KEGG ORTHOLOGY: K17388

ORTHOLOGY: K17388

Entry

K17388                      KO

Symbol

ROCK2

Name

Rho-associated protein kinase 2 [EC:2.7.11.1]

Pathway

map04022

cGMP-PKG signaling pathway

map04024

cAMP signaling pathway

map04062

Chemokine signaling pathway

map04071

Sphingolipid signaling pathway

map04270

Vascular smooth muscle contraction

map04310

Wnt signaling pathway

map04360

Axon guidance

map04510

Focal adhesion

map04520

Adherens junction

map04530

Tight junction

map04611

Platelet activation

map04670

Leukocyte transendothelial migration

map04810

Regulation of actin cytoskeleton

map04921

Oxytocin signaling pathway

map05130

Pathogenic Escherichia coli infection

map05131

Shigellosis

map05132

Salmonella infection

map05135

Yersinia infection

map05163

Human cytomegalovirus infection

map05200

Pathways in cancer

map05205

Proteoglycans in cancer

map05417

Lipid and atherosclerosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K17388  ROCK2; Rho-associated protein kinase 2
   04071 Sphingolipid signaling pathway
    K17388  ROCK2; Rho-associated protein kinase 2
   04024 cAMP signaling pathway
    K17388  ROCK2; Rho-associated protein kinase 2
   04022 cGMP-PKG signaling pathway
    K17388  ROCK2; Rho-associated protein kinase 2
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K17388  ROCK2; Rho-associated protein kinase 2
   04520 Adherens junction
    K17388  ROCK2; Rho-associated protein kinase 2
   04530 Tight junction
    K17388  ROCK2; Rho-associated protein kinase 2
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K17388  ROCK2; Rho-associated protein kinase 2
09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K17388  ROCK2; Rho-associated protein kinase 2
   04670 Leukocyte transendothelial migration
    K17388  ROCK2; Rho-associated protein kinase 2
   04062 Chemokine signaling pathway
    K17388  ROCK2; Rho-associated protein kinase 2
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K17388  ROCK2; Rho-associated protein kinase 2
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K17388  ROCK2; Rho-associated protein kinase 2
  09158 Development and regeneration
   04360 Axon guidance
    K17388  ROCK2; Rho-associated protein kinase 2
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K17388  ROCK2; Rho-associated protein kinase 2
   05205 Proteoglycans in cancer
    K17388  ROCK2; Rho-associated protein kinase 2
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    K17388  ROCK2; Rho-associated protein kinase 2
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K17388  ROCK2; Rho-associated protein kinase 2
   05132 Salmonella infection
    K17388  ROCK2; Rho-associated protein kinase 2
   05131 Shigellosis
    K17388  ROCK2; Rho-associated protein kinase 2
   05135 Yersinia infection
    K17388  ROCK2; Rho-associated protein kinase 2
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K17388  ROCK2; Rho-associated protein kinase 2
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K17388  ROCK2; Rho-associated protein kinase 2
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K17388  ROCK2; Rho-associated protein kinase 2
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K17388  ROCK2; Rho-associated protein kinase 2
Protein kinases [BR:ko01001]
Serine/threonine kinases: AGC group
  DMPK family [OT]
   K17388  ROCK2; Rho-associated protein kinase 2
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Centrosome formation proteins
   Kinases and associated factors
    K17388  ROCK2; Rho-associated protein kinase 2

Genes

HSA:	9475(ROCK2)

PTR:	470307(ROCK2)

PPS:	100969111(ROCK2)

GGO:	101134988(ROCK2)

PON:	100461801(ROCK2)

NLE:	100585294(ROCK2)

HMH:	116480242(ROCK2)

MCC:	708444(ROCK2)

MCF:	102133054(ROCK2)

MTHB:

126933801

MNI:	105486481(ROCK2)

CSAB:

103220805(ROCK2)

CATY:

105578625(ROCK2)

PANU:

101003099(ROCK2)

TGE:	112604719(ROCK2)

MLEU:

105528513(ROCK2)

RRO:	104675191(ROCK2)

RBB:	108516461(ROCK2)

TFN:	117062719(ROCK2)

PTEH:

111532006(ROCK2)

CANG:

105525318(ROCK2)

CJC:	100408337(ROCK2)

SBQ:	101039371(ROCK2)

CIMI:

108301473(ROCK2)

CSYR:

103267985(ROCK2)

MMUR:

105880217(ROCK2)

LCAT:

123636599(ROCK2)

PCOQ:

105814034(ROCK2)

OGA:	100953342(ROCK2)

MMU:	19878(Rock2)

MCAL:

110306686(Rock2)

MPAH:

110324181(Rock2)

RNO:	25537(Rock2)

MCOC:

116080601(Rock2)

ANU:	117716790(Rock2)

MUN:	110541556(Rock2)

CGE:	100767265(Rock2)

MAUA:

101838535(Rock2)

PROB:

127219989(Rock2)

PLEU:

114698838(Rock2)

MORG:

121432519 121438936

MFOT:

126501334

AAMP:

119807701(Rock2)

NGI:	103747607(Rock2)

HGL:	101724195(Rock2)

CPOC:

100713798(Rock2)

CCAN:

109684863(Rock2)

DORD:

105983611(Rock2)

DSP:	122108760(Rock2)

PLOP:

125356729(Rock2)

NCAR:

124962770

MMMA:

107137496(Rock2)

OCU:

100346837

OPI:	101533973(ROCK2)

TUP:	102490242(ROCK2)

GVR:	103590666(ROCK2)

CFA:	482970(ROCK2)

CLUD:

112664826(ROCK2)

VVP:	112927709(ROCK2)

VLG:	121490634(ROCK2)

NPO:	129510900(ROCK2)

AML:	100466003(ROCK2)

UMR:	103660117(ROCK2)

UAH:	113269955(ROCK2)

UAR:	123778572(ROCK2)

ELK:

111154090

LLV:

125108362

MPUF:

101681879(ROCK2)

MNP:	132021141(ROCK2)

MLK:	131807367(ROCK2)

NVS:	122915310(ROCK2)

ORO:	101372971(ROCK2)

EJU:	114205781(ROCK2)

ZCA:	113937156(ROCK2)

MLX:	118007595(ROCK2)

NSU:	110587399(ROCK2)

LWW:

102747780

FCA:	101094501(ROCK2)

PYU:	121044101(ROCK2)

PCOO:

112864195(ROCK2)

PBG:	122497462(ROCK2)

PVIV:

125158293(ROCK2)

LRUF:

124504219

PTG:	102949986(ROCK2)

PPAD:

109268495(ROCK2)

PUC:

125937677

AJU:

106977263

HHV:	120231144(ROCK2)

BTA:	282041(ROCK2)

BOM:	102267122(ROCK2)

BIU:	109566382(ROCK2)

BBUB:

102409368(ROCK2)

BBIS:

104997365(ROCK2)

CHX:	102181692(ROCK2)

OAS:	101103800(ROCK2)

BTAX:

128055373(ROCK2)

ODA:	120851858(ROCK2)

CCAD:

122442064(ROCK2)

MBEZ:

129539650(ROCK2)

SSC:	397445(ROCK2)

CFR:	102512572(ROCK2)

CBAI:

105076019(ROCK2)

CDK:	105091254(ROCK2)

VPC:	102524824(ROCK2)

BACU:

102999355(ROCK2)

BMUS:

118905800(ROCK2)

LVE:	103081507(ROCK2)

OOR:	101289250(ROCK2)

DLE:	111164467(ROCK2)

PCAD:

102994518(ROCK2)

PSIU:

116764174(ROCK2)

NASI:

112394771(ROCK2)

ECB:	100072339(ROCK2)

EPZ:	103557393(ROCK2)

EAI:	106846040(ROCK2)

MYB:	102254781(ROCK2)

MYD:	102763604(ROCK2)

MMYO:

118669273(ROCK2)

MLF:	102431516(ROCK2)

PKL:	118717047(ROCK2)

EFUS:

103305588(ROCK2)

MNA:	107542396(ROCK2)

DRO:	112297718(ROCK2)

SHON:

118988767(ROCK2)

AJM:	119053927(ROCK2)

PDIC:

114498743(ROCK2)

PHAS:

123822396(ROCK2)

MMF:	118630612(ROCK2)

PPAM:

129067577(ROCK2)

HAI:	109386644(ROCK2)

RFQ:	117033436(ROCK2)

PALE:

102897424(ROCK2)

PGIG:

120621957(ROCK2)

PVP:	105295461(ROCK2)

RAY:	107501194(ROCK2)

MJV:	108409101(ROCK2)

TOD:	119259551(ROCK2)

SARA:

101539253(ROCK2)

SETR:

126024093(ROCK2)

LAV:	100658857(ROCK2)

TMU:

101345959

ETF:	101646611(ROCK2)

DNM:

101428161

MDO:	100032706(ROCK2)

GAS:	123233446(ROCK2)

SHR:	100916865(ROCK2)

AFZ:

127548167

PCW:	110207655(ROCK2)

OAA:	100073941(ROCK2)

GGA:	374182(ROCK2)

PCOC:

116240378(ROCK2)

MGP:	100538826(ROCK2)

CJO:	107312208(ROCK2)

TPAI:

128084251(ROCK2)

LMUT:

125690189(ROCK2)

NMEL:

110395385(ROCK2)

APLA:

101792620(ROCK2)

ACYG:

106030727(ROCK2)

CATA:

118255936(ROCK2)

AFUL:

116487357(ROCK2)

TGU:	100221127(ROCK2)

LSR:	110467944(ROCK2)

SCAN:

103820586(ROCK2)

PMOA:

120505313(ROCK2)

OTC:	121344529(ROCK2)

PRUF:

121359156(ROCK2)

GFR:	102032829(ROCK2)

FAB:	101817597(ROCK2)

OMA:	130250621(ROCK2)

PHI:	102103730(ROCK2)

PMAJ:

107201732(ROCK2)

CCAE:

111925960(ROCK2)

CCW:	104685437(ROCK2)

CBRC:

103622782(ROCK2)

ETL:	114061910(ROCK2)

ZAB:	102074600(ROCK2)

ACHL:

103804574(ROCK2)

SVG:	106865106(ROCK2)

MMEA:

130576097(ROCK2)

HRT:	120750590(ROCK2)

FPG:	101916990(ROCK2)

FCH:	102053908(ROCK2)

CLV:	102084971(ROCK2)

EGZ:	104127169(ROCK2)

NNI:	104013015(ROCK2)

PCRI:

104028422(ROCK2)

EHS:	104508170(ROCK2)

PCAO:

104044870

ACUN:

113477643(ROCK2)

TALA:

116964580(ROCK2)

PADL:

103924034(ROCK2)

AFOR:

103895854(ROCK2)

ACHC:

115351142(ROCK2)

HALD:

104315556(ROCK2)

HLE:	104831236(ROCK2)

AGEN:

126046771

GCL:

127013996

CCRI:

104164488(ROCK2)

CSTI:

104550202(ROCK2)

CMAC:

104483597(ROCK2)

FGA:	104084359(ROCK2)

LDI:	104351587(ROCK2)

MNB:	103781637(ROCK2)

OHA:	104332046(ROCK2)

NNT:	104399807(ROCK2)

SHAB:

115609284(ROCK2)

DPUB:

104308297(ROCK2)

PGUU:

104462869

ACAR:

104529708(ROCK2)

CPEA:

104395815(ROCK2)

AVIT:

104274421(ROCK2)

CVF:	104290646(ROCK2)

RTD:	128906645(ROCK2)

CUCA:

104058169(ROCK2)

TEO:	104379811(ROCK2)

BRHI:

104496671(ROCK2)

AAM:	106494758(ROCK2)

AROW:

112972425(ROCK2)

NPD:	112945436(ROCK2)

TGT:	104577346(ROCK2)

DNE:	112981510(ROCK2)

SCAM:

104141834(ROCK2)

ASN:	102371812(ROCK2)

AMJ:	102572451(ROCK2)

CPOO:

109312087(ROCK2)

GGN:	109300164(ROCK2)

PSS:	102457091(ROCK2)

CMY:	102934710(ROCK2)

CCAY:

125634574(ROCK2)

DCC:	119853191(ROCK2)

CPIC:

101952051(ROCK2)

TST:	117875524(ROCK2)

CABI:

116831963(ROCK2)

MRV:	120400793(ROCK2)

ACS:	100562729(rock2)

ASAO:

132782673(ROCK2)

PVT:	110083697(ROCK2)

SUND:

121921009(ROCK2)

PMUR:

107294640(ROCK2)

CTIG:

120302849(ROCK2)

TSR:	106549506(ROCK2)

PGUT:

117674233(ROCK2)

APRI:

131196144(ROCK2)

PTEX:

113432985(ROCK2)

NSS:	113416441(ROCK2)

VKO:	123017013(ROCK2)

PMUA:

114593802(ROCK2)

PRAF:

128410175(ROCK2)

ZVI:	118082382(ROCK2)

HCG:	128340480(ROCK2)

GJA:	107114818(ROCK2)

STOW:

125433814(ROCK2)

EMC:	129323385(ROCK2)

XLA:	100301953(rock2.S) 394289(rock2.L)

XTR:	100493965(rock2)

NPR:	108788599(ROCK2)

RTEM:

120936332(ROCK2)

BBUF:

120997288(ROCK2)

BGAR:

122933631

MUO:	115467137(ROCK2)

GSH:	117356645(ROCK2)

DRE:	317747(rock2a) 321070(rock2b)

SRX:	107707968 107726463 107726633 107757116(rock2)

SANH:

107675520(rock2) 107681539 107696174 107698402

SGH:	107555625 107585483(rock2) 107588686 107602474

CCAR:

109044970 109101104(rock2)

CAUA:

113056916 113062980 113112582 113120805

CGIB:

127938668 127970146 127984506 128026094

PTET:

122325531(rock2b) 122357107(rock2a)

LROH:

127175639(rock2a) 127183479(rock2b)

OMC:	131526545(rock2b) 131552115(rock2a)

PPRM:

120479411(rock2a) 120493647

RKG:	130073190(rock2a) 130102978(rock2b)

MAMB:

125277100(rock2a) 125278172(rock2b)

CIDE:

127502798 127524531

MASI:

127410351 127412511 127413975 127416177

TROS:

130558713(rock2a) 130565625

TDW:	130432203(rock2a) 130433915

MANU:

129415490(rock2a) 129429552

IPU:	108256302 108263171(rock2a)

IFU:	128605104(rock2a) 128621366

PHYP:

113528867 113541935

SMEO:

124397095(rock2a) 124400736

TFD:	113635696 113656145(rock2a)

TVC:	132846847(rock2a) 132854388

AMEX:

103042784 103045824

CMAO:

118811008(rock2a) 118815917(rock2b)

EEE:	113576241(rock2) 113588491

CHAR:

105895559(rock2a) 105901497(rock2b)

TRU:	101067715 101068674(rock2)

TFS:	130515843 130539781(rock2a)

TNG:	GSTEN00016969G001 GSTEN00023147G001

LCO:	104924772(rock2) 104926776

NCC:	104956174 104959841(rock2)

TBEN:

117486693(rock2a) 117492453

CGOB:

115003454 115027137(rock2)

PGEO:

117439791 117468191(rock2a)

GACU:

117539718(rock2a) 117556533

EMAC:

134876738 134881487(rock2a)

ELY:	117266968(rock2a) 117270871

EFO:	125896997 125901258(rock2a)

PLEP:

121954076(rock2a) 121955159

SLUC:

116065683(rock2a) 116066412

ECRA:

117935308(rock2a) 117961482

ESP:	116670634(rock2) 116705871

PFLV:

114546465(rock2) 114572998

GAT:	120807681 120832646(rock2a)

PPUG:

119194788 119227445(rock2a)

AFB:	129103071(rock2a) 129106890

CLUM:

117727562 117751367(rock2a)

PSWI:

130201873(rock2a) 130202379

MSAM:

119908433 119909923(rock2a)

SCHU:

122861382(rock2a) 122863432

CUD:	121521529 121525969(rock2a)

ALAT:

119012418 119034318(rock2a)

MZE:	101470679 101475967(rock2)

ONL:	100701417 100709780(rock2)

OAU:	116324174 116325287(rock2a)

OLA:	101159717 101172697

OML:	112158011(rock2a) 112158227

CSAI:

133418616 133461915 133462074

XMA:	102226221(rock2) 102230495

XCO:	114133879(rock2) 114158490

XHE:	116708718(rock2) 116734123

PRET:

103457451 103458704(rock2)

PFOR:

103134220 103154401(rock2) 103155428

PLAI:

106942340 106943130 106950198 106953737

PMEI:

106909746 106910538 106911054 106920666

GAF:	122825782 122846660(rock2a)

PPRL:

129365267(rock2a) 129375452

CVG:	107081643 107094724(rock2)

CTUL:

119779147 119794686(rock2a)

GMU:	124855144(rock2a) 124882189

NFU:	107377468 107396125(rock2)

KMR:	108233468 108241747(rock2a)

ALIM:

106518444(rock2) 106522615

NWH:	119418273 119427162(rock2a)

AOCE:

111566441 111568806(rock2)

MCEP:

124999124 125023444(rock2a)

CSEM:

103380939 103383692

POV:	109628087(rock2) 109636100

SSEN:

122782654(rock2a) 122784023

HHIP:

117755831(rock2a) 117757961

HSP:	118099269 118116262(rock2a)

SMAU:

118285968(rock2a) 118290327

LCF:	108895959 108896154(rock2a)

SDU:	111225444(rock2) 111239446

SLAL:

111653387 111656293 111661385 111673732

XGL:	120788791 120795120(rock2a)

HCQ:	109516807 109519530(rock2)

SSCV:

125981232 125990297

SBIA:

133496428 133513781(rock2a)

PEE:	133412540(rock2a) 133416884

PTAO:

133468003 133487668(rock2a)

BPEC:

110155690(rock2) 110172686

MALB:

109953729 109972800(rock2)

BSPL:

114848338(rock2a) 114849611

SJO:	128375944(rock2a) 128376668

SASA:

106571171 106600638(rock2) 106607561 106611132

STRU:

115162175 115172456 115175052 115195645

OTW:	112217395 112232894 112249925 112261645(rock2a)

OMY:	110497776(rock2a) 110505685 110522004 110529374

OGO:	123990551 124001317(rock2a) 124046572

ONE:	115107549 115138621 115139555 115146104

OKI:	109866154 109894400 109901330 109904161

OKE:	118362644(rock2a) 118368175 118386763 118397897

SALP:

111954063 111963391 111968599 111972970

SNH:	120019239 120023102 120024155 120060381(rock2a)

CCLU:

121539436(rock2a) 121544787 121549116 121552529

ELS:	105021675 105029946(rock2)

SFM:	108922224(rock2) 108929341

PKI:	111851538 111855542(rock2)

AANG:

118225980(rock2a) 118230628

LOC:	102688837(rock2)

PSPA:

121315517 121317519(rock2a)

ARUT:

117402932 117410455

PSEX:

120526057(rock2a)

LCM:	102354777(ROCK2)

CMK:	103180944(rock2a)

RTP:	109915504(rock2a)

CPLA:

122541114(rock2a)

HOC:	132834548(rock2a)

LERI:

129697093(rock2a)

PMRN:

116941692 116942542(ROCK2) 116945169

LRJ:	133344150 133349111 133353186

BFO:

BBEL:

CIN:

SCLV:

SPU:	579202(ROCK)

LPIC:

129280422

APLC:

110985687

AJC:

117116550

SKO:	100371856 102807548

NVI:

100119770

API:

100164812

PHU:	Phum_PHUM507390

HAME:

121868986

LOA:	LOAG_00709

LGI:	LOTGIDRAFT_215457

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:	111119669 111119736

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:

SMM:	Smp_151140

EGL:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:	114528761 114537688

XEN:

HMG:

HSY:

Reference

PMID:9933571

Authors

Takahashi N, Tuiki H, Saya H, Kaibuchi K

Title

Localization of the gene coding for ROCK II/Rho kinase on human chromosome 2p24.

Journal

Genomics 55:235-7 (1999)
DOI:10.1006/geno.1998.5344

Sequence

[hsa:9475]

LinkDB

DBGET integrated database retrieval system