KEGG   PATHWAY: cclu04370
Entry
cclu04370                   Pathway                                
Name
VEGF signaling pathway - Coregonus clupeaformis (lake whitefish)
Description
There is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic angiogenesis. The binding of VEGF to VEGFR-2 leads to a cascade of different signaling pathways, resulting in the up-regulation of genes involved in mediating the proliferation and migration of endothelial cells and promoting their survival and vascular permeability. For example, the binding of VEGF to VEGFR-2 leads to dimerization of the receptor, followed by intracellular activation of the PLCgamma;PKC-Raf kinase-MEK-mitogen-activated protein kinase (MAPK) pathway and subsequent initiation of DNA synthesis and cell growth, whereas activation of the phosphatidylinositol 3' -kinase (PI3K)-Akt pathway leads to increased endothelial-cell survival. Activation of PI3K, FAK, and p38 MAPK is implicated in cell migration signaling.
Class
Environmental Information Processing; Signal transduction
Pathway map
cclu04370  VEGF signaling pathway
cclu04370

Other DBs
GO: 0048010
Organism
Coregonus clupeaformis (lake whitefish) [GN:cclu]
Gene
121540037  vegfba; vascular endothelial growth factor A [KO:K05448]
121548842  vascular endothelial growth factor A-A isoform X1 [KO:K05448]
121533520  vascular endothelial growth factor A-like [KO:K05448]
121543499  vegfaa; vascular endothelial growth factor A-A isoform X1 [KO:K05448]
121552827  vascular endothelial growth factor A-A isoform X1 [KO:K05448]
121540153  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
121533948  vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
121571977  SH2 domain-containing protein 2A [KO:K08273]
121585977  SH2 domain-containing protein 2A isoform X2 [KO:K08273]
121533863  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
121546104  plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
121576695  plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
121557105  prkcab; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
121533158  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
121551465  protein kinase C alpha type-like [KO:K02677] [EC:2.7.11.13]
123483290  protein kinase C alpha type-like isoform X1 [KO:K02677] [EC:2.7.11.13]
121561893  protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
121557030  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
121543837  protein kinase C alpha type-like [KO:K19663] [EC:2.7.11.13]
121556473  protein kinase C alpha type-like [KO:K19663] [EC:2.7.11.13]
121532654  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
121551044  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
121570397  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
121543826  sphk2; LOW QUALITY PROTEIN: sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
121532188  GTPase HRas [KO:K02833]
121576390  GTPase HRas [KO:K02833]
121532244  kras; GTPase KRas isoform X1 [KO:K07827]
121551578  GTPase HRas [KO:K07827]
121577009  GTPase KRas isoform X1 [KO:K07827]
123482642  GTPase HRas-like [KO:K07827]
121538562  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
121545408  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
121540361  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
121533527  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
121535511  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
121581348  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
121530742  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121584339  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
123491220  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
121550334  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121581478  pla2g4aa; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
121540418  cytosolic phospholipase A2-like [KO:K16342] [EC:3.1.1.4]
121534072  pla2g4ab; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
121553727  pla2g4f.1; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
121583283  LOW QUALITY PROTEIN: cytosolic phospholipase A2 beta-like [KO:K16342] [EC:3.1.1.4]
121582220  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
121585043  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
121530670  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
121579593  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
121539826  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
121573891  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
121533584  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X2 [KO:K04348] [EC:3.1.3.16]
121541954  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X3 [KO:K04348] [EC:3.1.3.16]
121571171  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
121554748  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
121572407  calcineurin subunit B type 1 isoform X2 [KO:K06268]
121576548  ppp3r1a; calcineurin subunit B type 1 [KO:K06268]
123485572  calcineurin subunit B type 1-like [KO:K06268]
123489657  calcineurin subunit B type 1-like [KO:K06268]
123483062  calcineurin subunit B type 1 [KO:K06268]
121575592  nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
121577963  nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
121537964  nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
121545782  nuclear factor of activated T-cells, cytoplasmic 2-like isoform X2 [KO:K17332]
121580802  ptgs2a; prostaglandin G/H synthase 2a [KO:K11987] [EC:1.14.99.1]
121539927  prostaglandin G/H synthase 2-like [KO:K11987] [EC:1.14.99.1]
121534073  ptgs2b; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
121535088  prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
121571839  focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
121543307  focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
121542649  focal adhesion kinase 1-like isoform X1 [KO:K05725] [EC:2.7.10.2]
121586778  focal adhesion kinase 1-like isoform X1 [KO:K05725] [EC:2.7.10.2]
121540343  SHC-transforming protein 2 isoform X1 [KO:K17447]
121533510  SHC-transforming protein 2 isoform X1 [KO:K17447]
121584746  proline-rich protein 12 isoform X1 [KO:K05760]
121550967  paxillin isoform X2 [KO:K05760]
121575091  paxillin-like isoform X1 [KO:K05760]
121577764  paxillin-like isoform X1 [KO:K05760]
121538497  cell division control protein 42 homolog isoform X1 [KO:K04393]
121571554  cell division control protein 42 homolog [KO:K04393]
121575328  cell division control protein 42 homolog isoform X1 [KO:K04393]
121577683  cdc42; cell division control protein 42 homolog [KO:K04393]
121545645  cell division control protein 42 homolog isoform X1 [KO:K04393]
121542996  cell division control protein 42 homolog [KO:K04393]
121586431  cell division control protein 42 homolog [KO:K04393]
121586201  cell division control protein 42 homolog [KO:K04393]
121531434  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
121548693  mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
121548705  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
121574773  mitogen-activated protein kinase 14A [KO:K04441] [EC:2.7.11.24]
121543539  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
121543540  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
121576985  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
121537818  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
121578329  mitogen-activated protein kinase 14A [KO:K04441] [EC:2.7.11.24]
121537833  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
121538239  mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
121545911  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
121545919  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
121545988  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
121545358  MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
121577855  mapkapk2a; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
121574612  MAP kinase-activated protein kinase 2-like [KO:K04444] [EC:2.7.11.1]
121574975  MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
121578215  MAP kinase-activated protein kinase 2 [KO:K04444] [EC:2.7.11.1]
121578773  LOW QUALITY PROTEIN: MAP kinase-activated protein kinase 2-like [KO:K04444] [EC:2.7.11.1]
121582365  heat shock protein beta-1 [KO:K04455]
121557520  heat shock protein beta-1-like [KO:K04455]
121573815  heat shock protein beta-1 [KO:K04455]
121574092  heat shock protein beta-1 [KO:K04455]
121579139  hspb1; heat shock protein beta-1 [KO:K04455]
121575593  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
121577962  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
121537961  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
121545784  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
121538393  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
121580697  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
121533376  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
121566901  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
121534970  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
121567694  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
121557873  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
121584610  phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
121582619  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
121581087  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
121540427  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
121533661  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
121541581  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
121534059  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
121535055  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
121535583  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
121576870  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
121580765  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
121547551  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
121557115  ras-related C3 botulinum toxin substrate 1-like isoform X1 [KO:K04392]
121551381  ras-related C3 botulinum toxin substrate 1-like isoform X1 [KO:K04392]
121577599  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
121555849  ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
121551047  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
121568940  ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
121547550  rac3b; ras-related C3 botulinum toxin substrate 3b isoform X1 [KO:K07861]
121551449  ras-related C3 botulinum toxin substrate 3-like [KO:K07861]
121577608  ras-related C3 botulinum toxin substrate 3-like isoform X1 [KO:K07861]
121569982  ras-related C3 botulinum toxin substrate 3-like [KO:K07861]
121579671  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121539230  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121547648  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121533168  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121566954  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121541975  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121567780  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121552196  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121544961  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123481415  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121548848  RAC-alpha serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
121546727  caspase-9 [KO:K04399] [EC:3.4.22.62]
121537998  caspase-9 [KO:K04399] [EC:3.4.22.62]
121541833  bada; bcl2-associated agonist of cell death [KO:K02158]
121554365  badb; BCL2 associated agonist of cell death b [KO:K02158]
121571247  bcl2-associated agonist of cell death-like [KO:K02158]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01312  Prostaglandin I2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:13678960
  Authors
Cross MJ, Dixelius J, Matsumoto T, Claesson-Welsh L.
  Title
VEGF-receptor signal transduction.
  Journal
Trends Biochem Sci 28:488-94 (2003)
DOI:10.1016/S0968-0004(03)00193-2
Reference
PMID:11741095
  Authors
Matsumoto T, Claesson-Welsh L.
  Title
VEGF receptor signal transduction.
  Journal
Sci STKE 2001:RE21 (2001)
DOI:10.1126/stke.2001.112.re21
Reference
PMID:15602010
  Authors
Hoeben A, Landuyt B, Highley MS, Wildiers H, Van Oosterom AT, De Bruijn EA.
  Title
Vascular endothelial growth factor and angiogenesis.
  Journal
Pharmacol Rev 56:549-80 (2004)
DOI:10.1124/pr.56.4.3
Reference
PMID:16104843
  Authors
Takahashi H, Shibuya M.
  Title
The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions.
  Journal
Clin Sci (Lond) 109:227-41 (2005)
DOI:10.1042/CS20040370
Reference
PMID:14641020
  Authors
Zachary I.
  Title
VEGF signalling: integration and multi-tasking in endothelial cell biology.
  Journal
Biochem Soc Trans 31:1171-7 (2003)
DOI:10.1042/bst0311171
Reference
PMID:15338053
  Authors
Munoz-Chapuli R, Quesada AR, Angel Medina M.
  Title
Angiogenesis and signal transduction in endothelial cells.
  Journal
Cell Mol Life Sci 61:2224-43 (2004)
DOI:10.1007/s00018-004-4070-7
Reference
PMID:14724572
  Authors
Lamalice L, Houle F, Jourdan G, Huot J.
  Title
Phosphorylation of tyrosine 1214 on VEGFR2 is required for VEGF-induced activation of Cdc42 upstream of SAPK2/p38.
  Journal
Oncogene 23:434-45 (2004)
DOI:10.1038/sj.onc.1207034
Reference
PMID:12391145
  Authors
Shu X, Wu W, Mosteller RD, Broek D.
  Title
Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases.
  Journal
Mol Cell Biol 22:7758-68 (2002)
DOI:10.1128/MCB.22.22.7758-7768.2002
Related
pathway
cclu00590  Arachidonic acid metabolism
cclu04010  MAPK signaling pathway
cclu04020  Calcium signaling pathway
cclu04510  Focal adhesion
KO pathway
ko04370   
LinkDB

DBGET integrated database retrieval system