KEGG   PATHWAY: cfo04142
Entry
cfo04142                    Pathway                                
Name
Lysosome - Camponotus floridanus (Florida carpenter ant)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
cfo04142  Lysosome
cfo04142

Other DBs
GO: 0005764
Organism
Camponotus floridanus (Florida carpenter ant) [GN:cfo]
Gene
105254546  V-type proton ATPase 116 kDa subunit a isoform X2 [KO:K02154]
105253863  V-type proton ATPase 116 kDa subunit a [KO:K02154]
105248168  V-type proton ATPase subunit d [KO:K02146]
105257265  V-type proton ATPase subunit H isoform X1 [KO:K02144]
105248469  uncharacterized protein LOC105248469 [KO:K03662]
105253418  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
105251496  V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
105252696  dmX-like protein 2 isoform X1 [KO:K24155]
105249466  WD repeat-containing protein 7 isoform X1 [KO:K24738]
105248174  nuclear receptor coactivator 7 isoform X1 [KO:K25442]
105247755  lysosomal aspartic protease-like isoform X1 [KO:K01379] [EC:3.4.23.5]
105250119  lysosomal aspartic protease isoform X1 [KO:K01379] [EC:3.4.23.5]
105256303  lysosomal aspartic protease [KO:K01379] [EC:3.4.23.5]
112638633  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
112638662  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
112638666  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
112639245  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
105258678  lysosomal aspartic protease isoform X1 [KO:K01379] [EC:3.4.23.5]
105254125  lysosomal aspartic protease-like isoform X1 [KO:K01379] [EC:3.4.23.5]
105254126  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
105258491  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
105252159  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
112639466  cathepsin D-like [KO:K01379] [EC:3.4.23.5]
112639467  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
105247753  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
105255526  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
112639473  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
105256508  lysosomal aspartic protease isoform X1 [KO:K01379] [EC:3.4.23.5]
105248997  lysosomal aspartic protease isoform X1 [KO:K01379] [EC:3.4.23.5]
112639474  lysosomal aspartic protease-like isoform X1 [KO:K01379] [EC:3.4.23.5]
105257919  aspartic proteinase A3 [KO:K01379] [EC:3.4.23.5]
112639479  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
105255527  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
105252875  lysosomal aspartic protease [KO:K01379] [EC:3.4.23.5]
105256040  lysosomal aspartic protease [KO:K01379] [EC:3.4.23.5]
105252160  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
105247754  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
105255172  aspartic proteinase A3-like [KO:K01379] [EC:3.4.23.5]
105255173  lysosomal aspartic protease [KO:K01379] [EC:3.4.23.5]
105255320  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
105258344  lysosomal aspartic protease isoform X2 [KO:K01379] [EC:3.4.23.5]
112637953  lysosomal aspartic protease-like isoform X1 [KO:K01379] [EC:3.4.23.5]
112637954  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
112637955  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
112637956  lysosomal aspartic protease-like isoform X1 [KO:K01379] [EC:3.4.23.5]
112637957  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
112637958  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
112637959  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
112637320  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
105251298  lysosomal aspartic protease isoform X1 [KO:K01379] [EC:3.4.23.5]
105248149  lysosomal aspartic protease-like isoform X1 [KO:K01379] [EC:3.4.23.5]
112638135  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
112638136  lysosomal aspartic protease-like isoform X1 [KO:K01379] [EC:3.4.23.5]
112638138  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
105248148  aspartic proteinase A3-like [KO:K01379] [EC:3.4.23.5]
112638139  lysosomal aspartic protease-like isoform X1 [KO:K01379] [EC:3.4.23.5]
105247767  lysosomal aspartic protease [KO:K01379] [EC:3.4.23.5]
105259409  lysosomal aspartic protease [KO:K01379] [EC:3.4.23.5]
112638151  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
105257692  pepsin A-5 [KO:K01379] [EC:3.4.23.5]
112638152  renin-like [KO:K01379] [EC:3.4.23.5]
105257694  lysosomal aspartic protease [KO:K01379] [EC:3.4.23.5]
112638154  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
105255113  lysosomal aspartic protease [KO:K01379] [EC:3.4.23.5]
105257830  lysosomal aspartic protease [KO:K01379] [EC:3.4.23.5]
112638155  lysosomal aspartic protease-like isoform X1 [KO:K01379] [EC:3.4.23.5]
112638156  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
105255112  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
112638157  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
105254123  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
112637482  lysosomal aspartic protease-like isoform X1 [KO:K01379] [EC:3.4.23.5]
112637054  lysosomal aspartic protease-like isoform X1 [KO:K01379] [EC:3.4.23.5]
105248337  lysosomal aspartic protease [KO:K01379] [EC:3.4.23.5]
112637490  lysosomal aspartic protease-like isoform X1 [KO:K01379] [EC:3.4.23.5]
105257479  lysosomal aspartic protease [KO:K01379] [EC:3.4.23.5]
105257594  lysosomal aspartic protease [KO:K01379] [EC:3.4.23.5]
105257595  lysosomal aspartic protease [KO:K01379] [EC:3.4.23.5]
105253881  uncharacterized protein LOC105253881 [KO:K01373] [EC:3.4.22.41]
105252674  cathepsin L1 isoform X1 [KO:K01371] [EC:3.4.22.38]
105254176  cathepsin L1 [KO:K01365] [EC:3.4.22.15]
105254173  cathepsin L1 [KO:K01365] [EC:3.4.22.15]
105256710  cathepsin O [KO:K01374] [EC:3.4.22.42]
105258784  beta-galactosidase [KO:K12309] [EC:3.2.1.23]
105248635  lysosomal alpha-glucosidase [KO:K12316] [EC:3.2.1.20]
105249005  glucosylceramidase [KO:K01201] [EC:3.2.1.45]
105257874  glucosylceramidase isoform X2 [KO:K01201] [EC:3.2.1.45]
112639910  glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
105249395  alpha-N-acetylgalactosaminidase isoform X1 [KO:K01204] [EC:3.2.1.49]
105257378  alpha-N-acetylglucosaminidase isoform X1 [KO:K01205] [EC:3.2.1.50]
105252146  beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
105259371  alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
105250745  chitooligosaccharidolytic beta-N-acetylglucosaminidase [KO:K12373] [EC:3.2.1.52]
105255235  beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
105259542  beta-mannosidase [KO:K01192] [EC:3.2.1.25]
105250629  lysosomal alpha-mannosidase isoform X1 [KO:K12311] [EC:3.2.1.24]
105251112  hyaluronidase [KO:K01197] [EC:3.2.1.35]
105259243  arylsulfatase B isoform X1 [KO:K01135] [EC:3.1.6.12]
105259242  arylsulfatase B [KO:K01135] [EC:3.1.6.12]
105259244  arylsulfatase B [KO:K01135] [EC:3.1.6.12]
105257710  arylsulfatase B isoform X1 [KO:K01135] [EC:3.1.6.12]
105254293  N-acetylglucosamine-6-sulfatase [KO:K01137] [EC:3.1.6.14]
105253432  iduronate 2-sulfatase [KO:K01136] [EC:3.1.6.13]
105249090  N-sulphoglucosamine sulphohydrolase [KO:K01565] [EC:3.10.1.1]
105255041  uncharacterized protein LOC105255041 isoform X1 [KO:K01052] [EC:3.1.1.13]
105257158  lipase 3 [KO:K01052] [EC:3.1.1.13]
105252858  lipase 1 [KO:K01052] [EC:3.1.1.13]
105252425  lipase 3 [KO:K01052] [EC:3.1.1.13]
109610142  lipase 3-like [KO:K01052] [EC:3.1.1.13]
105249734  lipase 3-like [KO:K01052] [EC:3.1.1.13]
105255602  LOW QUALITY PROTEIN: lipase 3 [KO:K01052] [EC:3.1.1.13]
105255108  lipase 3 isoform X1 [KO:K01052] [EC:3.1.1.13]
105258675  gastric triacylglycerol lipase isoform X1 [KO:K01052] [EC:3.1.1.13]
105252424  lipase 1 [KO:K01052] [EC:3.1.1.13]
105259195  lipase 3 [KO:K01052] [EC:3.1.1.13]
105256342  LOW QUALITY PROTEIN: lipase 3 [KO:K01052] [EC:3.1.1.13]
112638142  lipase 3-like [KO:K01052] [EC:3.1.1.13]
105254133  lipase 3-like isoform X1 [KO:K01052] [EC:3.1.1.13]
105255749  lipase 3 [KO:K01052] [EC:3.1.1.13]
105254132  lipase 3 [KO:K01052] [EC:3.1.1.13]
105258348  lipase 1 [KO:K01052] [EC:3.1.1.13]
112638146  lipase 3-like [KO:K01052] [EC:3.1.1.13]
112638150  lipase 3-like [KO:K01052] [EC:3.1.1.13]
105258343  lipase 3-like [KO:K01052] [EC:3.1.1.13]
112638160  lipase 3-like [KO:K01052] [EC:3.1.1.13]
112638635  lipase 1-like [KO:K01052] [EC:3.1.1.13]
105256016  lipase 3-like [KO:K01052] [EC:3.1.1.13]
105256814  lipase 3-like [KO:K01052] [EC:3.1.1.13]
105249750  lipase 3 isoform X1 [KO:K01052] [EC:3.1.1.13]
105249191  LOW QUALITY PROTEIN: lipase 1 [KO:K01052] [EC:3.1.1.13]
112638637  lipase 3-like [KO:K01052] [EC:3.1.1.13]
112638145  lipase 3-like [KO:K01052] [EC:3.1.1.13]
105258965  group XV phospholipase A2 isoform X1 [KO:K06129] [EC:3.1.1.5]
105249606  plancitoxin-1 [KO:K01158] [EC:3.1.22.1]
105254495  prostatic acid phosphatase [KO:K14410] [EC:3.1.3.2]
105257682  lysosomal acid phosphatase [KO:K14410] [EC:3.1.3.2]
105249440  sphingomyelin phosphodiesterase isoform X1 [KO:K12350] [EC:3.1.4.12]
105249886  sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
112637142  sphingomyelin phosphodiesterase isoform X1 [KO:K12350] [EC:3.1.4.12]
105248121  N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase [KO:K01444] [EC:3.5.1.26]
105248126  N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase- like [KO:K01444] [EC:3.5.1.26]
105258196  prosaposin [KO:K12382]
105253573  palmitoyl-protein thioesterase 1 [KO:K01074] [EC:3.1.2.22]
105257229  lysosomal thioesterase PPT2 homolog isoform X1 [KO:K01074] [EC:3.1.2.22]
105255249  lysosome-associated membrane glycoprotein 1 [KO:K06528]
105249794  CD63 antigen [KO:K06497]
105249796  CD63 antigen [KO:K06497]
105258420  CD63 antigen [KO:K06497]
105258424  23 kDa integral membrane protein [KO:K06497]
105249795  CD63 antigen [KO:K06497]
105256769  sensory neuron membrane protein 1 isoform X1 [KO:K12384]
105255252  NPC intracellular cholesterol transporter 1 homolog 1b [KO:K12385]
105252991  NPC intracellular cholesterol transporter 1 isoform X1 [KO:K12385]
105255275  patched domain-containing protein 3 isoform X1 [KO:K12385]
105257106  patched domain-containing protein 3 isoform X1 [KO:K12385]
105250726  NPC intracellular cholesterol transporter 2 homolog a [KO:K13443]
105255829  uncharacterized protein LOC105255829 [KO:K13443]
105252936  NPC intracellular cholesterol transporter 2 [KO:K13443]
105256783  MD-2-related lipid-recognition protein [KO:K13443]
105254106  cystinosin homolog isoform X1 [KO:K12386]
105254105  uncharacterized protein LOC105254105 [KO:K12386]
105258176  sialin [KO:K12301]
105248072  putative inorganic phosphate cotransporter isoform X1 [KO:K12301]
105251375  putative inorganic phosphate cotransporter [KO:K12301]
105251376  putative inorganic phosphate cotransporter [KO:K12301]
105253322  sialin [KO:K12301]
105258519  sialin [KO:K12301]
105254494  protein Malvolio isoform X1 [KO:K21398]
105251193  integumentary mucin C.1 [KO:K06546]
105249741  battenin [KO:K12389]
105248747  major facilitator superfamily domain-containing protein 8 isoform X1 [KO:K12307]
105252366  heparan-alpha-glucosaminide N-acetyltransferase isoform X1 [KO:K10532] [EC:2.3.1.78]
105252337  heparan-alpha-glucosaminide N-acetyltransferase-like isoform X1 [KO:K10532] [EC:2.3.1.78]
105259017  formylglycine-generating enzyme [KO:K13444] [EC:1.8.3.7]
105259355  N-acetylglucosamine-1-phosphotransferase subunits alpha/beta isoform X2 [KO:K08239] [EC:2.7.8.17]
105250922  cation-independent mannose-6-phosphate receptor [KO:K06564]
105252892  uncharacterized protein LOC105252892 isoform X1 [KO:K10089]
105251879  clathrin light chain isoform X1 [KO:K04644]
105257444  clathrin heavy chain [KO:K04646]
105258427  AP-1 complex subunit gamma-1 isoform X5 [KO:K12391]
105250853  AP-1 complex subunit beta-1 isoform X1 [KO:K12392]
105254259  AP-1 complex subunit mu-1 [KO:K12393]
105250927  AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
105253801  AP-3 complex subunit delta-1 [KO:K12396]
105254852  AP-3 complex subunit beta-2 [KO:K12397]
105248098  AP-3 complex subunit mu-1 [KO:K12398]
105247811  AP-3 complex subunit sigma-2 isoform X1 [KO:K12399]
105253019  ADP-ribosylation factor-binding protein GGA1 [KO:K12404]
105248418  lipopolysaccharide-induced tumor necrosis factor-alpha factor [KO:K19363]
105253597  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
105250467  cell death-inducing p53-target protein 1 [KO:K19363]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8
Related
pathway
cfo00511  Other glycan degradation
cfo00531  Glycosaminoglycan degradation
cfo04130  SNARE interactions in vesicular transport
cfo04140  Autophagy - animal
cfo04144  Endocytosis
KO pathway
ko04142   
LinkDB

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