KEGG   PATHWAY: bmn02024
Entry
bmn02024                    Pathway                                
Name
Quorum sensing - Burkholderia mallei NCTC 10247
Description
Quorum sensing (QS) is a regulatory system that allows bacteria to share information about cell density and adjust gene expression accordingly. All QS bacteria produce and release chemical signal molecules called autoinducers (AIs) that increase in concentration as a function of cell density. The most commonly studied AIs belong to one of the following three categories: acylated homoserine lactones, also referred to as AI-1, used by Gram-negative bacteria; peptide signals, used by Gram-positive bacteria; and AI-2, used by both Gram-negative and Gram-positive bacteria. QS can be divided into at least 4 steps: production of AIs by the bacterial cell; release of AIs, either actively or passively, into the surrounding environment; recognition of AIs by specific receptors; and leading to changes in gene regulation once they exceed a threshold concentration. The processes controlled by QS include virulence, competence, conjugation, antibiotic production, motility, sporulation, and biofilm formation.
Class
Cellular Processes; Cellular community - prokaryotes
Pathway map
bmn02024  Quorum sensing
bmn02024

Other DBs
GO: 0009372
Organism
Burkholderia mallei NCTC 10247 [GN:bmn]
Gene
BMA10247_1101  hfq; RNA chaperone Hfq [KO:K03666]
BMA10247_1038  hfq protein [KO:K03666]
BMA10247_A1910  trpE; anthranilate synthase component I [KO:K01657] [EC:4.1.3.27]
BMA10247_A1911  trpG; anthranilate synthase component II [KO:K01658] [EC:4.1.3.27]
BMA10247_A0960  bpsI; autoinducer synthase BpsI [KO:K13061] [EC:2.3.1.184]
BMA10247_A1423  rhlA-2; rhamnosyltransferase I, subunit A [KO:K18100] [EC:2.4.1.-]
BMA10247_A1995  rhlA-1; rhamnosyltransferase I, subunit A [KO:K18100] [EC:2.4.1.-]
BMA10247_A1421  rhlB-2; rhamnosyltransferase I, subunit B [KO:K18101] [EC:2.4.1.-]
BMA10247_A1993  rhlB-1; rhamnosyltransferase I, subunit B [KO:K18101] [EC:2.4.1.-]
BMA10247_A1419  rhamnosyltransferase family protein [KO:K12990] [EC:2.4.1.-]
BMA10247_A1990  rhlC; rhamnosyltransferase II [KO:K12990] [EC:2.4.1.-]
BMA10247_2220  aroG; 3-deoxy-7-phosphoheptulonate synthase [KO:K01626] [EC:2.5.1.54]
BMA10247_A1341  3-deoxy-7-phosphoheptulonate synthase [KO:K01626] [EC:2.5.1.54]
BMA10247_3111  flagellar transcriptional activator FlhD [KO:K02403]
BMA10247_3112  flhC; flagellar transcriptional activator FlhC [KO:K02402]
BMA10247_0371  kdpE; DNA-binding response regulator KdpE [KO:K07667]
BMA10247_A0482  spermidine/putrescine ABC transporter, periplasmic spermidine/putrescine-binding protein [KO:K02055]
BMA10247_2308  putrescine-binding periplasmic protein [KO:K02055]
BMA10247_A2082  putative ABC transporter, periplasmic substrate-binding protein [KO:K02055]
BMA10247_0501  ABC transporter, periplasmic substrate-binding protein [KO:K02055]
BMA10247_2331  bacterial extracellular solute-binding protein [KO:K02055]
BMA10247_0500  ABC transporter, permease protein [KO:K02053]
BMA10247_A2084  ABC transporter, permease protein [KO:K02053]
BMA10247_0497  ABC transporter, permease protein [KO:K02053]
BMA10247_A2081  ABC transporter, permease protein [KO:K02053]
BMA10247_A0484  spermidine/putrescine ABC transporter, permease protein [KO:K02054]
BMA10247_A0481  spermidine/putrescine ABC transporter, ATP-binding protein [KO:K02052]
BMA10247_A2083  ABC transporter, ATP-binding protein [KO:K02052]
BMA10247_0496  ABC transporter, ATP-binding protein [KO:K02052]
BMA10247_1756  putative amino acid ABC transporter, periplasmic amino acid-binding protein [KO:K01999]
BMA10247_2962  putative amino acid ABC transporter, periplasmic amino acid-binding protein [KO:K01999]
BMA10247_A1769  putative amino acid ABC transporter, periplasmic amino acid-binding protein [KO:K01999]
BMA10247_0406  putative amino acid-binding protein [KO:K01999]
BMA10247_2714  putative branched-chain amino acid ABC transporter, periplasmic amino acid-binding protein [KO:K01999]
BMA10247_3027  putative periplasmic substrate-binding protein [KO:K01999]
BMA10247_2999  putative amino acid uptake ABC transporter, periplasmic amino acid-binding protein [KO:K01999]
BMA10247_0907  putative transporter, periplasmic substrate-binding protein [KO:K01999]
BMA10247_0720  ABC transporter, permease protein [KO:K01997]
BMA10247_3000  putative amino acid uptake ABC transporter, permease protein [KO:K01997]
BMA10247_2713  putative branched-chain amino acid ABC transporter, permease protein [KO:K01997]
BMA10247_2996  putative amino acid uptake ABC transporter, permease protein [KO:K01997]
BMA10247_0721  ABC transporter, permease/ATP-binding protein [KO:K01995 K01998]
BMA10247_2712  putative branched-chain amino acid ABC transporter, permease protein [KO:K01998]
BMA10247_2997  putative amino acid uptake ABC transporter, permease protein [KO:K01998]
BMA10247_3001  ABC transporter, hydrophobic amino acid uptake transporter (HAAT) family, ATP-binding/permease protein [KO:K01995 K01998]
BMA10247_0264  ABC transporter, hydrophobic amino acid uptake transporter (HAAT) family, permease protein [KO:K01998]
BMA10247_2711  branched-chain amino acid ABC transporter, ATP-binding protein [KO:K01995]
BMA10247_2992  ABC transporter, hydrophobic amino acid uptake transporter (HAAT) family, ATP-binding protein [KO:K01995]
BMA10247_0265  ABC transporter, hydrophobic amino acid uptake transporter (HAAT) family, ATP-binding protein [KO:K01995]
BMA10247_0266  ABC transporter, hydrophobic amino acid uptake transporter (HAAT) family, ATP-binding protein [KO:K01996]
BMA10247_3002  ABC transporter, hydrophobic amino acid uptake transporter (HAAT) family, ATP-binding protein [KO:K01996]
BMA10247_2993  branched-chain amino acid ABC transporter, ATP-binding protein [KO:K01996]
BMA10247_0722  ABC transporter, ATP-binding protein [KO:K01996]
BMA10247_A0962  bpsR; autoinducer-binding transcriptional regulator BpsR [KO:K19666]
BMA10247_A0700  bpmI; acyl-homoserine-lactone synthase BpmI [KO:K20250] [EC:2.3.1.184]
BMA10247_A0702  bmpR; autoinducer-binding transcriptional regulator BmpR [KO:K19731]
BMA10247_A0724  thermolysin metallopeptidase [KO:K20273]
BMA10247_A1961  metallopeptidase domain protein [KO:K20274]
BMA10247_1035  fadD; long-chain-fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
BMA10247_0119  AMP-binding enzyme domain protein [KO:K01897] [EC:6.2.1.3]
BMA10247_2143  putative transcriptional regulator [KO:K10914]
BMA10247_0075  transcriptional regulator, Fur family [KO:K09823]
BMA10247_A1205  toxB; GTP cyclohydrolase II [KO:K01497] [EC:3.5.4.25]
BMA10247_A0959  ribA; GTP cyclohydrolase II [KO:K01497] [EC:3.5.4.25]
BMA10247_A1206  WD domain protein [KO:K20332]
BMA10247_2013  ribD; riboflavin biosynthesis protein RibD [KO:K11752] [EC:3.5.4.26 1.1.1.193]
BMA10247_A1201  efflux transporter, RND family, MFP subunit [KO:K18306]
BMA10247_A1202  hydrophobe/amphiphile efflux family protein [KO:K18307]
BMA10247_A1203  oprM; outer membrane efflux protein OprM [KO:K18139]
BMA10247_0060  oprB; outer membrane efflux protein OprB [KO:K18139]
BMA10247_A0168  efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family [KO:K18139]
BMA10247_A0385  oppA; oligopeptide ABC transporter, periplasmic oligopeptide-binding protein [KO:K15580]
BMA10247_A0386  oppB; oligopeptide ABC transporter, permease protein OppB [KO:K15581]
BMA10247_A0387  oppC; oligopeptide ABC transporter, permease protein OppC [KO:K15582]
BMA10247_A0388  oppD; oligopeptide ABC transporter, ATP-binding protein OppD [KO:K15583]
BMA10247_A0389  oppF; oligopeptide ABC transporter, ATP-binding protein OppF [KO:K10823]
BMA10247_A1065  bacterial extracellular solute-binding protein, family 5 [KO:K02035]
BMA10247_A1050  ABC transporter, periplasmic substrate-binding protein [KO:K02035]
BMA10247_A1049  ABC transporter, permease protein [KO:K02033]
BMA10247_A1048  ABC transporter, permease protein [KO:K02034]
BMA10247_A1047  ABC transporter, ATP-binding protein [KO:K02031]
BMA10247_A1046  ABC transporter, ATP-binding protein [KO:K02032]
BMA10247_3550  inner membrane protein, 60 kDa [KO:K03217]
BMA10247_A1078  serine metalloprotease MrpA [KO:K14645] [EC:3.4.21.-]
BMA10247_3463  secE; preprotein translocase, SecE subunit [KO:K03073]
BMA10247_0411  secG; preprotein translocase, SecG subunit [KO:K03075]
BMA10247_3498  secY; preprotein translocase, SecY subunit [KO:K03076]
BMA10247_2572  yajC; preprotein translocase, YajC subunit [KO:K03210]
BMA10247_3242  secA; preprotein translocase, SecA subunit [KO:K03070] [EC:7.4.2.8]
BMA10247_2922  ftsY; signal recognition particle-docking protein FtsY [KO:K03110]
BMA10247_2841  secB; protein-export chaperone SecB [KO:K03071]
BMA10247_3268  ffh; signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
BMA10247_A0095  plcN; non-hemolytic phospholipase C [KO:K01114] [EC:3.1.4.3]
BMA10247_1743  plcN-2; non-hemolytic phospholipase C [KO:K01114] [EC:3.1.4.3]
BMA10247_1027  phosphoesterase family protein [KO:K01114] [EC:3.1.4.3]
BMA10247_A1368  phosphoesterase family protein [KO:K01114] [EC:3.1.4.3]
BMA10247_A1822  phosphoesterase family protein [KO:K01114] [EC:3.1.4.3]
Compound
C00007  Oxygen
C00009  Orthophosphate
C00059  Sulfate
C00232  Succinate semialdehyde
C00334  4-Aminobutanoate
C00547  L-Noradrenaline
C00788  L-Adrenaline
C01019  L-Fucose
C11837  N-Butyryl-L-homoserine lactone
C11841  N-(3-Oxooctanoyl)homoserine lactone
C11844  N-Heptanoylhomoserine lactone
C11845  N-(3-Hydroxy-7-cis-tetradecenoyl)homoserine lactone
C11848  2-Heptyl-3-hydroxy-quinolone
C16421  AI-2
C16463  3',5'-Cyclic diGMP
C16640  CAI-1
C18049  N-Acyl-L-homoserine lactone
C18206  cis-11-Methyl-2-dodecenoic acid
C20643  2-Heptyl-4(1H)-quinolone
C20677  N-(4-Coumaroyl)-L-homoserine lactone
C20959  (4S)-4-Hydroxy-5-phosphooxypentane-2,3-dione
C21195  N-(3-Hydroxybutanoyl)-L-homoserine lactone
C21197  N-Hexanoyl-L-homoserine lactone
C21198  N-(3-Oxohexanoyl)-L-homoserine lactone
C21199  N-Octanoyl-L-homoserine lactone
C21200  N-3-Hydroxyoctanoyl-L-homoserine lactone
C21201  N-3-Oxo-dodecanoyl-L-homoserine lactone
C21202  cis-2-Dodecenoic acid
C21220  AIP-1
C21221  CSP
C21222  CSP
C21223  Blp
C21224  SHP2
C21225  SHP3
C21226  cCF10
C21227  iCF10
C21228  cAD1
C21229  iAD1
C21230  ComX pheromone
C21231  PhrA pentapeptide
C21232  PhrC pentapeptide
C21233  PhrE pentapeptide
C21234  PhrF pentapeptide
C21235  PhrG pentapeptide
C21236  PhrH pentapeptide
C21237  PhrK pentapeptide
C21238  NprX peptide
C21239  PapR peptide
C21241  AIP-2
C21242  AIP-3
C21243  AIP-4
C21244  AgrD peptide
C21245  AgrD1 peptide
C21246  GBAP
C21382  R-THMF
Reference
PMID:22712853
  Authors
Pereira CS, Thompson JA, Xavier KB
  Title
AI-2-mediated signalling in bacteria.
  Journal
FEMS Microbiol Rev 37:156-81 (2013)
DOI:10.1111/j.1574-6976.2012.00345.x
Reference
PMID:23965960
  Authors
Verma SC, Miyashiro T
  Title
Quorum sensing in the squid-Vibrio symbiosis.
  Journal
Int J Mol Sci 14:16386-401 (2013)
DOI:10.3390/ijms140816386
Reference
PMID:24348467
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Norsworthy AN, Visick KL
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Gimme shelter: how Vibrio fischeri successfully navigates an animal's multiple environments.
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Front Microbiol 4:356 (2013)
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Reference
PMID:24065108
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Papaioannou E, Utari PD, Quax WJ
  Title
Choosing an appropriate infection model to study quorum sensing inhibition in Pseudomonas infections.
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Int J Mol Sci 14:19309-40 (2013)
DOI:10.3390/ijms140919309
Reference
PMID:20738404
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Heeb S, Fletcher MP, Chhabra SR, Diggle SP, Williams P, Camara M
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Quinolones: from antibiotics to autoinducers.
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FEMS Microbiol Rev 35:247-74 (2011)
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The formation of biofilms by Pseudomonas aeruginosa: a review of the natural and synthetic compounds interfering with control mechanisms.
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Biomed Res Int 2015:759348 (2015)
DOI:10.1155/2015/759348
Reference
PMID:11544214
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Whiteley M, Greenberg EP
  Title
Promoter specificity elements in Pseudomonas aeruginosa quorum-sensing-controlled genes.
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J Bacteriol 183:5529-34 (2001)
DOI:10.1128/JB.183.19.5529-5534.2001
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PMID:11497469
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Phenazine-1-carboxamide production in the biocontrol strain Pseudomonas chlororaphis PCL1391 is regulated by multiple factors secreted into the growth medium.
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Mol Plant Microbe Interact 14:969-79 (2001)
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Reference
PMID:19696934
  Authors
Hughes DT, Clarke MB, Yamamoto K, Rasko DA, Sperandio V
  Title
The QseC adrenergic signaling cascade in Enterohemorrhagic E. coli (EHEC).
  Journal
PLoS Pathog 5:e1000553 (2009)
DOI:10.1371/journal.ppat.1000553
Reference
PMID:22144490
  Authors
Njoroge J, Sperandio V
  Title
Enterohemorrhagic Escherichia coli virulence regulation by two bacterial adrenergic kinases, QseC and QseE.
  Journal
Infect Immun 80:688-703 (2012)
DOI:10.1128/IAI.05921-11
Reference
PMID:23160491
  Authors
Pacheco AR, Curtis MM, Ritchie JM, Munera D, Waldor MK, Moreira CG, Sperandio V
  Title
Fucose sensing regulates bacterial intestinal colonization.
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Nature 492:113-7 (2012)
DOI:10.1038/nature11623
Reference
PMID:22778415
  Authors
Hirakawa H, Harwood CS, Pechter KB, Schaefer AL, Greenberg EP
  Title
Antisense RNA that affects Rhodopseudomonas palustris quorum-sensing signal receptor expression.
  Journal
Proc Natl Acad Sci U S A 109:12141-6 (2012)
DOI:10.1073/pnas.1200243109
Reference
PMID:14617175
  Authors
Danino VE, Wilkinson A, Edwards A, Downie JA
  Title
Recipient-induced transfer of the symbiotic plasmid pRL1JI in Rhizobium leguminosarum bv. viciae is regulated by a quorum-sensing relay.
  Journal
Mol Microbiol 50:511-25 (2003)
DOI:10.1046/j.1365-2958.2003.03699.x
Reference
PMID:12448738
  Authors
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  Title
Quorum-sensing in Rhizobium.
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Antonie Van Leeuwenhoek 81:397-407 (2002)
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PMID:10368158
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Rodelas B, Lithgow JK, Wisniewski-Dye F, Hardman A, Wilkinson A, Economou A, Williams P, Downie JA
  Title
Analysis of quorum-sensing-dependent control of rhizosphere-expressed (rhi) genes in Rhizobium leguminosarum bv. viciae.
  Journal
J Bacteriol 181:3816-23 (1999)
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Reference
PMID:24550924
  Authors
Lang J, Faure D
  Title
Functions and regulation of quorum-sensing in Agrobacterium tumefaciens.
  Journal
Front Plant Sci 5:14 (2014)
DOI:10.3389/fpls.2014.00014
Reference
PMID:23710277
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  Title
In planta fitness-cost of the Atu4232-regulon encoding for a selective GABA-binding sensor in Agrobacterium.
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Commun Integr Biol 6:e23692 (2013)
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Reference
PMID:16943991
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  Title
Quorum sensing in Erwinia species.
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Anal Bioanal Chem 387:415-23 (2007)
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Reference
PMID:17360277
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Quorum sensing, virulence and secondary metabolite production in plant soft-rotting bacteria.
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Philos Trans R Soc Lond B Biol Sci 362:1165-83 (2007)
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Reference
PMID:19843225
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  Title
Identification and characterization of three novel EsaI/EsaR quorum-sensing controlled stewartan exopolysaccharide biosynthetic genes in Pantoea stewartii ssp. stewartii.
  Journal
Mol Microbiol 74:903-13 (2009)
DOI:10.1111/j.1365-2958.2009.06906.x
Reference
PMID:7665477
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Beck von Bodman S, Farrand SK
  Title
Capsular polysaccharide biosynthesis and pathogenicity in Erwinia stewartii require induction by an N-acylhomoserine lactone autoinducer.
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J Bacteriol 177:5000-8 (1995)
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Reference
PMID:19761612
  Authors
O'Grady EP, Viteri DF, Malott RJ, Sokol PA
  Title
Reciprocal regulation by the CepIR and CciIR quorum sensing systems in Burkholderia cenocepacia.
  Journal
BMC Genomics 10:441 (2009)
DOI:10.1186/1471-2164-10-441
Reference
PMID:16041013
  Authors
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  Title
Characterization of the cciIR quorum-sensing system in Burkholderia cenocepacia.
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Infect Immun 73:4982-92 (2005)
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PMID:22949660
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Cis-2-dodecenoic acid receptor RpfR links quorum-sensing signal perception with regulation of virulence through cyclic dimeric guanosine monophosphate turnover.
  Journal
Proc Natl Acad Sci U S A 109:15479-84 (2012)
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Reference
PMID:23799665
  Authors
Suppiger A, Schmid N, Aguilar C, Pessi G, Eberl L
  Title
Two quorum sensing systems control biofilm formation and virulence in members of the Burkholderia cepacia complex.
  Journal
Virulence 4:400-9 (2013)
DOI:10.4161/viru.25338
Reference
PMID:21166386
  Authors
Deng Y, Wu J, Tao F, Zhang LH
  Title
Listening to a new language: DSF-based quorum sensing in Gram-negative bacteria.
  Journal
Chem Rev 111:160-73 (2011)
DOI:10.1021/cr100354f
Reference
PMID:21227698
  Authors
Ryan RP, Dow JM
  Title
Communication with a growing family: diffusible signal factor (DSF) signaling in bacteria.
  Journal
Trends Microbiol 19:145-52 (2011)
DOI:10.1016/j.tim.2010.12.003
Reference
PMID:15522077
  Authors
Kim J, Kim JG, Kang Y, Jang JY, Jog GJ, Lim JY, Kim S, Suga H, Nagamatsu T, Hwang I
  Title
Quorum sensing and the LysR-type transcriptional activator ToxR regulate toxoflavin biosynthesis and transport in Burkholderia glumae.
  Journal
Mol Microbiol 54:921-34 (2004)
DOI:10.1111/j.1365-2958.2004.04338.x
Reference
PMID:17376080
  Authors
Kim J, Kang Y, Choi O, Jeong Y, Jeong JE, Lim JY, Kim M, Moon JS, Suga H, Hwang I
  Title
Regulation of polar flagellum genes is mediated by quorum sensing and FlhDC in Burkholderia glumae.
  Journal
Mol Microbiol 64:165-79 (2007)
DOI:10.1111/j.1365-2958.2007.05646.x
Reference
PMID:21622734
  Authors
Stauff DL, Bassler BL
  Title
Quorum sensing in Chromobacterium violaceum: DNA recognition and gene regulation by the CviR receptor.
  Journal
J Bacteriol 193:3871-8 (2011)
DOI:10.1128/JB.05125-11
Reference
PMID:21504831
  Authors
Chen G, Swem LR, Swem DL, Stauff DL, O'Loughlin CT, Jeffrey PD, Bassler BL, Hughson FM
  Title
A strategy for antagonizing quorum sensing.
  Journal
Mol Cell 42:199-209 (2011)
DOI:10.1016/j.molcel.2011.04.003
Reference
PMID:16513747
  Authors
Hao G, Burr TJ
  Title
Regulation of long-chain N-acyl-homoserine lactones in Agrobacterium vitis.
  Journal
J Bacteriol 188:2173-83 (2006)
DOI:10.1128/JB.188.6.2173-2183.2006
Reference
PMID:20514483
  Authors
Savka MA, Le PT, Burr TJ
  Title
LasR receptor for detection of long-chain quorum-sensing signals: identification of N-acyl-homoserine lactones encoded by the avsI locus of Agrobacterium vitis.
  Journal
Curr Microbiol 62:101-10 (2011)
DOI:10.1007/s00284-010-9679-1
Reference
PMID:26579084
  Authors
Le KY, Otto M
  Title
Quorum-sensing regulation in staphylococci-an overview.
  Journal
Front Microbiol 6:1174 (2015)
DOI:10.3389/fmicb.2015.01174
Reference
PMID:18851841
  Authors
Queck SY, Jameson-Lee M, Villaruz AE, Bach TH, Khan BA, Sturdevant DE, Ricklefs SM, Li M, Otto M
  Title
RNAIII-independent target gene control by the agr quorum-sensing system: insight into the evolution of virulence regulation in Staphylococcus aureus.
  Journal
Mol Cell 32:150-8 (2008)
DOI:10.1016/j.molcel.2008.08.005
Reference
PMID:25714717
  Authors
Darkoh C, DuPont HL, Norris SJ, Kaplan HB
  Title
Toxin synthesis by Clostridium difficile is regulated through quorum signaling.
  Journal
MBio 6:e02569 (2015)
DOI:10.1128/mBio.02569-14
Reference
PMID:25824838
  Authors
Vidal JE, Shak JR, Canizalez-Roman A
  Title
The CpAL quorum sensing system regulates production of hemolysins CPA and PFO to build Clostridium perfringens biofilms.
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Infect Immun 83:2430-42 (2015)
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Related
pathway
bmn00405  Phenazine biosynthesis
bmn02040  Flagellar assembly
KO pathway
ko02024   
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