Homo sapiens (human): 50964
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Entry
50964 CDS
T01001
Symbol
SOST, CDD, DAND6, SOST1, VBCH
Name
(RefSeq) sclerostin
KO
K16834
sclerostin
Organism
hsa
Homo sapiens (human)
Pathway
hsa04310
Wnt signaling pathway
hsa04928
Parathyroid hormone synthesis, secretion and action
Network
nt06505
WNT signaling
Element
N01441
Wnt signaling modulation, SOST/LRP4
Disease
H00486
Sclerosteosis
H01774
Hyperostosis corticalis generalisata
H02609
Craniodiaphyseal dysplasia
Drug target
Blosozumab:
D10094
Romosozumab:
D10156
<JP/US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04310 Wnt signaling pathway
50964 (SOST)
09150 Organismal Systems
09152 Endocrine system
04928 Parathyroid hormone synthesis, secretion and action
50964 (SOST)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Sclerostin
DAN
Cys_knot
Motif
Other DBs
NCBI-GeneID:
50964
NCBI-ProteinID:
NP_079513
OMIM:
605740
HGNC:
13771
Ensembl:
ENSG00000167941
UniProt:
Q9BQB4
Structure
PDB
LinkDB
All DBs
Position
17:complement(43753738..43758791)
Genome browser
AA seq
213 aa
AA seq
DB search
MQLPLALCLVCLLVHTAFRVVEGQGWQAFKNDATEIIPELGEYPEPPPELENNKTMNRAE
NGGRPPHHPFETKDVSEYSCRELHFTRYVTDGPCRSAKPVTELVCSGQCGPARLLPNAIG
RGKWWRPSGPDFRCIPDRYRAQRVQLLCPGGEAPRARKVRLVASCKCKRLTRFHNQSELK
DFGTEAARPQKGRKPRPRARSAKANQAELENAY
NT seq
642 nt
NT seq
+upstream
nt +downstream
nt
atgcagctcccactggccctgtgtctcgtctgcctgctggtacacacagccttccgtgta
gtggagggccaggggtggcaggcgttcaagaatgatgccacggaaatcatccccgagctc
ggagagtaccccgagcctccaccggagctggagaacaacaagaccatgaaccgggcggag
aacggagggcggcctccccaccacccctttgagaccaaagacgtgtccgagtacagctgc
cgcgagctgcacttcacccgctacgtgaccgatgggccgtgccgcagcgccaagccggtc
accgagctggtgtgctccggccagtgcggcccggcgcgcctgctgcccaacgccatcggc
cgcggcaagtggtggcgacctagtgggcccgacttccgctgcatccccgaccgctaccgc
gcgcagcgcgtgcagctgctgtgtcccggtggtgaggcgccgcgcgcgcgcaaggtgcgc
ctggtggcctcgtgcaagtgcaagcgcctcacccgcttccacaaccagtcggagctcaag
gacttcgggaccgaggccgctcggccgcagaagggccggaagccgcggccccgcgcccgg
agcgccaaagccaaccaggccgagctggagaacgcctactag
Homo sapiens (human): 4038
Help
Entry
4038 CDS
T01001
Symbol
LRP4, CLSS, CMS17, LRP-4, LRP10, MEGF7, SOST2
Name
(RefSeq) LDL receptor related protein 4
KO
K20051
low-density lipoprotein receptor-related protein 4
Organism
hsa
Homo sapiens (human)
Network
nt06505
WNT signaling
Element
N01441
Wnt signaling modulation, SOST/LRP4
Disease
H00486
Sclerosteosis
H00770
Congenital myasthenic syndrome
H00853
Cenani-Lenz syndactyly syndrome
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
4038 (LRP4)
09183 Protein families: signaling and cellular processes
04990 Domain-containing proteins not elsewhere classified [BR:
hsa04990
]
4038 (LRP4)
Membrane trafficking [BR:
hsa04131
]
Endocytosis
Clathrin-mediated endocytosis
Low-density lipoprotein receptor (LDLR) family proteins
4038 (LRP4)
Domain-containing proteins not elsewhere classified [BR:
hsa04990
]
Laminin domain-containing proteins
Laminin EGF-like domain-containing proteins
4038 (LRP4)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Ldl_recept_b
Ldl_recept_a
FXa_inhibition
SGL
cEGF
DUF5050
EGF_CA
Motif
Other DBs
NCBI-GeneID:
4038
NCBI-ProteinID:
NP_002325
OMIM:
604270
HGNC:
6696
Ensembl:
ENSG00000134569
UniProt:
O75096
Structure
PDB
LinkDB
All DBs
Position
11:complement(46856717..46918550)
Genome browser
AA seq
1905 aa
AA seq
DB search
MRRQWGALLLGALLCAHGLASSPECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDH
SDEDGCILPTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNG
YCIRSLWHCDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEE
NCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDS
GLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRCHSGRCVRLSWRCDGEDDCADNSD
EENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNV
NNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCTNSEGAFQCWC
ETGYELRPDRRSCKALGPEPVLLFANRIDIRQVLPHRSEYTLLLNNLENAIALDFHHRRE
LVFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANL
DGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWP
NGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQGLPHPFAITVFEDSLYWTDWHT
KSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDNNGGCTHLCLPSGQNY
TCACPTGFRKISSHACAQSLDKFLLFARRMDIRRISFDTEDLSDDVIPLADVRSAVALDW
DSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRI
EVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDASGRQVIISS
NLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGERIYW
TDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRS
PNPSGFSCTCPTGINLLSDGKTCSPGMNSFLIFARRIDIRMVSLDIPYFADVVVPINITM
KNTIAIGVDPQEGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIGRKVYW
TDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGS
DRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLVSPVQHPYGLTL
LDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAVDRAQPLGFNKCGSRNGGC
SHLCLPRPSGFSCACPTGIQLKGDGKTCDPSPETYLLFSSRGSIRRISLDTSDHTDVHVP
VPELNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGSNMETVIGRGLKTTDGLAVDWVAR
NLYWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERAN
LDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVSHVSHPF
ALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQTGTNACGVN
NGGCTHLCFARASDFVCACPDEPDSRPCSLVPGLVPPAPRATGMSEKSPVLPNTPPTTLY
SSTTRTRTSLEEVEGRCSERDARLGLCARSNDAVPAAPGEGLHISYAIGGLLSILLILVV
IAALMLYRHKKSKFTDPGMGNLTYSNPSYRTSTQEVKIEAIPKPAMYNQLCYKKEGGPDH
NYTKEKIKIVEGICLLSGDDAEWDDLKQLRSSRGGLLRDHVCMKTDTVSIQASSGSLDDT
ETEQLLQEEQSECSSVHTAATPERRGSLPDTGWKHERKLSSESQV
NT seq
5718 nt
NT seq
+upstream
nt +downstream
nt
atgaggcggcagtggggcgcgctgctgcttggcgccctgctctgcgcacacggcctggcc
agcagccccgagtgtgcttgtggtcggagccacttcacatgtgcagtgagtgctcttgga
gagtgtacctgcatccctgcccagtggcagtgtgatggagacaatgactgcggggaccac
agcgatgaggatggatgtatactacctacctgttcccctcttgactttcactgtgacaat
ggcaagtgcatccgccgctcctgggtgtgtgacggggacaacgactgtgaggatgactcg
gatgagcaggactgtcccccccgggagtgtgaggaggacgagtttccctgccagaatggc
tactgcatccggagtctgtggcactgcgatggtgacaatgactgtggcgacaacagcgat
gagcagtgtgacatgcgcaagtgctccgacaaggagttccgctgtagtgacggaagctgc
attgctgagcattggtactgcgacggtgacaccgactgcaaagatggctccgatgaggag
aactgtccctcagcagtgccagcgcccccctgcaacctggaggagttccagtgtgcctat
ggacgctgcatcctcgacatctaccactgcgatggcgacgatgactgtggagactggtca
gacgagtctgactgctcctcccaccagccctgccgctctggggagttcatgtgtgacagt
ggcctgtgcatcaatgcaggctggcgctgcgatggtgacgcggactgtgatgaccagtct
gatgagcgcaactgcaccacctccatgtgtacggcagaacagttccgctgtcactcaggc
cgctgtgtccgcctgtcctggcgctgtgatggggaggacgactgtgcagacaacagcgat
gaagagaactgtgagaatacaggaagcccccaatgtgccttggaccagttcctgtgttgg
aatgggcgctgcattgggcagaggaagctgtgcaacggggtcaacgactgtggtgacaac
agcgacgaaagcccacagcagaattgccggccccggacgggtgaggagaactgcaatgtt
aacaacggtggctgtgcccagaagtgccagatggtgcggggggcagtgcagtgtacctgc
cacacaggctaccggctcacagaggatgggcacacgtgccaagatgtgaatgaatgtgcc
gaggaggggtattgcagccagggctgcaccaacagcgaaggggctttccaatgctggtgt
gaaacaggctatgaactacggcccgaccggcgcagctgcaaggctctggggccagagcct
gtgctgctgttcgccaatcgcatcgacatccggcaggtgctgccacaccgctctgagtac
acactgctgcttaacaacctggagaatgccattgcccttgatttccaccaccgccgcgag
cttgtcttctggtcagatgtcaccctggaccggatcctccgtgccaacctcaacggcagc
aacgtggaggaggttgtgtctactgggctggagagcccagggggcctggctgtggattgg
gtccatgacaaactctactggaccgactcaggcacctcgaggattgaggtggccaatctg
gatggggcccaccggaaagtgttgctgtggcagaacctggagaagccccgggccattgcc
ttgcatcccatggagggtaccatttactggacagactggggcaacaccccccgtattgag
gcctccagcatggatggctctggacgccgcatcattgccgatacccatctcttctggccc
aatggcctcaccatcgactatgccgggcgccgtatgtactgggtggatgctaagcaccat
gtcatcgagagggccaatctggatgggagtcaccgtaaggctgtcattagccagggcctc
ccgcatcccttcgccatcacagtgtttgaagacagcctgtactggacagactggcacacc
aagagcatcaatagcgctaacaaatttacggggaagaaccaggaaatcattcgcaacaaa
ctccacttccctatggacatccacaccttgcacccccagcgccaacctgcagggaaaaac
cgctgtggggacaacaacggaggctgcacgcacctgtgtctgcccagtggccagaactac
acctgtgcctgccccactggcttccgcaagatcagcagccacgcctgtgcccagagtctt
gacaagttcctgctttttgcccgaaggatggacatccgtcgaatcagctttgacacagag
gacctgtctgatgatgtcatcccactggctgacgtgcgcagtgctgtggcccttgactgg
gactcccgggatgaccacgtgtactggacagatgtcagcactgataccatcagcagggcc
aagtgggatggaacaggacaggaggtggtagtggataccagtttggagagcccagctggc
ctggccattgattgggtcaccaacaaactgtactggacagatgcaggtacagaccggatt
gaagtagccaacacagatggcagcatgagaacagtactcatctgggagaaccttgatcgt
cctcgggacatcgtggtggaacccatgggcgggtacatgtattggactgactggggtgcg
agccccaagattgaacgagctggcatggatgcctcaggccgccaagtcattatctcttct
aatctgacctggcctaatgggttagctattgattatgggtcccagcgtctatactgggct
gacgccggcatgaagacaattgaatttgctggactggatggcagtaagaggaaggtgctg
attggaagccagctcccccacccatttgggctgaccctctatggagagcgcatctattgg
actgactggcagaccaagagcatacagagcgctgaccggctgacagggctggaccgggag
actctgcaggagaacctggaaaacctaatggacatccatgtcttccaccgccgccggccc
ccagtgtctacaccatgtgctatggagaatggcggctgtagccacctgtgtcttaggtcc
ccaaatccaagcggattcagctgtacctgccccacaggcatcaacctgctgtctgatggc
aagacctgctcaccaggcatgaacagtttcctcatcttcgccaggaggatagacattcgc
atggtctccctggacatcccttattttgctgatgtggtggtaccaatcaacattaccatg
aagaacaccattgccattggagtagacccccaggaaggaaaggtgtactggtctgacagc
acactgcacaggatcagtcgtgccaatctggatggctcacagcatgaggacatcatcacc
acagggctacagaccacagatgggctcgcggttgatgccattggccggaaagtatactgg
acagacacgggaacaaaccggattgaagtgggcaacctggacgggtccatgcggaaagtg
ttggtgtggcagaaccttgacagtccccgggccatcgtactgtaccatgagatggggttt
atgtactggacagactggggggagaatgccaagttagagcggtccggaatggatggctca
gaccgcgcggtgctcatcaacaacaacctaggatggcccaatggactgactgtggacaag
gccagctcccaactgctatgggccgatgcccacaccgagcgaattgaggctgctgacctg
aatggtgccaatcggcatacattggtgtcaccggtgcagcacccatatggcctcaccctg
ctcgactcctatatctactggactgactggcagactcggagcatccaccgtgctgacaag
ggtactggcagcaatgtcatcctcgtgaggtccaacctgccaggcctcatggacatgcag
gctgtggaccgggcacagccactaggttttaacaagtgcggctcgagaaatggcggctgc
tcccacctctgcttgcctcggccttctggcttctcctgtgcctgccccactggcatccag
ctgaagggagatgggaagacctgtgatccctctcctgagacctacctgctcttctccagc
cgtggctccatccggcgtatctcactggacaccagtgaccacaccgatgtgcatgtccct
gttcctgagctcaacaatgtcatctccctggactatgacagcgtggatggaaaggtctat
tacacagatgtgttcctggatgttatcaggcgagcagacctgaacggcagcaacatggag
acagtgatcgggcgagggctgaagaccactgacgggctggcagtggactgggtggccagg
aacctgtactggacagacacaggtcgaaataccattgaggcgtccaggctggatggttcc
tgccgcaaagtactgatcaacaatagcctggatgagccccgggccattgctgttttcccc
aggaaggggtacctcttctggacagactggggccacattgccaagatcgaacgggcaaac
ttggatggttctgagcggaaggtcctcatcaacacagacctgggttggcccaatggcctt
accctggactatgatacccgcaggatctactgggtggatgcgcatctggaccggatcgag
agtgctgacctcaatgggaaactgcggcaggtcttggtcagccatgtgtcccaccccttt
gccctcacacagcaagacaggtggatctactggacagactggcagaccaagtcaatccag
cgtgttgacaaatactcaggccggaacaaggagacagtgctggcaaatgtggaaggactc
atggatatcatcgtggtttcccctcagcggcagacagggaccaatgcctgtggtgtgaac
aatggtggctgcacccacctctgctttgccagagcctcggacttcgtatgtgcctgtcct
gacgaacctgatagccggccctgctcccttgtgcctggcctggtaccaccagctcctagg
gctactggcatgagtgaaaagagcccagtgctacccaacacaccacctaccaccttgtat
tcttcaaccacccggacccgcacgtctctggaggaggtggaaggaagatgctctgaaagg
gatgccaggctgggcctctgtgcacgttccaatgacgctgttcctgctgctccaggggaa
ggacttcatatcagctacgccattggtggactcctcagtattctgctgattttggtggtg
attgcagctttgatgctgtacagacacaaaaaatccaagttcactgatcctggaatgggg
aacctcacctacagcaacccctcctaccgaacatccacacaggaagtgaagattgaagca
atccccaaaccagccatgtacaaccagctgtgctataagaaagagggagggcctgaccat
aactacaccaaggagaagatcaagatcgtagagggaatctgcctcctgtctggggatgat
gctgagtgggatgacctcaagcaactgcgaagctcacgggggggcctcctccgggatcat
gtatgcatgaagacagacacggtgtccatccaggccagctctggctccctggatgacaca
gagacggagcagctgttacaggaagagcagtctgagtgtagcagcgtccatactgcagcc
actccagaaagacgaggctctctgccagacacgggctggaaacatgaacgcaagctctcc
tcagagagccaggtctaa
DBGET
integrated database retrieval system