KEGG PATHWAY: aten04142

KEGG

PATHWAY: aten04142

Entry

aten04142                   Pathway

Name

Lysosome - Actinia tenebrosa (Australian red waratah sea anemone)

Description

Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.

Class

Cellular Processes; Transport and catabolism

Pathway map

Lysosome

Other DBs

GO:

Organism

Actinia tenebrosa (Australian red waratah sea anemone) [GN:aten]

Gene

V-type proton ATPase 116 kDa subunit a-like [KO:K02154]

V-type proton ATPase subunit d 1-like [KO:K02146]

V-type proton ATPase subunit H-like [KO:K02144]

V-type proton ATPase subunit S1-like [KO:K03662]

V-type proton ATPase 16 kDa proteolipid subunit-like [KO:K02155]

V-type proton ATPase 21 kDa proteolipid subunit-like [KO:K03661]

dmX-like protein 1 isoform X1 [KO:K24155]

WD repeat-containing protein 7-like [KO:K24738]

cathepsin B-like [KO:K01363] [EC:3.4.22.1]

cathepsin B-like [KO:K01363] [EC:3.4.22.1]

lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]

cathepsin L-like [KO:K01373] [EC:3.4.22.41]

cathepsin L1-like [KO:K01365] [EC:3.4.22.15]

cathepsin L1-like [KO:K01365] [EC:3.4.22.15]

cathepsin L1-like [KO:K01365] [EC:3.4.22.15]

cathepsin L1-like [KO:K01365] [EC:3.4.22.15]

cathepsin L1-like [KO:K01365] [EC:3.4.22.15]

cathepsin O-like [KO:K01374] [EC:3.4.22.42]

cathepsin Z-like [KO:K08568] [EC:3.4.18.1]

legumain-like [KO:K01369] [EC:3.4.22.34]

tripeptidyl-peptidase 1-like [KO:K01279] [EC:3.4.14.9]

beta-galactosidase-like [KO:K12309] [EC:3.2.1.23]

lysosomal alpha-glucosidase-like [KO:K12316] [EC:3.2.1.20]

lysosomal acid glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]

alpha-L-iduronidase-like isoform X1 [KO:K01217] [EC:3.2.1.76]

alpha-N-acetylgalactosaminidase-like [KO:K01204] [EC:3.2.1.49]

alpha-N-acetylgalactosaminidase-like [KO:K01204] [EC:3.2.1.49]

alpha-N-acetylgalactosaminidase-like isoform X1 [KO:K01204] [EC:3.2.1.49]

alpha-N-acetylglucosaminidase-like [KO:K01205] [EC:3.2.1.50]

alpha-N-acetylglucosaminidase-like [KO:K01205] [EC:3.2.1.50]

beta-glucuronidase-like [KO:K01195] [EC:3.2.1.31]

beta-glucuronidase-like [KO:K01195] [EC:3.2.1.31]

alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]

alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]

alpha-L-fucosidase 1-like [KO:K01206] [EC:3.2.1.51]

alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]

alpha-L-fucosidase-like isoform X1 [KO:K01206] [EC:3.2.1.51]

alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]

beta-hexosaminidase 1-like [KO:K12373] [EC:3.2.1.52]

beta-hexosaminidase subunit beta-like [KO:K12373] [EC:3.2.1.52]

uncharacterized protein LOC116300345 isoform X1 [KO:K12373] [EC:3.2.1.52]

uncharacterized protein LOC116300346 [KO:K12373] [EC:3.2.1.52]

uncharacterized protein LOC116300354 [KO:K12373] [EC:3.2.1.52]

beta-mannosidase-like [KO:K01192] [EC:3.2.1.25]

lysosomal alpha-mannosidase-like isoform X1 [KO:K12311] [EC:3.2.1.24]

hyaluronidase-like [KO:K01197] [EC:3.2.1.35]

hyaluronidase-like [KO:K01197] [EC:3.2.1.35]

hyaluronidase-1-like [KO:K01197] [EC:3.2.1.35]

arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]

arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]

arylsulfatase I-like [KO:K01135] [EC:3.1.6.12]

arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]

arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]

arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]

arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]

arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]

N-acetylglucosamine-6-sulfatase-like [KO:K01137] [EC:3.1.6.14]

iduronate 2-sulfatase-like isoform X1 [KO:K01136] [EC:3.1.6.13]

N-sulphoglucosamine sulphohydrolase-like [KO:K01565] [EC:3.10.1.1]

gastric triacylglycerol lipase-like [KO:K01052] [EC:3.1.1.13]

lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]

putative lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]

group XV phospholipase A2-like [KO:K06129] [EC:3.1.1.5]

group XV phospholipase A2-like [KO:K06129] [EC:3.1.1.5]

group XV phospholipase A2-like [KO:K06129] [EC:3.1.1.5]

tartrate-resistant acid phosphatase type 5-like [KO:K14379] [EC:3.1.3.2]

tartrate-resistant acid phosphatase type 5-like [KO:K14379] [EC:3.1.3.2]

tartrate-resistant acid phosphatase type 5-like [KO:K14379] [EC:3.1.3.2]

sphingomyelin phosphodiesterase-like [KO:K12350] [EC:3.1.4.12]

acid ceramidase-like [KO:K12348] [EC:3.5.1.23]

uncharacterized protein LOC116289987 [KO:K01444] [EC:3.5.1.26]

N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase- like isoform X1 [KO:K01444] [EC:3.5.1.26]

N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase- like isoform X1 [KO:K01444] [EC:3.5.1.26]

prosaposin-like [KO:K12382]

prosaposin-like [KO:K12382]

ganglioside GM2 activator-like [KO:K12383]

palmitoyl-protein thioesterase 1-like [KO:K01074] [EC:3.1.2.22]

lysosomal thioesterase PPT2-A-like [KO:K01074] [EC:3.1.2.22]

lysosomal thioesterase PPT2-A-like [KO:K01074] [EC:3.1.2.22]

lysosome-associated membrane glycoprotein 1-like isoform X1 [KO:K06528]

lysosome-associated membrane glycoprotein 1-like [KO:K06528]

tetraspanin-9-like [KO:K06497]

CD63 antigen-like [KO:K06497]

CD63 antigen-like [KO:K06497]

CD63 antigen-like [KO:K06497]

tetraspanin-9-like [KO:K06497]

tetraspanin-8-like [KO:K06497]

tetraspanin-9-like [KO:K06497]

tetraspanin-4-like [KO:K06497]

lysosome membrane protein 2-like [KO:K12384]

lysosome membrane protein 2-like [KO:K12384]

lysosome membrane protein 2-like [KO:K12384]

NPC intracellular cholesterol transporter 1-like isoform X1 [KO:K12385]

patched domain-containing protein 3-like [KO:K12385]

NPC intracellular cholesterol transporter 2-like [KO:K13443]

NPC intracellular cholesterol transporter 2-like [KO:K13443]

NPC intracellular cholesterol transporter 2-like [KO:K13443]

NPC intracellular cholesterol transporter 2-like [KO:K13443]

NPC intracellular cholesterol transporter 2-like [KO:K13443]

NPC intracellular cholesterol transporter 2-like [KO:K13443]

NPC intracellular cholesterol transporter 2-like [KO:K13443]

NPC intracellular cholesterol transporter 2-like [KO:K13443]

cystinosin homolog [KO:K12386]

cystinosin-like [KO:K12386]

cystinosin-like [KO:K12386]

cystinosin homolog [KO:K12386]

sialin-like isoform X1 [KO:K12301]

sialin-like isoform X1 [KO:K12301]

sialin-like [KO:K12301]

vesicular glutamate transporter 3-like [KO:K12301]

natural resistance-associated macrophage protein 2-like isoform X1 [KO:K21398]

lysosomal-associated transmembrane protein 4A-like [KO:K12387]

ATP-binding cassette sub-family A member 2-like [KO:K05642]

ATP-binding cassette sub-family B member 9-like [KO:K05656]

sialomucin core protein 24-like [KO:K06546]

ectonucleoside triphosphate diphosphohydrolase 4-like [KO:K12305] [EC:3.6.1.6]

sortilin-like [KO:K12388]

battenin-like isoform X1 [KO:K12389]

protein BTN1-like [KO:K12389]

protein BTN1-like [KO:K12389]

protein BTN1-like [KO:K12389]

protein BTN1-like [KO:K12389]

protein BTN1-like isoform X1 [KO:K12389]

protein BTN1-like [KO:K12389]

battenin-like [KO:K12389]

protein BTN1-like [KO:K12389]

protein BTN1-like [KO:K12389]

protein BTN1-like [KO:K12389]

uncharacterized protein LOC116304968 [KO:K12389]

protein BTN1-like [KO:K12389]

protein BTN1-like [KO:K12389]

protein BTN1-like [KO:K12389]

protein BTN1-like [KO:K12389]

protein BTN1-like [KO:K12389]

protein BTN1-like [KO:K12389]

protein BTN1-like [KO:K12389]

protein btn-1-like [KO:K12389]

uncharacterized protein LOC116308325 [KO:K12389]

uncharacterized protein LOC116292209 [KO:K12389]

uncharacterized protein LOC116292215 [KO:K12389]

protein BTN1-like [KO:K12389]

battenin-like isoform X1 [KO:K12389]

uncharacterized protein LOC116294372 [KO:K12307]

major facilitator superfamily domain-containing protein 8-like [KO:K12307]

heparan-alpha-glucosaminide N-acetyltransferase-like isoform X1 [KO:K10532] [EC:2.3.1.78]

heparan-alpha-glucosaminide N-acetyltransferase-like isoform X1 [KO:K10532] [EC:2.3.1.78]

formylglycine-generating enzyme-like [KO:K13444] [EC:1.8.3.7]

N-acetylglucosamine-1-phosphotransferase subunits alpha/beta-like [KO:K08239] [EC:2.7.8.17]

N-acetylglucosamine-1-phosphotransferase subunit gamma-like [KO:K10087]

N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase-like [KO:K01125] [EC:3.1.4.45]

cation-independent mannose-6-phosphate receptor-like [KO:K06564]

cation-dependent mannose-6-phosphate receptor-like [KO:K10089]

uncharacterized protein LOC116288573 [KO:K10089]

uncharacterized protein LOC116288596 [KO:K10089]

uncharacterized protein LOC116305650 [KO:K10089]

uncharacterized protein LOC116301829 [KO:K10089]

clathrin light chain A-like [KO:K04644]

clathrin heavy chain 1-like [KO:K04646]

AP-1 complex subunit gamma-1-like isoform X1 [KO:K12391]

AP-1 complex subunit beta-1-like [KO:K12392]

AP-1 complex subunit mu-1-like [KO:K12393]

AP-1 complex subunit sigma-2-like isoform X1 [KO:K12394]

AP-3 complex subunit delta-1-like [KO:K12396]

AP-3 complex subunit beta-2-like [KO:K12397]

AP-3 complex subunit mu-1-like [KO:K12398]

AP-3 complex subunit sigma-1-like [KO:K12399]

AP-4 complex subunit epsilon-like [KO:K12400]

AP-4 complex subunit mu-like [KO:K12402]

AP-4 complex subunit sigma-like [KO:K12403]

ADP-ribosylation factor-binding protein GGA2-like [KO:K12404]

mucolipin-3-like isoform X1 [KO:K04992]

LITAF domain-containing protein-like [KO:K19363]

lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]

LITAF domain-containing protein-like [KO:K19363]

cell death-inducing p53-target protein 1 homolog [KO:K19363]

lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]

Compound

ATP

ADP

D-Mannose

D-Mannose 6-phosphate

Reference

Authors

Eskelinen EL, Tanaka Y, Saftig P

Title

At the acidic edge: emerging functions for lysosomal membrane proteins.

Journal

Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9

Reference

Authors

Neufeld EF

Title

Lysosomal storage diseases.

Journal

Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353

Reference

Authors

von Figura K, Hasilik A

Title

Lysosomal enzymes and their receptors.

Journal

Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123

Reference

Authors

Janvier K, Bonifacino JS

Title

Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.

Journal

Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213

Reference

Authors

Vergarajauregui S, Puertollano R

Title

Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.

Journal

Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567

Reference

Authors

Jaskolka MC, Winkley SR, Kane PM

Title

RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.

Journal

Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190

Reference

Authors

Majdoul S, Compton AA

Title

Lessons in self-defence: inhibition of virus entry by intrinsic immunity.

Journal

Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8

Related
pathway

Other glycan degradation

Glycosaminoglycan degradation

SNARE interactions in vesicular transport

Autophagy - animal

Endocytosis

KO pathway

LinkDB

DBGET integrated database retrieval system