KEGG   Homo sapiens (human): 50964
Entry
50964             CDS       T01001                                 
Symbol
SOST, CDD, DAND6, SOST1, VBCH
Name
(RefSeq) sclerostin
  KO
K16834  sclerostin
Organism
hsa  Homo sapiens (human)
Pathway
hsa04310  Wnt signaling pathway
hsa04928  Parathyroid hormone synthesis, secretion and action
Network
nt06505  WNT signaling
  Element
N01441  Wnt signaling modulation, SOST/LRP4
Disease
H00486  Sclerosteosis
H01774  Hyperostosis corticalis generalisata
H02609  Craniodiaphyseal dysplasia
Drug target
Blosozumab: D10094
Romosozumab: D10156<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    50964 (SOST)
 09150 Organismal Systems
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    50964 (SOST)
SSDB
Motif
Pfam: Sclerostin DAN Cys_knot
Other DBs
NCBI-GeneID: 50964
NCBI-ProteinID: NP_079513
OMIM: 605740
HGNC: 13771
Ensembl: ENSG00000167941
UniProt: Q9BQB4
Structure
LinkDB
Position
17:complement(43753738..43758791)
AA seq 213 aa
MQLPLALCLVCLLVHTAFRVVEGQGWQAFKNDATEIIPELGEYPEPPPELENNKTMNRAE
NGGRPPHHPFETKDVSEYSCRELHFTRYVTDGPCRSAKPVTELVCSGQCGPARLLPNAIG
RGKWWRPSGPDFRCIPDRYRAQRVQLLCPGGEAPRARKVRLVASCKCKRLTRFHNQSELK
DFGTEAARPQKGRKPRPRARSAKANQAELENAY
NT seq 642 nt   +upstreamnt  +downstreamnt
atgcagctcccactggccctgtgtctcgtctgcctgctggtacacacagccttccgtgta
gtggagggccaggggtggcaggcgttcaagaatgatgccacggaaatcatccccgagctc
ggagagtaccccgagcctccaccggagctggagaacaacaagaccatgaaccgggcggag
aacggagggcggcctccccaccacccctttgagaccaaagacgtgtccgagtacagctgc
cgcgagctgcacttcacccgctacgtgaccgatgggccgtgccgcagcgccaagccggtc
accgagctggtgtgctccggccagtgcggcccggcgcgcctgctgcccaacgccatcggc
cgcggcaagtggtggcgacctagtgggcccgacttccgctgcatccccgaccgctaccgc
gcgcagcgcgtgcagctgctgtgtcccggtggtgaggcgccgcgcgcgcgcaaggtgcgc
ctggtggcctcgtgcaagtgcaagcgcctcacccgcttccacaaccagtcggagctcaag
gacttcgggaccgaggccgctcggccgcagaagggccggaagccgcggccccgcgcccgg
agcgccaaagccaaccaggccgagctggagaacgcctactag

KEGG   Homo sapiens (human): 4038
Entry
4038              CDS       T01001                                 
Symbol
LRP4, CLSS, CMS17, LRP-4, LRP10, MEGF7, SOST2
Name
(RefSeq) LDL receptor related protein 4
  KO
K20051  low-density lipoprotein receptor-related protein 4
Organism
hsa  Homo sapiens (human)
Network
nt06505  WNT signaling
  Element
N01441  Wnt signaling modulation, SOST/LRP4
Disease
H00486  Sclerosteosis
H00770  Congenital myasthenic syndrome
H00853  Cenani-Lenz syndactyly syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    4038 (LRP4)
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified [BR:hsa04990]
    4038 (LRP4)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Low-density lipoprotein receptor (LDLR) family proteins
    4038 (LRP4)
Domain-containing proteins not elsewhere classified [BR:hsa04990]
 Laminin domain-containing proteins
  Laminin EGF-like domain-containing proteins
   4038 (LRP4)
SSDB
Motif
Pfam: Ldl_recept_b Ldl_recept_a FXa_inhibition SGL cEGF DUF5050 EGF_CA
Other DBs
NCBI-GeneID: 4038
NCBI-ProteinID: NP_002325
OMIM: 604270
HGNC: 6696
Ensembl: ENSG00000134569
UniProt: O75096
Structure
LinkDB
Position
11:complement(46856717..46918550)
AA seq 1905 aa
MRRQWGALLLGALLCAHGLASSPECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDH
SDEDGCILPTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNG
YCIRSLWHCDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEE
NCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDS
GLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRCHSGRCVRLSWRCDGEDDCADNSD
EENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNV
NNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCTNSEGAFQCWC
ETGYELRPDRRSCKALGPEPVLLFANRIDIRQVLPHRSEYTLLLNNLENAIALDFHHRRE
LVFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANL
DGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWP
NGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQGLPHPFAITVFEDSLYWTDWHT
KSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDNNGGCTHLCLPSGQNY
TCACPTGFRKISSHACAQSLDKFLLFARRMDIRRISFDTEDLSDDVIPLADVRSAVALDW
DSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRI
EVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDASGRQVIISS
NLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGERIYW
TDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRS
PNPSGFSCTCPTGINLLSDGKTCSPGMNSFLIFARRIDIRMVSLDIPYFADVVVPINITM
KNTIAIGVDPQEGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIGRKVYW
TDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGS
DRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLVSPVQHPYGLTL
LDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAVDRAQPLGFNKCGSRNGGC
SHLCLPRPSGFSCACPTGIQLKGDGKTCDPSPETYLLFSSRGSIRRISLDTSDHTDVHVP
VPELNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGSNMETVIGRGLKTTDGLAVDWVAR
NLYWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERAN
LDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVSHVSHPF
ALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQTGTNACGVN
NGGCTHLCFARASDFVCACPDEPDSRPCSLVPGLVPPAPRATGMSEKSPVLPNTPPTTLY
SSTTRTRTSLEEVEGRCSERDARLGLCARSNDAVPAAPGEGLHISYAIGGLLSILLILVV
IAALMLYRHKKSKFTDPGMGNLTYSNPSYRTSTQEVKIEAIPKPAMYNQLCYKKEGGPDH
NYTKEKIKIVEGICLLSGDDAEWDDLKQLRSSRGGLLRDHVCMKTDTVSIQASSGSLDDT
ETEQLLQEEQSECSSVHTAATPERRGSLPDTGWKHERKLSSESQV
NT seq 5718 nt   +upstreamnt  +downstreamnt
atgaggcggcagtggggcgcgctgctgcttggcgccctgctctgcgcacacggcctggcc
agcagccccgagtgtgcttgtggtcggagccacttcacatgtgcagtgagtgctcttgga
gagtgtacctgcatccctgcccagtggcagtgtgatggagacaatgactgcggggaccac
agcgatgaggatggatgtatactacctacctgttcccctcttgactttcactgtgacaat
ggcaagtgcatccgccgctcctgggtgtgtgacggggacaacgactgtgaggatgactcg
gatgagcaggactgtcccccccgggagtgtgaggaggacgagtttccctgccagaatggc
tactgcatccggagtctgtggcactgcgatggtgacaatgactgtggcgacaacagcgat
gagcagtgtgacatgcgcaagtgctccgacaaggagttccgctgtagtgacggaagctgc
attgctgagcattggtactgcgacggtgacaccgactgcaaagatggctccgatgaggag
aactgtccctcagcagtgccagcgcccccctgcaacctggaggagttccagtgtgcctat
ggacgctgcatcctcgacatctaccactgcgatggcgacgatgactgtggagactggtca
gacgagtctgactgctcctcccaccagccctgccgctctggggagttcatgtgtgacagt
ggcctgtgcatcaatgcaggctggcgctgcgatggtgacgcggactgtgatgaccagtct
gatgagcgcaactgcaccacctccatgtgtacggcagaacagttccgctgtcactcaggc
cgctgtgtccgcctgtcctggcgctgtgatggggaggacgactgtgcagacaacagcgat
gaagagaactgtgagaatacaggaagcccccaatgtgccttggaccagttcctgtgttgg
aatgggcgctgcattgggcagaggaagctgtgcaacggggtcaacgactgtggtgacaac
agcgacgaaagcccacagcagaattgccggccccggacgggtgaggagaactgcaatgtt
aacaacggtggctgtgcccagaagtgccagatggtgcggggggcagtgcagtgtacctgc
cacacaggctaccggctcacagaggatgggcacacgtgccaagatgtgaatgaatgtgcc
gaggaggggtattgcagccagggctgcaccaacagcgaaggggctttccaatgctggtgt
gaaacaggctatgaactacggcccgaccggcgcagctgcaaggctctggggccagagcct
gtgctgctgttcgccaatcgcatcgacatccggcaggtgctgccacaccgctctgagtac
acactgctgcttaacaacctggagaatgccattgcccttgatttccaccaccgccgcgag
cttgtcttctggtcagatgtcaccctggaccggatcctccgtgccaacctcaacggcagc
aacgtggaggaggttgtgtctactgggctggagagcccagggggcctggctgtggattgg
gtccatgacaaactctactggaccgactcaggcacctcgaggattgaggtggccaatctg
gatggggcccaccggaaagtgttgctgtggcagaacctggagaagccccgggccattgcc
ttgcatcccatggagggtaccatttactggacagactggggcaacaccccccgtattgag
gcctccagcatggatggctctggacgccgcatcattgccgatacccatctcttctggccc
aatggcctcaccatcgactatgccgggcgccgtatgtactgggtggatgctaagcaccat
gtcatcgagagggccaatctggatgggagtcaccgtaaggctgtcattagccagggcctc
ccgcatcccttcgccatcacagtgtttgaagacagcctgtactggacagactggcacacc
aagagcatcaatagcgctaacaaatttacggggaagaaccaggaaatcattcgcaacaaa
ctccacttccctatggacatccacaccttgcacccccagcgccaacctgcagggaaaaac
cgctgtggggacaacaacggaggctgcacgcacctgtgtctgcccagtggccagaactac
acctgtgcctgccccactggcttccgcaagatcagcagccacgcctgtgcccagagtctt
gacaagttcctgctttttgcccgaaggatggacatccgtcgaatcagctttgacacagag
gacctgtctgatgatgtcatcccactggctgacgtgcgcagtgctgtggcccttgactgg
gactcccgggatgaccacgtgtactggacagatgtcagcactgataccatcagcagggcc
aagtgggatggaacaggacaggaggtggtagtggataccagtttggagagcccagctggc
ctggccattgattgggtcaccaacaaactgtactggacagatgcaggtacagaccggatt
gaagtagccaacacagatggcagcatgagaacagtactcatctgggagaaccttgatcgt
cctcgggacatcgtggtggaacccatgggcgggtacatgtattggactgactggggtgcg
agccccaagattgaacgagctggcatggatgcctcaggccgccaagtcattatctcttct
aatctgacctggcctaatgggttagctattgattatgggtcccagcgtctatactgggct
gacgccggcatgaagacaattgaatttgctggactggatggcagtaagaggaaggtgctg
attggaagccagctcccccacccatttgggctgaccctctatggagagcgcatctattgg
actgactggcagaccaagagcatacagagcgctgaccggctgacagggctggaccgggag
actctgcaggagaacctggaaaacctaatggacatccatgtcttccaccgccgccggccc
ccagtgtctacaccatgtgctatggagaatggcggctgtagccacctgtgtcttaggtcc
ccaaatccaagcggattcagctgtacctgccccacaggcatcaacctgctgtctgatggc
aagacctgctcaccaggcatgaacagtttcctcatcttcgccaggaggatagacattcgc
atggtctccctggacatcccttattttgctgatgtggtggtaccaatcaacattaccatg
aagaacaccattgccattggagtagacccccaggaaggaaaggtgtactggtctgacagc
acactgcacaggatcagtcgtgccaatctggatggctcacagcatgaggacatcatcacc
acagggctacagaccacagatgggctcgcggttgatgccattggccggaaagtatactgg
acagacacgggaacaaaccggattgaagtgggcaacctggacgggtccatgcggaaagtg
ttggtgtggcagaaccttgacagtccccgggccatcgtactgtaccatgagatggggttt
atgtactggacagactggggggagaatgccaagttagagcggtccggaatggatggctca
gaccgcgcggtgctcatcaacaacaacctaggatggcccaatggactgactgtggacaag
gccagctcccaactgctatgggccgatgcccacaccgagcgaattgaggctgctgacctg
aatggtgccaatcggcatacattggtgtcaccggtgcagcacccatatggcctcaccctg
ctcgactcctatatctactggactgactggcagactcggagcatccaccgtgctgacaag
ggtactggcagcaatgtcatcctcgtgaggtccaacctgccaggcctcatggacatgcag
gctgtggaccgggcacagccactaggttttaacaagtgcggctcgagaaatggcggctgc
tcccacctctgcttgcctcggccttctggcttctcctgtgcctgccccactggcatccag
ctgaagggagatgggaagacctgtgatccctctcctgagacctacctgctcttctccagc
cgtggctccatccggcgtatctcactggacaccagtgaccacaccgatgtgcatgtccct
gttcctgagctcaacaatgtcatctccctggactatgacagcgtggatggaaaggtctat
tacacagatgtgttcctggatgttatcaggcgagcagacctgaacggcagcaacatggag
acagtgatcgggcgagggctgaagaccactgacgggctggcagtggactgggtggccagg
aacctgtactggacagacacaggtcgaaataccattgaggcgtccaggctggatggttcc
tgccgcaaagtactgatcaacaatagcctggatgagccccgggccattgctgttttcccc
aggaaggggtacctcttctggacagactggggccacattgccaagatcgaacgggcaaac
ttggatggttctgagcggaaggtcctcatcaacacagacctgggttggcccaatggcctt
accctggactatgatacccgcaggatctactgggtggatgcgcatctggaccggatcgag
agtgctgacctcaatgggaaactgcggcaggtcttggtcagccatgtgtcccaccccttt
gccctcacacagcaagacaggtggatctactggacagactggcagaccaagtcaatccag
cgtgttgacaaatactcaggccggaacaaggagacagtgctggcaaatgtggaaggactc
atggatatcatcgtggtttcccctcagcggcagacagggaccaatgcctgtggtgtgaac
aatggtggctgcacccacctctgctttgccagagcctcggacttcgtatgtgcctgtcct
gacgaacctgatagccggccctgctcccttgtgcctggcctggtaccaccagctcctagg
gctactggcatgagtgaaaagagcccagtgctacccaacacaccacctaccaccttgtat
tcttcaaccacccggacccgcacgtctctggaggaggtggaaggaagatgctctgaaagg
gatgccaggctgggcctctgtgcacgttccaatgacgctgttcctgctgctccaggggaa
ggacttcatatcagctacgccattggtggactcctcagtattctgctgattttggtggtg
attgcagctttgatgctgtacagacacaaaaaatccaagttcactgatcctggaatgggg
aacctcacctacagcaacccctcctaccgaacatccacacaggaagtgaagattgaagca
atccccaaaccagccatgtacaaccagctgtgctataagaaagagggagggcctgaccat
aactacaccaaggagaagatcaagatcgtagagggaatctgcctcctgtctggggatgat
gctgagtgggatgacctcaagcaactgcgaagctcacgggggggcctcctccgggatcat
gtatgcatgaagacagacacggtgtccatccaggccagctctggctccctggatgacaca
gagacggagcagctgttacaggaagagcagtctgagtgtagcagcgtccatactgcagcc
actccagaaagacgaggctctctgccagacacgggctggaaacatgaacgcaagctctcc
tcagagagccaggtctaa

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