KEGG   MODULE: M00902
Entry
M00902            Pathway   Module                                 
Name
Podophyllotoxin biosynthesis, coniferyl alcohol => podophyllotoxin
Definition
K21568 K19650 K21207 K21203 K21205 K21204 K21202
Diagram
M00902

Orthology
K21568  
pinoresinol/lariciresinol reductase [EC:1.23.1.1 1.23.1.2 1.23.1.3 1.23.1.4] [RN:R10225 R10226]
K19650  
secoisolariciresinol dehydrogenase [EC:1.1.1.331] [RN:R10129]
K21207  
(-)-pluviatolide synthase [EC:1.14.19.72] [RN:R11222]
K21203  
(-)-pluviatolide 4-O-methyltransferase [EC:2.1.1.323] [RN:R11230]
K21205  
bursehernin 5'-monooxygenase [EC:1.14.14.131] [RN:R11211]
K21204  
5'-demethylyatein 5'-O-methyltransferase [EC:2.1.1.330] [RN:R11545]
K21202  
(-)-deoxypodophyllotoxin synthase [EC:1.14.20.8] [RN:R11210]
Class
Pathway modules; Biosynthesis of other secondary metabolites; Biosynthesis of phytochemical compounds
Pathway
map00999  Biosynthesis of various plant secondary metabolites
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R12126  
R10225  
R10226  
R10129  
R11222  
R11230  
R11211  
R11545  
R11210  
R12127  
Compound
C00590  Coniferyl alcohol
C05366  (+)-Pinoresinol
C10646  Lariciresinol
C18167  Secoisolariciresinol
C10682  Matairesinol
C21191  Pluviatolide
C21183  Bursehernin
C21184  (-)-5'-Demethylyatein
C10577  Casimiroedine
C10556  Deoxypodophyllotoxin
C10874  Podophyllotoxin
Reference
PMID:26359402
  Authors
Lau W, Sattely ES
  Title
Six enzymes from mayapple that complete the biosynthetic pathway to the etoposide aglycone.
  Journal
Science 349:1224-8 (2015)
DOI:10.1126/science.aac7202
Reference
PMID:27314513
  Authors
Yang L, Sun P, Li MF
  Title
Chilling temperature stimulates growth, gene over-expression and podophyllotoxin biosynthesis in Podophyllum hexandrum Royle.
  Journal
Plant Physiol Biochem 107:197-203 (2016)
DOI:10.1016/j.plaphy.2016.06.010
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