KEGG   PATHWAY: achc04150
Entry
achc04150                   Pathway                                
Name
mTOR signaling pathway - Aquila chrysaetos chrysaetos (golden eagle)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
achc04150  mTOR signaling pathway
achc04150

Organism
Aquila chrysaetos chrysaetos (golden eagle) [GN:achc]
Gene
115345351  SLC7A5; large neutral amino acids transporter small subunit 1 [KO:K13780]
115347763  SLC3A2; LOW QUALITY PROTEIN: 4F2 cell-surface antigen heavy chain [KO:K06519]
115336930  SLC38A9; sodium-coupled neutral amino acid transporter 9 isoform X1 [KO:K14995]
115344050  ATP6V1A; V-type proton ATPase catalytic subunit A isoform X1 [KO:K02145] [EC:7.1.2.2]
115346515  V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
115350188  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
115342501  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
115351022  ATP6V1C2; V-type proton ATPase subunit C 2 [KO:K02148]
115340758  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
115348322  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
115352739  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
115341648  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
115335014  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
115349176  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
115340346  ATP6V1H; V-type proton ATPase subunit H [KO:K02144]
115353539  LAMTOR1; ragulator complex protein LAMTOR1 [KO:K20397]
115346038  LAMTOR2; ragulator complex protein LAMTOR2 [KO:K20398]
115346709  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
115338365  LAMTOR4; ragulator complex protein LAMTOR4 isoform X1 [KO:K20399]
115335468  LAMTOR5; ragulator complex protein LAMTOR5 [KO:K16344]
115335874  FLCN; folliculin isoform X2 [KO:K09594]
115334304  FNIP1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
115340000  FNIP2; folliculin-interacting protein 2 isoform X1 [KO:K20401]
115333696  ras-related GTP-binding protein A isoform X1 [KO:K16185]
115336730  RRAGD; ras-related GTP-binding protein D [KO:K16186]
115351977  RRAGC; ras-related GTP-binding protein C [KO:K16186]
115351456  SESN2; sestrin-2 isoform X1 [KO:K20394]
115346221  CASTOR1; cytosolic arginine sensor for mTORC1 subunit 1 isoform X1 [KO:K23080]
115346760  CASTOR2; cytosolic arginine sensor for mTORC1 subunit 2 isoform X1 [KO:K23081]
115338904  MIOS; GATOR complex protein MIOS [KO:K20407]
115335712  WDR24; GATOR complex protein WDR24 [KO:K20408]
115345874  WDR59; GATOR complex protein WDR59 [KO:K20409]
115333287  SEC13; protein SEC13 homolog [KO:K14004]
115345588  DEPDC5; GATOR complex protein DEPDC5 isoform X1 [KO:K20404]
115353840  NPRL2; GATOR complex protein NPRL2 [KO:K20405]
115336049  NPRL3; GATOR complex protein NPRL3 isoform X4 [KO:K20406]
115336928  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
115353003  RNF152; E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
115341029  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
115342569  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
115338867  DEP domain-containing mTOR-interacting protein-like isoform X1 [KO:K20402]
115340279  DEPTOR; DEP domain-containing mTOR-interacting protein isoform X2 [KO:K20402]
115335850  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
115335546  TELO2; telomere length regulation protein TEL2 homolog isoform X1 [KO:K11137]
115339137  TTI1; TELO2-interacting protein 1 homolog isoform X1 [KO:K20403]
115345324  CLIP1; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
115340159  GRB10; growth factor receptor-bound protein 10 isoform X2 [KO:K20064]
115351107  LPIN1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
115339620  LPIN3; phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
115340089  LPIN2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
115345420  ULK1; serine/threonine-protein kinase ULK1 isoform X7 [KO:K21357] [EC:2.7.11.1]
115347569  ULK2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
115350303  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
115338645  EIF4E; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
115346837  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
115334240  EIF4E1B; eukaryotic translation initiation factor 4E type 1B isoform X1 [KO:K03259]
115346749  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
115337432  RPS6; 40S ribosomal protein S6 [KO:K02991]
115344365  STRADA; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
115342551  STRADB; STE20-related kinase adapter protein beta isoform X1 [KO:K17532]
115348852  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
115350560  CAB39L; calcium-binding protein 39-like isoform X1 [KO:K08272]
115347322  CAB39; calcium-binding protein 39 [KO:K08272]
115336440  PRKAA1; LOW QUALITY PROTEIN: 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
121233007  5'-AMP-activated protein kinase catalytic subunit alpha-1-like isoform X1 [KO:K07198] [EC:2.7.11.31]
115348780  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
115334918  TSC1; hamartin isoform X1 [KO:K07206]
115335525  TSC2; tuberin isoform X1 [KO:K07207]
115353053  TBC1D7; TBC1 domain family member 7 [KO:K20396]
115339861  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
115348003  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
115351113  WNT1; LOW QUALITY PROTEIN: proto-oncogene Wnt-1 [KO:K03209]
115335433  WNT2B; protein Wnt-2b [KO:K00182]
115342257  WNT2; protein Wnt-2 [KO:K00182]
115344707  WNT3; proto-oncogene Wnt-3 [KO:K00312]
115339363  WNT3A; protein Wnt-3a [KO:K00312]
115343217  WNT4; protein Wnt-4 [KO:K00408]
115343886  protein Wnt-4a-like [KO:K00408]
115333352  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
115352517  WNT5B; protein Wnt-5b [KO:K00444]
115343354  WNT6; LOW QUALITY PROTEIN: protein Wnt-6 [KO:K00445]
115333382  WNT7A; protein Wnt-7a [KO:K00572]
115352672  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
115334136  WNT8A; protein Wnt-8a [KO:K00714]
115348071  WNT8B; protein Wnt-8b [KO:K00714]
115345239  WNT9B; protein Wnt-9b [KO:K01064]
115339845  WNT9A; protein Wnt-9a [KO:K01064]
115342861  WNT10A; protein Wnt-10a [KO:K01357]
115353549  WNT11; protein Wnt-11 isoform X1 [KO:K01384]
115333836  protein Wnt-11b-like isoform X1 [KO:K01384]
115341993  WNT16; protein Wnt-16 [KO:K01558]
115343029  FZD7; frizzled-7 [KO:K02432]
115339009  FZD1; frizzled-1 [KO:K02432]
115344209  FZD2; frizzled-2 [KO:K02235]
115351181  FZD3; frizzled-3 [KO:K02329]
115353477  FZD4; frizzled-4 [KO:K02354]
115343375  FZD5; frizzled-5 [KO:K02375]
115339834  FZD8; LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
115340565  FZD6; frizzled-6 [KO:K02376]
115346534  FZD10; frizzled-10 [KO:K02842]
115347601  FZD9; frizzled-9 [KO:K02842]
115351812  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
115352573  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
115347399  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
115342686  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
115344107  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
115343515  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X2 [KO:K03158]
115350500  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
115352123  insulin [KO:K04526]
115352695  IGF1; insulin-like growth factor I [KO:K05459]
115348898  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
115341184  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
115341010  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
115351224  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
115352127  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
115351819  HRAS; GTPase HRas [KO:K02833]
115352540  KRAS; GTPase KRas isoform X2 [KO:K07827]
115335439  NRAS; GTPase NRas isoform X1 [KO:K07828]
115352782  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
115353699  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
115342153  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
115349300  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
115346261  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
115333634  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
115343644  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
115344756  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
115351860  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
115347412  IRS1; insulin receptor substrate 1 [KO:K16172]
115349575  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
115337134  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
121233034  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
115348975  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
115347173  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
115347305  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
115342450  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
115348120  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
115335528  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
115350251  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
115338049  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
115338050  RAC-beta serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
115347910  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
115348471  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
115335076  MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410]
115336486  RICTOR; rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267]
121232865  rapamycin-insensitive companion of mTOR-like isoform X1 [KO:K08267]
115352560  PRR5; proline-rich protein 5 isoform X1 [KO:K20411]
115335600  PRR5L; proline-rich protein 5-like isoform X1 [KO:K20411]
115353760  RHOA; transforming protein RhoA [KO:K04513]
115341437  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
115335844  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
115344814  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
achc00561  Glycerolipid metabolism
achc04010  MAPK signaling pathway
achc04140  Autophagy - animal
achc04810  Regulation of actin cytoskeleton
achc04910  Insulin signaling pathway
KO pathway
ko04150   
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