Mirounga leonina (Southern elephant seal): 118009801
Help
Entry
118009801 CDS
T07472
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf
KO
K08845
A-Raf proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
mlx
Mirounga leonina (Southern elephant seal)
Pathway
mlx01521
EGFR tyrosine kinase inhibitor resistance
mlx01522
Endocrine resistance
mlx04010
MAPK signaling pathway
mlx04012
ErbB signaling pathway
mlx04068
FoxO signaling pathway
mlx04270
Vascular smooth muscle contraction
mlx04650
Natural killer cell mediated cytotoxicity
mlx04720
Long-term potentiation
mlx04726
Serotonergic synapse
mlx04730
Long-term depression
mlx04810
Regulation of actin cytoskeleton
mlx04910
Insulin signaling pathway
mlx04914
Progesterone-mediated oocyte maturation
mlx04928
Parathyroid hormone synthesis, secretion and action
mlx05010
Alzheimer disease
mlx05022
Pathways of neurodegeneration - multiple diseases
mlx05034
Alcoholism
mlx05160
Hepatitis C
mlx05161
Hepatitis B
mlx05200
Pathways in cancer
mlx05205
Proteoglycans in cancer
mlx05208
Chemical carcinogenesis - reactive oxygen species
mlx05210
Colorectal cancer
mlx05211
Renal cell carcinoma
mlx05212
Pancreatic cancer
mlx05213
Endometrial cancer
mlx05214
Glioma
mlx05215
Prostate cancer
mlx05218
Melanoma
mlx05219
Bladder cancer
mlx05220
Chronic myeloid leukemia
mlx05221
Acute myeloid leukemia
mlx05223
Non-small cell lung cancer
mlx05224
Breast cancer
mlx05225
Hepatocellular carcinoma
mlx05226
Gastric cancer
Brite
KEGG Orthology (KO) [BR:
mlx00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
118009801 (ARAF)
04012 ErbB signaling pathway
118009801 (ARAF)
04068 FoxO signaling pathway
118009801 (ARAF)
09140 Cellular Processes
09142 Cell motility
04810 Regulation of actin cytoskeleton
118009801 (ARAF)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
118009801 (ARAF)
09152 Endocrine system
04910 Insulin signaling pathway
118009801 (ARAF)
04914 Progesterone-mediated oocyte maturation
118009801 (ARAF)
04928 Parathyroid hormone synthesis, secretion and action
118009801 (ARAF)
09153 Circulatory system
04270 Vascular smooth muscle contraction
118009801 (ARAF)
09156 Nervous system
04726 Serotonergic synapse
118009801 (ARAF)
04720 Long-term potentiation
118009801 (ARAF)
04730 Long-term depression
118009801 (ARAF)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
118009801 (ARAF)
05205 Proteoglycans in cancer
118009801 (ARAF)
05208 Chemical carcinogenesis - reactive oxygen species
118009801 (ARAF)
09162 Cancer: specific types
05210 Colorectal cancer
118009801 (ARAF)
05212 Pancreatic cancer
118009801 (ARAF)
05225 Hepatocellular carcinoma
118009801 (ARAF)
05226 Gastric cancer
118009801 (ARAF)
05214 Glioma
118009801 (ARAF)
05221 Acute myeloid leukemia
118009801 (ARAF)
05220 Chronic myeloid leukemia
118009801 (ARAF)
05218 Melanoma
118009801 (ARAF)
05211 Renal cell carcinoma
118009801 (ARAF)
05219 Bladder cancer
118009801 (ARAF)
05215 Prostate cancer
118009801 (ARAF)
05213 Endometrial cancer
118009801 (ARAF)
05224 Breast cancer
118009801 (ARAF)
05223 Non-small cell lung cancer
118009801 (ARAF)
09172 Infectious disease: viral
05161 Hepatitis B
118009801 (ARAF)
05160 Hepatitis C
118009801 (ARAF)
09164 Neurodegenerative disease
05010 Alzheimer disease
118009801 (ARAF)
05022 Pathways of neurodegeneration - multiple diseases
118009801 (ARAF)
09165 Substance dependence
05034 Alcoholism
118009801 (ARAF)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
118009801 (ARAF)
01522 Endocrine resistance
118009801 (ARAF)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
mlx01001
]
118009801 (ARAF)
Enzymes [BR:
mlx01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
118009801 (ARAF)
Protein kinases [BR:
mlx01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
118009801 (ARAF)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
ABC1
Pkinase_fungal
zf-RING-like
TUG-UBL1
Kdo
Motif
Other DBs
NCBI-GeneID:
118009801
NCBI-ProteinID:
XP_034859725
LinkDB
All DBs
Position
Unknown
AA seq
606 aa
AA seq
DB search
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIEGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNCRQFYHSVQDLSGGSRQHEAPSHRPLNEPL
TPQGPSSCTQHREPEHFPFPATANAPLQRIRSTSTPNVHMVSTTAPMDSSLVQLTAPSFS
TDAAGSRGGGDGAPRGSPSPASVSSGRKSPHSKSPSEQRERKSVADDKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS
AARLVP
NT seq
1821 nt
NT seq
+upstream
nt +downstream
nt
atggagccaccacggggcccccctgccaacggggccgagccatcccgggcagtgggcact
gtcaaagtatacctacccaacaagcaacgcacggtggtgactgtccgggatggcatgagt
gtctacgactctctagacaaggccctcaaggtacggggtctcaatcaggattgctgtgtg
gtctaccggctcatcgaggggcgaaagacagtcaccgcctgggacacggccattgccccg
ctggatggagaggagctcatcgtagaggtccttgaagacgtcccactgaccatgcacaat
tttgtacggaagacgttcttcagcctggcgttctgcgacttctgccttaagtttctgttc
cacggcttccgctgccaaacctgtggctacaagttccaccagcattgttcctccaaagtc
cccacagtctgtgttgacatgagcaccaactgccgacagttctaccacagtgtccaggat
ttgtccggaggctccagacagcacgaagctccctcacaccgccccctgaatgagccgtta
acccctcagggtcccagctcctgcacccagcaccgcgagcctgagcactttcccttcccc
gccacggccaacgcccctctccagcgcatccgctccacgtccactcccaacgtccacatg
gtcagcaccacagcccccatggactccagccttgtccagctcactgccccgagtttcagc
accgatgctgccggtagtagaggtggtggcgatggagccccccgggggagccccagcccg
gccagcgtgtcctcggggaggaagtctccccattccaagtccccatcagaacagcgggag
cggaagtccgtggccgatgacaagaagaaagtgaagaatctggggtaccgggactcgggc
tattactgggaggtgccgcccagtgaggtgcagctgctgaagaggatcgggacgggctcg
tttggcaccgtgtttcgcgggcggtggcatggcgatgtggccgtgaaggtgctcaaggtg
gcccaacccacagctgagcaggcccaggccttcaagaacgagatgcaggtgctcaggaag
acacggcacgtcaacatcctgctgttcatgggcttcatgacgcggccgggcttcgccatc
atcacgcagtggtgcgagggttccagcctctaccaccacctgcatgtggccgacacgcgc
ttcgacatggtccagctcattgacgtggcccggcagaccgcccagggcatggactacctc
catgccaagaacatcatccaccgagatctcaagtctaacaacatcttcctacacgagggg
ctcacggtgaagatcggtgacttcggcctggccacggtgaagacacggtggagtggggcc
cagcccttggaacagccctcaggctccgtgctgtggatggcggctgaggtgatccgtatg
caggacccgaacccctacagcttccagtcagatgtctacgcctatggggttgtgctctat
gagctcatgaccggctcgctgccctacagccacattggcagccgtgaccagattatcttc
atggtgggccgtggctatctgtccccggacctcagcaaaatctccagcaactgccccaag
gccatgcggcgcctgctgtctgactgcctcaagttccagcgggaggaacgtcccctcttc
ccccagatcctggccacgattgagctgctgcagcggtcactccccaagattgagcggagt
gcctccgaaccctccttgcatcgcacccaggccgatgagctgcctgcctgcctgctcagt
gcagcccgccttgtgccttag
DBGET
integrated database retrieval system