Salinispora arenicola: Sare_1246
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Entry
Sare_1246 CDS
T00613
Name
(GenBank) AMP-dependent synthetase and ligase
KO
K15670
rifamycin polyketide synthase modules 1, 2 and 3 [EC:
6.2.1.74
]
Organism
saq
Salinispora arenicola
Pathway
saq01051
Biosynthesis of ansamycins
saq01052
Type I polyketide structures
Brite
KEGG Orthology (KO) [BR:
saq00001
]
09100 Metabolism
09109 Metabolism of terpenoids and polyketides
01052 Type I polyketide structures
Sare_1246
01051 Biosynthesis of ansamycins
Sare_1246
09180 Brite Hierarchies
09181 Protein families: metabolism
01008 Polyketide biosynthesis proteins [BR:
saq01008
]
Sare_1246
Enzymes [BR:
saq01000
]
6. Ligases
6.2 Forming carbon-sulfur bonds
6.2.1 Acid-thiol ligases
6.2.1.74 3-amino-5-hydroxybenzoate---[acyl-carrier protein] ligase
Sare_1246
Polyketide biosynthesis proteins [BR:
saq01008
]
Polyketide synthase (PKS)
Modular type I PKS
cis-AT PKS
Rifamycin PKS
Sare_1246
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
ketoacyl-synt
Acyl_transf_1
Ketoacyl-synt_C
KR
AMP-binding
PP-binding
KAsynt_C_assoc
PKS_DH_N
adh_short
Thiolase_N
AMP-binding_C
PKS_DE
Epimerase
PS-DH
ACP_syn_III
Polysacc_synt_2
GDP_Man_Dehyd
Motif
Other DBs
NCBI-ProteinID:
ABV97151
UniProt:
A8M6C6
LinkDB
All DBs
Position
1395747..1411211
Genome browser
AA seq
5154 aa
AA seq
DB search
MRTDLIKPLPVALQENAARFPGKVAFEDDRRAVTYADLEARTRRLAGHLRGLGVKRGDRV
AIWLRQSVSTVESYLAVVRAGGVGVPLNPDAAQAELEYLLSDSGATAVITDAVQAQRLRP
TPHRALVVTGDVPAGALSYDELAVSEPEQPAGDDLGLDDVAWMFYTSGTTGRPKGVLSTQ
RNCLWSVASCYVPIPGLTDQDRVLWPLPLFHSLSHIACVLSVTVVGATARIMDGSSVQDV
MRALQQEEPTFLAGVPTTYQQLVSAARRHGFTAPSLRIGLAGGAVLGAELRQEFEETFGV
PLVDAYGSTETCGAITINPPDGPRINGSCGLPVPGVGVRIVDPTTGGDLPAGAEGEVWVS
GPNVMVGYHNSPEATAKAMRDGWFRTGDLARRDGAGYLTISGRIKELVIRGGENIHPVEV
EAVLRTVPGVADVAVAGVPHETLGEVPVAYVIPGPDGFDVESLVTRCREQLSAYKVPHQV
HEVASIPRTASGKVQRRLLVEQPGRLTYAAVDHHDTYPSVDEPDAANTATLRDQLADLDE
RAQLALLEDLVRTQTAAVLRQPGPDAVPAGRAFRDQGLTSMAIVELRNRLMSRTGLRLPT
SVVFDHPTPTALAACLRAEVLGITQSVAEPALVADPTEPIAIVGMACRLPGGVADPDDLW
NLVAGEVDAVSEFPGDRGWDLDRLFDPDPDRAGTSYTGQGGFLPEAGLFDAAFFGISPRE
ALAMDPQQRLLLETSWEALERAGIDALSLKGADVGVFAGVFGHGYGVGTDAAELEGFATT
GSAASVASGRISYVFGFEGPAVTVDTACSSSLVAMHLAAQALRQGECSIALAGGATVMAT
PSTFVEFSRQRALAPDGRCKAYAAAADGTGWAEGAGVVVLERLSVARERGHRILAVLRGS
AVNQDGASNGLTAPNGLAQQRVVRRALAAAGLSPSEVDAVEGHGTGTTLGDPIEAQALLA
TYGKDRAPERPLWLGSLKSNIGHAQAAAGVASVIKMVQALRHGILPATLHVDAPTPGVHW
SAGAVQLLTESRDWSRNGRPRRAGVSSFGISGTNAHVILEEAPEEPAADEVSEEPAADDA
PRVGVMPLVVSARSVASLAGQAGRLAAFVEGVGPPMPDLAGALAKNRAVLDERAVVLAGS
GGEAVTGLAALARGEPAVGVVTGRADVEGKVVWVFPGQGTQWVGMGRELLDSSLVFAERI
AECAAALEPWVDWSLVDVLRGDADPGLMDRVDVVQPATFAVMVGLAAVWSSVGVRPDAVV
GHSQGEIAAACVAGALSLADAARVVALRSQAIASVLSGRGGMASVALSEEDAAAQLAPWA
DRVEVAAVNGPSSVVIAGDGPPLDEVLESLAHRAVRVRRVAVDYASHTRQVEDIEGVLAE
SLAGIGAVAPVVPFFSTVGGGWVRGAGEVDGGYWYRNLRGQVRFGAAVAELIGQGYGVFV
EVSAHPVLVQSIVDVVDGVEADVVVGGSLRRDDGGVRRLVTSMAELFVRGVPVDWSGLLP
PVVGWVDLPTYAFDHRHYWLPPVESATDARSLGQVATDHPLLDAVVGSPRSTGFTATSRW
SVRSHPWLADHLVTDTVLVPNAALVEAAIRLGDLAATPVLEDLTVDVPVLLPARDGRDIQ
ALVGEPDETRRRPVEIFSRAAEAPLDAAWTRHAHGTLAPAASRSARPEPGAATEIAVDGA
ALRDADRYGMHPVLLDAAARTVIPDGTLPSRWTGVTLLASGATALRVRPGSTSRWGTGLA
LTDPTGQPVMTIDAVLGTPASPDQAQISGGPPPDTLFRVEWTELPLPVVDRAGAVVPVAT
GEDVAAAAGATPDVLRYEAGTGDPRASVEAALEVLQAWLAEPALAETRLAVVTGDCTELG
AAAVWGLVRSAQSEHPGRIVLADLDDASRSVLPALLRSGEAQLRVRDGVAQVPRLARASL
DLPEERRRLDPDGTVLITGGTGTLGATTARHLVTVHGIRHLVLLSRRGCAPDLQAELTEL
GASVTVAACDTADRAQLEAVLAAVAAEHPLTAVVHVAGVLDDGVLTELTPERVDTVLRPK
LDAALHLHELTRDLDLAAFVLFSSAAGVLGNPGQANYAAANACLDAIARQRHHLGLPAVS
LAWGYWTPVSTMTEHLGAADLSRNRRTGMSGLSAAEGMAILDAALGAADTLVAAKLDVPA
LRRAAAGGDPIPPLLRALAPPPRPTAKATAGPVSLAQRLAGVAEAEATEVVLDLVRRYAA
EVLGHADADAVHPGRTFKDAGFDSLTAVELRNRLATATGLTLSPALVFDYPKPAALAEHL
HARLLGVAPRRQNEPGAPTRTTDEPIAIVAMACRFPAGVHSPEDLWRVVVDGVDAVTEFP
RDRGWDTEGLYHEDPDHPGTTYVRHGAFLDDAAGFDAAFFGISPKEATAMDPQQRLLLET
SWEAFERAAIDPTTLAGQDVGVFVGVNSHDYSVRTHQASDLEGFRLTGSSGSVVSGRVAY
HFGFEGPAITVDTACSSSLVALHMASQALRRGECSMALAGGVMVIGALETFVEFSRQGGL
APDGRCKAFADGADGTGWSEGVGLLLVERLSEARRRGHQVLAVVRGSAVNQDGASNGLTA
PNGPSQQRVIRKALCDAGLGAPDVDAVEAHGTGTVLGDPIEAQALLATYGQDRPAGRPLW
LGSVKSNIGHTQAAAGVAGVTKMVMAIRHGVLPRTLHVDRPSTNVDWASGEVELLTEARD
WPETGRARRAAVSSFGIGGTNAHVIIEAAPDQPMPPNPEPAPEPDGFPAPLPLSARTAAG
LRGQAGRLARHLGDRSTLPLTDTAYALATTRAHLEHRAVVLAADRRQAEADLSAMERGGT
GPTVLSGTPVTGKLAILFTGQGSQWPGMGRELAETFPVFRAAFAAACTAVEQHLEPVRPL
RDVVFAADGELLDQTMYTQAALFALETALFRLVESWGVRPDLLAGHSIGEVTAAHVAGVL
DLGEAAKLVATRGRLMQALPAGGAMVAVQASEADVAPLLARAGGVVCVAAVNGPDSVVLS
GHEDAVLALAGELAGRGCRTRRLPVSHAFHSPLMAPMLDEFRAVVAELSFQPGNLPIAST
LTGLLARDGQFRTPDYWVDQARSPVRFGDAVTALREHGATTFLELGPGGSLAAMALSTLG
APEQACIAALRKDGAEASDLVAAVAGLHVRGVAVDWAELLGRRSAVAGTDLPTYAFQHQR
YWVETEDTATGGAEALGATDARHPLLGTVIEVPDTGGLVLTGRLSPLSPGLLPGSGNRVP
VAVLLELLVRAGSEVGCGSLDQIVVEVPLAVSEHGHTQVRVTVDAPGLDGRRGVTVHGRL
DGGQRGAWTRHVRAVLVPGMPQPSFDLRDLSGPEITLPDELTEQAATFALHPLLLDAALR
VPAGDDHRDVSACASMTVYAQGATALRLRTTPTRDGRHLLELADTAGEPVAAIGPLTLDA
ATADPVEPDSEPLPVPVPLTRRVAARGEAAGGAILGRLAGLAEAEQLRVVTAVVKESIAA
VLGHRESDAFAEGQAFKDLGFDSLSAVRLRNRLRDLTGVSLSSTLVFDHPTPAILAAHLR
DELLGERRELPVATARAALSDEPVAIVAMSTRLPGGVDTPEELWNLVLERRDAVAGFPVD
RGWDLDRLYDPDPASPGTSYTRLGGFLYDAAQFDGTLFGISPREALAMDPQQRLLLETSW
EALERAGIDPLSLKGSDVGVFTGIVHHDYVSRLHRVPDDVQGYLMTGAASSVASGRVSYV
FGFEGPAVTLDTACSSSLVAMHLAAQALRQGECSLALAGGATVMASPDAFLEFSRQRGLS
ADGRCKAYADGADGTGWAEGVGVVLLERLSVARERGHPVLAVLRGSAVNQDGASNGLTAP
NGPSQQRVIRSALAAAGLSPGDVDVVEGHGTGTALGDPIEAQALLATYGQGRDAEHPLWL
GSLKSNIGHTQAAAGVAGVIKMVQAMQHEVLPATLHVETPTTEVDWSAGAVRVLTEPRDW
PRGARVRRAAVSSFGASGTNAHVILEEASVERARSATAEGPAAGVVPLVVSAGSTGALAG
QASRLASFIKGSVEVPLAAVAGALVSGRAMLGKRAVVVAGSGDEALAGLAALARGESSPA
LVTGSVDTPGKVVWVFPGQGWQWVGMGRELLDTSPVFAERIAECAAALEPWVDWSLVDVL
RGEAAAELLERVDVLQPASFAVMVGLAAVWSSVGVRPDAVVGHSQGEIAAACVAGALSLE
DAARVAALRSQAIAVKLSGRGGMASVALPEEDLVVRLTPWAERVEVAAVNSPSSVVISGD
AEALDDALEFLSGQGVRVRRVAVDYASHSRHVDDLRDTLADMLAGLDAQAPAIPFFSTVT
GGWVRDGGVVDGAYWYRNLRDRVGFGPAVADLVEQGHAVFVELSAHPVLVQPVNEVADAV
VVGSLRRDDGGLPRLLASMAELFVRGVAVDWSRVLPARSGWVGLPTYAFDHRHYWLHEAQ
AGTDAADPAEGADSDFWAAVEHANLDSLAELLEMASADQRGALNTVVPVLADWRKKRREL
STAEGLRYHVNWQPLDGEAAGVPGGRWLVVVPSGHGEDTLLAGLGEQGLDLIRLEVGERD
RGRERLAERLSTVLADHELTGVLSLLALDPRAQDPTTVAAPTLALVQALGDSDVTAPLWC
VTRGAVNIGIQDAVTAPAQAALWGLGRAVALERLDRWGGLVDLPASSDARTAQALLGVLN
TTGEDQLAIRRSGSYGRRLVRKPLPEPVTGGRWQPRGTVVVTGGAEGLGRHAAVWLAQAG
VDRLVVTTTAHAPVDGVPELRAELAGLGLHTVVESCADADRDAIAALVAATVPEQPITAV
VHAADVTQTSSVDDTGERDLAEVFATKVDSAVWLDNMFEDIPLDAFVAFSSIAGVWGGGG
QGPSGAANAVLDALIEWRRARGLRATSVGWGALNQIGVGMDEAALAQLRRRGVLPMEPSV
AMAAMVQAVQGNEKFVAVADMDWASFIPAFTSVRPSPLFADLPEAQAALAASQPDTENSD
AAASLAESLRAVTDSEQNRILLRLVRGHASTVLGHGGAEGIGPRQPFQEVGFDSLAAVNL
RNSLHTATGLRLPATLIFDYPTPETLVGYLRAELLREPDDGLPGREDDLRRVLASVPIAR
FKEAGVLEALLGLADVDDDPAVPDEPVPSGANDVELIDALDIAALVQRALGKAS
NT seq
15465 nt
NT seq
+upstream
nt +downstream
nt
gtgcgcaccgatctcatcaagccgctgcccgtcgcacttcaggagaacgcggcccgcttc
cccggcaaggtggccttcgaggacgatcgccgagcggtgacgtatgccgatctcgaggca
cggacgcgccggctcgccgggcatctgagaggcctcggcgtcaaacgcggcgaccgggta
gctatctggctacgtcaatctgtgtcgaccgtggaaagctacctggcggtcgtgcgcgcg
ggtggcgtcggggtgccgctcaaccccgacgccgcgcaggccgagctggagtacctgctg
tccgacagcggcgccacggcggtcatcaccgatgccgtccaggcgcagcggctccggccg
acaccacaccgtgcgctggtggtgacgggtgacgtcccggcgggagcgctgtcgtacgac
gaactcgccgtcagcgagccggagcagccagccggggacgacctcggcctcgacgacgtg
gcctggatgttctacacctcggggacgaccggtcggcccaagggcgtcctgtccacgcag
cgcaactgcctctggtccgtcgcctcgtgctatgtgccgatccccgggctgacggaccag
gatcgggtgctctggccgctcccgctgttccacagcctctcgcacatcgcctgcgtgctg
tccgtcaccgtggtcggcgcgaccgcccggatcatggacggtagttccgtacaagacgtg
atgcgggccctgcagcaggaggagccgacgttcctggccggtgtgcccacgacctaccag
cagttggtgtcggccgccaggaggcacggcttcaccgcaccgagcctgcggatcggcctg
gccggaggagccgttctcggggcggagctgcgccaggagttcgaggagaccttcggggtg
ccgctggtcgacgcctacggcagcaccgagacgtgcggggcgatcaccatcaacccgccg
gacggcccgcggatcaacgggtcctgcggattgcccgtgccgggtgtcggggtccgcatc
gtcgacccgaccaccgggggagacctccccgctggcgctgagggggaggtgtgggtcagc
gggccgaatgtcatggtcggctatcacaacagtccggaggcgaccgccaaagcgatgcga
gacggctggttccgcacgggcgacctggcccgccgtgacggcgccggctacctcaccatc
agcggccggatcaaggagctggtgatccgcggtggggagaacatccaccccgtcgaggtg
gaagcggtgctgcggaccgtcccaggtgtcgccgacgtcgcggtggctggcgtgccgcac
gagaccctcggcgaggtgccggtcgcgtacgtgatccccggcccggatgggttcgacgtc
gagtccctggtgacccgctgccgcgagcagctctccgcctacaaggtgccgcaccaggtc
cacgaggtcgcgagcatcccccggaccgcctcgggcaaggttcagcggcggctcttggtg
gagcaacccggccggttgacgtacgcggcagtcgatcatcacgacacgtatccgagcgtg
gacgagcctgacgccgccaacacggcaacgctgcgcgaccaactcgctgatttggacgag
cgcgcgcagctggcactgctggaggacctggtccgaacgcagaccgcggcggtgctgcgc
caaccggggcccgacgcggttccggccggccgggcgttccgtgatcagggtctcacctcg
atggccatcgtcgaactgcgcaatcggctgatgtcgcgcaccgggctgcggctgccgacc
agcgtcgtcttcgaccaccccaccccgacggcgttggccgcctgtctccgggccgaggtg
ctgggaatcacccagtccgtcgccgagccggccctggtggccgaccccacggaaccgatc
gccatcgtggggatggcctgccggctccccggtggcgtggcagatccggacgatctgtgg
aacctggtggccggcgaagtcgacgccgtctccgagtttcccggcgaccggggctgggac
ctcgaccgcctgttcgatcccgaccccgaccgcgccggcacctcgtacacgggtcagggc
gggttcctgcccgaggcggggctgttcgacgcggcattcttcgggatctcgccgcgtgag
gcactggccatggatccgcaacagcgactgctgctggaaacctcgtgggaggcgctggag
cgggcgggcatcgacgccctgtcgctgaagggcgcggacgtcggcgtgttcgccggtgtt
ttcggccacggctacggagtcggcaccgacgcggcggagctggaaggattcgcgaccacc
gggtcggccgccagcgtggcatcgggccggatctcctacgtgttcggcttcgaggggccg
gcggtcaccgtggacacggcctgttcgtcgtcactggtggcgatgcacctcgccgcgcag
gcgctgcggcagggcgaatgctccatcgcgctggccggcggtgcgaccgtgatggccacg
cccagtaccttcgtggagttctcccgccagcgagcgctggcacccgacgggcggtgcaag
gcgtacgcggccgccgccgacggcaccggttgggccgagggcgcgggtgtggtcgtactg
gagcggctgtcggtggcccgcgagcgcgggcaccgaattctggccgtgctgcggggcagc
gcggtgaaccaggacggcgcgtcgaacggtctgacggcgccgaacgggctggcgcagcag
cgggtcgtccggcgggctctcgccgccgccggcctctccccatccgaggtggacgccgtc
gaggggcacggtaccgggaccaccctgggtgatccgatcgaggcgcaggcgttgctggcg
acctacggcaaggaccgtgccccagagcgtccgctgtggttgggctcgctgaagtcgaac
atcgggcatgcgcaggctgccgcaggtgtcgccagcgtgatcaaaatggtgcaggcgttg
cggcacgggatcctgccggcgacgctgcacgtcgacgcgcccactcccggcgtgcactgg
tcggcgggtgccgtgcagctgttgacggagtcgcgtgactggtcgcgcaacggtcgtccg
cgccgggccggggtgtcgtcgttcggaatcagcggaacgaatgcccacgtgatcctcgag
gaggcgcccgaggaaccagcagccgacgaggtgtccgaggaaccagcagccgacgacgcg
ccccgggtgggcgtgatgccgctggtcgtgtcggcgcggagtgtggcgtcgctggccggc
caggcaggtcggctggccgcgttcgtggaaggcgttgggccgccgatgcccgatctggcc
ggcgcgttggcgaagaaccgggcggtgttggacgagcgagccgtcgtgctggccggctcc
ggcggcgaggcggtgaccggcctggctgccctggcccgcggtgaacccgcggtcggtgtc
gtgaccggccgcgccgacgtcgagggcaaggtggtgtgggtgttcccggggcaggggaca
cagtgggtcgggatgggccgggaactgttggactcgtccctggtgttcgccgagcggatc
gccgagtgcgccgccgcgttggagccgtgggtcgactggtccctggtggacgtgttgcgc
ggtgacgccgatcccgggttgatggaccgggtcgacgtggtgcagccggcgacgttcgcg
gtcatggtgggtctcgcggcggtgtggtcgtcggtgggggtgcggccggacgcggtcgtg
ggccactcgcagggtgagatcgcggccgcctgcgtggcaggtgcgctgtccctcgcggat
gcggcgcgggtggtggcgttgcgcagtcaggctatcgcctcggtgctgtcaggccgtggt
ggtatggcttccgtcgcgttgagcgaggaagacgcggcggcgcaactggcgccctgggcg
gaccgcgtggaggtcgccgcagtcaacgggccctcctcggtggtgatcgccggtgacggc
ccgccgttggacgaggtgctcgagtcactggcgcaccgggctgtccgggtgcggcgggtg
gcggtggattacgcctcgcatacgcgtcaggtggaggacatcgagggtgtgttggctgag
tcgttggctgggattggtgcggtggcgccggtggtgccgttcttttccacggtcggtggt
gggtgggttcggggggctggggaggttgatggtgggtattggtatcgcaatttgcgtggt
caggtgcggtttggtgcggctgttgcggagctgattggtcaggggtacggggtgtttgtg
gaggtgagtgcgcacccggttttggttcagtcgattgtggatgttgttgatggtgttgag
gctgatgtggtggtggggggtagcctgcggcgcgacgacggtggtgtgcggcggcttgtg
acgtcgatggctgagctgtttgtccgtggggtgccggtggattggagtggtctgctgccg
ccggtcgtcggctgggtggatctgccgacgtatgccttcgaccaccggcactactggcta
ccgccggtggaatcggcgaccgacgcgaggtcgctgggacaggtggcgactgaccacccg
ttgctggatgcggtcgtcggctccccgcggtcgaccggattcacggctacctcgagatgg
tcggtgcggtcgcacccctggctcgccgaccacctggtgacagacaccgtcctggtgccg
aacgcggccctcgtggaggccgccatccggctcggcgatctggccgccacccccgtcctc
gaggacctgaccgtcgacgttcccgtgctgctgccggcacgggacggccgcgacatccaa
gccctcgtcggtgagcccgacgagacacggcgacggcccgtggagatcttctcccgggcg
gcggaagccccgctggacgccgcgtggacgcgccacgcacacggcacactggcccctgcc
gcatcccggtcggcccgcccggagcccggggccgccaccgagatcgccgtggacggcgcc
gcacttcgggacgccgaccggtatgggatgcaccccgtcctgctcgacgcggccgcccgc
accgtcatcccggacggcacgctgccgtccaggtggaccggggtgaccctgttggcctcc
ggcgccaccgcactgcgagtgcgaccgggctcgacctcgcggtgggggaccggtctggcc
ttgaccgaccccaccggacaacccgtcatgaccatcgacgcggtcctcggtacgcccgcc
tcccccgatcaggcgcagatctccggcggtccgccacccgacaccctgttccgtgtcgag
tggaccgaactgccgctgccggtcgtggatcgggcgggcgccgtcgtgcccgtcgcgacc
ggcgaggacgtcgccgcggcggccggggcgacgccggacgtcctgcggtacgaagccggc
accggagacccccgcgcgtcggtcgaggccgccctggaggttctccaggcatggcttgcc
gaaccggccctggcggagacccggctagccgtcgtcactggcgactgcaccgaactcggc
gcagccgcggtgtgggggttggtgcgctcggcgcagtcggagcacccgggtcggatcgtg
ttggccgacctcgacgacgcgtcccggtccgtgctgcctgcgctgctgcgcagcggcgag
gcccaactgagggtgcgcgacggcgtcgcgcaggtgccccgcctggcccgcgcctcgctt
gaccttccggaggagcgacgccggctcgaccccgacggcaccgtactgatcaccggcggt
acgggaacgctgggtgccacgacggcccggcatctggtcaccgtgcacggcatccggcac
ctggtcctgctcagccggcgcggctgtgccccggacctgcaggccgagttgaccgagctg
ggggcctctgtcaccgtggccgcctgcgacaccgcggaccgggcccaactcgaggccgtg
ctggccgccgtcgcggccgagcatccgctcaccgccgtggtgcacgtggccggtgtcctc
gatgacggagtgctcaccgagctgaccccggaacgcgtcgacacggtgttgcggccgaag
ctggatgcggcactgcatctgcacgagctcacccgggatctggacctcgccgcgttcgtg
ttgttctcctccgcggccggtgtgctgggcaaccctgggcaggcgaactacgcggcggcc
aacgcctgcctggacgcgatcgcgcgtcagcgtcaccacctcggccttcccgcggtgtcc
ctggcctggggctactggacgccggtcagcaccatgaccgagcacctgggagccgcggac
ctgagccgcaacaggcgaacgggcatgagtggcctgtccgccgccgagggaatggccatt
ctggacgccgccctcggcgccgccgacacgttggtcgcggcgaagctggacgttcccgcc
ctgcgcagggcagcggcgggtggtgatccgatcccgccgctgctgcgtgctctggcgcca
ccgccacgaccgacagccaaggccacggccggtcccgtctcgctcgcccaacgcctcgcc
ggtgttgccgaggccgaggccaccgaggtcgtgctcgacctggtgcgcaggtacgccgcc
gaggtgctcgggcacgccgacgccgacgccgtccaccccggccggaccttcaaggacgcc
ggcttcgactcgctgacggcggtggaactacgaaaccggttggccaccgcgaccggcctc
accctgtccccggcgctggtcttcgactacccgaaacccgcggcgctggccgagcacctg
cacgccaggctgctcggtgtggcgccgcgccgtcagaacgaacccggtgcccccaccagg
acgaccgacgagcccatcgcgatcgtcgcgatggcctgccgtttcccggcgggtgtgcac
agtccggaggacctgtggcgggtggtggtcgacggggtcgacgcggtcaccgagttcccc
cgggaccgtggttgggacaccgaggggctctaccacgaagaccccgaccacccgggcacc
acgtacgtgcggcacggcgccttcctcgacgacgccgccggattcgacgccgccttcttc
ggtatctcgccgaaggaggcgacggcgatggatccgcagcagcggctgctgctggagacc
tcgtgggaggcgttcgaacgcgccgcgatcgacccgaccaccctggccggtcaggacgtc
ggcgtcttcgtcggcgtcaacagccacgactacagcgtgcgcacgcaccaggcgtcggac
ctcgagggtttccggctcaccggaagttcgggcagcgtcgtctccggtcgcgtcgcctac
cactttggcttcgagggccccgccatcacggtcgacaccgcctgctcctcatcgctggtg
gcgctgcacatggcgagccaggcgctgcgccgcggcgagtgcagcatggcgctggccggg
ggcgtgatggtgataggcgccctcgaaaccttcgtggagttctcccggcagggcgggctg
gccccggatggccggtgcaaggcgttcgcggacggcgcggacggcaccggctggtccgag
ggcgtgggactgctgttggtggagcggctgtccgaggcccgccgccgaggccaccaggtg
ttggcggtggtgcgcggatcggcggtgaaccaggacggcgcgtcgaacggtctcaccgcc
ccgaacgggccgtcgcagcagcgggtgatccgcaaggcactgtgcgacgccggcctgggc
gccccggacgtggacgcggtcgaggcacacggaacgggaaccgtactcggtgacccgatc
gaggcccaggcgctgctcgcgacctacggacaggaccgccccgccggccgaccgctgtgg
ctcggatcggtcaagtcgaacatcgggcacacccaggcagcagcgggcgtcgcgggcgtc
accaagatggtgatggccatccggcatggtgtccttccgcggaccctgcacgtcgatcgc
ccgtccaccaacgtggactgggcgtcgggcgaggtggaactgctgaccgaggcacgcgac
tggccggagaccggccgggcccgccgggctgcggtgtcgtccttcggcatcggcggcacc
aacgcgcacgtcatcatcgaggccgcccccgaccagccgatgccccccaacccggagccg
gccccggagcccgacggtttcccggcaccgctcccgttgtcggcgcggacggctgccggg
ctgcgtggccaggcgggccgactcgcccggcacctcggcgaccggtccacgctgcccctc
accgacaccgcctacgccctcgccaccacccgtgcccacctcgagcaccgggcggtcgta
ctcgccgccgaccggcggcaggccgaggccgacctcagcgccatggagcgcggcgggacc
ggtcccacggtcctgtccggtaccccggtcaccggcaagctggccattctcttcaccggt
cagggcagtcagtggccgggcatgggacgcgagctcgccgaaacgttcccggtcttccgc
gccgcgttcgccgccgcctgcaccgccgtcgaacaacacctggaaccggtgcgcccgctg
cgcgacgtggtgttcgcggcggacggtgaactgctcgaccagaccatgtacacgcaggcc
gccctgttcgccctggagaccgcgctgttccggctcgtcgagtcctggggagtgcgaccc
gacctcctcgccggtcactcgatcggggaggtcaccgccgctcacgtcgccggggtgttg
gacctgggggaggcggccaagctggtcgccacgcgcggccggctgatgcaggccctgccc
gccggcggcgcgatggtcgccgttcaggcgagcgaggccgacgtcgcgcccctgctcgcc
cgagctggcggcgtggtctgtgtcgcggcggtgaacggccccgactcggtggtgctctcg
ggccacgaggacgcggtgctcgccctggcgggcgagctggccggtcggggctgtaggacg
cgtcgactaccggtcagccacgccttccactcaccgctgatggcacccatgctggacgag
ttccgggccgtcgtggcggagctgtcgttccagccgggtaaccttcccatcgcctccacg
ctcaccggtctcctcgcccgggacgggcagttccgcacgccggactactgggtcgaccag
gcacgcagcccggtccgattcggcgacgccgtcaccgcgttgcgtgagcacggcgcgacg
accttcctggagctgggaccgggcggctccctcgccgcgatggcgctcagcacgctcggc
gcgccggaacaggcgtgcatcgcagccctgcgcaaggacggcgcggaggccagcgacctc
gtggctgcggtcgcggggctgcacgtgcgtggggtggccgtcgactgggcggagctgctc
ggccggcggtccgccgtggccggcaccgacctgcccacctacgccttccagcaccagcgg
tactgggtcgagaccgaggacaccgcgacgggcggcgccgaggccctcggcgccaccgac
gcccggcacccgctactcggcactgtgatcgaggtgccggacaccggcggcctcgtgctg
accggccgcctgtccccgctgagccccggcctgcttcccggcagtggcaaccgggttccg
gtggccgtgctcctcgaacttctggtccgggcgggcagcgaggtcggatgcggcagcctc
gaccagatcgttgtcgaggtgccgctggcggtgtcggagcacggacacacccaggtgcgg
gtgaccgtggatgctcccggcctggacggacgtcgcggcgtcaccgtccatggcaggctc
gacggtggccagcgtggagcatggacccgccatgttcgcgcggtgctggtccccggcatg
ccgcagccgagcttcgacctccgggacctgtcggggcccgagatcaccctgccggacgag
ctgaccgagcaggctgccacgttcgccctccacccgctgctcctcgacgccgcgctgcgc
gtcccggccggcgacgaccaccgggacgtgtccgcctgcgccagcatgacggtgtacgcg
caaggggcgaccgccctacgcctgcggacgacgccgacgcgggacggccggcacctgctg
gagctggcggacaccgcgggggaaccggtcgccgccatcggcccgctgaccctcgacgcc
gccaccgccgacccggtggagcccgacagcgagccgctgccggtgccggtgccgctcacc
cgccgcgtggccgcgcggggtgaggcggcgggcggggcgatcctgggccggttggcgggt
ctggccgaggctgagcagcttcgggtcgtgacggccgtggtcaaggagagcatcgccgcc
gtcctcggtcatcgcgagtcggacgcgttcgccgagggacaggccttcaaggatcttgga
ttcgattcgctgagcgcggtcagactgcgaaaccggctgcgggacctcaccggtgtgagc
ctgtccagcaccctggtcttcgaccatcccacacctgccatcctcgccgcccatctgcgc
gacgaactactcggcgagcgccgtgagctgcccgttgccactgctcgggccgcgctgtcc
gacgaacccgtcgcgatcgtcgcgatgagcacccggctgcccggcggcgtggacacaccc
gaggagctgtggaacctggtgctggagcgccgggacgcggtcgccggcttcccggtcgac
cggggctgggacctcgaccggctgtacgatcctgaccccgccagcccgggcacgagctac
acccgcctgggcgggttcctgtatgacgccgcgcagttcgacggcacgctgttcgggatc
tcgccgcgcgaggcgctggcgatggacccacagcagcggttgctgctggagacgtcctgg
gaggcgttggaacgggcgggcatcgacccactgtcgctcaagggcagtgacgtcggcgtc
ttcaccggcatcgtccaccacgactatgtgagccggttgcaccgggtacccgacgatgtc
cagggctacctcatgaccggcgccgcctccagcgtggcgtccggccgggtgtcctacgtg
ttcggcttcgagggcccggcggtgacgctggacacggcgtgctcgtcctcgctggtggcg
atgcacctcgccgcgcaggcgttgcgacagggcgagtgttcgctcgcgctggcgggcggc
gcgaccgtgatggccagtccggacgcgttcctggagttctcccggcagcggggcctgtcc
gccgacggccgctgtaaggcctacgcggacggcgcggacggtacgggatgggccgagggc
gtcggtgtcgtactgctggagcggttgtccgtggcacgggagcgtgggcacccggtcctg
gccgtgctgcggggcagcgcggtgaaccaggacggggcgtcgaacggtctgacggccccg
aacggtccgtcgcagcagcgggtgatccgcagcgcgttggcggctgccggcctgtcgccg
ggtgacgtggacgtcgtggaggggcatgggaccgggacggcgttgggcgacccgatcgag
gcacaggccctgctggccacgtacgggcagggccgggatgccgagcatccgctgtggttg
gggtcgttgaagtcgaacatcgggcacacccaggcagccgcgggggtggctggtgtgatc
aagatggtgcaggcgatgcaacacgaggtgctgccggcgacgctgcacgtggagacgccc
accaccgaggtcgactggtcggctggggcggtccgggtgctgaccgagccgcgtgactgg
ccccgcggcgctcgtgtccgccgggccgccgtgtcctccttcggcgcgagcgggacgaac
gcgcacgtgatcctggaggaagcgtccgtcgagcgggcccggtccgccacggcggagggc
cccgcggccggtgtggtgccgctggtggtgtcggccgggagcaccggtgcgctggccggg
caggccagccggctggcgtccttcatcaagggctccgtcgaggtgccgctcgccgcggtg
gccggcgcgctggtgtcgggccgggcgatgctcggcaagcgggccgtcgtggtggctggc
tccggtgacgaggcactggccggcctggcagcgttggcgcgcggcgagagcagtcccgcc
ctggtgaccggcagtgtggacacgccgggaaaggtcgtctgggtgttcccgggccagggc
tggcagtgggtcggcatgggccgggagttgttggacacgtcgccggtcttcgccgagcgg
atcgccgagtgcgccgccgcgctggagccctgggtcgactggtccctggtggacgtgctg
cgcggtgaggcggccgccgagctgctggagcgggtcgacgtgctgcagccggcgagcttc
gccgtgatggtgggtctggccgcggtgtggtcgtcggtgggggtgcggccggacgccgtg
gtcggtcattcacagggtgagatcgcggccgcgtgtgtggccggtgcgctgtccctcgag
gatgccgcccgggtggcggcgctacgcagccaggccatcgccgtgaagctgtccggccgc
ggtggcatggcgtcggtcgccctgcccgaggaggacctggtcgtgcggttgacgccctgg
gcggagcgggtcgaggtggccgcggtcaacagcccctcctccgtggtcatctcgggcgac
gccgaggcgctggacgacgccctggagttcctgtccggtcagggggtgcgggtgcggcgg
gtggctgtcgactacgcctcccacagccgccatgtggacgacctccgggacaccctcgcc
gacatgctggccgggctcgacgcacaggcaccggccattccgttcttctcgaccgtcacc
ggcggctgggtccgggacggcggagtcgtcgacggtgcctactggtaccggaatctgcgg
gatcgggtcggcttcggcccggcggtggcggacctggtcgagcagggccacgccgtgttc
gtggaactcagcgcgcacccggtgctggtgcaaccggtcaacgaggtcgccgacgcggtg
gtggtcgggtcgctgcggcgcgacgacggcggcctgccgcggctgctggcctcgatggcc
gaactcttcgtacgcggggtggcggtggactggtcccgggtgctcccggcccggtccggc
tgggtgggcctgccgacctacgccttcgaccaccggcactactggctgcacgaggctcag
gcgggtaccgacgcggccgacccggccgagggcgccgactccgatttctgggccgcggtc
gagcacgcgaacctggactccctcgccgaactgctggagatggcctcagccgaccagcgc
ggcgctctgaacaccgtcgtgccggtactggcggactggcggaagaagcgccgcgagctg
tcaaccgcggaggggctgcgctaccacgtcaactggcaaccgctcgacggcgaagccgcc
ggcgtgcccggcggccggtggctcgtcgtcgtgccgtcggggcacggtgaggacacgctt
ctcgccgggctgggcgagcaggggctggacctgatccgactggaggtcggcgagcgggac
cgtggccgggaacgtctcgccgaacgactgagcaccgtcctcgccgaccacgagctgacc
ggggtgctgtccctgctcgccctcgacccccgggcgcaggacccgacaaccgtcgcggcg
ccgacgctcgcactcgtgcaggcgctgggcgacagcgacgtcaccgcaccactgtggtgt
gtgaccaggggcgcggtgaacatcggcatccaggacgcggtgaccgcaccggctcaggcc
gcgctctggggtcttggccgtgccgttgccctggagcggctcgatcgctggggtggtctg
gtcgatctgcccgcgtcgagcgacgcgcgtacggcgcaggccctgctcggggtgctgaac
accaccggtgaggatcagctcgcgatccggcggtcgggcagctacggcaggcggctggtc
cgtaagccgctgccggagcccgtgaccggcggacgctggcagccccggggcacggtcgtg
gtgaccggcggagccgaggggctcggcaggcatgccgcggtctggctcgcgcaggccggc
gtggaccggctcgtggtcaccaccaccgcccacgcgcccgtggacggcgtgccggagctt
cgcgccgaactggccgggctcggtctgcacacggtggtggagtcctgcgccgatgccgac
cgggacgcgatcgccgcgctggtggccgcgaccgtaccggaacaaccgatcacggccgtg
gtgcacgccgccgacgtcacgcagaccagttccgtcgacgacaccggtgagcgcgacctc
gccgaggtgttcgccacgaaggtggacagcgcggtgtggctcgacaacatgttcgaggac
atcccacttgatgcctttgtcgcgttctcctcgatcgccggtgtctggggtggtggcggc
cagggcccgtccggtgcggcgaacgcggtgctcgacgccctcatcgagtggcgtcgggcc
aggggcctgcgggcgacgtccgtcgggtggggggcgttgaaccagatcggcgtgggcatg
gacgaggccgcgctcgcccaactccgtcgccgtggtgtgctgccgatggagccctcggtg
gcgatggccgcgatggtccaggccgtccagggcaacgagaagttcgtggcggtcgcagac
atggactgggcttccttcatcccggccttcacctccgtccgtcccagtccgctgttcgcg
gacctgcccgaggcccaggcggctctggcagcgtcgcagcccgacaccgagaacagcgac
gccgccgcgtccctcgcggagtccctgcgcgcagtgacggacagtgagcagaaccggatt
ctgctccgactggtccgcgggcacgcctcgacggtcctcggccacggcggggcggagggc
atcggcccacgacagccgttccaggaggtcggcttcgactcgctggccgccgtcaatctc
cgcaacagtttgcataccgccaccgggctgcgccttcccgcgacgttgatcttcgactac
cccaccccggagacgctggtcggctacctgcgtgccgagcttctccgggagcccgacgac
ggcctaccggggcgggaggacgacctgcggcgggtcctcgcgtccgtgccgatcgcccgg
ttcaaggaggcgggcgtgttggaagccctgctgggtctggccgacgtggacgacgacccg
gccgtgccggacgaaccagtgcccagcggggcgaacgacgtggaactgatcgacgcactg
gacatcgccgccctcgtccagcgagcgctgggcaaggcgagctga
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