KEGG ORTHOLOGY: K05747

ORTHOLOGY: K05747

Entry

K05747                      KO

Symbol

WAS

Name

Wiskott-Aldrich syndrome protein

Pathway

map04062

Chemokine signaling pathway

map04520

Adherens junction

map04530

Tight junction

map04666

Fc gamma R-mediated phagocytosis

map05135

Yersinia infection

map05231

Choline metabolism in cancer

Disease

H00100

Neutropenic disorders

H00107

Other well-defined immunodeficiency syndromes

H00978

Thrombocytopenia (THC)

H01523

Wiskott-Aldrich syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K05747  WAS; Wiskott-Aldrich syndrome protein
   04530 Tight junction
    K05747  WAS; Wiskott-Aldrich syndrome protein
09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    K05747  WAS; Wiskott-Aldrich syndrome protein
   04062 Chemokine signaling pathway
    K05747  WAS; Wiskott-Aldrich syndrome protein
09160 Human Diseases
  09161 Cancer: overview
   05231 Choline metabolism in cancer
    K05747  WAS; Wiskott-Aldrich syndrome protein
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    K05747  WAS; Wiskott-Aldrich syndrome protein
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K05747  WAS; Wiskott-Aldrich syndrome protein
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins
    K05747  WAS; Wiskott-Aldrich syndrome protein
   04990 Domain-containing proteins not elsewhere classified
    K05747  WAS; Wiskott-Aldrich syndrome protein
Membrane trafficking [BR:ko04131]
Others
  Actin-binding proteins
   Nucleation-promoting factors (NPFs)
    K05747  WAS; Wiskott-Aldrich syndrome protein
Cytoskeleton proteins [BR:ko04812]
Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    WASP / WAVE
     K05747  WAS; Wiskott-Aldrich syndrome protein
Domain-containing proteins not elsewhere classified [BR:ko04990]
EVH1 / WASP  homology  (WH) domain-containing proteins
  WH1 domain-containing proteins
   K05747  WAS; Wiskott-Aldrich syndrome protein

Genes

HSA:

7454(WAS)

PTR:	743187(WAS)

PPS:	100977168(WAS)

GGO:	101154232(WAS)

PON:	100452449(WAS)

NLE:	100598058(WAS)

HMH:	116811660(WAS)

MCC:	714474(WAS)

MCF:	102133786(WAS)

MTHB:

126945579

MNI:	105493902(WAS)

CSAB:

103231940(WAS)

CATY:

105573131(WAS)

PANU:

101015005(WAS)

TGE:	112615786(WAS)

MLEU:

105547725(WAS)

RRO:	104660661(WAS)

RBB:	108517463(WAS)

TFN:	117078274(WAS)

PTEH:

111535699(WAS)

CANG:

105515013(WAS)

CJC:	100412947(WAS)

SBQ:	101051876(WAS)

CIMI:

108300895(WAS)

CSYR:

103254225(WAS)

MMUR:

105856374(WAS)

LCAT:

123628361(WAS)

PCOQ:

105816786(WAS)

OGA:	100956227(WAS)

MMU:	22376(Was)

MCAL:

110287161(Was)

MPAH:

110314062(Was)

MCOC:

116090946(Was)

ANU:	117694799(Was)

MUN:	110541344(Was)

CGE:	100769113(Was)

MAUA:

101838897(Was)

PLEU:

114701271(Was)

MORG:

121442572 121442675

MFOT:

126512846

AAMP:

119804972(Was)

NGI:	103741643(Was)

HGL:	101704700(Was)

CPOC:

100730969(Was)

CCAN:

109675666(Was)

DORD:

105997815(Was)

DSP:	122098811(Was)

PLOP:

125343309(Was)

NCAR:

124971986

MMMA:

107159819(Was)

OCU:

100354471

OPI:	101533339(WAS)

TUP:	102469132(WAS)

GVR:	103589453(WAS)

CFA:	491867(WAS)

CLUD:

112673141(WAS)

VVP:	112907257(WAS)

VLG:	121483421(WAS)

NPO:	129518251(WAS)

AML:	100479480(WAS)

UMR:	103663384(WAS)

UAH:	113265921(WAS)

UAR:	123790892(WAS)

ELK:

111150530

LLV:

125092194

MPUF:

101674132(WAS)

MNP:	132007306(WAS)

MLK:	131821720(WAS)

NVS:	122896409(WAS)

ORO:	101380859(WAS)

EJU:	114216830(WAS)

ZCA:	113930794(WAS)

MLX:	118010043(WAS)

NSU:	110571269(WAS)

LWW:	102734384(WAS)

FCA:	101095721(WAS)

PYU:	121025958(WAS)

PCOO:

112870856(WAS)

PBG:	122477941(WAS)

PVIV:

125157822(WAS)

LRUF:

124509509

PTG:	102951203(WAS)

PPAD:

109248068(WAS)

PUC:

125931658

AJU:

106970863

HHV:	120221010(WAS)

BTA:	107131173(WAS)

BOM:	102271473(WAS)

BBUB:

102403922(WAS)

CHX:	102183859(WAS)

OAS:	101114336(WAS)

BTAX:

128070214(WAS)

ODA:	120882095(WAS)

CCAD:

122434491(WAS)

MBEZ:

129564332(WAS)

SSC:	445527(WAS)

CFR:	102512738(WAS)

CBAI:

105079392(WAS)

CDK:	105103310(WAS)

VPC:	102534036(WAS)

BACU:

103013907(WAS)

BMUS:

118889063(WAS)

LVE:	103073648(WAS)

OOR:	101289436(WAS)

DLE:	111169497(WAS)

PCAD:

102988824(WAS)

PSIU:

116747304(WAS)

NASI:

112415994(WAS)

ECB:	100147507(WAS)

EPZ:

103542531

EAI:	106827440(WAS)

MYB:	102242874(WAS)

MYD:	102763663(WAS)

MMYO:

118654648(WAS)

MLF:	102425167(WAS)

PKL:	118731766(WAS)

EFUS:

103301284(WAS)

MNA:	107541349(WAS)

DRO:	112322501(WAS)

SHON:

118998319(WAS)

AJM:	119059815(WAS)

PDIC:

114505476(WAS)

PHAS:

123832781(WAS)

MMF:	118635814(WAS)

PPAM:

129065127(WAS)

HAI:	109374777(WAS)

RFQ:	117016439(WAS)

PALE:

102888774(WAS)

PGIG:

120587093(WAS)

PVP:	105310012(WAS)

RAY:	107515028(WAS)

MJV:	108408402(WAS)

TOD:	119246725(WAS)

SARA:

101552109(WAS)

SETR:

125999254(WAS)

LAV:	100677772(WAS)

TMU:

101348260

ETF:	101643118(WAS)

DNM:	101430109(WAS)

MDO:	100018699(WAS)

GAS:	123253721(WAS)

SHR:	100934222(WAS)

AFZ:

127542584

PCW:	110201059(WAS)

OAA:	100089883(WAS)

GGA:	100857640(SUV39H1)

PCOC:

116240914(WAS)

CJO:	107307196(WAS)

AFUL:

116501663

PHI:	102112094(WAS)

AGEN:

126035166

SHAB:

115602831(WAS)

RTD:	128903157(WAS)

ASN:	102370091(WAS)

AMJ:	102561988(WAS)

CMY:	102938058(WAS)

CCAY:

125628292(WAS)

DCC:	119846988(WAS)

CPIC:

101951223(WAS)

TST:	117888524(WAS)

CABI:

116818915(WAS)

MRV:	120388532(WAS)

ACS:	100565618(was)

ASAO:

132767603(WAS)

PVT:	110081165(WAS)

SUND:

121924071(WAS)

PBI:	103051900(WAS)

PMUR:

107300285(WAS)

CTIG:

120306630(WAS)

TSR:	106546034(WAS)

PGUT:

117675423(WAS)

APRI:

131193272(WAS)

PTEX:

113443384(WAS)

NSS:	113417782(WAS)

VKO:	123023974(WAS)

PMUA:

114588108(WAS)

PRAF:

128405040(WAS)

ZVI:	118097687(WAS)

HCG:	128343986(WAS)

STOW:

125429437(WAS)

EMC:	129346319(WAS)

XLA:	100036872(was.S) 100037214(was.L) 733265(wasll.S)

XTR:	496673(was)

NPR:	108788265(WAS)

RTEM:

120914072(WAS) 120946188

BBUF:

120977516(WAS)

BGAR:

122919622(WAS)

MUO:	115463450(WAS)

GSH:	117349863(WAS)

DRE:	335158(wasb) 571256(wasa)

SRX:	107711966 107731143 107731288 107745750

SANH:

107668059 107669662 107678704 107680068

SGH:	107549603 107549977 107550460 107591865

CCAR:

109050851 109067163

CAUA:

113076461 113079519 113093980 113100937 113107590 113107641

CGIB:

127963011 127963458 128018629 128018686

PTET:

122350166(wasa) 122350191(wasb)

LROH:

127169258(wasb) 127169557(wasa)

OMC:	131545601(wasb) 131545736(wasa)

PPRM:

120469231(wasb) 120483426(wasa)

RKG:	130094593(wasa) 130094649(wasb)

MAMB:

125279635(wasb) 125280005(wasa)

CIDE:

127517453 127517476

MASI:

127414792 127415436 127423827 127424180

TROS:

130568029(wasa) 130568118(wasb)

TDW:	130440265(wasa) 130440271(wasb)

MANU:

129414735(wasa) 129414894(wasb)

IPU:	108265497(wasb) 108265595(wasa)

IFU:	128607870(wasb) 128607934(wasa)

PHYP:

113528430 113536338(was)

SMEO:

124399515(wasa) 124400448(wasb)

TFD:	113656065(wasa) 113656136(wasb)

TVC:	132853174(wasb) 132854217(wasa)

AMEX:

103022907 103041172(was)

CMAO:

118813206(wasb) 118813763(wasa)

EEE:	113579131(was) 113581095

CHAR:

105893634(wasa) 105898903(wasb)

TRU:

101071646

TFS:

130529929

LCO:	104924684(was)

NCC:	104951558(was)

TBEN:

117483519(wasb)

CGOB:

115010837

PGEO:

117449778(wasb)

GACU:

117547451(wasb)

EMAC:

134868392

ELY:

117258280

EFO:

125891094

PLEP:

121946561(wasb)

SLUC:

116043492(wasb)

ECRA:

117947421(wasa)

ESP:	116692383(was)

PFLV:

114558386(was)

GAT:

120828787

PPUG:

119222813(wasb)

AFB:

129100183

CLUM:

117734166

PSWI:

130199033(wasb)

MSAM:

119905223

SCHU:

122883149

CUD:

121517396

ALAT:

119023265(wasa)

MZE:	101473005(was)

ONL:	100703588(was)

OAU:	116319495(wasb)

OLA:	101169454(was)

OML:

112159533

CSAI:

133456691

XMA:	102228585(was)

XCO:	114148545(was)

XHE:	116736853(was)

PRET:

103467699(was)

PFOR:

103139043(was)

PLAI:

106954426(was)

PMEI:

106906927

GAF:	122839303(wasb)

PPRL:

129370189(wasb)

CVG:	107086771(was)

CTUL:

119781988

GMU:	124883654(wasb)

NFU:	107390524(was)

KMR:	108231959(wasb)

ALIM:

106519334(was)

NWH:	119417556(wasb)

AOCE:

111588329(was)

MCEP:

125013105

CSEM:

103385368(was)

POV:	109635246(was)

SSEN:

122777001

HHIP:

117765380

HSP:	118111231(wasb)

SMAU:

118317369

LCF:

108882168

SDU:	111235011(was)

SLAL:

111654216(was)

XGL:	120803591(wasb)

HCQ:	109512953(was)

SSCV:

125988186

SBIA:

133514718(wasb)

PEE:	133401575(wasb)

PTAO:

133477026

BPEC:

110164836(was)

MALB:

109966727(was)

BSPL:

114858219(wasb)

SJO:

128357191

SASA:

106567248(WASP) 106572383(WASP)

STRU:

115165753(was) 115168088

OTW:

112216175

OMY:	110492137 110532474

OGO:	124032094 124045920

ONE:	115102359 115132326

OKI:	109869031 109908154

OKE:	118359879 118360851

SALP:

111966635(was)

SNH:	120058873 120061160

CCLU:

121538513 121546691

ELS:	105022376(was)

SFM:	108934794(was)

PKI:	111847811(was)

AANG:

118208253(wasb)

LOC:	102689969(was)

PSPA:

121305492 121328447 121328987(wasb)

ARUT:

117401734 117404208(wasb) 117412548 117963400 117963403

PSEX:

120542323

LCM:	102351644(WAS)

PMRN:

116942362

LRJ:	133349477 133351775

TPRE:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

AGB:

LDC:

PPYR:

OTU:	111427686 111427687

MSEX:

115447837

FOC:

113212242

IEL:

124166533

DMK:	116925877 116925883

PVM:

113827926

PJA:	122250582 122250583 122250584 122250587

PCHN:

125035346 125035410 125035423 125035433

PCLA:

CQD:

PTRU:

MNZ:

HAZT:

LSM:	121126600 121127749

TCF:

PPOI:

VDE:

VJA:

DFR:

ABRU:

SDM:

LPOL:

PMEO:

PVUL:

HRF:	124121383 124122609

HRJ:

124290949

CRG:

105348313

CVN:	111105724 111105791

CANU:

128157682

OED:

125653525

MMER:

123528684 123528823 123528982

RPHI:

DPOL:

ATEN:

AMIL:

XEN:

HSY:

RSX:	RhiXN_05544

EDI:	EDI_061520 EDI_062410

EIV:	EIN_306550

ACAN:

ACA1_112590

» show all

Reference

PMID:12235133

Authors

Cory GO, Garg R, Cramer R, Ridley AJ

Title

Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein.

Journal

J Biol Chem 277:45115-21 (2002)
DOI:10.1074/jbc.M203346200

Reference

PMID:8069912

Authors

Derry JM, Ochs HD, Francke U

Title

Isolation of a novel gene mutated in Wiskott-Aldrich syndrome.

Journal

Cell 78:635-44 (1994)
DOI:10.1016/0092-8674(94)90528-2

Sequence

[hsa:7454]

LinkDB

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