KEGG PATHWAY: arut03420

KEGG

PATHWAY: arut03420

Entry

arut03420                   Pathway

Name

Nucleotide excision repair - Acipenser ruthenus (sterlet)

Description

Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.

Class

Genetic Information Processing; Replication and repair

Pathway map

Nucleotide excision repair

Other DBs

GO:

Organism

Acipenser ruthenus (sterlet) [GN:arut]

Gene

[KO:K02326] [EC:2.7.7.7]

lig1; DNA ligase 1 isoform X1 [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]

rpa3; replication protein A 14 kDa subunit [KO:K10740]

[KO:K03506] [EC:2.7.7.7]

ercc3; general transcription and DNA repair factor IIH helicase subunit XPB [KO:K10843] [EC:5.6.2.4]

[KO:K02202] [EC:2.7.11.22 2.7.11.23]

[KO:K02202] [EC:2.7.11.22 2.7.11.23]

[KO:K03006] [EC:2.7.7.6]

ercc1; DNA excision repair protein ERCC-1 [KO:K10849]

ercc5; DNA repair protein complementing XP-G cells homolog isoform X1 [KO:K10846]

polr2b; DNA-directed RNA polymerase II subunit RPB2 [KO:K03010] [EC:2.7.7.6]

gtf2h5; general transcription factor IIH subunit 5 [KO:K10845]

rpa2; replication protein A 32 kDa subunit [KO:K10739]

ercc6; DNA excision repair protein ERCC-6 isoform X1 [KO:K10841]

ercc2; general transcription and DNA repair factor IIH helicase subunit XPD isoform X1 [KO:K10844] [EC:5.6.2.3]

[KO:K02325] [EC:2.7.7.7]

[KO:K03010] [EC:2.7.7.6]

uvssa; UV-stimulated scaffold protein A [KO:K23720]

xpa; DNA repair protein complementing XP-A cells isoform X2 [KO:K10847]

[KO:K02325] [EC:2.7.7.7]

[KO:K02326] [EC:2.7.7.7]

polr2c; DNA-directed RNA polymerase II subunit RPB3 [KO:K03011]

[KO:K02324] [EC:2.7.7.7]

[KO:K02324] [EC:2.7.7.7]

polr2j; DNA-directed RNA polymerase II subunit RPB11-a [KO:K03008]

polr2i; DNA-directed RNA polymerase II subunit RPB9 [KO:K03017]

ercc4; DNA repair endonuclease XPF isoform X1 [KO:K10848] [EC:3.1.-.-]

ddb2; DNA damage-binding protein 2 isoform X1 [KO:K10140]

ddb1; DNA damage-binding protein 1 [KO:K10610]

polr2l; DNA-directed RNA polymerases I, II, and III subunit RPABC5 [KO:K03007]

[KO:K03506] [EC:2.7.7.7]

polr2m; protein GRINL1A isoform X1 [KO:K21987]

gtf2h4; general transcription factor IIH subunit 4 [KO:K03144]

[KO:K03006] [EC:2.7.7.6]

[KO:K02202] [EC:2.7.11.22 2.7.11.23]

[KO:K02202] [EC:2.7.11.22 2.7.11.23]

Reference

Authors

Sugasawa K.

Title

[Molecular mechanism of mammalian nucleotide excision repair]

Journal

Tanpakushitsu Kakusan Koso 46:893-901 (2001)

Reference

Authors

Nakatsu Y.

Title

[Transcription-coupled repair and Cockayne syndrome]

Journal

Tanpakushitsu Kakusan Koso 46:908-15 (2001)

Reference

Authors

Nakagawa N, Masui R, Kuramitsu S.

Title

[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8]

Journal

Tanpakushitsu Kakusan Koso 46:968-75 (2001)

Reference

Authors

Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.

Title

Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.

Journal

Neuroscience 145:1388-96 (2007)
DOI:10.1016/j.neuroscience.2006.12.020

Reference

Authors

Saldivar JS, Wu X, Follen M, Gershenson D.

Title

Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.

Journal

Gynecol Oncol 107:S56-71 (2007)
DOI:10.1016/j.ygyno.2007.07.043

Reference

Authors

Sugasawa K.

Title

[DNA repair pathways involving Cul4A ubiquitin ligases]

Journal

Tanpakushitsu Kakusan Koso 51:1339-44 (2006)

Reference

Authors

Ito S, Ando D, Tanaka K.

Title

[Cross-talk between DNA repair and transcription: molecular mechanism and disorders]

Journal

Tanpakushitsu Kakusan Koso 52:1823-31 (2007)

Related
pathway

RNA polymerase

Ubiquitin mediated proteolysis

KO pathway

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