KEGG   PATHWAY: ccar04216
Entry
ccar04216                   Pathway                                
Name
Ferroptosis - Cyprinus carpio (common carp)
Description
Ferroptosis is a regulated form of cell death and characterized by a production of reactive oxygen species (ROS) from accumulated iron and lipid peroxidation. It can be induced by experimental compounds (e.g.,erastin, RSL3) or clinical drugs(e.g., sulfasalazine, sorafenib) in cancer cell and certain normal cells. It is involved in multiple physiological and pathological processes, such as cancer cell death, neurodegenerative disease, tissue damage and acute renal failure.
Class
Cellular Processes; Cell growth and death
Pathway map
ccar04216  Ferroptosis
ccar04216

Other DBs
GO: 0097707
Organism
Cyprinus carpio (common carp) [GN:ccar]
Gene
109092598  4F2 cell-surface antigen heavy chain-like [KO:K06519]
109046265  4F2 cell-surface antigen heavy chain-like [KO:K06519]
109045996  slc3a2; 4F2 cell-surface antigen heavy chain [KO:K06519]
109093027  4F2 cell-surface antigen heavy chain-like [KO:K06519]
109066090  LOW QUALITY PROTEIN: cystine/glutamate transporter-like [KO:K13869]
109060290  cystine/glutamate transporter-like [KO:K13869]
109069508  cystine/glutamate transporter-like [KO:K13869]
109083614  LOW QUALITY PROTEIN: cellular tumor antigen p53-like [KO:K04451]
109082764  cellular tumor antigen p53-like isoform X1 [KO:K04451]
109053387  glutamate--cysteine ligase catalytic subunit-like [KO:K11204] [EC:6.3.2.2]
109102318  glutamate--cysteine ligase catalytic subunit-like isoform X1 [KO:K11204] [EC:6.3.2.2]
109085167  LOW QUALITY PROTEIN: glutamate--cysteine ligase regulatory subunit-like [KO:K11205]
109085050  LOW QUALITY PROTEIN: glutamate--cysteine ligase regulatory subunit-like [KO:K11205]
109101289  gss; glutathione synthetase [KO:K21456] [EC:6.3.2.3]
109071199  LOW QUALITY PROTEIN: phospholipid hydroperoxide glutathione peroxidase, mitochondrial-like [KO:K05361] [EC:1.11.1.12]
109095832  phospholipid hydroperoxide glutathione peroxidase, mitochondrial-like [KO:K05361] [EC:1.11.1.12]
109091432  acsl1; long-chain-fatty-acid--CoA ligase 1 [KO:K01897] [EC:6.2.1.3]
109108891  long-chain-fatty-acid--CoA ligase 3-like [KO:K01897] [EC:6.2.1.3]
109080628  long-chain-fatty-acid--CoA ligase 3-like [KO:K01897] [EC:6.2.1.3]
109106443  long-chain-fatty-acid--CoA ligase 3-like [KO:K01897] [EC:6.2.1.3]
109078244  long-chain-fatty-acid--CoA ligase 6-like [KO:K01897] [EC:6.2.1.3]
109055516  long-chain-fatty-acid--CoA ligase 5-like [KO:K01897] [EC:6.2.1.3]
109081291  long-chain-fatty-acid--CoA ligase 1-like [KO:K01897] [EC:6.2.1.3]
109081151  long-chain-fatty-acid--CoA ligase 6-like [KO:K01897] [EC:6.2.1.3]
109081400  long-chain-fatty-acid--CoA ligase 4-like [KO:K01897] [EC:6.2.1.3]
109099956  LOW QUALITY PROTEIN: long-chain-fatty-acid--CoA ligase 5-like [KO:K01897] [EC:6.2.1.3]
109112619  long-chain-fatty-acid--CoA ligase 1-like [KO:K01897] [EC:6.2.1.3]
109107411  long-chain-fatty-acid--CoA ligase 6-like [KO:K01897] [EC:6.2.1.3]
109048698  LOW QUALITY PROTEIN: lysophospholipid acyltransferase 5-like [KO:K13515] [EC:2.3.1.23 2.3.1.-]
109081746  LOW QUALITY PROTEIN: lysophospholipid acyltransferase 5-like [KO:K13515] [EC:2.3.1.23 2.3.1.-]
109103987  LOW QUALITY PROTEIN: lysophospholipid acyltransferase 5-like [KO:K13515] [EC:2.3.1.23 2.3.1.-]
109062288  diamine acetyltransferase 1-like [KO:K00657] [EC:2.3.1.57]
109062289  diamine acetyltransferase 1-like [KO:K00657] [EC:2.3.1.57]
109067356  sat2; diamine acetyltransferase 2 [KO:K00657] [EC:2.3.1.57]
109091495  diamine acetyltransferase 2-like isoform X1 [KO:K00657] [EC:2.3.1.57]
109066053  diamine acetyltransferase 2-like isoform X1 [KO:K00657] [EC:2.3.1.57]
109048549  diamine acetyltransferase 1-like [KO:K00657] [EC:2.3.1.57]
109049840  diamine acetyltransferase 1-like isoform X1 [KO:K00657] [EC:2.3.1.57]
109066461  diamine acetyltransferase 1-like [KO:K00657] [EC:2.3.1.57]
109101040  diamine acetyltransferase 1-like [KO:K00657] [EC:2.3.1.57]
109066395  diamine acetyltransferase 1-like [KO:K00657] [EC:2.3.1.57]
109069568  diamine acetyltransferase 1-like [KO:K00657] [EC:2.3.1.57]
109082100  LOW QUALITY PROTEIN: serotransferrin-1-like [KO:K14736]
109099116  transferrin receptor protein 1-like [KO:K06503]
109101992  transferrin receptor protein 1-like [KO:K06503]
109061839  transferrin receptor protein 1-like [KO:K06503]
109102145  tfrc; transferrin receptor protein 1 [KO:K06503]
109066839  metalloreductase STEAP3-like [KO:K10142] [EC:1.16.1.-]
109070414  natural resistance-associated macrophage protein 2-like [KO:K21398]
109055878  zinc transporter ZIP8-like isoform X1 [KO:K14714]
109093300  LOW QUALITY PROTEIN: zinc transporter ZIP8-like [KO:K14714]
109075994  zinc transporter ZIP14-like isoform X1 [KO:K14720]
109065704  zinc transporter ZIP14-like [KO:K14720]
109061516  LOW QUALITY PROTEIN: poly(rC)-binding protein 2-like [KO:K13162]
109106450  solute carrier family 40 member 1-like [KO:K14685]
109058299  LOW QUALITY PROTEIN: solute carrier family 40 member 1-like [KO:K14685]
109096053  solute carrier family 40 member 1-like [KO:K14685]
109072436  solute carrier family 40 member 1-like [KO:K14685]
109053366  LOW QUALITY PROTEIN: ceruloplasmin-like [KO:K13624] [EC:1.16.3.1]
109084530  ferritin, heavy subunit [KO:K00522] [EC:1.16.3.1]
109096328  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
109074116  ferritin, heavy subunit-like [KO:K00522] [EC:1.16.3.1]
109064940  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
109048948  ferritin, lower subunit-like isoform X1 [KO:K00522] [EC:1.16.3.1]
109047183  ferritin, heavy subunit-like [KO:K00522] [EC:1.16.3.1]
109050109  ferritin, lower subunit-like [KO:K00522] [EC:1.16.3.1]
109054930  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
109075521  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
109075523  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
109075524  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
109080087  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
109080088  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
109080089  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
109080092  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
109080095  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
109080096  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
109080172  ferritin, heavy subunit-like [KO:K00522] [EC:1.16.3.1]
109064716  microtubule-associated proteins 1A/1B light chain 3B-like [KO:K10435]
109079395  LOW QUALITY PROTEIN: microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
109101903  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
109056358  microtubule-associated proteins 1A/1B light chain 3C-like isoform X1 [KO:K10435]
109055349  microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
109113325  microtubule-associated proteins 1A/1B light chain 3B isoform X1 [KO:K10435]
109058611  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
109059920  microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
109065423  LOW QUALITY PROTEIN: autophagy protein 5-like [KO:K08339]
109065425  autophagy protein 5-like [KO:K08339]
109100594  nuclear receptor coactivator 4-like [KO:K09289]
109045959  nuclear receptor coactivator 4-like isoform X1 [KO:K09289]
109094264  nuclear receptor coactivator 4-like [KO:K09289]
109088025  nuclear receptor coactivator 4-like [KO:K09289]
109057953  heme oxygenase-like [KO:K00510] [EC:1.14.14.18]
109110078  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
109100970  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
109100973  voltage-dependent anion-selective channel protein 2 [KO:K15040]
109095152  voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15041]
109091469  voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15041]
109048786  voltage-dependent anion-selective channel protein 2-like [KO:K15041]
109061574  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
Compound
C00010  CoA
C00024  Acetyl-CoA
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00032  Heme
C00051  Glutathione
C00097  L-Cysteine
C00127  Glutathione disulfide
C00129  Isopentenyl diphosphate
C00219  Arachidonate
C00356  (S)-3-Hydroxy-3-methylglutaryl-CoA
C00418  (R)-Mevalonate
C00491  L-Cystine
C00669  gamma-L-Glutamyl-L-cysteine
C02249  Arachidonyl-CoA
C02477  alpha-Tocopherol
C11378  Ubiquinone-10
C14818  Fe2+
C14819  Fe3+
C16170  (7Z,10Z,13Z,16Z)-Docosatetraenoyl-CoA
C16527  Adrenic acid
C16844  Hydroxyl radical
C21478  Erastin
C21479  RSL3
C21480  1-Octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine
C21481  1-Octadecanoyl-2-(7Z,10Z,13Z,16Z-docosatetraenoyl)-sn-glycero-3-phosphoethanolamine
C21482  1-Octadecanoyl-2-(15S-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine
C21483  1-Octadecanoyl-2-(15S-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine
C21484  1-Octadecanoyl-sn-glycero-3-phosphoethanolamine
D00448  Sulfasalazine (USP/INN)
D08524  Sorafenib (USAN/INN)
Reference
PMID:26775689
  Authors
Conrad M, Angeli JP, Vandenabeele P, Stockwell BR
  Title
Regulated necrosis: disease relevance and therapeutic opportunities.
  Journal
Nat Rev Drug Discov 15:348-66 (2016)
DOI:10.1038/nrd.2015.6
Reference
PMID:26653790
  Authors
Yang WS, Stockwell BR
  Title
Ferroptosis: Death by Lipid Peroxidation.
  Journal
Trends Cell Biol 26:165-76 (2016)
DOI:10.1016/j.tcb.2015.10.014
Reference
PMID:27842066
  Authors
Kagan VE, Mao G, Qu F, Angeli JP, Doll S, Croix CS, Dar HH, Liu B, Tyurin VA, Ritov VB, Kapralov AA, Amoscato AA, Jiang J, Anthonymuthu T, Mohammadyani D, Yang Q, Proneth B, Klein-Seetharaman J, Watkins S, Bahar I, Greenberger J, Mallampalli RK, Stockwell BR, Tyurina YY, Conrad M, Bayir H
  Title
Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis.
  Journal
Nat Chem Biol 13:81-90 (2017)
DOI:10.1038/nchembio.2238
Reference
PMID:27842067
  Authors
D'Herde K, Krysko DV
  Title
Ferroptosis: Oxidized PEs trigger death.
  Journal
Nat Chem Biol 13:4-5 (2017)
DOI:10.1038/nchembio.2261
Reference
PMID:28082232
  Authors
Guiney SJ, Adlard PA, Bush AI, Finkelstein DI, Ayton S
  Title
Ferroptosis and cell death mechanisms in Parkinson's disease.
  Journal
Neurochem Int 104:34-48 (2017)
DOI:10.1016/j.neuint.2017.01.004
Reference
PMID:26725301
  Authors
Bogdan AR, Miyazawa M, Hashimoto K, Tsuji Y
  Title
Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease.
  Journal
Trends Biochem Sci 41:274-86 (2016)
DOI:10.1016/j.tibs.2015.11.012
Reference
PMID:26794443
  Authors
Xie Y, Hou W, Song X, Yu Y, Huang J, Sun X, Kang R, Tang D
  Title
Ferroptosis: process and function.
  Journal
Cell Death Differ 23:369-79 (2016)
DOI:10.1038/cdd.2015.158
Reference
PMID:27791175
  Authors
Murphy ME
  Title
Ironing out how p53 regulates ferroptosis.
  Journal
Proc Natl Acad Sci U S A 113:12350-12352 (2016)
DOI:10.1073/pnas.1615159113
Reference
PMID:28129536
  Authors
Muckenthaler MU, Rivella S, Hentze MW, Galy B
  Title
A Red Carpet for Iron Metabolism.
  Journal
Cell 168:344-361 (2017)
DOI:10.1016/j.cell.2016.12.034
Reference
PMID:27860262
  Authors
Yu H, Guo P, Xie X, Wang Y, Chen G
  Title
Ferroptosis, a new form of cell death, and its relationships with tumourous diseases.
  Journal
J Cell Mol Med 21:648-657 (2017)
DOI:10.1111/jcmm.13008
Reference
PMID:27314071
  Authors
Wang SJ, Ou Y, Jiang L, Gu W
  Title
Ferroptosis: A missing puzzle piece in the p53 blueprint?
  Journal
Mol Cell Oncol 3:e1046581 (2016)
DOI:10.1080/23723556.2015.1046581
Reference
PMID:27048822
  Authors
Cao JY, Dixon SJ
  Title
Mechanisms of ferroptosis.
  Journal
Cell Mol Life Sci 73:2195-209 (2016)
DOI:10.1007/s00018-016-2194-1
Reference
PMID:26436293
  Authors
Mancias JD, Pontano Vaites L, Nissim S, Biancur DE, Kim AJ, Wang X, Liu Y, Goessling W, Kimmelman AC, Harper JW
  Title
Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis.
  Journal
Elife 4:e10308 (2015)
DOI:10.7554/eLife.10308
Reference
PMID:28066232
  Authors
Wang YQ, Chang SY, Wu Q, Gou YJ, Jia L, Cui YM, Yu P, Shi ZH, Wu WS, Gao G, Chang YZ
  Title
The Protective Role of Mitochondrial Ferritin on Erastin-Induced Ferroptosis.
  Journal
Front Aging Neurosci 8:308 (2016)
DOI:10.3389/fnagi.2016.00308
Reference
PMID:26405158
  Authors
Kwon MY, Park E, Lee SJ, Chung SW
  Title
Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death.
  Journal
Oncotarget 6:24393-403 (2015)
DOI:10.18632/oncotarget.5162
Reference
PMID:22632964
  Authors
Reed JC, Pellecchia M
  Title
Ironing out cell death mechanisms.
  Journal
Cell 149:963-5 (2012)
DOI:10.1016/j.cell.2012.05.009
Related
pathway
ccar00480  Glutathione metabolism
ccar00900  Terpenoid backbone biosynthesis
KO pathway
ko04216   
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