KEGG   ORTHOLOGY: K15670
Entry
K15670                      KO                                     
Symbol
rifA
Name
rifamycin polyketide synthase modules 1, 2 and 3 [EC:6.2.1.74]
Pathway
map01051  Biosynthesis of ansamycins
map01052  Type I polyketide structures
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K15670  rifA; rifamycin polyketide synthase modules 1, 2 and 3
   01051 Biosynthesis of ansamycins
    K15670  rifA; rifamycin polyketide synthase modules 1, 2 and 3
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K15670  rifA; rifamycin polyketide synthase modules 1, 2 and 3
Enzymes [BR:ko01000]
 6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.74  3-amino-5-hydroxybenzoate---[acyl-carrier protein] ligase
     K15670  rifA; rifamycin polyketide synthase modules 1, 2 and 3
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Modular type I PKS
   cis-AT PKS
    Rifamycin PKS
     K15670  rifA; rifamycin polyketide synthase modules 1, 2 and 3
Other DBs
COG: COG3321 COG0318 COG1028
Genes
SSOI: I1A49_05870 I1A49_10320
SRW: TUE45_00070(eryA_1)
SLE: cxmA(cxmA)
SPAV: Spa2297_32540
SSPB: CP982_35280
SCYG: S1361_33940(eryA7)
SDD: D9753_04230
STAA: LDH80_10610
AMD: AMED_0617(rifA)
AMN: RAM_03155
AMM: AMES_0615(rifA)
AMZ: B737_0616(rifA)
SAQ: Sare_1246
 » show all
Reference
PMID:20567260
  Authors
Zhao W, Zhong Y, Yuan H, Wang J, Zheng H, Wang Y, Cen X, Xu F, Bai J, Han X, Lu G, Zhu Y, Shao Z, Yan H, Li C, Peng N, Zhang Z, Zhang Y, Lin W, Fan Y, Qin Z, Hu Y, Zhu B, Wang S, Ding X, Zhao GP
  Title
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.
  Journal
Cell Res 20:1096-108 (2010)
DOI:10.1038/cr.2010.87
  Sequence
[amd:AMED_0617]
Reference
PMID:9512878
  Authors
August PR, Tang L, Yoon YJ, Ning S, Muller R, Yu TW, Taylor M, Hoffmann D, Kim CG, Zhang X, Hutchinson CR, Floss HG
  Title
Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699.
  Journal
Chem Biol 5:69-79 (1998)
DOI:10.1016/S1074-5521(98)90141-7
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