KEGG   PATHWAY: asn04914
Entry
asn04914                    Pathway                                
Name
Progesterone-mediated oocyte maturation - Alligator sinensis (Chinese alligator)
Description
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Class
Organismal Systems; Endocrine system
Pathway map
asn04914  Progesterone-mediated oocyte maturation
asn04914

Other DBs
GO: 0001556
Organism
Alligator sinensis (Chinese alligator) [GN:asn]
Gene
102372066  PGR; progesterone receptor [KO:K08556]
102382060  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102377899  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
102380057  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
102388304  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102372482  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102387818  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102376154  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102374542  mitogen-activated protein kinase 10 isoform X6 [KO:K04440] [EC:2.7.11.24]
102376040  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
102374196  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
102375954  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
102376541  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
102375835  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
102383800  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
102379966  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
102377099  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
102372645  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
102383838  ADCY2; LOW QUALITY PROTEIN: adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
102374249  ADCY3; adenylate cyclase type 3 isoform X2 [KO:K08043] [EC:4.6.1.1]
102385636  ADCY4; LOW QUALITY PROTEIN: adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
102387635  adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
102388125  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
102368976  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
102369910  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
102370673  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
102373860  ADCY9; adenylate cyclase type 9 isoform X3 [KO:K08049] [EC:4.6.1.1]
102369602  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
102373080  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
102379019  AURKA; aurora kinase A [KO:K11481] [EC:2.7.11.1]
102388221  CPEB1; cytoplasmic polyadenylation element-binding protein 1 isoform X1 [KO:K02602]
102368538  CPEB4; cytoplasmic polyadenylation element-binding protein 4 [KO:K02602]
102375879  CPEB3; cytoplasmic polyadenylation element-binding protein 3 [KO:K02602]
102380227  CPEB2; cytoplasmic polyadenylation element-binding protein 2 isoform X1 [KO:K02602]
102375247  SPDYC; speedy protein C isoform X1 [KO:K08694]
102383506  SPDYA; speedy protein A [KO:K08694]
102376317  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
102385352  CDK1; LOW QUALITY PROTEIN: cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
102388230  CCNA2; cyclin-A2 [KO:K06627]
102377779  CCNA1; cyclin-A1 isoform X1 [KO:K06627]
102382426  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
102369112  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
102379894  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
102373880  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102376690  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102375250  glycogen synthase kinase-3 alpha-like [KO:K04371] [EC:2.7.11.24]
102374386  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X3 [KO:K04373] [EC:2.7.11.1]
102382254  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X2 [KO:K04373] [EC:2.7.11.1]
102378267  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
102368134  ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
102372270  PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
102381467  CCNB1; G2/mitotic-specific cyclin-B1 isoform X2 [KO:K05868]
102376865  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
102373322  CCNB3; LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B3 [KO:K21771]
102369631  STK10; serine/threonine-protein kinase 10 [KO:K08837] [EC:2.7.11.1]
102370156  PLK1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
102384816  CDC25A; LOW QUALITY PROTEIN: M-phase inducer phosphatase 1 [KO:K06645] [EC:3.1.3.48]
102369674  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
102384314  CDC25C; M-phase inducer phosphatase 3 isoform X2 [KO:K05867] [EC:3.1.3.48]
102378642  INS; insulin [KO:K04526]
102372626  IGF1; insulin-like growth factor I [KO:K05459]
102387852  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
102388514  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
102388207  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102372104  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102368588  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
112547860  GTPase HRas-like [KO:K07827]
102373235  KRAS; GTPase KRas [KO:K07827]
102380007  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
102374398  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102383453  BUB1; mitotic checkpoint serine/threonine-protein kinase BUB1 [KO:K02178] [EC:2.7.11.1]
102373658  mitotic spindle assembly checkpoint protein MAD1-like [KO:K06679]
102382343  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
102386165  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
102372859  MAD2L2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
102377576  FZR1; fizzy-related protein homolog [KO:K03364]
102381729  ANAPC1; anaphase-promoting complex subunit 1 [KO:K03348]
102369659  ANAPC2; anaphase-promoting complex subunit 2 isoform X1 [KO:K03349]
102377005  CDC27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
102374314  ANAPC4; anaphase-promoting complex subunit 4 [KO:K03351]
102380220  ANAPC5; anaphase-promoting complex subunit 5 isoform X2 [KO:K03352]
102376565  CDC16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
102381938  ANAPC7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
102386626  CDC23; cell division cycle protein 23 homolog [KO:K03355]
102372148  ANAPC10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
102382940  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
102377802  CDC26; anaphase-promoting complex subunit CDC26 [KO:K03359]
102377327  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
102387073  ANAPC15; anaphase-promoting complex subunit 15 [KO:K25228]
102388528  ANAPC16; anaphase-promoting complex subunit 16 isoform X1 [KO:K25229]
102377393  KIF22; kinesin-like protein KIF22 isoform X1 [KO:K10403]
Compound
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
  Authors
Schmitt A, Nebreda AR.
  Title
Signalling pathways in oocyte meiotic maturation.
  Journal
J Cell Sci 115:2457-9 (2002)
Reference
  Authors
Cato AC, Nestl A, Mink S.
  Title
Rapid actions of steroid receptors in cellular signaling pathways.
  Journal
Sci STKE 2002:RE9 (2002)
DOI:10.1126/stke.2002.138.re9
Reference
  Authors
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
  Title
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
  Journal
Biol Cell 93:27-33 (2001)
DOI:10.1016/S0248-4900(01)01127-3
Reference
  Authors
Nebreda AR, Ferby I.
  Title
Regulation of the meiotic cell cycle in oocytes.
  Journal
Curr Opin Cell Biol 12:666-75 (2000)
DOI:10.1016/S0955-0674(00)00150-2
Reference
  Authors
Ferrell JE Jr.
  Title
Xenopus oocyte maturation: new lessons from a good egg.
  Journal
Reference
  Authors
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
  Title
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
  Journal
Biochem J 369:227-38 (2003)
DOI:10.1042/BJ20021243
Reference
  Authors
Duckworth BC, Weaver JS, Ruderman JV.
  Title
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
  Journal
Proc Natl Acad Sci U S A 99:16794-9 (2002)
DOI:10.1073/pnas.222661299
Reference
  Authors
Abrieu A, Doree M, Fisher D.
  Title
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
  Journal
J Cell Sci 114:257-67 (2001)
Related
pathway
asn04010  MAPK signaling pathway
asn04110  Cell cycle
KO pathway
ko04914   
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