Entry
Name
Renin secretion - Bos indicus (zebu cattle)
Description
The aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. Renin is synthesized, stored in, and released into circulation by the juxtaglomerular (JG) cells of the kidney. Secretion of renin from JG cells at the organ level is controlled by the four main mechanisms: the sympathetic nervous system, the local JG apparatus baroreflex, the macula densa mechanism, and several hormones acting locally within the JG apparatus. Renin secretion at the level of renal JG cells appears to be controlled mainly by classic second messengers, namely cAMP, cGMP, and free cytosolic calcium concentration. While cAMP generally stimulates renin release and the intracellular calcium concentration suppresses the exocytosis of renin, the effects of cGMP in the regulation of the renin system are more complex as it both may stimulate or inhibit renin release.
Class
Organismal Systems; Endocrine system
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Bos indicus (zebu cattle) [GN:
biu ]
Gene
109578023 ADCYAP1; pituitary adenylate cyclase-activating polypeptide [KO:K05262 ]
109557471 ADCYAP1R1; pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1 [KO:K04587 ]
109567291 guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas-like [KO:K04632 ]
109570093 CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870 ]
109553636 KCNMA1; calcium-activated potassium channel subunit alpha-1 [KO:K04936 ]
109565817 PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755 ] [EC:3.1.4.17 ]
109557469 PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755 ] [EC:3.1.4.17 ]
109559000 PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755 ] [EC:3.1.4.17 ]
109557337 GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
109576257 GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
109555970 GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630 ]
109571127 ORAI1; calcium release-activated calcium channel protein 1 isoform X1 [KO:K16056 ]
109556107 CLCA1; calcium-activated chloride channel regulator 1 [KO:K05027 ]
109556821 CLCA2; calcium-activated chloride channel regulator 2 [KO:K05028 ]
109556105 LOW QUALITY PROTEIN: epithelial chloride channel protein-like [KO:K05030 ]
109556106 CLCA4; calcium-activated chloride channel regulator 4 [KO:K05030 ]
109558615 CACNA1C; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850 ]
109576190 CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851 ]
109554975 CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853 ]
109562978 GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634 ]
109567852 PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
109567854 PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
109564927 PLCB2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858 ] [EC:3.1.4.11 ]
109576135 ITPR1; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958 ]
109570679 CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183 ]
109563107 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
109553732 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
109560300 PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference
Authors
Kurtz A
Title
Renin release: sites, mechanisms, and control.
Journal
Reference
Authors
Schweda F, Friis U, Wagner C, Skott O, Kurtz A
Title
Renin release.
Journal
Reference
Authors
Castrop H, Hocherl K, Kurtz A, Schweda F, Todorov V, Wagner C
Title
Physiology of kidney renin.
Journal
Reference
Authors
Friis UG, Madsen K, Stubbe J, Hansen PB, Svenningsen P, Bie P, Skott O, Jensen BL
Title
Regulation of renin secretion by renal juxtaglomerular cells.
Journal
Reference
Authors
Kim SM, Briggs JP, Schnermann J
Title
Convergence of major physiological stimuli for renin release on the Gs-alpha/cyclic adenosine monophosphate signaling pathway.
Journal
Reference
Authors
Kurtz A
Title
Control of renin synthesis and secretion.
Journal
Reference
Authors
Kurtz A, Wagner C
Title
Cellular control of renin secretion.
Journal
J Exp Biol 202:219-25 (1999)
Reference
Authors
Persson PB
Title
Renin: origin, secretion and synthesis.
Journal
Reference
Authors
Schweda F, Kurtz A
Title
Cellular mechanism of renin release.
Journal
Reference
Authors
Sparks MA, Crowley SD, Gurley SB, Mirotsou M, Coffman TM
Title
Classical Renin-Angiotensin system in kidney physiology.
Journal
Reference
Authors
Harrison-Bernard LM
Title
The renal renin-angiotensin system.
Journal
Reference
Authors
Schnermann J, Briggs JP
Title
Synthesis and secretion of renin in mice with induced genetic mutations.
Journal
Reference
Authors
Ryan MJ, Black TA, Millard SL, Gross KW, Hajduczok G
Title
Endothelin-1 increases calcium and attenuates renin gene expression in As4.1 cells.
Journal
Reference
Authors
Hautmann M, Friis UG, Desch M, Todorov V, Castrop H, Segerer F, Otto C, Schutz G, Schweda F
Title
Pituitary adenylate cyclase-activating polypeptide stimulates renin secretion via activation of PAC1 receptors.
Journal
Related pathway
KO pathway
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