive oxygen species

map05222

Small cell lung cancer

map05417

Lipid and atherosclerosis

map05418

Fluid shear stress and atherosclerosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K05725  PTK2, FAK; focal adhesion kinase 1
   04370 VEGF signaling pathway
    K05725  PTK2, FAK; focal adhesion kinase 1
   04151 PI3K-Akt signaling pathway
    K05725  PTK2, FAK; focal adhesion kinase 1
09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    K05725  PTK2, FAK; focal adhesion kinase 1
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05725  PTK2, FAK; focal adhesion kinase 1
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K05725  PTK2, FAK; focal adhesion kinase 1
09150 Organismal Systems
  09151 Immune system
   04670 Leukocyte transendothelial migration
    K05725  PTK2, FAK; focal adhesion kinase 1
   04062 Chemokine signaling pathway
    K05725  PTK2, FAK; focal adhesion kinase 1
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    K05725  PTK2, FAK; focal adhesion kinase 1
  09158 Development and regeneration
   04360 Axon guidance
    K05725  PTK2, FAK; focal adhesion kinase 1
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05725  PTK2, FAK; focal adhesion kinase 1
   05202 Transcriptional misregulation in cancer
    K05725  PTK2, FAK; focal adhesion kinase 1
   05205 Proteoglycans in cancer
    K05725  PTK2, FAK; focal adhesion kinase 1
   05208 Chemical carcinogenesis - reactive oxygen species
    K05725  PTK2, FAK; focal adhesion kinase 1
  09162 Cancer: specific types
   05222 Small cell lung cancer
    K05725  PTK2, FAK; focal adhesion kinase 1
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K05725  PTK2, FAK; focal adhesion kinase 1
   05163 Human cytomegalovirus infection
    K05725  PTK2, FAK; focal adhesion kinase 1
   05165 Human papillomavirus infection
    K05725  PTK2, FAK; focal adhesion kinase 1
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K05725  PTK2, FAK; focal adhesion kinase 1
   05135 Yersinia infection
    K05725  PTK2, FAK; focal adhesion kinase 1
   05100 Bacterial invasion of epithelial cells
    K05725  PTK2, FAK; focal adhesion kinase 1
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K05725  PTK2, FAK; focal adhesion kinase 1
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K05725  PTK2, FAK; focal adhesion kinase 1
   05418 Fluid shear stress and atherosclerosis
    K05725  PTK2, FAK; focal adhesion kinase 1
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K05725  PTK2, FAK; focal adhesion kinase 1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05725  PTK2, FAK; focal adhesion kinase 1
   01009 Protein phosphatases and associated proteins
    K05725  PTK2, FAK; focal adhesion kinase 1
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K05725  PTK2, FAK; focal adhesion kinase 1
Protein kinases [BR:ko01001]
Non-receptor tyrosine kinases
  FAK family
   K05725  PTK2, FAK; focal adhesion kinase 1
Protein phosphatases and associated proteins [BR:ko01009]
Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K05725  PTK2, FAK; focal adhesion kinase 1

Other DBs

GO:

0004715

Genes

HSA:	5747(PTK2)

PTR:	464422(PTK2)

PPS:	100989953(PTK2)

GGO:	101128620(PTK2)

PON:	100447959(PTK2)

HMH:	116813620(PTK2)

MCC:	700634(PTK2)

MCF:	101925550(PTK2)

MTHB:

126961367

MNI:	105488506(PTK2)

CSAB:

103237724(PTK2)

CATY:

105581292(PTK2)

PANU:

101022936(PTK2)

TGE:	112630666(PTK2)

MLEU:

105546847(PTK2)

RRO:	104679749(PTK2)

RBB:	108544148(PTK2)

TFN:	117079459(PTK2)

PTEH:

111553372(PTK2)

CANG:

105509031(PTK2)

CJC:	100395283(PTK2)

SBQ:	101052217(PTK2)

CIMI:

108284810(PTK2)

CSYR:

103249709(PTK2)

MMUR:

105855154(PTK2)

LCAT:

123644599(PTK2)

PCOQ:

105813423(PTK2)

OGA:	100962373(PTK2)

MMU:	14083(Ptk2)

MCAL:

110310271(Ptk2)

MPAH:

110334478(Ptk2)

RNO:	25614(Ptk2)

MCOC:

116073569(Ptk2)

ANU:	117718495(Ptk2)

MUN:	110542391(Ptk2)

CGE:	100759464(Ptk2)

MAUA:

101843989(Ptk2)

PROB:

127235404(Ptk2)

PLEU:

114704659(Ptk2)

MORG:

121461246(Ptk2)

MFOT:

126503359

AAMP:

119823930(Ptk2)

NGI:	103748419(Ptk2)

HGL:	101711587(Ptk2)

CCAN:

109681968(Ptk2)

DORD:

105992308(Ptk2)

DSP:	122125312(Ptk2)

PLOP:

125360764(Ptk2)

NCAR:

124964882

MMMA:

107142960(Ptk2)

OCU:

100347455

OPI:	101527700(PTK2)

TUP:	102483369(PTK2)

GVR:	103587023(PTK2)

CFA:	475108(PTK2)

CLUD:

112662017(PTK2)

VVP:	112909230(PTK2)

VLG:	121498821(PTK2)

NPO:	129502645(PTK2)

AML:	100464496(PTK2)

UMR:	103670589(PTK2)

UAH:	113248466(PTK2)

UAR:	123779697(PTK2)

ELK:

111146744

LLV:

125097541

MPUF:

101681759(PTK2)

MNP:	132014328(PTK2)

MLK:	131826363(PTK2)

NVS:	122904271(PTK2)

ORO:	101371010(PTK2)

EJU:	114211152(PTK2)

ZCA:	113910123(PTK2)

MLX:	118015244(PTK2)

NSU:	110579255(PTK2)

LWW:

102734509

FCA:	101095952(PTK2)

PYU:	121043038(PTK2)

PCOO:

112859711

PBG:	122495851(PTK2)

PVIV:

125156382(PTK2)

LRUF:

124507840

PTG:	102953254(PTK2)

PPAD:

109273067(PTK2)

PUC:

125924709

AJU:

106984404

HHV:	120232325(PTK2)

BTA:	506270(PTK2)

BOM:	102280095(PTK2)

BIU:	109568429(PTK2)

BBUB:

102389136(PTK2)

BBIS:

104984862(PTK2)

CHX:	102177814(PTK2)

OAS:	101120842(PTK2)

BTAX:

128059235(PTK2)

ODA:	120878853(PTK2)

CCAD:

122451056(PTK2)

MBEZ:

129559901(PTK2)

SSC:	102167153(PTK2)

CBAI:

105074777

CDK:	105095121(PTK2)

VPC:	102530388(PTK2)

BACU:

103013388(PTK2)

BMUS:

118883713(PTK2)

LVE:	103082438(PTK2)

OOR:	101275490(PTK2)

DLE:	111165046(PTK2)

PCAD:

102982229(PTK2)

PSIU:

116742653(PTK2)

NASI:

112397030(PTK2)

ECB:	100058245(PTK2)

EPZ:	103561848(PTK2)

EAI:	106846305(PTK2)

MYB:	102245460(PTK2)

MYD:	102754742(PTK2)

MMYO:

118670566(PTK2)

MLF:	102442955(PTK2)

PKL:	118718637(PTK2)

EFUS:

103299759(PTK2)

MNA:	107533206(PTK2)

SHON:

118988708(PTK2)

AJM:	119064798(PTK2)

PDIC:

114514474(PTK2)

PHAS:

123833261(PTK2)

MMF:	118631501(PTK2)

PPAM:

129084348(PTK2)

HAI:	109390857(PTK2)

RFQ:	117033640(PTK2)

PALE:

102898998(PTK2)

PGIG:

120588751(PTK2)

PVP:	105307748(PTK2)

RAY:	107504408(PTK2)

MJV:	108394624(PTK2)

TOD:	119235583(PTK2)

SARA:

101540332(PTK2)

SETR:

126009430(PTK2)

LAV:	100668436(PTK2)

TMU:

101351714

ETF:	101647889(PTK2)

DNM:	101420176(PTK2)

MDO:	100027188(PTK2)

GAS:	123241697(PTK2)

SHR:	100933019(PTK2)

AFZ:

127544493

PCW:	110194600(PTK2)

OAA:	100076789(PTK2)

GGA:	396416(PTK2)

PCOC:

116227775(PTK2)

CJO:	107310587(PTK2)

TPAI:

128090859(PTK2)

LMUT:

125691260(PTK2)

NMEL:

110393818(PTK2)

APLA:

101796890(PTK2)

ACYG:

106043708(PTK2)

CATA:

118255495(PTK2)

AFUL:

116485476(PTK2)

TGU:	100221659(PTK2)

LSR:	110471669(PTK2)

SCAN:

103814761(PTK2)

PMOA:

120512796(PTK2)

OTC:	121344662(PTK2)

PRUF:

121360033(PTK2)

GFR:	102043366(PTK2)

FAB:	101814936(PTK2)

OMA:	130248859(PTK2)

PHI:	102104319(PTK2)

PMAJ:

107199979(PTK2)

CCAE:

111925177(PTK2)

CCW:	104692616(PTK2)

CBRC:

103623893(PTK2)

ETL:	114061597(PTK2)

ZAB:	102065685(PTK2)

SVG:	106862603(PTK2)

MMEA:

130575336(PTK2)

HRT:	120762784(PTK2)

FPG:	101922646(PTK2)

FCH:	102059158(PTK2)

CLV:	102093049(PTK2)

EGZ:	104135598(PTK2)

NNI:	104020584(PTK2)

PCRI:

104037500(PTK2)

TALA:

104358987(PTK2)

PADL:

103920642(PTK2)

AFOR:

103903803(PTK2)

ACHC:

115340288(PTK2)

HLE:	104842104(PTK2)

AGEN:

126046742

GCL:

127013239

BREG:

104631809

FGA:	104077771(PTK2)

MNB:

103782464

OHA:	104331111(PTK2)

NNT:	104408133(PTK2)

SHAB:

115614758(PTK2)

DPUB:

104300945(PTK2)

ACAR:

104532969(PTK2)

CPEA:

104387818(PTK2)

CVF:	104289254(PTK2)

RTD:	128905630(PTK2)

CUCA:

104063932(PTK2)

AAM:

106482268

AROW:

112962424(PTK2)

NPD:	112953989(PTK2)

TGT:	104578073(PTK2)

DNE:	112991286(PTK2)

SCAM:

104149888(PTK2)

ASN:	102375664(PTK2)

AMJ:	106736955(PTK2)

CPOO:

109322207(PTK2)

GGN:	109305225(PTK2)

PSS:	102453077(PTK2)

CCAY:

125632875(PTK2)

DCC:	119850809(PTK2)

CPIC:

101943190(PTK2)

TST:	117873845(PTK2)

CABI:

116838184(PTK2)

MRV:	120399415(PTK2)

ACS:	100554871(ptk2)

ASAO:

132775134(PTK2)

PVT:	110084855(PTK2)

SUND:

121928719(PTK2)

PBI:	103060776(PTK2)

CTIG:

120304233(PTK2)

PGUT:

117676523(PTK2)

APRI:

131195965(PTK2)

PTEX:

113446402(PTK2)

NSS:	113422691(PTK2)

VKO:	123035001(PTK2)

PMUA:

114600216(PTK2)

PRAF:

128417033(PTK2)

ZVI:	118090037(PTK2)

HCG:	128322287(PTK2)

EMC:	129333879(PTK2)

XLA:	399286(ptk2.L) 432072(ptk2.S)

XTR:	733890(ptk2)

NPR:	108792768(PTK2)

RTEM:

120941562(PTK2)

BBUF:

121000897(PTK2)

BGAR:

122937761(PTK2)

MUO:	115480731(PTK2)

GSH:	117354054(PTK2)

DRE:	142986(ptk2ab) 386705(ptk2aa)

SRX:

107741772

SANH:

107655096 107672068 107704895

SGH:	107552863 107559761 107587873

CCAR:

109092941

CAUA:

113059175 113062549 113079404 113116086 113119735 113119742

CGIB:

127935309 127974942 127979075 128031034

PTET:

122335189(ptk2aa) 122360284(ptk2ab)

LROH:

127178815(ptk2ab) 127181451(ptk2aa)

OMC:	131521265(ptk2ab) 131525327(ptk2aa)

PPRM:

120483315 120483467 120484713(ptk2ab)

RKG:	130078415(ptk2aa) 130097201(ptk2ab)

MAMB:

125244231(ptk2ab) 125275844(ptk2aa)

CIDE:

127497148 127500741

MASI:

127420662 127425225 127452819 127454507

TROS:

130558020(ptk2ab) 130566708(ptk2aa)

TDW:	130415882(ptk2aa) 130433195(ptk2ab)

MANU:

129448161(ptk2ab) 129456107(ptk2aa)

IPU:	108256909(ptk2aa) 108267913(ptk2ab)

IFU:	128600648(ptk2aa) 128610049(ptk2ab)

PHYP:

113533847 113536245(ptk2)

SMEO:

124376325(ptk2aa) 124385324(ptk2ab)

TFD:	113644728(ptk2ab) 113661577(ptk2aa)

TVC:	132837600(ptk2aa) 132845908(ptk2ab)

AMEX:

103033402 103041623(ptk2)

CMAO:

118806181(ptk2aa) 118817252(ptk2ab)

EEE:	113571245 113590645(ptk2)

CHAR:

105904945(ptk2aa) 105910607(ptk2ab) 122129975

TRU:	101062908 101075909

TFS:	130518720 130532344

TNG:	GSTEN00018300G001

LCO:	104919513 104938545

NCC:

104942825

TBEN:

117477841(ptk2aa) 117480748(ptk2ab)

CGOB:

115015974 115021192(ptk2)

PGEO:

117455505(ptk2aa) 117461154

GACU:

117542611(ptk2aa) 117553681

EMAC:

134862465 134874721(ptk2aa)

ELY:	117263460 117266168

EFO:	125893403 125904231

PLEP:

121945745 121957499(ptk2aa)

SLUC:

116047383(ptk2aa) 116049241

ECRA:

117945717(ptk2ab) 117957177(ptk2aa)

ESP:	116691433 116701641

PFLV:

114557222 114567908

GAT:	120810078 120826323(ptk2aa)

PPUG:

119197006 119219073(ptk2aa)

AFB:	129097362(ptk2aa) 129109785

CLUM:

117738859(ptk2aa) 117745047

PSWI:

130188028 130195436(ptk2aa)

MSAM:

119897851 119906977(ptk2aa)

SCHU:

122864944(ptk2aa) 122881575

CUD:	121514041 121523996(ptk2aa)

ALAT:

119005547 119016611(ptk2aa)

MZE:	101465038(ptk2) 101470500

ONL:	100692252 100700494(ptk2)

OAU:	116322622(ptk2aa) 116329849

OLA:	101155713(ptk2)

OML:	112138958(ptk2aa) 112143206

CSAI:

133427240 133461459

XMA:	102223109 102233733

XCO:	114142248 114155741

XHE:	116717721 116731195

PRET:

103472469 103478404(ptk2)

PFOR:

103151179(ptk2)

PLAI:

106960438(ptk2)

PMEI:

106933008(ptk2)

GAF:	122831778 122843807(ptk2aa)

PPRL:

129367622 129375129(ptk2aa)

CVG:	107088538 107096201

CTUL:

119779657(ptk2aa) 119791340

GMU:	124866061 124878855(ptk2aa)

NFU:	107394601 107396176(ptk2)

KMR:	108232279 108240385(ptk2aa)

ALIM:

106518143 106524118

NWH:	119409504 119425991(ptk2aa)

AOCE:

111567389 111579833

MCEP:

125016724 125019908(ptk2aa)

CSEM:

103388446(ptk2) 103394159

POV:	109632156 109638831(ptk2)

SSEN:

122774131 122786190(ptk2aa)

HHIP:

117770382(ptk2aa) 117777069

HSP:	118113315 118124380(ptk2aa)

SMAU:

118291845(ptk2aa) 118291873

LCF:	108889485 108898202

SDU:

111223196

SLAL:

111657213 111662376(ptk2)

XGL:	120784342 120786730(ptk2aa)

HCQ:	109512081 109517642

SSCV:

125974889 125986721

SBIA:

133498097 133500276

PEE:	133396003(ptk2aa) 133401786

PTAO:

133471543(ptk2aa) 133479796

BPEC:

110168868 110171400(ptk2)

MALB:

109958620 109964850

BSPL:

114842523 114865544(ptk2aa)

SJO:	128365761 128374719(ptk2aa)

SASA:

106570401 106588992

STRU:

115174064 115175580 115176657 115185451

OTW:	112229535(ptk2aa) 112245979

OMY:	110488057(ptk2aa) 110496881 110507293 110520760

OGO:	124005058 124012359 124043282(ptk2aa)

ONE:	115128731 115131343

OKI:	109884790 109884792 109903421 109908430

OKE:	118381619 118397982 118399008

SALP:

111955697 111970529

SNH:	120022156 120027258(ptk2aa) 120048831 120048834

CCLU:

121542649 121543307 121571839 121586778

ELS:	105012371 105018852

SFM:	108922037(ptk2) 108940645

PKI:	111843830(ptk2) 111844688

AANG:

118228163 118233353

PSPA:

121313706 121315174

ARUT:

117400717 117435256 117962688 117972064

PSEX:

120515784

LCM:	102356941(PTK2)

CMK:	103181063(ptk2aa)

CPLA:

122548888(ptk2aa)

HOC:

132815081

LERI:

129696222

PMRN:

116941705 116946622

LRJ:	133344092 133352972

BFO:

BBEL:

CIN:

SCLV:

SPU:

AJC:

DME:	Dmel_CG10023(Fak)

DER:

6547429

DSE:

6609940

DSI:	Dsimw501_GD25321(Dsim_GD25321)

DYA:	Dyak_GE13847

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI18838

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:	119674574 119682482

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

HIS:

ACOZ:

AFUN:

AMOU:

AAG:

AALB:

CQU:	CpipJ_CPIJ017572 CpipJ_CPIJ017573

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

AROA:

TCA:

DPA:

SOY:	115877444 115886291

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_213478

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

PGW:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

CLEC:

HHAL:

NLU:

HVI:

MQU:	128994684 129004849

PHU:	Phum_PHUM551930

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_309895

DMK:

DPZ:

PVM:

PJA:

HAME:

PCLA:

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

DFR:

CSCU:

PTEP:

ABRU:

UDV:	129217364 129219238

SDM:

118192492

LPOL:

106459183

PMEO:

129583757

CEL:	CELE_C30F8.4(kin-32)

CBR:	CBG_10801(Cbr-kin-32)

CRQ:	GCK72_000321

LGI:	LOTGIDRAFT_120690

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:

NVE:

EPA:

ATEN:

AMIL:

PDAM:

SPIS:

XEN:

HMG:

HSY:

TAD:	TRIADDRAFT_27547

» show all

Reference

PMID:8422239

Authors

Andre E, Becker-Andre M

Title

Expression of an N-terminally truncated form of human focal adhesion kinase in brain.

Journal

Biochem Biophys Res Commun 190:140-7 (1993)
DOI:10.1006/bbrc.1993.1022

Sequence

[hsa:5747]

Reference

PMID:20332118

Authors

Schaller MD

Title

Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions.

Journal

J Cell Sci 123:1007-13 (2010)
DOI:10.1242/jcs.045112

Sequence

[hsa:5747]

LinkDB

DBGET integrated database retrieval system