KEGG ORTHOLOGY: K09255

ORTHOLOGY: K09255

Entry

K09255                      KO

Symbol

ANK2, ANKB

Name

ankyrin-2

Pathway

map04624

Toll and Imd signaling pathway

map04820

Cytoskeleton in muscle cells

map05205

Proteoglycans in cancer

Disease

H00720

Long QT syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09142 Cell motility
   04820 Cytoskeleton in muscle cells
    K09255  ANK2, ANKB; ankyrin-2
09150 Organismal Systems
  09151 Immune system
   04624 Toll and Imd signaling pathway
    K09255  ANK2, ANKB; ankyrin-2
09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K09255  ANK2, ANKB; ankyrin-2
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins
    K09255  ANK2, ANKB; ankyrin-2
Cytoskeleton proteins [BR:ko04812]
Eukaryotic cytoskeleton proteins
  Intermediate filaments
   Intermediate filament-binding proteins
    K09255  ANK2, ANKB; ankyrin-2

Other DBs

TC:	8.A.28.1.1

Genes

HSA:

287(ANK2)

PTR:	461444(ANK2)

PPS:	100983512(ANK2)

GGO:	101133513(ANK2)

PON:	100436372(ANK2)

NLE:	100582056(ANK2)

HMH:	116462895(ANK2)

MCC:	702180(ANK2)

MCF:	101865310(ANK2)

MTHB:

126955620

MNI:	105486421(ANK2)

CSAB:

103236140(ANK2)

CATY:

105571457(ANK2)

PANU:

101008608(ANK2)

TGE:	112624250(ANK2)

MLEU:

105551853(ANK2)

RRO:	104682595(ANK2)

RBB:	108512477(ANK2)

TFN:	117085807(ANK2)

PTEH:

111547904(ANK2)

CANG:

105516256(ANK2)

CJC:	100398667(ANK2)

SBQ:	101039279(ANK2)

CIMI:

108290311(ANK2)

CSYR:

103261951(ANK2)

MMUR:

105879485(ANK2)

LCAT:

123627770(ANK2)

PCOQ:

105818928(ANK2)

OGA:	100956317(ANK2)

MMU:	109676(Ank2)

MCAL:

110291743(Ank2)

MPAH:

110319801(Ank2)

RNO:	362036(Ank2)

MCOC:

116093750(Ank2)

ANU:	117706892(Ank2)

MUN:	110565978(Ank2)

CGE:	100757830(Ank2)

MAUA:

101833016(Ank2)

PROB:

127223053(Ank2)

PLEU:

114682333(Ank2)

MORG:

121452835(Ank2)

MFOT:

126499856

AAMP:

119800603(Ank2)

NGI:	103734682(Ank2)

HGL:	101697466(Ank2)

CPOC:

100717265(Ank2)

CCAN:

109686828(Ank2)

DORD:

105991217(Ank2)

DSP:	122123174(Ank2)

PLOP:

125341393(Ank2)

NCAR:

124994116

MMMA:

107141404(Ank2)

OCU:

100354205

OPI:	101533767(ANK2)

TUP:	102487222(ANK2)

GVR:	103585344(ANK2)

CFA:	487908(ANK2)

CLUD:

112671683(ANK2)

VVP:	112931022(ANK2)

VLG:	121493716(ANK2)

NPO:	129521148(ANK2)

AML:	100465763(ANK2)

UMR:	103661760(ANK2)

UAH:	113255588(ANK2)

UAR:	123793343(ANK2)

ELK:

111152577

LLV:

125093300

MPUF:

101671186(ANK2)

MNP:	132002386(ANK2)

MLK:	131828966(ANK2)

NVS:	122889235(ANK2)

ORO:	101370723(ANK2)

EJU:	114222688(ANK2)

ZCA:	113924058(ANK2)

MLX:	118027106(ANK2)

NSU:	110575494(ANK2)

LWW:	102743487(ANK2)

FCA:	101100129(ANK2)

PYU:	121030716(ANK2)

PCOO:

112858804(ANK2)

PBG:	122476996(ANK2)

PVIV:

125163608(ANK2)

LRUF:

124520206

PTG:	102952373(ANK2)

PPAD:

109248339(ANK2)

PUC:

125923037

AJU:

106977312

HHV:	120220209(ANK2)

BTA:	539238(ANK2)

BOM:	102275647(ANK2)

BIU:	109560237(ANK2)

BBUB:

102396781(ANK2)

BBIS:

105002058(ANK2)

CHX:	102169655(ANK2)

OAS:	101115623(ANK2)

BTAX:

128049449(ANK2)

ODA:	120861706(ANK2)

CCAD:

122421986(ANK2)

MBEZ:

129561458(ANK2)

SSC:	100512728(ANK2)

CFR:	102524124(ANK2)

CBAI:

105067143(ANK2)

CDK:	105089929(ANK2)

VPC:	102533203(ANK2)

BACU:

103011300(ANK2)

BMUS:

118895256(ANK2)

LVE:	103087910(ANK2)

OOR:	101270747(ANK2)

DLE:	111186125(ANK2)

PCAD:

102973953(ANK2)

PSIU:

116753868(ANK2)

NASI:

112400107(ANK2)

ECB:	100064198(ANK2)

EPZ:	103549614(ANK2)

EAI:	106844489(ANK2)

MYB:	102251961(ANK2)

MYD:	102767866(ANK2)

MMYO:

118652950(ANK2)

MLF:	102428352(ANK2)

PKL:	118726107(ANK2)

EFUS:

103298153(ANK2)

MNA:	107527852(ANK2)

DRO:	112312513(ANK2)

SHON:

118975476(ANK2)

AJM:	119037681(ANK2)

PDIC:

114502293(ANK2)

PHAS:

123813628(ANK2)

MMF:	118616294(ANK2)

PPAM:

129062667(ANK2)

HAI:	109390281(ANK2)

RFQ:	117037521(ANK2)

PALE:

102880607(ANK2)

PGIG:

120589337(ANK2)

PVP:	105302766(ANK2)

RAY:	107510864(ANK2)

MJV:	108383769(ANK2)

TOD:	119243612(ANK2)

SARA:

101543914(ANK2)

SETR:

126027576(ANK2)

LAV:	104845944(ANK2)

TMU:

101354866

ETF:	101650952(ANK2)

DNM:	101446269(ANK2)

MDO:	100010497(ANK2)

GAS:	123252037(ANK2)

SHR:	100913708(ANK2)

AFZ:

127541843

PCW:	110218591(ANK2)

OAA:	100076099(ANK2)

GGA:	422689(ANK2)

PCOC:

116231257(ANK2)

MGP:	100541509(ANK2)

CJO:	107313591(ANK2)

TPAI:

128080736(ANK2)

LMUT:

125692547(ANK2)

NMEL:

110397587(ANK2)

APLA:

101802101(ANK2)

ACYG:

106038616(ANK2)

CATA:

118247693(ANK2)

AFUL:

116488600(ANK2)

TGU:	751974(ANK2)

LSR:	110471180(ANK2)

SCAN:

103815713(ANK2)

PMOA:

120502781(ANK2)

OTC:	121331977(ANK2)

PRUF:

121349146(ANK2)

GFR:	102038981(ANK2)

FAB:	101805787(ANK2)

OMA:	130252210(ANK2)

PHI:	102111847(ANK2)

PMAJ:

107203148(ANK2)

CCAE:

111928973(ANK2)

CCW:	104696843(ANK2)

CBRC:

103618942(ANK2)

ETL:	114069534(ANK2)

ZAB:	102065704(ANK2)

ACHL:

103797242(ANK2)

SVG:	106858331(ANK2)

MMEA:

130583142(ANK2)

HRT:	120752507(ANK2)

FPG:	101914416(ANK2)

FCH:	102051635(ANK2)

CLV:	102091167(ANK2)

EGZ:

104125256

NNI:	104017515(ANK2)

PCRI:

104027521

PLET:

104616737

EHS:	104505368 104511341(ANK2)

PCAO:

104043998

ACUN:

113479460(ANK2)

TALA:

104358638(ANK2)

PADL:

103913860(ANK2)

AFOR:

103901708(ANK2)

ACHC:

115344042(ANK2)

HALD:

104325881

HLE:	104836797(ANK2)

AGEN:

126044664

GCL:

127015855

CCRI:

104156363

CSTI:

104552971(ANK2)

CMAC:

104480304(ANK2)

MUI:	104545354(ANK2)

BREG:

104632450 104642069

FGA:

104083885

GSTE:

104253263

LDI:	104346896(ANK2)

MNB:	103775936(ANK2)

OHA:	104336725(ANK2)

NNT:

104403480

SHAB:

115605490(ANK2)

DPUB:

104296202(ANK2)

PGUU:

104468080

ACAR:

104532547

CPEA:

104393376(ANK2)

AVIT:

104269922

CVF:	104289265(ANK2)

RTD:	128910678(ANK2)

CUCA:

104063881(ANK2)

TEO:

104372759

BRHI:

104501227

AAM:	106491999(ANK2)

AROW:

112971363(ANK2)

NPD:	112943447(ANK2)

TGT:

104577242

DNE:

112986156

SCAM:

104138025(ANK2)

ASN:

102384966

AMJ:	102562627(ANK2)

CPOO:

109309369(ANK2)

GGN:	109301092(ANK2)

PSS:	102449043(ANK2)

CMY:	102934982(ANK2)

CCAY:

125635278(ANK2)

DCC:	119854294(ANK2)

CPIC:

101939055(ANK2)

TST:	117877998(ANK2)

CABI:

116826979

MRV:	120407120(ANK2)

ACS:	100561446(ank2)

ASAO:

132776904(ANK2)

PVT:

110083900

SUND:

121932038(ANK2)

PBI:

103063352

PMUR:

107286690(ANK2)

CTIG:

120305902(ANK2)

TSR:	106557170(ANK2)

PGUT:

117679958(ANK2)

APRI:

131203453(ANK2)

VKO:	123022993(ANK2)

PMUA:

114604779(ANK2)

PRAF:

128421219(ANK2)

ZVI:	118083948(ANK2)

HCG:	128326876(ANK2)

GJA:	107110252(ANK2)

STOW:

125439754(ANK2)

EMC:	129336493(ANK2)

XLA:	108706710 108710308

XTR:	100494806(ank2)

NPR:	108798234(ANK2)

RTEM:

120917398(ANK2)

BBUF:

120989897(ANK2)

BGAR:

122943537(ANK2)

MUO:	115461189(ANK2)

GSH:	117365370(ANK2)

DRE:	450043(ank2b)

SRX:	107714218 107730105 107732595 107739937 107742502

SANH:

107677060 107692594 107698677 107702307

SGH:	107559840 107561528 107562978 107564962

CCAR:

109057566 109100910 109113206

CAUA:

113044307 113105852 113106323

CGIB:

127961188 127973324

PTET:

122342643(ank2a) 122347997(ank2b)

LROH:

127168297(ank2b) 127169799(ank2a)

OMC:	131543236(ank2a) 131543673(ank2b)

PPRM:

120480122(ank2b) 120481216(ank2a)

RKG:	130071381(ank2a) 130106266(ank2b)

MAMB:

125265884(ank2b) 125272495(ank2a)

CIDE:

127509872

MASI:

127423106 127443394 127445274 127453993

TROS:

130551844(ank2b) 130553668(ank2a)

TDW:	130407426(ank2b) 130410559(ank2a)

MANU:

129444842(ank2a) 129452861(ank2b)

IPU:

108260557

IFU:	128604119(ank2a) 128609899(ank2b)

PHYP:

113525467 113540676(ank2)

SMEO:

124381398 124386866(ank2b)

TFD:	113661786(ank2a)

TVC:	132842040(ank2a)

AMEX:

103023189(ank2) 103030885

CMAO:

118817035(ank2a) 118825714(ank2b)

EEE:	113579296 113587339

CHAR:

105903497(ank2a) 105907238

TRU:	101064954 101079965(ank2)

TFS:	130522373(ank2b) 130526723

TNG:	GSTEN00009460G001

LCO:	104924359 104925009

NCC:	104947246 104958800

TBEN:

117474648 117482683(ank2b)

CGOB:

115015902

PGEO:

117440935 117463326(ank2b)

GACU:

117543398(ank2a)

EMAC:

134864610(ank2a) 134875764(ank2b)

ELY:	117255392(ank2a)

EFO:	125883963 125884056(ank2b) 125886449

PLEP:

121941902 121962375(ank2b)

SLUC:

116040539(ank2a) 116049817(ank2b)

ECRA:

117934606(ank2b) 117935502

ESP:	116669872 116686617

PFLV:

114545696(ank2) 114562638

GAT:	120822395(ank2b) 120825589

PPUG:

119218316(ank2a) 119222761(ank2b)

AFB:	129093132 129095745

CLUM:

117742059 117748171(ank2b)

PSWI:

130211753(ank2b)

MSAM:

119899093 119912135(ank2b)

SCHU:

122869723(ank2b) 122873220

CUD:	121507753(ank2a)

ALAT:

119028664

MZE:	101465317 101467899 101474584 112429916

ONL:	100696152 100710955

OAU:	116325958(ank2a) 116328974

OLA:

101168180

OML:	112155869(ank2b) 112157539(ank2a)

CSAI:

133420537 133423091(ank2a)

XMA:	102236804(ank2) 102237700

XCO:	114143851 114157071(ank2)

XHE:	116720811 116732191(ank2)

PRET:

103469399 103480090(ank2)

PFOR:

103129595 103137806

PLAI:

106938312 106954678

PMEI:

106903446(ank2) 106928655

GAF:	122819996(ank2b) 122828908(ank2a)

CVG:	107085715(ank2) 107103578

CTUL:

119778218

GMU:	124868792(ank2a) 124880681(ank2b)

NFU:	107382168 107384730

KMR:	108244260(ank2b) 108246274(ank2a)

ALIM:

106523891 106531118

NWH:	119407960(ank2b) 119430806(ank2a)

AOCE:

111574644 111580260

MCEP:

125000616(ank2a)

CSEM:

103383733 103385245

POV:	109637638(ank2) 109637821

SSEN:

122770765(ank2a)

HHIP:

117774394(ank2a) 117779155(ank2b)

HSP:	118102237(ank2b) 118115966(ank2a)

SMAU:

118301119(ank2b) 118312392(ank2a)

LCF:	108882077 108896439 108896460

SDU:	111223597(ank2) 111231472

SLAL:

111664528 111667978

XGL:	120797337(ank2b) 120800640(ank2a)

HCQ:	109511025 109522779

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

MALB:

BSPL:

114857232(ank2a) 114870845(ank2b)

SJO:	128365885 128384385(ank2b)

SASA:

106592866 106602086 106608576

STRU:

115189388 115189439 115194125 115198134 115199220

OTW:	112214895 112239785 112260090(ank2b)

OMY:	110500727 110515949 110532981(ank2b)

OGO:	124007949 124014455 124022294

ONE:	115133654 115138192(ank2)

OKI:	109885492 109887481 109896512 109906763

OKE:	118368638 118391878

SALP:

111960393 111980852

SNH:	120030209 120049577

CCLU:

121554286 121564115 121571093

ELS:	105005841 105020772(ank2)

SFM:	108920682 108925875

PKI:	111836783 111850983

AANG:

118227567(ank2a) 118232307

LOC:	102699014(ank2)

PSPA:

121295531 121322510

ARUT:

117408919 117421068

PSEX:

120533089

LCM:	102356224(ANK2)

CMK:	103180900(ank2b)

RTP:

109928744

CPLA:

122553439(ank2b)

HOC:	132816691(ank2b)

LERI:

129700480

PMRN:

116940156 116944339 116951038

LRJ:	133341979 133350739 133354331

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

AJC:

DME:	Dmel_CG1651(Ank) Dmel_CG42734(Ank2)

DER:	6544119 6555876

DSE:	6611183 6620280

DSI:	Dsimw501_GD13038(Dsim_GD13038) Dsimw501_GD27865(Dsim_GD27865)

DYA:	Dyak_GE14529 Dyak_GE20395

DAN:	6506034 6506409

DSR:	110176724 110185477

DPO:	4811801 6900405

DPE:	6602554 6604665

DMN:	108151974 108164421

DWI:	6646463 6651169

DGR:	6559006 6570284

DMO:	Dmoj_GI13078 Dmoj_GI26183

DAZ:	108612836 108617784

DNV:	108651114 115561821 115561896

DHE:	111595148 111597407

DVI:	6622416 6636259

CCAT:

101456405 101463458

BOD:	106619664 106623293

BDR:

105224889

RZE:	108358525 108362798 108371180 108375977

AOQ:	129242383 129251490

TDA:	119677742 119677863 119677950 119680590

MDE:

101900112

SCAC:

106087778 106087780

LCQ:	111676593 111678747

LSQ:	119604770 119606780 119607447

GFS:

119643002

ECOE:

129945116 129946008 129953386

CLON:

129606927 129613778

HIS:	119648082 119648489 119661039

AGA:

1279352

ACOZ:

120947809 120947810 120958814

AARA:

120902280 120908528

AMER:

121587695 121587696 121597658

ASTE:

118506675 118509040

AFUN:

125765755 125765762 125766100

AMOU:

128305144

AALI:

118458822 118459703 118459704

AAG:	5575014 5575021 5578031

AALB:

109414989 109417689 109423438

CQU:	CpipJ_CPIJ010503 CpipJ_CPIJ017439

CPII:

120420934 120422628

CNS:

116351140

BCOO:

119076509 119077204 119085049

AME:	406139 409051

ACER:

107996060 107996073

ALAB:

122719854 122720093

ADR:	102671181 102681644

AFLR:

100871617 100872575

BIM:	100742486 100744281

BBIF:

117204142 117204252

BVK:	117230732 117235660

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:	122529128 122531354 122537953

CCAL:

108626093 108633006

OBB:	114871038 114872202

OLG:	117601383 117601738

MGEN:

117220538 117220855

NMEA:

116427278 116427791

CGIG:

122397779 122401896

SOC:	105201790 105205869

MPHA:

105835668 105837307

AEC:	105148838 105154656

ACEP:

105622489 105625877

PBAR:

105431552 105432220

VEM:	105564684 105565752

HST:	105189045 105190196

DQU:	106743577 106751240

CFO:	105248873 105258172

FEX:	115238234 115239216

LHU:	105672144 105672208

PGC:	109858281 109863641

OBO:	105276369 105277501

PCF:	106785242 106789620

PFUC:

122513481 122526225

VPS:	122633334 122637087

VCRB:

124421930 124431025

VVE:	124951526 124957137

NVI:	100119861 100122475

CSOL:

105364030

TPRE:

106651230 106651724

LHT:	122504792 122509148

LBD:	127278965 127281548

MDL:	103573905 103577032

CGLO:

123268449 123270925

FAS:	105265240 105267930

DAM:	107038477 107044551

AGIF:

CINS:

VCAN:

CCIN:

DSM:	124407472 124410039

NPT:	124216522 124222499

NFB:	124187781 124188124

NLO:	107220941 107221824

NVG:	124310137 124310161

AROA:

105688578 105692132

TCA:	100142605 656174

DPA:	109534489 109536103 125503637

SOY:

115877118

AGRG:

126733491 126736209

ATD:	109601925 109602414

CSET:

123309797 123322683

AGB:	108914242 108915261 108916150

LDC:	111504733 111507952 111507953

NVL:	108558424 108564454

APLN:

108735735 108735913

PPYR:

116180184 116181395

OTU:	111414890 111418996 111426693

BMOR:

101740231 101743161

BMAN:

114239543 114239604 114239624

MSEX:

115440460 115451861

DPL:	KGM_208612 KGM_215446

BANY:

112044040 112058327 112058328

MJU:	123877329 123877372

NIQ:	126777815 126777816

VCD:	124540455 124540582

MCIX:

123666433 123666447 123666449

PMAC:

106715320 106719996

PPOT:

106111357 106111412

PXU:	106123114 106123133

PRAP:

110997549 110998977

PBX:	123714802 123714971

PNAP:

125057046 125057225

ZCE:	119837537 119837550

CCRC:

123703430 123703574

LSIN:

126970074 126979682

AAGE:

121736645 121736712

HAW:	110372625 110382982

HZE:	124642662 124642683

TNL:	113497879 113498071 113498074

SLIU:

111364422 111364468

OFU:	114352322 114353723

PXY:	105381197 105390376

PGW:	126377794 126377796

CFEL:

113376733 113378780

CCRN:

123298970 123299234

API:	100158972 100167995 103308433 115033541

DNX:	107169047 107171088 107173987

AGS:	114128335 114130215 114130217 114131581

RMD:	113558317 113558821 113559008

ACOO:

126841633 126846128 126846130 126846133 126846177

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:	111049354 111064079

HVI:	124359187 124359658

PHU:	Phum_PHUM596790

FOC:

113210314

TPAL:

117645322

ZNE:	110835660 110838043

CSEC:

SGRE:

BROR:

IEL:

FCD:

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:	128689221 128689421

PTRU:

ESN:

HAZT:

EAF:

LSM:

TCF:	131883726 131891703

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

111613455 111626691 111631113

PTEP:

107449053 107453194

ABRU:

129981785 129989335

UDV:	129222607 129226948

SDM:	118191434 118204034

LPOL:

106456833 106457879 106458236 106460829 106463825

PMEO:

129591553

CEL:	CELE_B0350.2(unc-44)

CBR:

CBG_09456

CRQ:	GCK72_013631

NAI:	NECAME_12067

BMY:	BM_BM1770(Bma-unc-44)

TSP:

Tsp_02713

LGI:	LOTGIDRAFT_235987

PVUL:

126811732

PCAN:

112572817

BGT:	106059375 106063623

GAE:

HRF:

HRJ:

CRG:

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:

SMM:	Smp_145700 Smp_154020

SHX:	MS3_00003176(ANK2_4) MS3_00009180(ANK2_13)

OVI:	T265_06030 T265_14770 T265_15306

EGL:	EGR_01004 EGR_01934 EGR_09648

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

Reference

PMID:12571597

Authors

Mohler PJ, Schott JJ, Gramolini AO, Dilly KW, Guatimosim S, duBell WH, Song LS, Haurogne K, Kyndt F, Ali ME, Rogers TB, Lederer WJ, Escande D, Le Marec H, Bennett V

Title

Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death.

Journal

Nature 421:634-9 (2003)
DOI:10.1038/nature01335

Sequence

[hsa:287]

LinkDB

DBGET integrated database retrieval system