KEGG ORTHOLOGY: K16743

ORTHOLOGY: K16743

Entry

K16743                      KO

Symbol

ASPM, ASP

Name

abnormal spindle-like microcephaly-associated protein

Disease

H00269

Primary microcephaly

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K16743  ASPM, ASP; abnormal spindle-like microcephaly-associated protein
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Centrosome formation proteins
   Other centriole associated proteins
    K16743  ASPM, ASP; abnormal spindle-like microcephaly-associated protein

Genes

HSA:	259266(ASPM)

PTR:	449566(ASPM)

PPS:	100995785(ASPM)

GGO:	101132110(ASPM)

PON:	100452771(ASPM)

NLE:	100600942(ASPM)

HMH:	116457496(ASPM)

MCC:	711153(ASPM)

MCF:	102137528(ASPM)

MTHB:

126949710

MNI:	105484656(ASPM)

CSAB:

103230377(ASPM)

CATY:

105574869(ASPM)

PANU:

101009256(ASPM)

TGE:	112607189(ASPM)

MLEU:

105550721(ASPM)

RRO:	104658407(ASPM)

RBB:	108523858(ASPM)

TFN:	117074967(ASPM)

PTEH:

111536906(ASPM)

CANG:

105518573(ASPM)

CJC:	100414728(ASPM)

CIMI:

108287556(ASPM)

CSYR:

103273717(ASPM)

MMUR:

105860024(ASPM)

LCAT:

123627002(ASPM)

PCOQ:

105815311(ASPM)

OGA:	100946627(ASPM)

MMU:	12316(Aspm)

MCAL:

110298694(Aspm)

MPAH:

110321400(Aspm)

RNO:	289054(Aspm)

MCOC:

116100410(Aspm)

ANU:	117716172(Aspm)

MUN:	110540306(Aspm)

CGE:	100764564(Aspm)

MAUA:

101830335(Aspm)

PROB:

127221290(Aspm)

PLEU:

114707208(Aspm)

MORG:

121446358(Aspm)

MFOT:

126507353

AAMP:

119827455(Aspm)

NGI:	103732856(Aspm)

HGL:	101714580(Aspm)

CPOC:

100713679(Aspm)

CCAN:

109693059(Aspm)

DORD:

105986402(Aspm)

DSP:	122126741(Aspm)

PLOP:

125360232(Aspm)

NCAR:

124962439

MMMA:

107140635(Aspm)

OCU:

100346224

OPI:	101517789(ASPM)

TUP:	102476509(ASPM)

GVR:	103604175(ASPM)

CFA:	480009(ASPM)

CLUD:

112648294(ASPM)

VVP:	112911000(ASPM)

VLG:	121484409(ASPM)

NPO:	129505815(ASPM)

AML:	100484684(ASPM)

UMR:	103657757(ASPM)

UAH:	113242590(ASPM)

UAR:	123785782(ASPM)

ELK:

111151090

LLV:

125085524

MPUF:

101674606(ASPM)

MNP:	132025576(ASPM)

MLK:	131814799(ASPM)

NVS:	122918748(ASPM)

ORO:	101368404(ASPM)

EJU:	114222009(ASPM)

ZCA:	113933440(ASPM)

MLX:	118014246(ASPM)

NSU:	110573879(ASPM)

LWW:	102745763(ASPM)

FCA:	493695(ASPM)

PYU:	121022427(ASPM)

PCOO:

112857944(ASPM)

PBG:	122476437(ASPM)

PVIV:

125155398(ASPM)

LRUF:

124510052

PTG:	102960783(ASPM)

PPAD:

109255672(ASPM)

PUC:

125925359

AJU:

106981769

HHV:	120245596(ASPM)

BTA:	534849(ASPM)

BOM:	102268705(ASPM)

BIU:	109570753(ASPM)

BBUB:

102396607(ASPM)

BBIS:

104981849(ASPM)

CHX:	102170625(ASPM)

OAS:	443284(ASPM)

BTAX:

128061694(ASPM)

ODA:	120880387(ASPM)

CCAD:

122452037(ASPM)

MBEZ:

129551218(ASPM)

SSC:	100520688(ASPM)

CFR:	102508072(ASPM)

CBAI:

105070039(ASPM)

CDK:	105090837(ASPM)

VPC:	102532138(ASPM)

BACU:

102997824(ASPM)

BMUS:

118882013(ASPM)

LVE:	103084524(ASPM)

OOR:

101270759

DLE:	111177440(ASPM)

PCAD:

102992644(ASPM)

PSIU:

116764264

NASI:

112412381

ECB:	100060893(ASPM)

EPZ:	103554609(ASPM)

EAI:	106823393(ASPM)

MYB:	102252092(ASPM)

MYD:	102756991(ASPM)

MMYO:

118678725(ASPM)

MLF:	102417473(ASPM)

PKL:	118710311(ASPM)

EFUS:

103303891(ASPM)

MNA:	107540234(ASPM)

DRO:	112318789(ASPM)

SHON:

119003948(ASPM)

AJM:	119053390(ASPM)

PDIC:

114512479(ASPM)

PHAS:

123804479(ASPM)

MMF:	118640766(ASPM)

PPAM:

129072872(ASPM)

HAI:	109380434(ASPM)

RFQ:	117018608(ASPM)

PALE:

102878272(ASPM)

PGIG:

120619314(ASPM)

PVP:	105296926(ASPM)

RAY:	107520852(ASPM)

TOD:	119234843(ASPM)

SARA:

101539157(ASPM)

SETR:

126004329(ASPM)

LAV:	100666737(ASPM)

TMU:

101351671

ETF:	101652684(ASPM)

DNM:	101426109(ASPM)

MDO:	100026570(ASPM)

GAS:	123244370(ASPM)

SHR:	100914049(ASPM)

AFZ:

127562763

PCW:	110197686(ASPM)

OAA:	100074627(ASPM)

GGA:	424354(ASPM)

PCOC:

116230552(ASPM)

MGP:	100542021(ASPM)

CJO:	107317094(ASPM)

TPAI:

128072468(ASPM)

LMUT:

125693646(ASPM)

NMEL:

110402266(ASPM)

APLA:

101800003(ASPM)

ACYG:

106041984(ASPM)

CATA:

118243317(ASPM)

AFUL:

116491930(ASPM)

TGU:	100232605(ASPM)

LSR:	110467823(ASPM)

SCAN:

103815118(ASPM)

PMOA:

120510501(ASPM)

OTC:	121344605(ASPM)

PRUF:

121360096(ASPM)

GFR:	102042739(ASPM)

FAB:	101806690(ASPM)

OMA:	130256501(ASPM)

PHI:	102104450(ASPM)

PMAJ:

107208348(ASPM)

CCAE:

111932547(ASPM)

CCW:	104695586(ASPM)

CBRC:

103612751(ASPM)

ETL:	114055842(ASPM)

ZAB:	102075178(ASPM)

ACHL:

103802018(ASPM)

SVG:	106857303(ASPM)

MMEA:

130572517(ASPM)

HRT:	120756790(ASPM)

FPG:	101920902(ASPM)

FCH:	102050404(ASPM)

CLV:	102095740(ASPM)

EGZ:

104133980

NNI:	104020945(ASPM)

PCRI:

104029703(ASPM)

PLET:

104621167(ASPM)

EHS:	104513265(ASPM)

PCAO:

104051324(ASPM)

ACUN:

113482880(ASPM)

TALA:

104367923(ASPM)

PADL:

103918769(ASPM)

AFOR:

103902195(ASPM)

ACHC:

115349336(ASPM)

HALD:

104322974(ASPM)

HLE:	104829286(ASPM)

AGEN:

126041670

GCL:

127018973

CCRI:

104163644(ASPM)

CMAC:

104475612(ASPM)

BREG:

104641805(ASPM)

FGA:	104082655(ASPM)

GSTE:

104257015(ASPM)

LDI:

104342244

MNB:	103770085(ASPM)

OHA:	104329717(ASPM)

NNT:	104405121(ASPM)

SHAB:

115611908(ASPM)

DPUB:

104303679(ASPM)

PGUU:

104470201(ASPM)

ACAR:

104529966(ASPM)

CPEA:

104390743(ASPM)

CVF:	104286355(ASPM)

RTD:	128913994(ASPM)

CUCA:

104054760(ASPM)

TEO:	104375240(ASPM)

BRHI:

104493113

AAM:	106499451(ASPM)

AROW:

112962166 112976523(ASPM)

NPD:	112951147(ASPM)

TGT:	104577223(ASPM)

DNE:	112994292(ASPM)

SCAM:

104140839(ASPM)

ASN:	102387151(ASPM)

AMJ:	102567603(ASPM)

CPOO:

109306942(ASPM)

GGN:	109305361(ASPM)

PSS:	102461663(ASPM)

CMY:	102944222(ASPM)

CCAY:

125641514(ASPM)

DCC:	119860309(ASPM)

CPIC:

101940131(ASPM)

TST:	117881856(ASPM)

CABI:

116819287(ASPM)

MRV:	120369990(ASPM) 120394980

ACS:	100565657(aspm)

ASAO:

132774435(ASPM)

PVT:	110070961(ASPM)

SUND:

121929500(ASPM)

PBI:

103059145

PMUR:

107292521(ASPM)

CTIG:

120313365(ASPM)

TSR:	106540560(ASPM)

PGUT:

117677312(ASPM)

APRI:

131194502(ASPM)

PTEX:

113436185(ASPM)

NSS:	113414729(ASPM)

VKO:	123024535(ASPM)

PMUA:

114598642(ASPM)

PRAF:

128415367(ASPM)

ZVI:	118089141(ASPM)

HCG:	128322191(ASPM)

GJA:	107106090(ASPM)

STOW:

125433832(ASPM)

EMC:	129331109(ASPM)

XLA:

108714434

XTR:	100379990(aspm)

NPR:	108793570(ASPM)

RTEM:

120945597(ASPM)

BBUF:

120979047(ASPM)

BGAR:

122943237(ASPM)

MUO:	115472457(ASPM)

GSH:	117346588(ASPM)

DRE:	554173(aspm)

SRX:	107712224 107741567

SANH:

107664681 107699437

SGH:	107556171 107586448

CCAR:

109050908 109059328 109066488

CAUA:

113039895 113064973(aspm)

CGIB:

127943227 127988344

PTET:

122327787(aspm)

LROH:

127153571(aspm)

OMC:	131529812(aspm) 131531014

PPRM:

120477219(aspm)

RKG:	130071951(aspm)

MAMB:

125263737(aspm)

CIDE:

127520639

MASI:

127438243 127439049

TROS:

130549126(aspm)

TDW:	130430061(aspm)

MANU:

129453587(aspm)

IPU:

108271230

IFU:	128613631(aspm)

PHYP:

113528669(aspm)

SMEO:

124390982(aspm)

TFD:	113646148(aspm)

TVC:	132851083(aspm)

AMEX:

103040679(aspm)

CMAO:

118819495(aspm)

EEE:

113567977

CHAR:

105898234(aspm)

TRU:	101061381(aspm)

TFS:	130528517(aspm)

TNG:	GSTEN00023179G001

LCO:	104936273(aspm)

NCC:

104946764

TBEN:

117495540(aspm)

CGOB:

115006704(aspm)

PGEO:

117445444(aspm)

GACU:

117560498(aspm)

EMAC:

134869640(aspm)

ELY:	117254109(aspm)

EFO:	125895615(aspm)

PLEP:

121963799(aspm)

SLUC:

116038158(aspm)

ECRA:

117950019(aspm)

ESP:

116695759

PFLV:

114560974(aspm)

PPUG:

119216672(aspm)

AFB:	129095154(aspm)

CLUM:

117729160

PSWI:

130194124

MSAM:

119900316(aspm)

SCHU:

122877990(aspm)

CUD:	121511943(aspm)

ALAT:

119028869(aspm)

MZE:	101478798(aspm)

ONL:	100697832(aspm)

OAU:

116334348

OLA:	101174988(aspm)

OML:	112150350(aspm)

CSAI:

133458840(aspm)

XMA:

102232300

XCO:	114151051(aspm)

XHE:

116730862

PRET:

103463131

PFOR:

103153756(aspm)

PLAI:

106939957(aspm)

PMEI:

106932820(aspm)

GAF:	122838586(aspm)

PPRL:

129375769(aspm)

CVG:

107101166

CTUL:

119789864(aspm)

GMU:	124873840(aspm)

NFU:	107393011(aspm)

KMR:	108249804(aspm)

ALIM:

106531272(aspm)

NWH:	119430514(aspm)

AOCE:

111583701(aspm)

MCEP:

125009765(aspM)

CSEM:

103399775(aspm)

SSEN:

122780833(aspm)

HHIP:

117759763(aspm)

HSP:	118121248(aspm)

SMAU:

118318064(aspm)

LCF:

108879551

SDU:	111239203(aspm)

SLAL:

111671726(aspm)

XGL:	120790595(aspm)

HCQ:	109524558(aspm)

SSCV:

125968342

SBIA:

133503097(aspm)

PEE:	133406375(aspm)

PTAO:

133480917(aspm)

BPEC:

110160239(aspm)

MALB:

109952229(aspm)

BSPL:

114853177(aspm)

SJO:	128362195(aspm)

SASA:

106560548

STRU:

115158771(aspm)

OTW:	112214837(aspm)

OMY:	110524785(aspm)

OGO:	123996606(aspm)

ONE:

115119846

OKI:	109902888(aspm)

OKE:	118373657(aspm)

SALP:

111975414(aspm)

SNH:	120054344(aspm)

CCLU:

121534079(aspm)

ELS:	105007979(aspm)

SFM:	108935308(aspm)

PKI:	111834885(aspm)

AANG:

118225038(aspm)

LOC:	102682443(aspm)

PSPA:

121326733(aspm) 121331293

ARUT:

117411135 117417477(aspm)

PSEX:

120514494(aspm)

LCM:	102365679(ASPM)

CMK:	103180084(aspm)

RTP:	109912160(aspm)

CPLA:

122554560(aspm)

HOC:	132818983(aspm)

LERI:

129701268(aspm)

BFO:

BBEL:

SCLV:

SPU:

LPIC:

APLC:

SKO:

DME:	Dmel_CG6875(asp)

DER:

6554544

DSE:

6607793

DSI:	Dsimw501_GD21126(Dsim_GD21126)

DYA:	Dyak_GE23511

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI24024

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:	108363119 108363124

AOQ:

129253164

TDA:	119673919 119677050

MDE:

SCAC:

LCQ:

LSQ:

GFS:	119639747 119640597

ECOE:

CLON:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AAG:

AALB:

CQU:	CpipJ_CPIJ012473

CPII:

CNS:

BCOO:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

AROA:

TCA:

DPA:

SOY:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:	111418217 111420498

BMOR:

101737979

BMAN:

114253229

MSEX:

115440714

DPL:	KGM_214690

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:	119832449 119832662

CCRC:

123695684

AAGE:

121732206

HAW:	110371349 135118627

HZE:

TNL:

SLIU:

OFU:

PXY:	105393844 105394997

CCRN:

123302167

API:	100160614 100167154

DNX:	107163985 107166120

AGS:	114119866 114120604

RMD:	113547922 113556909

DVT:

BTAB:

CLEC:

NLU:

FOC:

TPAL:

ZNE:

CSEC:

DMK:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:	111705010 111710980

LSM:	121119089 121128906 121129505

TCF:

DPTE:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

CEL:	CELE_C45G3.1(aspm-1)

CRQ:	GCK72_001417

LOA:	LOAG_04014

TSP:

Tsp_06395

HRO:	HELRODRAFT_190172

LGI:	LOTGIDRAFT_232956

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:	106161729 106180340

SMM:	Smp_176000.1

OVI:	T265_15470

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

TAD:	TRIADDRAFT_53434

AQU:

ATH:

ALY:

CRB:

CSAT:

104718142 104722867 104731355

EUS:	EUTSA_v10024235mg

BRP:

103859500

BNA:	106347894 106369174

BOE:

RSZ:

THJ:

CPAP:

CIT:

CIC:	CICLE_v10014034mg

MINC:

123192989

TCC:

18597129

GRA:	105773088 105776417

GHI:	107900180 107925046 107935408 107961987

GAB:	108485556 108487076

HSYR:

120147234 120183418 120190094

DZI:

111275182

EGR:

104441392

GMX:	100788871 100817636

GSJ:	114394118 114420161

PVU:	PHAVU_003G077600g

VRA:

VAR:

VUN:

VUM:

CCAJ:

APRC:

MTR:

TPRA:

CAM:

PSAT:

VVO:

LJA:	Lj4g3v0153910.1(Lj4g3v0153910.1)

ADU:

107466793

AIP:	107613536 107615155

AHF:	112705685 112722932 112723260

LANG:

PCIN:

FVE:

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:

MSYL:

PXB:

ZJU:

MNT:

CSAV:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

JCU:

HBR:

MESC:

POP:

PEU:

PALZ:

JRE:

CILL:

CAVE:

QSU:

QLO:

TWL:

VVI:

VRI:

SLY:

SPEN:

SOT:

SSTN:

SDUL:

CANN:

LBB:

NTA:

NSY:

NTO:

NAU:

INI:

ITR:

SIND:

OEU:

EGT:

SSPL:

SMIL:

SHIS:

APAN:

HAN:

ECAD:

LSV:

CCAV:

DCR:

CSIN:

RVL:

AEW:	130783194 130795050

BVG:

104882842

SOE:

110790746

CQI:	110687351 110731354

ATRI:

MOF:

NNU:

MING:

TSS:	122639850 122644128

PSOM:

OSA:

OBR:

OGL:

BDI:

ATS:

TDC:	119354307 119363471

TAES:

123044669 123052543 123188423

TUA:

125536860

LPER:

127333313

LRD:	124675621 124675787

SBI:

ZMA:

SITA:

SVS:

PVIR:

PDA:

EGU:

MUS:

ZOF:	122002099 122006355

DCT:

PEQ:

AOF:

MSIN:

NCOL:

ATR:

SMO:	SELMODRAFT_419634 SELMODRAFT_430867

PPP:

112276865

CRE:	CHLRE_06g281200v5

VCN:	VOLCADRAFT_121726(asp)

MNG:	MNEG_11242 MNEG_6320

CSL:	COCSUDRAFT_62930

CVR:	CHLNCDRAFT_139429

APRO:

F751_4972

OLU:	OSTLU_31390

OTA:	OT_ostta04g04680

BPG:	Bathy08g04300

MIS:	MICPUN_62340

MPP:	MICPUCDRAFT_60334(JGI:MicpuC2_60334)

ANI:	ANIA_00414

AFM:	AFUA_1G04920

ACT:	ACLA_029720

NFI:	NFIA_019810

AOR:	AO090003000844

ANG:	An01g03970

AFV:	AFLA_000832

TMF:	EYB26_008300

TRG:	TRUGW13939_00465

CIM:	CIMG_13400(CIMG04901)

CPW:	CPC735_069750

URE:	UREG_06649

PBL:	PAAG_00921

PBN:	PADG_03907

ABE:

ARB_06132

TVE:

TRV_03819

AJE:	HCAG_04837

BGH:	BDBG_09077

PNO:	SNOG_12008

PTE:

PTT_16057

BZE:	COCCADRAFT_21345

BSC:	COCSADRAFT_167813

BOR:	COCMIDRAFT_83907

AALT:

CC77DRAFT_1046896

ARAB:

EKO05_0009812

PFJ:	MYCFIDRAFT_79194

CBET:

CB0940_09592

BCOM:

BAUCODRAFT_30467

NPA:	UCRNP2_5106

MBR:	MONBRDRAFT_13032

SRE:	PTSG_08483

SMIN:

v1.2.007486.t1(symbB.v1.2.007486.t1)

PTI:	PHATRDRAFT_35233

FCY:	FRACYDRAFT_259782 FRACYDRAFT_261552 FRACYDRAFT_264002

TPS:	THAPSDRAFT_2653

PIF:	PITG_15637

PSOJ:

PHYSODRAFT_511790

SPAR:

SPRG_11489 SPRG_13231

GTT:	GUITHDRAFT_139469

NGR:	NAEGRDRAFT_48956 NAEGRDRAFT_74233

GLA:	GL50803_00113219

» show all

Reference

PMID:16123590

Authors

Zhong X, Liu L, Zhao A, Pfeifer GP, Xu X

Title

The abnormal spindle-like, microcephaly-associated (ASPM) gene encodes a centrosomal protein.

Journal

Cell Cycle 4:1227-9 (2005)
DOI:10.4161/cc.4.9.2029

Sequence

[hsa:259266]

Reference

PMID:10073938

Authors

do Carmo Avides M, Glover DM

Title

Abnormal spindle protein, Asp, and the integrity of mitotic centrosomal microtubule organizing centers.

Journal

Science 283:1733-5 (1999)
DOI:10.1126/science.283.5408.1733

Sequence

[dme:Dmel_CG6875]

LinkDB

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