KEGG   PATHWAY: oro00590
Entry
oro00590                    Pathway                                
Name
Arachidonic acid metabolism - Odobenus rosmarus divergens (Pacific walrus)
Class
Metabolism; Lipid metabolism
Pathway map
oro00590  Arachidonic acid metabolism
oro00590

Other DBs
GO: 0019369
Organism
Odobenus rosmarus divergens (Pacific walrus) [GN:oro]
Gene
101375978  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101385106  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
101366454  PLA2G5; calcium-dependent phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101377802  group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101369096  PLA2G1B; phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
101366171  PLA2G2C; LOW QUALITY PROTEIN: putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101371267  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101371554  PLA2G2D; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101371862  group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101366777  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101377203  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
101377493  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
101374803  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
101362322  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
101386671  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
101377812  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 [KO:K16343] [EC:3.1.1.4]
101374070  PLB1; phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]
101384196  HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
101370362  PTGS1; prostaglandin G/H synthase 1 isoform X1 [KO:K00509] [EC:1.14.99.1]
101375484  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
101375511  PTGES; prostaglandin E synthase [KO:K15729] [EC:5.3.99.3]
101366532  PTGES2; prostaglandin E synthase 2 [KO:K05309] [EC:5.3.99.3]
101371583  PTGES3; prostaglandin E synthase 3 isoform X1 [KO:K15730] [EC:5.3.99.3]
101365418  LOW QUALITY PROTEIN: carbonyl reductase [NADPH] 2-like [KO:K00081] [EC:1.1.1.184]
101366810  carbonyl reductase [NADPH] 3 [KO:K00084] [EC:1.1.1.184]
101379247  FAM213B; prostamide/prostaglandin F synthase [KO:K15717] [EC:1.11.1.20]
101372450  HPGD; 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform X1 [KO:K00069] [EC:1.1.1.141]
101374074  TBXAS1; thromboxane-A synthase isoform X1 [KO:K01832] [EC:5.3.99.5]
101372918  PTGDS; prostaglandin-H2 D-isomerase [KO:K01830] [EC:5.3.99.2]
101376365  HPGDS; hematopoietic prostaglandin D synthase [KO:K04097] [EC:5.3.99.2 2.5.1.18]
101377633  aldo-keto reductase family 1 member C3-like [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
101379669  aldo-keto reductase family 1 member C1 homolog [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
101382580  PTGIS; prostacyclin synthase [KO:K01831] [EC:5.3.99.4]
101381769  ALOX5; arachidonate 5-lipoxygenase isoform X1 [KO:K00461] [EC:1.13.11.34]
101366375  LTA4H; leukotriene A-4 hydrolase [KO:K01254] [EC:3.3.2.6]
101368827  LOW QUALITY PROTEIN: zinc-binding alcohol dehydrogenase domain-containing protein 2-like [KO:K07119] [EC:1.3.1.48]
101369791  ZADH2; zinc-binding alcohol dehydrogenase domain-containing protein 2 [KO:K07119] [EC:1.3.1.48]
101376717  PTGR2; prostaglandin reductase 2 [KO:K13949] [EC:1.3.1.48]
101370295  PTGR1; prostaglandin reductase 1 [KO:K13948] [EC:1.3.1.74 1.3.1.48]
101378794  LTC4S; leukotriene C4 synthase [KO:K00807] [EC:4.4.1.20]
101379030  GGT5; gamma-glutamyltransferase 5 isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
101379513  GGT1; gamma-glutamyltranspeptidase 1 isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
101377930  GPX4; phospholipid hydroperoxide glutathione peroxidase, mitochondrial isoform X2 [KO:K05361] [EC:1.11.1.12]
101365364  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
101382939  cytochrome P450 2J2 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
101371519  cytochrome P450 2U1 [KO:K07422] [EC:1.14.14.80]
101381707  cytochrome P450 4A11 [KO:K07425] [EC:1.14.14.80]
101379600  ALOX12; arachidonate 12-lipoxygenase, 12S-type [KO:K00458] [EC:1.13.11.31]
101371570  ALOXE3; hydroperoxide isomerase ALOXE3 [KO:K18684] [EC:4.2.1.152 5.4.4.7]
101382607  ALOX12B; arachidonate 12-lipoxygenase, 12R-type [KO:K08021] [EC:1.13.11.-]
101382890  ALOX15B; arachidonate 15-lipoxygenase B isoform X1 [KO:K08022] [EC:1.13.11.33 1.13.11.-]
101366852  cytochrome P450 2B11 [KO:K07412] [EC:1.14.14.1]
101385757  LOW QUALITY PROTEIN: cytochrome P450 2B4-like [KO:K07412] [EC:1.14.14.1]
101365655  cytochrome P450 2C41 isoform X1 [KO:K07413] [EC:1.14.14.1]
101365057  cytochrome P450 2C23-like [KO:K07413] [EC:1.14.14.1]
101383285  cytochrome P450 2C21 isoform X1 [KO:K07413] [EC:1.14.14.1]
101373863  EPHX2; bifunctional epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
101380189  ALOX15; arachidonate 15-lipoxygenase [KO:K00460] [EC:1.13.11.33]
101379891  LOW QUALITY PROTEIN: arachidonate 12-lipoxygenase, epidermal-type-like [KO:K00460] [EC:1.13.11.33]
Compound
C00157  Phosphatidylcholine
C00219  Arachidonate
C00427  Prostaglandin H2
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00696  Prostaglandin D2
C00909  Leukotriene A4
C01312  Prostaglandin I2
C02165  Leukotriene B4
C02166  Leukotriene C4
C02198  Thromboxane A2
C03577  20-Hydroxyleukotriene E4
C04577  15-OxoETE
C04671  (5Z)-11alpha-Hydroxy-9,15-dioxoprostanoate
C04707  (5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-5,13-dienoate
C04742  (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
C04758  (5Z,13E)-9alpha-Hydroxy-11,15-dioxoprosta-5,13-dienoate
C04805  5(S)-HETE
C04822  8(R)-HPETE
C04835  (5Z,13E)-6,9alpha-Epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate
C04853  20-OH-Leukotriene B4
C05356  5(S)-HPETE
C05949  12-Keto-leukotriene B4
C05950  20-COOH-Leukotriene B4
C05951  Leukotriene D4
C05952  Leukotriene E4
C05953  Prostaglandin A2
C05954  Prostaglandin B2
C05955  Prostaglandin C2
C05956  Prostaglandin G2
C05957  Prostaglandin J2
C05958  Delta-12-Prostaglandin J2
C05959  11-epi-Prostaglandin F2alpha
C05960  15-Keto-prostaglandin F2alpha
C05961  6-Keto-prostaglandin F1alpha
C05962  6-Keto-prostaglandin E1
C05963  Thromboxane B2
C05964  11-Dehydro-thromboxane B2
C05965  12(S)-HPETE
C05966  15(S)-HPETE
C06314  Lipoxin A4
C06315  Lipoxin B4
C06462  Leukotriene F4
C13809  9,11,15-Trihydroxy-prosta-5,13-dien-1-oic acid
C14717  15-Deoxy-Delta12,14-PGJ2
C14732  5-OxoETE
C14748  20-HETE
C14749  19(S)-HETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
C14772  5,6-DHET
C14773  8,9-DHET
C14774  11,12-DHET
C14775  14,15-DHET
C14776  8(S)-HETE
C14777  12(S)-HETE
C14778  16(R)-HETE
C14779  9(S)-HETE
C14780  11(R)-HETE
C14781  15H-11,12-EETA
C14782  11,12,15-THETA
C14794  2,3-Dinor-8-iso prostaglandin F2alpha
C14795  2,3-Dinor-8-iso prostaglandin F1alpha
C14807  12-OxoETE
C14808  Hepoxilin A3
C14809  Trioxilin A3
C14810  Hepoxilin B3
C14811  Trioxilin B3
C14812  12(R)-HPETE
C14813  11H-14,15-EETA
C14814  11,14,15-THETA
C14815  5,6-Epoxytetraene
C14820  11(R)-HPETE
C14821  9(S)-HPETE
C14822  12(R)-HETE
C14823  8(S)-HPETE
C14824  8(R)-HETE
Reference
PMID:14636671
  Authors
Spector AA, Fang X, Snyder GD, Weintraub NL.
  Title
Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function.
  Journal
Prog Lipid Res 43:55-90 (2004)
DOI:10.1016/S0163-7827(03)00049-3
Reference
PMID:15292194
  Authors
Harman CA, Rieke CJ, Garavito RM, Smith WL.
  Title
Crystal structure of arachidonic acid bound to a mutant of prostaglandin endoperoxide H synthase-1 that forms predominantly 11-hydroperoxyeicosatetraenoic acid.
  Journal
J Biol Chem 279:42929-35 (2004)
DOI:10.1074/jbc.M403013200
Reference
PMID:15205388
  Authors
Poloyac SM, Tortorici MA, Przychodzin DI, Reynolds RB, Xie W, Frye RF, Zemaitis MA.
  Title
The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney.
  Journal
Drug Metab Dispos 32:727-33 (2004)
DOI:10.1124/dmd.32.7.727
Reference
PMID:14660610
  Authors
Chuang SS, Helvig C, Taimi M, Ramshaw HA, Collop AH, Amad M, White JA, Petkovich M, Jones G, Korczak B.
  Title
CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids.
  Journal
J Biol Chem 279:6305-14 (2004)
DOI:10.1074/jbc.M311830200
Reference
PMID:14626496
  Authors
Sacerdoti D, Gatta A, McGiff JC.
  Title
Role of cytochrome P450-dependent arachidonic acid metabolites in liver physiology and pathophysiology.
  Journal
Prostaglandins Other Lipid Mediat 72:51-71 (2003)
DOI:10.1016/S1098-8823(03)00077-7
Reference
PMID:14622984
  Authors
Pfister SL, Spitzbarth N, Zeldin DC, Lafite P, Mansuy D, Campbell WB.
  Title
Rabbit aorta converts 15-HPETE to trihydroxyeicosatrienoic acids: potential role of cytochrome P450.
  Journal
Arch Biochem Biophys 420:142-52 (2003)
DOI:10.1016/j.abb.2003.09.026
Reference
PMID:11679404
  Authors
Fleming I.
  Title
Cytochrome p450 and vascular homeostasis.
  Journal
Circ Res 89:753-62 (2001)
DOI:10.1161/hh2101.099268
Reference
PMID:11328810
  Authors
Qu W, Bradbury JA, Tsao CC, Maronpot R, Harry GJ, Parker CE, Davis LS, Breyer MD, Waalkes MP, Falck JR, Chen J, Rosenberg RL, Zeldin DC.
  Title
Cytochrome P450 CYP2J9, a new mouse arachidonic acid omega-1 hydroxylase predominantly expressed in brain.
  Journal
J Biol Chem 276:25467-79 (2001)
DOI:10.1074/jbc.M100545200
Reference
PMID:10908295
  Authors
Tsao CC, Foley J, Coulter SJ, Maronpot R, Zeldin DC, Goldstein JA.
  Title
CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major CYP2C in murine intestinal tract.
  Journal
Mol Pharmacol 58:279-87 (2000)
DOI:10.1124/mol.58.2.279
Reference
PMID:9812980
  Authors
Pfister SL, Spitzbarth N, Nithipatikom K, Edgemond WS, Falck JR, Campbell WB.
  Title
Identification of the 11,14,15- and 11,12, 15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta.
  Journal
J Biol Chem 273:30879-87 (1998)
DOI:10.1074/jbc.273.47.30879
Related
pathway
oro00591  Linoleic acid metabolism
KO pathway
ko00590   
LinkDB

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