KEGG   REACTION: R00424
Entry
R00424                      Reaction                               
Name
GTP 7,8-8,9-dihydrolase
Definition
GTP + H2O <=> 7,8-Dihydroneopterin 3'-triphosphate + Formate
Equation
C00044 + C00001 <=> C04895 + C00058
Comment
four-step reaction (see R00428+R05046+R05048+R04639)
Reaction class
RC00292  C00044_C04895
RC02504  C00044_C00058
Enzyme
3.5.4.16
Pathway
rn01240  Biosynthesis of cofactors
Brite
Enzymatic reactions [BR:br08201]
 3. Hydrolase reactions
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.16
     R00424  GTP + H2O <=> 7,8-Dihydroneopterin 3'-triphosphate + Formate
Orthology
K01495  GTP cyclohydrolase IA [EC:3.5.4.16]
K09007  GTP cyclohydrolase IB [EC:3.5.4.16]
K22391  GTP cyclohydrolase I [EC:3.5.4.16]
Other DBs
RHEA: 17476
LinkDB

KEGG   REACTION: R00428
Entry
R00428                      Reaction                               
Name
GTP 8,9-hydrolase
Definition
GTP + H2O <=> Formamidopyrimidine nucleoside triphosphate
Equation
C00044 + C00001 <=> C05922
Comment
the first step of four-step reaction (see R00424, R00428+R05046+R05048+R04639)
subsequently R05046
Reaction class
RC00294  C00044_C05922
Enzyme
3.5.4.16
Pathway
rn00790  Folate biosynthesis
rn01100  Metabolic pathways
Module
M00126  Tetrahydrofolate biosynthesis, GTP => THF
M00841  Tetrahydrofolate biosynthesis, mediated by PTPS, GTP => THF
M00842  Tetrahydrobiopterin biosynthesis, GTP => BH4
M00843  L-threo-Tetrahydrobiopterin biosynthesis, GTP => L-threo-BH4
Brite
Enzymatic reactions [BR:br08201]
 3. Hydrolase reactions
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.16
     R00428  GTP + H2O <=> Formamidopyrimidine nucleoside triphosphate
Orthology
K01495  GTP cyclohydrolase IA [EC:3.5.4.16]
K09007  GTP cyclohydrolase IB [EC:3.5.4.16]
K22391  GTP cyclohydrolase I [EC:3.5.4.16]
LinkDB

KEGG   REACTION: R05046
Entry
R05046                      Reaction                               
Name
formamidopyrimidine nucleoside triphosphate amidohydrolase
Definition
Formamidopyrimidine nucleoside triphosphate + H2O <=> 2,5-Diaminopyrimidine nucleoside triphosphate + Formate
Equation
C05922 + C00001 <=> C05923 + C00058
Comment
the second step of four-step reaction (see R00424, R00428+R05046+R05048+R04639)
following after R00428
subsequently R05048
Reaction class
RC00263  C05922_C05923
RC00323  C00058_C05922
Enzyme
3.5.4.16
Pathway
rn00790  Folate biosynthesis
rn01100  Metabolic pathways
Module
M00126  Tetrahydrofolate biosynthesis, GTP => THF
M00841  Tetrahydrofolate biosynthesis, mediated by PTPS, GTP => THF
M00842  Tetrahydrobiopterin biosynthesis, GTP => BH4
M00843  L-threo-Tetrahydrobiopterin biosynthesis, GTP => L-threo-BH4
Brite
Enzymatic reactions [BR:br08201]
 3. Hydrolase reactions
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.16
     R05046  Formamidopyrimidine nucleoside triphosphate + H2O <=> 2,5-Diaminopyrimidine nucleoside triphosphate + Formate
Orthology
K01495  GTP cyclohydrolase IA [EC:3.5.4.16]
K09007  GTP cyclohydrolase IB [EC:3.5.4.16]
K22391  GTP cyclohydrolase I [EC:3.5.4.16]
LinkDB

KEGG   REACTION: R05048
Entry
R05048                      Reaction                               
Name
2,5-diaminopyrimidine nucleoside triphosphate mutase
Definition
2,5-Diaminopyrimidine nucleoside triphosphate <=> 2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
Equation
C05923 <=> C06148
Comment
the third step of four-step reaction (see R00424, R00428+R05046+R05048+R04639)
maybe spontaneous (Amadori rearrangement)
following after R05046
subsequently R04639
Reaction class
RC00945  C05923_C06148
Enzyme
3.5.4.16
Pathway
rn00790  Folate biosynthesis
rn01100  Metabolic pathways
Module
M00126  Tetrahydrofolate biosynthesis, GTP => THF
M00841  Tetrahydrofolate biosynthesis, mediated by PTPS, GTP => THF
M00842  Tetrahydrobiopterin biosynthesis, GTP => BH4
M00843  L-threo-Tetrahydrobiopterin biosynthesis, GTP => L-threo-BH4
Brite
Enzymatic reactions [BR:br08201]
 3. Hydrolase reactions
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.16
     R05048  2,5-Diaminopyrimidine nucleoside triphosphate <=> 2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
Orthology
K01495  GTP cyclohydrolase IA [EC:3.5.4.16]
K09007  GTP cyclohydrolase IB [EC:3.5.4.16]
K22391  GTP cyclohydrolase I [EC:3.5.4.16]
LinkDB

KEGG   REACTION: R04639
Entry
R04639                      Reaction                               
Name
2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate hydrolase
Definition
7,8-Dihydroneopterin 3'-triphosphate + H2O <=> 2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
Equation
C04895 + C00001 <=> C06148
Comment
the last step of four-step reaction (see R00424, R00428+R05046+R05048+R04639)
possibly spontaneous
following after R05048
Reaction class
RC01188  C04895_C06148
Enzyme
3.5.4.16
Pathway
rn00790  Folate biosynthesis
rn01100  Metabolic pathways
Module
M00126  Tetrahydrofolate biosynthesis, GTP => THF
M00841  Tetrahydrofolate biosynthesis, mediated by PTPS, GTP => THF
M00842  Tetrahydrobiopterin biosynthesis, GTP => BH4
M00843  L-threo-Tetrahydrobiopterin biosynthesis, GTP => L-threo-BH4
Brite
Enzymatic reactions [BR:br08201]
 3. Hydrolase reactions
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.16
     R04639  7,8-Dihydroneopterin 3'-triphosphate + H2O <=> 2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
Orthology
K01495  GTP cyclohydrolase IA [EC:3.5.4.16]
K09007  GTP cyclohydrolase IB [EC:3.5.4.16]
K22391  GTP cyclohydrolase I [EC:3.5.4.16]
LinkDB

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