Entry Name ABC transporters - Capra hircus (goat)
Description The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class Environmental Information Processing; Membrane transportBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Capra hircus (goat) [GN:
chx ]
Gene 102179197 ABCA1; ATP-binding cassette sub-family A member 1 isoform X1 [KO:K05641 ]
102183428 ABCA2; LOW QUALITY PROTEIN: ATP-binding cassette sub-family A member 2 [KO:K05642 ]
102183842 ATP-binding cassette sub-family A member 17 isoform X1 [KO:K05643 ]
102185888 ABCA4; retinal-specific ATP-binding cassette transporter [KO:K05644 ]
102175208 ABCA7; ATP-binding cassette sub-family A member 7 isoform X1 [KO:K05645 ]
102174076 ABCA12; ATP-binding cassette sub-family A member 12 isoform X1 [KO:K05646 ]
102177279 ABCA5; ATP-binding cassette sub-family A member 5 isoform X1 [KO:K05648 ]
102177837 ABCA6; ATP-binding cassette sub-family A member 6 isoform X1 [KO:K05649 ]
102178109 ATP-binding cassette sub-family A member 9 isoform X1 [KO:K05651 ]
102177563 ABCA10; ATP-binding cassette sub-family A member 10 isoform X1 [KO:K05652 ]
102185895 ABCB8; ATP-binding cassette sub-family B member 8, mitochondrial [KO:K05655 ]
102183293 ABCB10; ATP-binding cassette sub-family B member 10, mitochondrial [KO:K05657 ]
100861157 ABCB6; ATP-binding cassette sub-family B member 6, mitochondrial [KO:K05661 ]
102188929 ABCB7; LOW QUALITY PROTEIN: ATP-binding cassette sub-family B member 7, mitochondrial [KO:K05662 ]
102179626 ABCC2; canalicular multispecific organic anion transporter 1 [KO:K05666 ]
102181156 ABCC3; canalicular multispecific organic anion transporter 2 isoform X1 [KO:K05667 ]
108637248 LOW QUALITY PROTEIN: multidrug resistance-associated protein 4-like [KO:K05673 ]
102187779 LOW QUALITY PROTEIN: multidrug resistance-associated protein 4-like [KO:K05673 ]
108637249 LOW QUALITY PROTEIN: multidrug resistance-associated protein 4-like [KO:K05673 ]
108637253 LOW QUALITY PROTEIN: multidrug resistance-associated protein 4-like [KO:K05673 ]
108637254 LOW QUALITY PROTEIN: multidrug resistance-associated protein 4-like [KO:K05673 ]
102173859 LOW QUALITY PROTEIN: multidrug resistance-associated protein 4-like [KO:K05673 ]
102181111 LOW QUALITY PROTEIN: multidrug resistance-associated protein 4-like [KO:K05673 ]
102180583 multidrug resistance-associated protein 4-like isoform X1 [KO:K05673 ]
102185549 LOW QUALITY PROTEIN: multidrug resistance-associated protein 4 [KO:K05673 ]
102179751 multidrug resistance-associated protein 4-like isoform X1 [KO:K05673 ]
102170612 ABCC4; LOW QUALITY PROTEIN: multidrug resistance-associated protein 4 [KO:K05673 ]
102186159 ABCC5; multidrug resistance-associated protein 5 isoform X1 [KO:K05668 ]
102178034 ABCC6; multidrug resistance-associated protein 6 isoform X1 [KO:K05669 ]
102174986 ABCC10; multidrug resistance-associated protein 7 isoform X1 [KO:K05674 ]
102183626 ABCC12; LOW QUALITY PROTEIN: multidrug resistance-associated protein 9 [KO:K05672 ]
102185675 ABCC8; ATP-binding cassette sub-family C member 8 isoform X1 [KO:K05032 ]
102187656 ABCC9; ATP-binding cassette sub-family C member 9 isoform X2 [KO:K05033 ]
102181242 ABCG1; ATP-binding cassette sub-family G member 1 isoform X1 [KO:K05679 ]
102175224 ABCG4; ATP-binding cassette sub-family G member 4 isoform X1 [KO:K05680 ]
100860857 ABCG2; broad substrate specificity ATP-binding cassette transporter ABCG2 [KO:K05681 ]
102189408 ABCG8; ATP-binding cassette sub-family G member 8 isoform X1 [KO:K05684 ]
Compound C00093 sn-Glycerol 3-phosphate
C01153 Orthophosphoric monoester
C01181 4-Trimethylammoniobutanoate
C01279 4-Amino-5-hydroxymethyl-2-methylpyrimidine
C03557 2-Aminoethylphosphonate
C03611 Galactose oligosaccharide
C03619 Methyl beta-D-galactoside
C04114 (E)-4-(Trimethylammonio)but-2-enoate
C06705 Capsular polysaccharide
C19872 N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570 alpha-1,5-L-Arabinobiose
C20571 alpha-1,5-L-Arabinotriose
C20572 alpha-1,5-L-Arabinotetraose
Reference Authors Tomii K, Kanehisa M.
Title A comparative analysis of ABC transporters in complete microbial genomes.
Journal Reference Authors Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
Title Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal Reference Authors Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
Title Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal Reference Authors Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
Title Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
Journal Reference Authors Quintero MJ, Montesinos ML, Herrero A, Flores E
Title Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
Journal Reference Authors Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
Title ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
Journal Reference Authors Valladares A, Montesinos ML, Herrero A, Flores E.
Title An ABC-type, high-affinity urea permease identified in cyanobacteria.
Journal Reference Authors Richard-Fogal CL, Frawley ER, Kranz RG
Title Topology and function of CcmD in cytochrome c maturation.
Journal Reference Authors Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
Title The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
Journal Reference Authors Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
Title The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
Journal Reference Authors Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
Title Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
Journal Reference Authors Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
Title MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
Journal KO pathway LinkDB All DBs
