KEGG   PATHWAY: acar04625
Entry
acar04625                   Pathway                                
Name
C-type lectin receptor signaling pathway - Antrostomus carolinensis (chuck-will's-widow)
Description
C-type lectin receptors (CLRs) are a large superfamily of proteins characterized by the presence of one or more C-type lectin-like domains (CTLDs). CLRs function as pattern-recognition receptors (PRRs) for pathogen-derived ligands in dendric cells, macrophages, neutrophils, etc., such as Dectin-1 and Dectin-2 for recognition of fungi-derived B-glucan and high mannose-type carbohydrates. Upon ligand binding, CLRs stimulate intracellular signaling cascades that induce the production of inflammatory cytokines and chemokines, consequently triggering innate and adaptive immunity to pathogens.
Class
Organismal Systems; Immune system
Pathway map
acar04625  C-type lectin receptor signaling pathway
acar04625

Organism
Antrostomus carolinensis (chuck-will's-widow) [GN:acar]
Gene
104517675  lymphocyte-specific protein 1 [KO:K14957]
104523735  GTPase KRas [KO:K07827]
104531552  GTPase NRas [KO:K07828]
104527717  MRAS; ras-related protein M-Ras [KO:K07831]
104532212  RRAS2; ras-related protein R-Ras2 [KO:K07830]
104527077  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
104518036  IL12B; interleukin-12 subunit beta [KO:K05425]
104523566  interleukin-1 receptor antagonist protein-like isoform X2 [KO:K04519]
104519362  tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
104524022  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
104531019  tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
104532303  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
104522667  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
104523042  LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
104532633  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
104518104  CALML4; calmodulin-like protein 4 [KO:K02183]
104529106  calmodulin, striated muscle [KO:K02183]
104519836  calmodulin isoform X1 [KO:K02183]
104531079  CALM2; calmodulin-2 [KO:K02183]
104520832  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
104532428  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
104532933  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X3 [KO:K04348] [EC:3.1.3.16]
104519561  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
104529339  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
104530997  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
104523982  IL10; interleukin-10 [KO:K05443]
104520971  LOW QUALITY PROTEIN: early growth response protein 3-like [KO:K12497]
104520827  PTGS2; prostaglandin G/H synthase 2 isoform X1 [KO:K11987] [EC:1.14.99.1]
104520783  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
104519041  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104523057  LOW QUALITY PROTEIN: caspase-1-like [KO:K01370] [EC:3.4.22.36]
104522268  CARD9; caspase recruitment domain-containing protein 9 [KO:K12794]
104519929  BCL10; B-cell lymphoma/leukemia 10 [KO:K07368]
104524841  mucosa-associated lymphoid tissue lymphoma translocation protein 1 [KO:K07369] [EC:3.4.22.-]
104525388  MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 [KO:K07369] [EC:3.4.22.-]
104521135  mucosa-associated lymphoid tissue lymphoma translocation protein 1-like [KO:K07369] [EC:3.4.22.-]
104523966  caspase-8 [KO:K04398] [EC:3.4.22.61]
104532423  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
104518147  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
104519341  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
104524289  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
104520595  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
104519375  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
104523137  mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
104528537  mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
104530925  mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
104520979  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
104527571  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
104520248  JUN; transcription factor AP-1 [KO:K04448]
104522117  hepatic lectin-like [KO:K06563]
104526724  ARHGEF12; rho guanine nucleotide exchange factor 12 [KO:K07532]
104525482  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
104528155  KSR1; kinase suppressor of Ras 1 [KO:K14958]
104530747  serine/threonine-protein kinase PLK3 [KO:K08862] [EC:2.7.11.21]
104527841  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
104521188  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
104525996  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
104529053  CYLD; ubiquitin carboxyl-terminal hydrolase CYLD [KO:K08601] [EC:3.4.19.12]
104531133  C-C motif chemokine 3-like [KO:K21083]
104528782  C-C motif chemokine 5 [KO:K21083]
104530635  MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
104529416  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104530649  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
104523728  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
104523932  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
104526170  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
104528001  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
104519416  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104531302  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104527791  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104531859  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
104525175  IRF1; interferon regulatory factor 1 isoform X1 [KO:K09444]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00159  D-Mannose
C00165  Diacylglycerol
C00584  Prostaglandin E2
C00965  1,3-beta-D-Glucan
C01019  L-Fucose
C01245  D-myo-Inositol 1,4,5-trisphosphate
C16844  Hydroxyl radical
C21790  Mycobacterial trehalose dimycolate
C21791  Rhodocytin
G13115  Mannose-capped lipoarabinomannan
Reference
PMID:27291962
  Authors
Geijtenbeek TB, Gringhuis SI
  Title
C-type lectin receptors in the control of T helper cell differentiation.
  Journal
Nat Rev Immunol 16:433-48 (2016)
DOI:10.1038/nri.2016.55
Reference
PMID:21350579
  Authors
Hajishengallis G, Lambris JD
  Title
Microbial manipulation of receptor crosstalk in innate immunity.
  Journal
Nat Rev Immunol 11:187-200 (2011)
DOI:10.1038/nri2918
Reference
PMID:28604735
  Authors
Iliev ID, Leonardi I
  Title
Fungal dysbiosis: immunity and interactions at mucosal barriers.
  Journal
Nat Rev Immunol 17:635-646 (2017)
DOI:10.1038/nri.2017.55
Reference
PMID:25002863
  Authors
Richardson MB, Williams SJ
  Title
MCL and Mincle: C-Type Lectin Receptors That Sense Damaged Self and Pathogen-Associated Molecular Patterns.
  Journal
Front Immunol 5:288 (2014)
DOI:10.3389/fimmu.2014.00288
Reference
PMID:21924922
  Authors
Vautier S, MacCallum DM, Brown GD
  Title
C-type lectin receptors and cytokines in fungal immunity.
  Journal
Cytokine 58:89-99 (2012)
DOI:10.1016/j.cyto.2011.08.031
Reference
PMID:22170181
  Authors
Gauglitz GG, Callenberg H, Weindl G, Korting HC
  Title
Host defence against Candida albicans and the role of pattern-recognition receptors.
  Journal
Acta Derm Venereol 92:291-8 (2012)
DOI:10.2340/00015555-1250
Reference
PMID:22973279
  Authors
Cunha C, Carvalho A, Esposito A, Bistoni F, Romani L
  Title
DAMP signaling in fungal infections and diseases.
  Journal
Front Immunol 3:286 (2012)
DOI:10.3389/fimmu.2012.00286
Reference
PMID:29449845
  Authors
Tang J, Lin G, Langdon WY, Tao L, Zhang J
  Title
Regulation of C-Type Lectin Receptor-Mediated Antifungal Immunity.
  Journal
Front Immunol 9:123 (2018)
DOI:10.3389/fimmu.2018.00123
Reference
PMID:27999992
  Authors
Mayer S, Raulf MK, Lepenies B
  Title
C-type lectins: their network and roles in pathogen recognition and immunity.
  Journal
Histochem Cell Biol 147:223-237 (2017)
DOI:10.1007/s00418-016-1523-7
Reference
PMID:23570314
  Authors
Plato A, Willment JA, Brown GD
  Title
C-type lectin-like receptors of the dectin-1 cluster: ligands and signaling pathways.
  Journal
Int Rev Immunol 32:134-56 (2013)
DOI:10.3109/08830185.2013.777065
Reference
PMID:22344277
  Authors
Dupaul-Chicoine J, Saleh M
  Title
A new path to IL-1beta production controlled by caspase-8.
  Journal
Nat Immunol 13:211-2 (2012)
DOI:10.1038/ni.2241
Reference
PMID:24009832
  Authors
Batbayar S, Lee DH, Kim HW
  Title
Immunomodulation of Fungal beta-Glucan in Host Defense Signaling by Dectin-1.
  Journal
Biomol Ther (Seoul) 20:433-45 (2012)
DOI:10.4062/biomolther.2012.20.5.433
Reference
PMID:28606994
  Authors
Bendickova K, Tidu F, Fric J
  Title
Calcineurin-NFAT signalling in myeloid leucocytes: new prospects and pitfalls in immunosuppressive therapy.
  Journal
EMBO Mol Med 9:990-999 (2017)
DOI:10.15252/emmm.201707698
Reference
PMID:18998127
  Authors
den Dunnen J, Gringhuis SI, Geijtenbeek TB
  Title
Innate signaling by the C-type lectin DC-SIGN dictates immune responses.
  Journal
Cancer Immunol Immunother 58:1149-57 (2009)
DOI:10.1007/s00262-008-0615-1
Reference
PMID:28640912
  Authors
Marakalala MJ, Ndlovu H
  Title
Signaling C-type lectin receptors in antimycobacterial immunity.
  Journal
PLoS Pathog 13:e1006333 (2017)
DOI:10.1371/journal.ppat.1006333
Reference
PMID:24867235
  Authors
Gringhuis SI, Kaptein TM, Wevers BA, Mesman AW, Geijtenbeek TB
  Title
Fucose-specific DC-SIGN signalling directs T helper cell type-2 responses via IKKepsilon- and CYLD-dependent Bcl3 activation.
  Journal
Nat Commun 5:3898 (2014)
DOI:10.1038/ncomms4898
Reference
PMID:19521399
  Authors
Geijtenbeek TB, Gringhuis SI
  Title
Signalling through C-type lectin receptors: shaping immune responses.
  Journal
Nat Rev Immunol 9:465-79 (2009)
DOI:10.1038/nri2569
Reference
PMID:19122653
  Authors
Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Wevers B, Bruijns SC, Geijtenbeek TB
  Title
Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk.
  Journal
Nat Immunol 10:203-13 (2009)
DOI:10.1038/ni.1692
KO pathway
ko04625   
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