KEGG   PATHWAY: afb04150
Entry
afb04150                    Pathway                                
Name
mTOR signaling pathway - Anoplopoma fimbria (sablefish)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
afb04150  mTOR signaling pathway
afb04150

Organism
Anoplopoma fimbria (sablefish) [GN:afb]
Gene
129099624  large neutral amino acids transporter small subunit 1-like [KO:K13780]
129107753  slc7a5; LOW QUALITY PROTEIN: large neutral amino acids transporter small subunit 1 [KO:K13780]
129092584  si:dkey-202g17.3; LOW QUALITY PROTEIN: 4F2 cell-surface antigen heavy chain [KO:K06519]
129093290  slc3a2a; solute carrier family 3 member 2a [KO:K06519]
129103923  4F2 cell-surface antigen heavy chain-like [KO:K06519]
129102427  slc38a9; neutral amino acid transporter 9 [KO:K14995]
129110452  atp6v1ab; LOW QUALITY PROTEIN: V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
129113207  V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
129091922  atp6v1ba; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
129097267  atp6v1c1b; V-type proton ATPase subunit C 1-B [KO:K02148]
129103862  V-type proton ATPase subunit C 1-B-like [KO:K02148]
129109201  V-type proton ATPase subunit C 1-A-like [KO:K02148]
129107080  atp6v1d; V-type proton ATPase subunit D [KO:K02149]
129112331  atp6v1e1b; V-type proton ATPase subunit E 1 [KO:K02150]
129108246  atp6v1e1a; V-type proton ATPase subunit E 1a [KO:K02150]
129112239  atp6v1f; V-type proton ATPase subunit F [KO:K02151]
129102722  atp6v1g1; V-type proton ATPase subunit G 1 [KO:K02152]
129114400  atp6v1h; V-type proton ATPase subunit H [KO:K02144]
129114115  lamtor1; ragulator complex protein LAMTOR1 [KO:K20397]
129109792  lamtor2; ragulator complex protein LAMTOR2 [KO:K20398]
129103410  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
129112240  lamtor4; ragulator complex protein LAMTOR4 [KO:K20399]
129100118  lamtor5; ragulator complex protein LAMTOR5 [KO:K16344]
129109663  flcn; folliculin isoform X1 [KO:K09594]
129113456  fnip1; LOW QUALITY PROTEIN: folliculin-interacting protein 1 [KO:K20400]
129113502  rraga; ras-related GTP-binding protein A [KO:K16185]
129109422  rragca; ras-related GTP binding Ca [KO:K16186]
129097520  rragcb; ras-related GTP binding Cb [KO:K16186]
129103556  rragd; ras-related GTP-binding protein D [KO:K16186]
129097098  sesn2; sestrin-2 isoform X1 [KO:K20394]
129101263  castor1; cytosolic arginine sensor for mTORC1 subunit 1 [KO:K23080]
129113741  castor2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
129109627  mios; GATOR complex protein MIOS [KO:K20407]
129109255  seh1l; nucleoporin SEH1 isoform X1 [KO:K14299]
129091186  wdr24; GATOR complex protein WDR24 [KO:K20408]
129107889  wdr59; GATOR complex protein WDR59 isoform X1 [KO:K20409]
129105695  sec13; protein SEC13 homolog [KO:K14004]
129089094  depdc5; GATOR complex protein DEPDC5 isoform X1 [KO:K20404]
129106041  nprl2; GATOR complex protein NPRL2 [KO:K20405]
129098158  nprl3; GATOR complex protein NPRL3 isoform X1 [KO:K20406]
129102453  skp2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
129110829  rnf152; E3 ubiquitin-protein ligase rnf152 [KO:K15705] [EC:2.3.2.27]
129095641  rptor; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
129098640  akt1s1; uncharacterized protein akt1s1 [KO:K16184]
129099278  mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
129109631  deptor; DEP domain-containing mTOR-interacting protein [KO:K20402]
129105638  si:dkeyp-97e7.9; DEP domain-containing mTOR-interacting protein [KO:K20402]
129091441  mlst8; target of rapamycin complex subunit lst8 [KO:K08266]
129091163  telo2; LOW QUALITY PROTEIN: telomere length regulation protein TEL2 homolog [KO:K11137]
129099725  tti1; TELO2-interacting protein 1 homolog [KO:K20403]
129100778  clip1a; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
129102498  clip1b; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
129097111  growth factor receptor-bound protein 10-like isoform X1 [KO:K20064]
129109123  grb10b; growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
129105278  zgc:123305 isoform X1 [KO:K15728] [EC:3.1.3.4]
129110604  phosphatidate phosphatase LPIN2-like [KO:K15728] [EC:3.1.3.4]
129110988  lpin2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
129106824  phosphatidate phosphatase LPIN1-like [KO:K15728] [EC:3.1.3.4]
129102662  lpin1a; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
129100919  ulk1a; serine/threonine-protein kinase ULK1a isoform X1 [KO:K21357] [EC:2.7.11.1]
129102204  ulk1b; serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
129106572  ulk2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
129101212  eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205]
129102552  eukaryotic translation initiation factor 4E-binding protein 2-like [KO:K07205]
129089923  eif4ea; eukaryotic translation initiation factor 4E-1A [KO:K03259]
129091948  eif4e1c; eukaryotic translation initiation factor 4E family member 1c [KO:K03259]
129103302  eif4eb; eukaryotic translation initiation factor 4eb [KO:K03259]
129114328  eif4e2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
129093034  eif4e2rs1; eukaryotic translation initiation factor 4E family member 2 related sequence 1 [KO:K03259]
129101457  rps6kb1b; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
129113162  rps6kb1a; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
129096518  ribosomal protein S6 kinase beta-2-like [KO:K04688] [EC:2.7.11.1]
129105962  eif4ba; eukaryotic translation initiation factor 4Ba isoform X1 [KO:K03258]
129095450  rps6; 40S ribosomal protein S6 [KO:K02991]
129097905  strada; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
129111753  stradb; STE20-related kinase adapter protein beta [KO:K17532]
129114179  stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
129089920  cab39l1; calcium binding protein 39, like 1 [KO:K08272]
129111595  cab39l; calcium-binding protein 39-like [KO:K08272]
129114327  cab39; calcium-binding protein 39 [KO:K08272]
129094555  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
129102391  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
129101167  LOW QUALITY PROTEIN: hamartin-like [KO:K07206]
129102195  tsc1b; TSC complex subunit 1b isoform X1 [KO:K07206]
129095966  tsc2; tuberin isoform X1 [KO:K07207]
129095031  tbc1d7; TBC1 domain family member 7 [KO:K20396]
129105603  rhebl1; ras homolog, mTORC1 binding like 1 [KO:K07208]
129088911  rheb; GTP-binding protein Rheb [KO:K07208]
129091571  ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
129092639  DNA damage-inducible transcript 4 protein-like [KO:K08270]
129099406  wnt1; protein Wnt-1 [KO:K03209]
129099303  protein Wnt-2b-A [KO:K00182]
129105346  protein Wnt-2b-A-like [KO:K00182]
129107752  wnt2; LOW QUALITY PROTEIN: protein Wnt-2 [KO:K00182]
129091128  wnt3; proto-oncogene Wnt-3 isoform X1 [KO:K00312]
129113399  wnt3a; LOW QUALITY PROTEIN: protein Wnt-3a [KO:K00312]
129109554  wnt4b; wingless-type MMTV integration site family, member 4b [KO:K00408]
129106481  wnt4; protein Wnt-4a [KO:K00408]
129112778  wnt5b; protein Wnt-5b isoform X1 [KO:K00444]
129099238  wnt5a; protein Wnt-5a [KO:K00444]
129104659  wnt6b; protein Wnt-6 [KO:K00445]
129099678  protein Wnt-7a [KO:K00572]
129105529  wnt7aa; wingless-type MMTV integration site family, member 7Aa [KO:K00572]
129112243  wnt7ba; protein Wnt-7b [KO:K00572]
129107732  wnt7bb; protein Wnt-7b isoform X1 [KO:K00572]
129089868  LOW QUALITY PROTEIN: protein Wnt-8a-like [KO:K00714]
129090529  protein Wnt-8a-like [KO:K00714]
129092397  wnt8b; protein Wnt-8b [KO:K00714]
129089174  wnt9a; protein Wnt-9a [KO:K01064]
129099000  wnt9b; protein Wnt-9b [KO:K01064]
129099405  wnt10b; protein Wnt-10b [KO:K01357]
129104254  wnt10a; protein Wnt-10a [KO:K01357]
129113678  wnt11; protein Wnt-11 [KO:K01384]
129112802  wnt16; protein Wnt-16 [KO:K01558]
129110219  fzd1; frizzled-1 [KO:K02432]
129111988  frizzled-7-like [KO:K02432]
129104597  frizzled-7-A-like [KO:K02432]
129098138  fzd2; frizzled-2 [KO:K02235]
129099846  frizzled-3-like isoform X1 [KO:K02329]
129106976  fzd3a; LOW QUALITY PROTEIN: frizzled-3a [KO:K02329]
129103244  fzd4; frizzled-4 [KO:K02354]
129110589  fzd8a; frizzled-8a [KO:K02375]
129104338  fzd5; frizzled-5 [KO:K02375]
129088879  frizzled-8-like [KO:K02375]
129109392  frizzled-6-like [KO:K02376]
129109439  fzd9b; frizzled-9b [KO:K02842]
129101425  fzd10; frizzled-10 [KO:K02842]
129112703  lrp6; LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 6 [KO:K03068]
129107720  lrp5; LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 5 [KO:K03068]
129099287  segment polarity protein dishevelled homolog DVL-1-like isoform X1 [KO:K02353]
129113176  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
129093127  dvl2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
129088993  segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
129104375  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
129097347  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
129099422  si:ch211-112c15.8; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A [KO:K03158]
129109549  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
129101396  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
129090325  insulin-like isoform X1 [KO:K04526]
129113266  ins; insulin [KO:K04526]
129100310  igf3; insulin-like growth factor 3 [KO:K05459]
129112224  igf1; insulin-like growth factor I [KO:K05459]
129089410  insra; LOW QUALITY PROTEIN: insulin receptor a [KO:K04527] [EC:2.7.10.1]
129094199  insrb; insulin receptor b [KO:K04527] [EC:2.7.10.1]
129107750  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
129108015  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
129098114  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
129095261  son of sevenless homolog 1-like [KO:K03099]
129103159  sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
129108847  GTPase HRas [KO:K02833]
129107733  kras; GTPase KRas isoform X1 [KO:K07827]
129097851  zgc:55558; GTPase KRas [KO:K07827]
129112235  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
129099416  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
129108367  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
129112227  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
129094155  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
129100791  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
129097938  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
129089849  rps6kal; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
129110509  ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
129105844  rps6ka2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
129103123  rps6ka1; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
129113916  si:ch211-284e13.4; insulin receptor substrate 1-B [KO:K16172]
129093522  si:ch73-335l21.1; LOW QUALITY PROTEIN: insulin receptor substrate 1-B [KO:K16172]
129094332  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) [KO:K02649]
129094609  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
129110782  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
129101175  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
129112007  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
129102021  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
129099623  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
129090356  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
129115605  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
129093032  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
129094279  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
129091573  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
129092302  ptena; phosphatase and tensin homolog A isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
129091729  pdpk1b; 3-phosphoinositide dependent protein kinase 1b [KO:K06276] [EC:2.7.11.1]
129105750  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129096351  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129091996  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129103636  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129115847  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
129116975  RAC-beta serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
129091327  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
129092009  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
129102633  mapkap1; target of rapamycin complex 2 subunit MAPKAP1 [KO:K20410]
129101836  rapamycin-insensitive companion of mTOR-like [KO:K08267]
129112472  proline-rich protein 5-like isoform X1 [KO:K20411]
129108731  proline-rich protein 5-like [KO:K20411]
129108899  prr5a; proline-rich protein 5a [KO:K20411]
129099318  LOW QUALITY PROTEIN: rho-related GTP-binding protein RhoA-D-like [KO:K04513]
129099319  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
129105477  rho-related GTP-binding protein RhoA-B [KO:K04513]
129100387  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
129100403  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
129106029  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
129096510  prkcaa; protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
129097995  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
129095247  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
129099170  LOW QUALITY PROTEIN: protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
129109298  prkcg; protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
129106837  sgk1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
129097060  si:ch211-195b13.1; STKc_SGK domain-containing protein isoform X1 [KO:K13302] [EC:2.7.11.1]
129109325  sgk2b; serine/threonine-protein kinase Sgk2b isoform X1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
afb00561  Glycerolipid metabolism
afb04010  MAPK signaling pathway
afb04140  Autophagy - animal
afb04810  Regulation of actin cytoskeleton
afb04910  Insulin signaling pathway
KO pathway
ko04150   
LinkDB

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