KEGG   PATHWAY: bta05160
Entry
bta05160                    Pathway                                
Name
Hepatitis C - Bos taurus (cow)
Description
Hepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the cytoplasm of the host cell and forms membrane-associated replication complexes along with non-structural proteins. Viral RNA can trigger the RIG-I pathway and interferon production during this process. Translated HCV protein products regulate immune response to inhibit the action of interferon. HCV core and NS5A proteins appear to be the most important molecules with regulatory functions that modulate transcription, cellular proliferation, and apoptosis.
Class
Human Diseases; Infectious disease: viral
Pathway map
bta05160  Hepatitis C
bta05160

Organism
Bos taurus (cow) [GN:bta]
Gene
281276  LDLR; low-density lipoprotein receptor precursor [KO:K12473]
282346  SCARB1; scavenger receptor class B member 1 [KO:K13885]
511435  CD81; CD81 antigen [KO:K06508]
404089  CLDN2; claudin-2 [KO:K06087]
404153  CLDN3; claudin-3 [KO:K06087]
414921  CLDN4; claudin-4 [KO:K06087]
414922  CLDN1; claudin-1 [KO:K06087]
511460  CLDN18; claudin-18 precursor [KO:K06087]
282184  CLDN16; claudin-16 [KO:K06087]
508268  CLDN11; claudin-11 [KO:K06087]
512703  CLDN17; claudin-17 [KO:K06087]
512975  CLDN7; claudin-7 precursor [KO:K06087]
513034  CLDN19; claudin-19 [KO:K06087]
617453  CLDN5; claudin-5 [KO:K06087]
783180  CLDN14; claudin-14 [KO:K06087]
511318  CLDN6; claudin-6 [KO:K06087]
514634  CLDN23; claudin-23 [KO:K06087]
514998  CLDN15; claudin-15 [KO:K06087]
538761  CLDN8; claudin-8 [KO:K06087]
506545  CLDN10; claudin-10 isoform a precursor [KO:K06087]
617449  CLDN9; claudin-9 [KO:K06087]
100847650  CLDN34; claudin-34 [KO:K06087]
522679  CLDN25; putative claudin-25 [KO:K06087]
536739  claudin-22 [KO:K06087]
101907895  CLDN20; claudin-20 [KO:K06087]
112444630  putative claudin-24 [KO:K06087]
538709  CLDN12; claudin-12 [KO:K06087]
112446354  LOW QUALITY PROTEIN: claudin-12 [KO:K06087]
512405  OCLN; occludin [KO:K06088]
654488  OAS1Y; 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
529660  OAS2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
347699  OAS1X; 2',5'-oligoadenylate synthetase 1, 40/46kDa [KO:K14216] [EC:2.7.7.84]
519922  OAS1Z; 2',5'-oligoadenylate synthetase 1 [KO:K14216] [EC:2.7.7.84]
100048947  RNASEL; 2-5A-dependent ribonuclease [KO:K01165]
504760  RIGI; antiviral innate immune response receptor RIG-I isoform X1 [KO:K12646] [EC:5.6.2.6]
618508  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
506182  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
533141  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
533216  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
516979  IRF3; interferon regulatory factor 3 [KO:K05411]
100125591  IRF7; interferon regulatory factor 7 [KO:K09447]
281236  IFNAC; interferon alpha-C precursor [KO:K05414]
510726  IFNA16; interferon alpha-H [KO:K05414]
523244  interferon alpha-B-like [KO:K05414]
517108  interferon alpha-2 [KO:K05414]
618947  interferon alpha-B-like [KO:K05414]
787343  interferon alpha-2 [KO:K05414]
515951  IFNAA; interferon alpha-A precursor [KO:K05414]
100329207  IFNAH; interferon alpha-H precursor [KO:K05414]
100335490  interferon alpha-G-like [KO:K05414]
100329204  IFNAD; interferon alpha-D [KO:K05414]
100329206  IFNAG; interferon alpha-G precursor [KO:K05414]
100329210  INFAF; interferon alpha-F precursor [KO:K05414]
783912  interferon alpha-H [KO:K05414]
617556  LOW QUALITY PROTEIN: interferon alpha-1-like [KO:K05414]
132345931  interferon alpha-H-like [KO:K05414]
281845  IFNB1; interferon beta precursor [KO:K05415]
525550  interferon beta-2 [KO:K05415]
517016  interferon beta-2 precursor [KO:K05415]
784525  interferon beta-2 [KO:K05415]
618946  IFNB3; interferon beta-3 precursor [KO:K05415]
100848709  interferon beta-3 [KO:K05415]
616977  interferon beta-2 [KO:K05415]
112441480  interferon beta-3 [KO:K05415]
112447877  interferon beta-3 [KO:K05415]
112447878  interferon beta-3 [KO:K05415]
112447879  interferon beta-3 [KO:K05415]
112447880  interferon beta-3 [KO:K05415]
112441471  interferon beta [KO:K05415]
281237  IFNG; interferon gamma precursor [KO:K04687]
281535  TLR3; toll-like receptor 3 precursor [KO:K05401]
510427  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
539124  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
782032  LOW QUALITY PROTEIN: TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
504727  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
281073  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
281854  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
281855  IKBKG; NF-kappa-B essential modulator [KO:K07210]
282291  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
616115  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
508233  RELA; transcription factor p65 [KO:K04735]
280943  TNF; tumor necrosis factor [KO:K03156]
615107  CXCL10; C-X-C motif chemokine 10 precursor [KO:K12671]
507689  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 [KO:K16194] [EC:2.7.11.1]
347700  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
535820  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 precursor [KO:K08860] [EC:2.7.11.1]
513829  EIF2AK4; eIF-2-alpha kinase GCN2 isoform X2 [KO:K16196] [EC:2.7.11.1]
100139670  interferon-induced protein with tetratricopeptide repeats 1 isoform X3 [KO:K14217]
534165  EIF3E; eukaryotic translation initiation factor 3 subunit E [KO:K03250]
327694  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
508541  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
282081  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
282257  IFNAR1; interferon alpha/beta receptor 1 precursor [KO:K05130]
282258  IFNAR2; interferon alpha/beta receptor 2 precursor [KO:K05131]
537201  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
512484  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
510814  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
511023  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
509855  IRF9; interferon regulatory factor 9 [KO:K04693]
280872  MX1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
280873  MX2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
506415  RSAD2; S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 precursor [KO:K15045]
616695  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
535321  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
100138150  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X4 [KO:K03456]
132344360  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like [KO:K03456]
508045  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
509290  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
782110  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
282320  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
524361  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
509231  PIAS1; E3 SUMO-protein ligase PIAS1 [KO:K04706] [EC:2.3.2.-]
530315  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
407217  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
535298  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
537682  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100138040  SOS2; son of sevenless homolog 2 [KO:K03099]
100298939  HRAS; GTPase HRas isoform 1 [KO:K02833]
100847184  GTPase HRas-like [KO:K02833]
541140  KRAS; GTPase KRas [KO:K07827]
506322  NRAS; GTPase NRas [KO:K07828]
536051  BRAF; serine/threonine-protein kinase B-raf isoform X9 [KO:K04365] [EC:2.7.11.1]
521196  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
540421  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
287022  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
286863  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
768311  YWHAQ; 14-3-3 protein theta [KO:K16197]
282125  YWHAE; 14-3-3 protein epsilon [KO:K06630]
282126  YWHAH; 14-3-3 protein eta [KO:K16198]
286862  YWHAG; 14-3-3 protein gamma [KO:K16198]
533199  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101905399  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
510434  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
327672  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
531391  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
282308  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
286865  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
282307  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
282306  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
517948  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
504531  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
534923  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
280991  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100137872  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
790875  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
539003  CTNNB1; catenin beta-1 [KO:K02105]
615013  BAD; bcl2-associated agonist of cell death [KO:K02158]
513497  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
281542  TP53; cellular tumor antigen p53 [KO:K04451]
519217  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
510618  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
511754  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
534712  RB1; retinoblastoma-associated protein [KO:K06618]
535369  E2F1; transcription factor E2F1 [KO:K17454]
617024  E2F2; transcription factor E2F2 isoform X2 [KO:K09389]
541184  E2F3; transcription factor E2F3 [KO:K06620]
282527  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158]
504707  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
512355  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
407111  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
282488  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
493720  FADD; FAS-associated death domain protein [KO:K02373]
507481  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
408016  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
497199  CFLAR; CASP8 and FADD-like apoptosis regulator [KO:K04724]
510373  BID; BH3-interacting domain death agonist [KO:K04726]
280730  BAX; apoptosis regulator BAX [KO:K02159]
514090  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
510767  CYCS; cytochrome c [KO:K08738]
781996  CYCT; cytochrome c 2 [KO:K08738]
100847700  cytochrome c [KO:K08738]
100847304  cytochrome c-like [KO:K08738]
112447733  cytochrome c-like [KO:K08738]
537782  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
100140945  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
100336105  PSME3; proteasome activator complex subunit 3 isoform X2 [KO:K06698]
132344816  proteasome activator complex subunit 3-like [KO:K06698]
507554  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
281992  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
507176  NR1H3; oxysterols receptor LXR-alpha [KO:K08536]
524530  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
511077  MYC; myc proto-oncogene protein [KO:K04377]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20935  2-5A
Reference
PMID:24520529
  Authors
Hassan M, Selimovic D, El-Khattouti A, Ghozlan H, Haikel Y, Abdelkader O
  Title
Hepatitis C virus-host interactions: Etiopathogenesis and therapeutic strategies.
  Journal
World J Exp Med 2:7-25 (2012)
DOI:10.5493/wjem.v2.i2.7
Reference
PMID:23641066
  Authors
Yamauchi Y, Helenius A
  Title
Virus entry at a glance.
  Journal
J Cell Sci 126:1289-95 (2013)
DOI:10.1242/jcs.119685
Reference
PMID:24509809
  Authors
Feneant L, Levy S, Cocquerel L
  Title
CD81 and hepatitis C virus (HCV) infection.
  Journal
Viruses 6:535-72 (2014)
DOI:10.3390/v6020535
Reference
PMID:18081727
  Authors
Dubuisson J, Helle F, Cocquerel L
  Title
Early steps of the hepatitis C virus life cycle.
  Journal
Cell Microbiol 10:821-7 (2008)
DOI:10.1111/j.1462-5822.2007.01107.x
Reference
PMID:23675659
  Authors
Liang TJ, Ghany MG
  Title
Current and future therapies for hepatitis C virus infection.
  Journal
N Engl J Med 368:1907-17 (2013)
DOI:10.1056/NEJMra1213651
Reference
PMID:23836234
  Authors
Scheel TK, Rice CM
  Title
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.
  Journal
Nat Med 19:837-49 (2013)
DOI:10.1038/nm.3248
Reference
PMID:26586968
  Authors
Holmes JA, Thompson AJ
  Title
Interferon-free combination therapies for the treatment of hepatitis C: current insights.
  Journal
Hepat Med 7:51-70 (2015)
DOI:10.2147/HMER.S55864
Reference
PMID:15039538
  Authors
Taguchi T, Nagano-Fujii M, Akutsu M, Kadoya H, Ohgimoto S, Ishido S, Hotta H
  Title
Hepatitis C virus NS5A protein interacts with 2',5'-oligoadenylate synthetase and inhibits antiviral activity of IFN in an IFN sensitivity-determining region-independent manner.
  Journal
J Gen Virol 85:959-69 (2004)
DOI:10.1099/vir.0.19513-0
Reference
PMID:19708811
  Authors
Horner SM, Gale M Jr
  Title
Intracellular innate immune cascades and interferon defenses that control hepatitis C virus.
  Journal
J Interferon Cytokine Res 29:489-98 (2009)
DOI:10.1089/jir.2009.0063
Reference
PMID:20457596
  Authors
Lemon SM
  Title
Induction and evasion of innate antiviral responses by hepatitis C virus.
  Journal
J Biol Chem 285:22741-7 (2010)
DOI:10.1074/jbc.R109.099556
Reference
PMID:23836238
  Authors
Horner SM, Gale M Jr
  Title
Regulation of hepatic innate immunity by hepatitis C virus.
  Journal
Nat Med 19:879-88 (2013)
DOI:10.1038/nm.3253
Reference
PMID:28862649
  Authors
Ortega-Prieto AM, Dorner M
  Title
Immune Evasion Strategies during Chronic Hepatitis B and C Virus Infection.
  Journal
Vaccines (Basel) 5:E24 (2017)
DOI:10.3390/vaccines5030024
Reference
PMID:25852264
  Authors
Yang DR, Zhu HZ
  Title
Hepatitis C virus and antiviral innate immunity: who wins at tug-of-war?
  Journal
World J Gastroenterol 21:3786-800 (2015)
DOI:10.3748/wjg.v21.i13.3786
Reference
PMID:16107833
  Authors
Gale M Jr, Foy EM
  Title
Evasion of intracellular host defence by hepatitis C virus.
  Journal
Nature 436:939-45 (2005)
DOI:10.1038/nature04078
Reference
PMID:17467654
  Authors
Bode JG, Brenndorfer ED, Haussinger D
  Title
Subversion of innate host antiviral strategies by the hepatitis C virus.
  Journal
Arch Biochem Biophys 462:254-65 (2007)
DOI:10.1016/j.abb.2007.03.033
Reference
PMID:12686421
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
PMID:16239065
  Authors
Pang R, Tse E, Poon RT
  Title
Molecular pathways in hepatocellular carcinoma.
  Journal
Cancer Lett 240:157-69 (2006)
DOI:10.1016/j.canlet.2005.08.031
Reference
PMID:15302943
  Authors
Macdonald A, Harris M
  Title
Hepatitis C virus NS5A: tales of a promiscuous protein.
  Journal
J Gen Virol 85:2485-502 (2004)
DOI:10.1099/vir.0.80204-0
Reference
PMID:21250384
  Authors
He Y, Staschke KA, Tan SL
  Title
HCV NS5A: A Multifunctional Regulator of Cellular Pathways and Virus Replication
  Journal
Hepatitis C Viruses: Genomes and Molecular Biology (2006)
Reference
PMID:12101418
  Authors
Lan KH, Sheu ML, Hwang SJ, Yen SH, Chen SY, Wu JC, Wang YJ, Kato N, Omata M, Chang FY, Lee SD
  Title
HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis.
  Journal
Oncogene 21:4801-11 (2002)
DOI:10.1038/sj.onc.1205589
Reference
PMID:11886269
  Authors
Majumder M, Ghosh AK, Steele R, Zhou XY, Phillips NJ, Ray R, Ray RB
  Title
Hepatitis C virus NS5A protein impairs TNF-mediated hepatic apoptosis, but not by an anti-FAS antibody, in transgenic mice.
  Journal
Virology 294:94-105 (2002)
DOI:10.1006/viro.2001.1309
Reference
PMID:15381253
  Authors
Hassan M, Ghozlan H, Abdel-Kader O
  Title
Activation of RB/E2F signaling pathway is required for the modulation of hepatitis C virus core protein-induced cell growth in liver and non-liver cells.
  Journal
Cell Signal 16:1375-85 (2004)
DOI:10.1016/j.cellsig.2004.04.005
Reference
PMID:11514734
  Authors
Kwun HJ, Jung EY, Ahn JY, Lee MN, Jang KL
  Title
p53-dependent transcriptional repression of p21(waf1) by hepatitis C virus NS3.
  Journal
J Gen Virol 82:2235-41 (2001)
DOI:10.1099/0022-1317-82-9-2235
Reference
PMID:12056797
  Authors
Yamanaka T, Uchida M, Doi T
  Title
Innate form of HCV core protein plays an important role in the localization and the function of HCV core protein.
  Journal
Biochem Biophys Res Commun 294:521-7 (2002)
DOI:10.1016/S0006-291X(02)00507-7
Reference
PMID:22611309
  Authors
Lim EJ, Chin R, Angus PW, Torresi J
  Title
Enhanced apoptosis in post-liver transplant hepatitis C: effects of virus and immunosuppressants.
  Journal
World J Gastroenterol 18:2172-9 (2012)
DOI:10.3748/wjg.v18.i18.2172
Reference
PMID:17828818
  Authors
Fischer R, Baumert T, Blum HE
  Title
Hepatitis C virus infection and apoptosis.
  Journal
World J Gastroenterol 13:4865-72 (2007)
DOI:10.3748/wjg.v13.i36.4865
Reference
PMID:16611896
  Authors
Saito K, Meyer K, Warner R, Basu A, Ray RB, Ray R
  Title
Hepatitis C virus core protein inhibits tumor necrosis factor alpha-mediated apoptosis by a protective effect involving cellular FLICE inhibitory protein.
  Journal
J Virol 80:4372-9 (2006)
DOI:10.1128/JVI.80.9.4372-4379.2006
Reference
PMID:19148799
  Authors
Koike K
  Title
Steatosis, liver injury, and hepatocarcinogenesis in hepatitis C viral infection.
  Journal
J Gastroenterol 44 Suppl 19:82-8 (2009)
DOI:10.1007/s00535-008-2276-4
Reference
PMID:17764115
  Authors
Tanaka N, Moriya K, Kiyosawa K, Koike K, Aoyama T
  Title
Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor alpha in transgenic mice: implications for HCV-associated hepatocarcinogenesis.
  Journal
Int J Cancer 122:124-31 (2008)
DOI:10.1002/ijc.23056
Reference
PMID:18251977
  Authors
Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
  Title
Viral hepatocarcinogenesis: from infection to cancer.
  Journal
Liver Int 28:175-88 (2008)
DOI:10.1111/j.1478-3231.2007.01652.x
Related
pathway
bta03320  PPAR signaling pathway
bta04010  MAPK signaling pathway
bta04144  Endocytosis
bta04210  Apoptosis
bta04514  Cell adhesion molecules
bta04620  Toll-like receptor signaling pathway
bta04622  RIG-I-like receptor signaling pathway
bta04630  JAK-STAT signaling pathway
bta04668  TNF signaling pathway
KO pathway
ko05160   
LinkDB

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