KEGG   PATHWAY: agen04514
Entry
agen04514                   Pathway                                
Name
Cell adhesion molecules - Accipiter gentilis (Northern goshawk)
Description
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
agen04514  Cell adhesion molecules
agen04514

Other DBs
GO: 0050839
Organism
Accipiter gentilis (Northern goshawk) [GN:agen]
Gene
126048962  T-cell surface antigen CD2 [KO:K06449]
126042687  V-type immunoglobulin domain-containing suppressor of T-cell activation isoform X1 [KO:K23268]
126049067  immunoglobulin superfamily member 11 [KO:K06791]
126048913  T-lymphocyte activation antigen CD80-like [KO:K05412]
126035758  programmed cell death 1 ligand 1-like [KO:K06745]
126038331  T-cell-specific surface glycoprotein CD28 [KO:K06470]
126048960  T-lymphocyte activation antigen CD86 [KO:K05413]
126038344  cytotoxic T-lymphocyte protein 4 [KO:K06538]
126053263  ICOS ligand [KO:K06710]
126038336  inducible T-cell costimulator-like [KO:K06713]
126034976  HLA class II histocompatibility antigen, DM beta chain-like isoform X1 [KO:K06752]
126034982  class II histocompatibility antigen, B-L beta chain-like isoform X1 [KO:K06752]
126034984  HLA class II histocompatibility antigen, DR alpha chain-like isoform X1 [KO:K06752]
126034989  class II histocompatibility antigen, M alpha chain [KO:K06752]
126048957  T-cell surface glycoprotein CD4-like [KO:K06454]
126034962  class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751]
126052940  T-cell surface glycoprotein CD8 alpha chain [KO:K06458]
126037025  LOW QUALITY PROTEIN: T-cell surface glycoprotein CD8 beta chain [KO:K06459]
126035759  programmed cell death 1 ligand 2-like [KO:K06708]
126043652  CD276 antigen [KO:K06746]
126049003  V-set domain-containing T-cell activation inhibitor 1 isoform X1 [KO:K06747]
126039549  programmed cell death protein 1 [KO:K06744]
126045706  tumor necrosis factor receptor superfamily member 5 [KO:K03160]
126050259  CD40 ligand isoform X1 [KO:K03161]
126049013  CD166 antigen isoform X1 [KO:K06547]
126047152  T-cell differentiation antigen CD6 [KO:K06456]
126051264  CD226 antigen [KO:K06567]
126036652  LOW QUALITY PROTEIN: integrin alpha-L-like [KO:K05718]
126041106  integrin beta-2 [KO:K06464]
126041673  receptor-type tyrosine-protein phosphatase C isoform X1 [KO:K06478] [EC:3.1.3.48]
126051498  LOW QUALITY PROTEIN: sialoadhesin [KO:K06548]
126048833  nectin-3 isoform X1 [KO:K06592]
126037816  claudin-12 [KO:K06087]
126038130  putative claudin-25 [KO:K06087]
126038863  claudin-20 [KO:K06087]
126044652  claudin-23 [KO:K06087]
126039282  claudin-19-like isoform X1 [KO:K06087]
126039394  claudin-3-like [KO:K06087]
126039486  claudin-18 isoform X1 [KO:K06087]
126039548  claudin-16 [KO:K06087]
126039683  claudin-1 [KO:K06087]
126039739  claudin-4-like [KO:K06087]
126039740  claudin-4-like [KO:K06087]
126045175  claudin-10 isoform X1 [KO:K06087]
126040013  claudin-11 [KO:K06087]
126034005  claudin-22-like [KO:K06087]
126034680  claudin-7 [KO:K06087]
126041101  claudin-5 [KO:K06087]
126037721  claudin-19 [KO:K06087]
126037747  claudin-16-like [KO:K06087]
126050301  claudin-2 [KO:K06087]
126052953  claudin-34 [KO:K06087]
126053181  claudin-14 [KO:K06087]
126053226  LOW QUALITY PROTEIN: claudin-8-like [KO:K06087]
126053227  claudin-8-like [KO:K06087]
126042166  occludin [KO:K06088]
126041036  junctional adhesion molecule A [KO:K06089]
126053240  junctional adhesion molecule B [KO:K06735]
126038854  junctional adhesion molecule C [KO:K06785]
126038711  endothelial cell-selective adhesion molecule isoform X1 [KO:K06787]
126041180  cadherin-5 [KO:K06533]
126043358  platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
126050232  CD99 antigen-like protein 2 [KO:K06520]
126053021  CD99 antigen isoform X1 [KO:K06520]
126053022  glycoprotein Xg isoform X1 [KO:K06520]
126041023  mucin-2-like [KO:K06544]
126041830  P-selectin-like isoform X1 [KO:K06496]
126037975  LOW QUALITY PROTEIN: integrin alpha-4 [KO:K06483]
126037838  integrin beta-1 [KO:K05719]
126045681  integrin alpha-9 [KO:K06585]
126037350  LOW QUALITY PROTEIN: integrin beta-7 [KO:K06590]
126041752  mucosal addressin cell adhesion molecule 1 [KO:K06779]
126052210  hematopoietic progenitor cell antigen CD34 isoform X1 [KO:K06474]
126040521  Golgi apparatus protein 1 [KO:K06816]
126042061  E-selectin isoform X1 [KO:K06494]
126038451  nectin-1 isoform X1 [KO:K06081]
126049316  cadherin-2 [KO:K06736]
126038183  neural cell adhesion molecule 1 isoform X1 [KO:K06491]
126049076  neural cell adhesion molecule 2 [KO:K06491]
126035167  LOW QUALITY PROTEIN: neural cell adhesion molecule L1 [KO:K06550]
126038120  cell adhesion molecule 1 isoform X1 [KO:K06781]
126041863  neuronal growth regulator 1 [KO:K06775]
126041877  netrin-G1 isoform X1 [KO:K07522]
126049456  leucine-rich repeat-containing protein 4C [KO:K07523]
126052202  netrin-G2 isoform X1 [KO:K16359]
126044393  leucine-rich repeat-containing protein 4 [KO:K16351]
126041709  receptor-type tyrosine-protein phosphatase F isoform X1 [KO:K05695] [EC:3.1.3.48]
126034879  leucine-rich repeat-containing protein 4B [KO:K16360]
126046627  syndecan-1 [KO:K06257]
126049164  syndecan-2 [KO:K16336]
126047334  syndecan-3 [KO:K16337]
126045840  syndecan-4 isoform X1 [KO:K16338]
126042812  integrin alpha-V [KO:K06487]
126037840  integrin beta-8 isoform X1 [KO:K06591]
126037757  integrin alpha-8 isoform X1 [KO:K06584]
126049339  neurexin 3 isoform X1 [KO:K07377]
126052753  neurexin-1 isoform X1 [KO:K07377]
126053391  uncharacterized protein LOC126053391 isoform X1 [KO:K07377]
126039137  neuroligin-1 isoform X1 [KO:K07378]
126034644  LOW QUALITY PROTEIN: neuroligin-2 [KO:K07378]
126050176  neuroligin-3 isoform X1 [KO:K07378]
126053011  neuroligin-4, X-linked isoform X1 [KO:K07378]
126041636  receptor-type tyrosine-protein phosphatase S isoform X1 [KO:K06778] [EC:3.1.3.48]
126045064  SLIT and NTRK-like protein 1 [KO:K25832]
126050283  SLIT and NTRK-like protein 2 [KO:K25833]
126050282  SLIT and NTRK-like protein 4 isoform X1 [KO:K25835]
126045235  SLIT and NTRK-like protein 5 [KO:K25836]
126045149  SLIT and NTRK-like protein 6 [KO:K25837]
126035781  receptor-type tyrosine-protein phosphatase delta isoform X1 [KO:K06777] [EC:3.1.3.48]
126039596  SLIT and NTRK-like protein 3 [KO:K25834]
126040795  cell adhesion molecule 3 isoform X1 [KO:K06780]
126044367  neuronal cell adhesion molecule isoform X1 [KO:K06756]
126044416  contactin-1 [KO:K06759]
126051232  receptor-type tyrosine-protein phosphatase mu isoform X1 [KO:K05693] [EC:3.1.3.48]
126051878  contactin-2 [KO:K06760]
126051876  neurofascin isoform X1 [KO:K06757]
126038708  contactin-associated protein 1 [KO:K07379]
126045366  contactin-associated protein-like 2 isoform X1 [KO:K07380]
126041262  LOW QUALITY PROTEIN: myelin protein P0 [KO:K06770]
126040274  cadherin-1-like [KO:K05689]
126035706  versican core protein isoform X1 [KO:K06793]
126043531  integrin alpha-6 isoform X1 [KO:K06485]
126045411  cadherin-4 [KO:K06797]
126040228  cadherin-15 [KO:K06809]
126043645  neogenin isoform X1 [KO:K06766]
Reference
PMID:14690046
  Authors
Barclay AN.
  Title
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
  Journal
Semin Immunol 15:215-23 (2003)
DOI:10.1016/S1044-5323(03)00047-2
Reference
PMID:11910893
  Authors
Sharpe AH, Freeman GJ.
  Title
The B7-CD28 superfamily.
  Journal
Nat Rev Immunol 2:116-26 (2002)
DOI:10.1038/nri727
Reference
PMID:9597126
  Authors
Grewal IS, Flavell RA.
  Title
CD40 and CD154 in cell-mediated immunity.
  Journal
Annu Rev Immunol 16:111-35 (1998)
DOI:10.1146/annurev.immunol.16.1.111
Reference
PMID:16034094
  Authors
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
  Title
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
  Journal
J Immunol 175:1558-65 (2005)
DOI:10.4049/jimmunol.175.3.1558
Reference
PMID:12234363
  Authors
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
  Title
Cell adhesion and polarity during immune interactions.
  Journal
Immunol Rev 186:68-82 (2002)
DOI:10.1034/j.1600-065X.2002.18607.x
Reference
PMID:15071551
  Authors
Dejana E.
  Title
Endothelial cell-cell junctions: happy together.
  Journal
Nat Rev Mol Cell Biol 5:261-70 (2004)
DOI:10.1038/nrm1357
Reference
PMID:14519386
  Authors
Bazzoni G.
  Title
The JAM family of junctional adhesion molecules.
  Journal
Curr Opin Cell Biol 15:525-30 (2003)
DOI:10.1016/S0955-0674(03)00104-2
Reference
PMID:10798271
  Authors
Becker BF, Heindl B, Kupatt C, Zahler S.
  Title
Endothelial function and hemostasis.
  Journal
Z Kardiol 89:160-7 (2000)
DOI:10.1007/PL00007320
Reference
PMID:9150551
  Authors
Elangbam CS, Qualls CW Jr, Dahlgren RR.
  Title
Cell adhesion molecules--update.
  Journal
Vet Pathol 34:61-73 (1997)
DOI:10.1177/030098589703400113
Reference
PMID:12810109
  Authors
Muller WA.
  Title
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
  Journal
Trends Immunol 24:327-34 (2003)
DOI:10.1016/S1471-4906(03)00117-0
Reference
PMID:14519398
  Authors
Yamagata M, Sanes JR, Weiner JA.
  Title
Synaptic adhesion molecules.
  Journal
Curr Opin Cell Biol 15:621-32 (2003)
DOI:10.1016/S0955-0674(03)00107-8
Reference
PMID:15882774
  Authors
Ethell IM, Pasquale EB.
  Title
Molecular mechanisms of dendritic spine development and remodeling.
  Journal
Prog Neurobiol 75:161-205 (2005)
DOI:10.1016/j.pneurobio.2005.02.003
Reference
PMID:11050419
  Authors
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
  Title
Making memories stick: cell-adhesion molecules in synaptic plasticity.
  Journal
Trends Cell Biol 10:473-82 (2000)
DOI:10.1016/S0962-8924(00)01838-9
Reference
PMID:11860281
  Authors
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
  Title
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
  Journal
Mol Cell Neurosci 19:292-306 (2002)
DOI:10.1006/mcne.2001.1071
Reference
PMID:10964748
  Authors
Dunican DJ, Doherty P.
  Title
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
  Journal
Mol Cell Biol Res Commun 3:255-63 (2000)
DOI:10.1006/mcbr.2000.0225
Reference
PMID:12367625
  Authors
Girault JA, Peles E.
  Title
Development of nodes of Ranvier.
  Journal
Curr Opin Neurobiol 12:476-85 (2002)
DOI:10.1016/S0959-4388(02)00370-7
Reference
PMID:10664064
  Authors
Arroyo EJ, Scherer SS.
  Title
On the molecular architecture of myelinated fibers.
  Journal
Histochem Cell Biol 113:1-18 (2000)
DOI:10.1007/s004180050001
Reference
PMID:14556710
  Authors
Salzer JL.
  Title
Polarized domains of myelinated axons.
  Journal
Neuron 40:297-318 (2003)
DOI:10.1016/S0896-6273(03)00628-7
Reference
PMID:15561584
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Reference
PMID:15551862
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
PMID:15115723
  Authors
Siu MK, Cheng CY.
  Title
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
  Journal
Biol Reprod 71:375-91 (2004)
DOI:10.1095/biolreprod.104.028225
Reference
PMID:15056568
  Authors
Lee NP, Cheng CY.
  Title
Adaptors, junction dynamics, and spermatogenesis.
  Journal
Biol Reprod 71:392-404 (2004)
DOI:10.1095/biolreprod.104.027268
Reference
PMID:15728677
  Authors
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
  Title
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
  Journal
Development 132:1525-37 (2005)
DOI:10.1242/dev.01697
Reference
PMID:12500939
  Authors
Marthiens V, Gavard J, Lambert M, Mege RM.
  Title
Cadherin-based cell adhesion in neuromuscular development.
  Journal
Biol Cell 94:315-26 (2002)
DOI:10.1016/S0248-4900(02)00005-9
Reference
PMID:15923648
  Authors
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
  Title
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
  Journal
J Cell Sci 118:2355-62 (2005)
DOI:10.1242/jcs.02397
Related
pathway
agen04520  Adherens junction
agen04530  Tight junction
KO pathway
ko04514   
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