KEGG   PATHWAY: bdr04141
Entry
bdr04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Bactrocera dorsalis (oriental fruit fly)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
bdr04141  Protein processing in endoplasmic reticulum
bdr04141

Other DBs
GO: 0030433 0034976
Organism
Bactrocera dorsalis (oriental fruit fly) [GN:bdr]
Gene
105233951  protein transport protein Sec61 subunit alpha [KO:K10956]
105228412  protein transport protein Sec61 subunit beta [KO:K09481]
105228596  protein transport protein Sec61 gamma-2 subunit [KO:K07342]
105225317  translocation protein SEC62 isoform X1 [KO:K12275]
105228013  translocation protein SEC63 homolog [KO:K09540]
105233566  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 [KO:K12666]
105230695  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform X1 [KO:K12667]
109579495  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
105222757  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
105224362  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
105224598  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
105223088  tumor suppressor candidate 3 [KO:K19478]
105229252  putative oligosaccharyltransferase complex subunit CG9662 [KO:K26501]
105233710  transmembrane protein 258 [KO:K26502]
105226933  mannosyl-oligosaccharide glucosidase [KO:K01228] [EC:3.2.1.106]
105228843  nucleotide exchange factor Sil1 [KO:K14001]
105222202  hypoxia up-regulated protein 1 [KO:K09486]
105224939  endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
105229265  dnaJ homolog shv [KO:K09517]
105223701  uncharacterized protein F54F2.9 [KO:K09521]
105228530  dnaJ homolog subfamily C member 3 [KO:K09523]
105232524  endoplasmin [KO:K09487]
105228793  neutral alpha-glucosidase AB [KO:K05546] [EC:3.2.1.207]
105225131  glucosidase 2 subunit beta [KO:K08288]
105226376  calnexin isoform X1 [KO:K08054]
105225421  protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
105232867  calreticulin [KO:K08057]
105229728  mannosyl-oligosaccharide alpha-1,2-mannosidase IA isoform X1 [KO:K01230] [EC:3.2.1.113]
105229826  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase [KO:K23741] [EC:3.2.1.209]
105229825  vesicular integral-membrane protein VIP36 [KO:K10082]
105224891  protein ERGIC-53 [KO:K10080]
105225333  prolactin regulatory element-binding protein [KO:K14003]
105227035  GTP-binding protein SAR1 [KO:K07953] [EC:3.6.5.-]
105231897  protein SEC13 homolog [KO:K14004]
105222345  protein transport protein Sec31A isoform X2 [KO:K14005]
105234156  protein transport protein Sec23A isoform X1 [KO:K14006]
105231218  protein transport protein Sec24C [KO:K14007]
105227760  protein transport protein Sec24A [KO:K14007]
105224257  UDP-glucose:glycoprotein glucosyltransferase [KO:K11718] [EC:2.4.1.-]
105223018  ER degradation-enhancing alpha-mannosidase-like protein 2 [KO:K10085]
105224273  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1 [KO:K10086]
105229475  protein disulfide-isomerase [KO:K09580] [EC:5.3.4.1]
105228716  protein disulfide-isomerase A6 homolog [KO:K09584] [EC:5.3.4.1]
105224693  protein windbeutel [KO:K09586]
105231425  ero1-like protein [KO:K10950] [EC:1.8.4.-]
105231207  endoplasmic reticulum lectin 1 [KO:K14008]
105227233  translocon-associated protein subunit alpha [KO:K13249]
105229048  translocon-associated protein subunit beta [KO:K13250]
105221784  translocon-associated protein subunit gamma [KO:K13251]
105228992  translocon-associated protein subunit delta [KO:K04571]
105224427  B-cell receptor-associated protein 31 [KO:K14009]
105228544  translocating chain-associated membrane protein 1 [KO:K14010]
105224409  derlin-1 [KO:K11519]
105225892  derlin-2 [KO:K13989]
105223275  UBX domain-containing protein 4 [KO:K24348]
105230038  UBX domain-containing protein 1 [KO:K24348]
105230650  UBX domain-containing protein 6 [KO:K14011]
105228963  NSFL1 cofactor p47 [KO:K14012]
105225050  small VCP/p97-interacting protein [KO:K14014]
105230599  transitional endoplasmic reticulum ATPase TER94 [KO:K13525]
105229621  nuclear protein localization protein 4 homolog isoform X1 [KO:K14015]
105229449  ubiquitin fusion degradation protein 1 homolog isoform X1 [KO:K14016]
105231830  heat shock 70 kDa protein cognate 2 [KO:K03283]
105224006  heat shock 70 kDa protein cognate 1 [KO:K03283]
105233698  heat shock protein 68 [KO:K03283]
125775801  heat shock protein 70-like [KO:K03283]
125775802  heat shock protein 70-like [KO:K03283]
125775803  heat shock protein 70-like [KO:K03283]
125775804  heat shock protein 70 [KO:K03283]
125775805  heat shock protein 70-like [KO:K03283]
125775806  heat shock protein 70-like [KO:K03283]
125776475  heat shock protein 68-like [KO:K03283]
125775287  heat shock protein 68-like isoform X1 [KO:K03283]
105229596  heat shock 70 kDa protein cognate 4 [KO:K03283]
105230421  heat shock protein 68 [KO:K03283]
105229900  dnaJ homolog subfamily A member 4 [KO:K09502]
105223120  dnaJ homolog subfamily A member 2 [KO:K09503]
105230931  dnaJ homolog subfamily B member 12 [KO:K09518]
105229241  dnaJ homolog subfamily C member 5 homolog isoform X1 [KO:K09525]
105226434  heat shock protein 83 [KO:K04079]
105223445  heat shock 70 kDa protein 4 isoform X1 [KO:K09485]
105229432  BAG family molecular chaperone regulator 2 isoform X2 [KO:K09556]
105227733  protein lethal(2)essential for life [KO:K09542]
105232909  ubiquitin thioesterase OTU1 [KO:K13719] [EC:3.1.2.-]
105223891  phospholipase A-2-activating protein [KO:K14018]
105225006  UV excision repair protein RAD23 homolog B [KO:K10839]
105231980  ubiquilin-1 [KO:K04523]
105225479  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase isoform X1 [KO:K01456] [EC:3.5.1.52]
105222370  ubiquitin conjugation factor E4 B [KO:K10597] [EC:2.3.2.27]
105233466  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
105224058  uncharacterized protein LOC105224058 isoform X1 [KO:K04374]
105225350  cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
105229820  wolframin [KO:K14020]
105233020  membrane-bound transcription factor site-1 protease [KO:K08653] [EC:3.4.21.112]
105230170  membrane-bound transcription factor site-2 protease [KO:K07765] [EC:3.4.24.85]
105223861  uncharacterized protein LOC105223861 [KO:K09027]
105231585  serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
105230906  mitogen-activated protein kinase kinase kinase 15 [KO:K04426] [EC:2.7.11.25]
105229652  stress-activated protein kinase JNK [KO:K04440] [EC:2.7.11.24]
105227956  E3 ubiquitin-protein ligase MARCHF6 [KO:K10661] [EC:2.3.2.27]
105233768  ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
105233769  ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
105231136  ubiquitin-conjugating enzyme E2 G1 isoform X4 [KO:K10575] [EC:2.3.2.23]
105228809  ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
105223342  E3 ubiquitin-protein ligase HRD1 [KO:K10601] [EC:2.3.2.27]
105223675  E3 ubiquitin-protein ligase RNF185 isoform X3 [KO:K10666] [EC:2.3.2.27]
105226736  protein sel-1 homolog 1 [KO:K14026]
105227919  E3 ubiquitin-protein ligase CHIP isoform X1 [KO:K09561] [EC:2.3.2.27]
105234234  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
105225264  E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
105233202  RING-box protein 1A [KO:K03868] [EC:2.3.2.32]
105225495  RING-box protein 1 [KO:K03868] [EC:2.3.2.32]
105229136  cullin homolog 1 isoform X1 [KO:K03347]
105233204  S-phase kinase-associated protein 1 [KO:K03094]
125778321  uncharacterized protein LOC125778321 [KO:K03094]
125778325  uncharacterized protein LOC125778325 [KO:K03094]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
bdr00510  N-Glycan biosynthesis
bdr03050  Proteasome
bdr03060  Protein export
KO pathway
ko04141   
LinkDB

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