KEGG   PATHWAY: cfr05160
Entry
cfr05160                    Pathway                                
Name
Hepatitis C - Camelus ferus (Wild Bactrian camel)
Description
Hepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the cytoplasm of the host cell and forms membrane-associated replication complexes along with non-structural proteins. Viral RNA can trigger the RIG-I pathway and interferon production during this process. Translated HCV protein products regulate immune response to inhibit the action of interferon. HCV core and NS5A proteins appear to be the most important molecules with regulatory functions that modulate transcription, cellular proliferation, and apoptosis.
Class
Human Diseases; Infectious disease: viral
Pathway map
cfr05160  Hepatitis C
cfr05160

Organism
Camelus ferus (Wild Bactrian camel) [GN:cfr]
Gene
102506814  LDLR; low-density lipoprotein receptor isoform X1 [KO:K12473]
102512545  SCARB1; LOW QUALITY PROTEIN: scavenger receptor class B member 1 [KO:K13885]
116666551  CD81; CD81 antigen [KO:K06508]
102517227  CLDN19; claudin-19 isoform X2 [KO:K06087]
116656633  CLDN34; claudin-34 isoform X1 [KO:K06087]
102521570  CLDN20; LOW QUALITY PROTEIN: claudin-20 [KO:K06087]
102521251  CLDN14; claudin-14 [KO:K06087]
102517494  CLDN7; claudin-7 [KO:K06087]
102522374  CLDN6; claudin-6 [KO:K06087]
102522633  CLDN9; claudin-9 [KO:K06087]
102517174  CLDN18; claudin-18 isoform X1 [KO:K06087]
102506216  CLDN15; claudin-15 [KO:K06087]
102514218  CLDN3; claudin-3 [KO:K06087]
102514458  CLDN4; claudin-4 [KO:K06087]
102508764  CLDN25; putative claudin-25 [KO:K06087]
102514640  CLDN23; claudin-23 [KO:K06087]
102521584  putative claudin-24 [KO:K06087]
102517146  CLDN16; LOW QUALITY PROTEIN: claudin-16 [KO:K06087]
102516888  CLDN1; claudin-1 [KO:K06087]
102523179  CLDN11; claudin-11 [KO:K06087]
102520318  CLDN10; claudin-10 isoform X1 [KO:K06087]
106730937  putative claudin-25 [KO:K06087]
102523383  CLDN8; claudin-8 [KO:K06087]
102523136  CLDN17; claudin-17 [KO:K06087]
102515148  CLDN2; claudin-2 [KO:K06087]
102508100  CLDN12; claudin-12 [KO:K06087]
116660018  claudin-22-like [KO:K06087]
116660982  CLDN5; claudin-5 [KO:K06087]
102524099  OCLN; occludin [KO:K06088]
102524147  OAS1; LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
102512334  RNASEL; LOW QUALITY PROTEIN: 2-5A-dependent ribonuclease [KO:K01165]
102524392  DDX58; probable ATP-dependent RNA helicase DDX58 isoform X1 [KO:K12646] [EC:5.6.2.6]
102509188  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
102515034  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
102514948  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
102519234  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
102506077  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
116666573  IRF7; interferon regulatory factor 7 [KO:K09447]
102519964  interferon alpha-1-like [KO:K05414]
102513158  LOW QUALITY PROTEIN: interferon alpha-14 [KO:K05414]
102516460  interferon alpha-14-like [KO:K05414]
106730619  LOW QUALITY PROTEIN: interferon alpha-14-like [KO:K05414]
102513056  interferon alpha-3-like [KO:K05414]
102512333  interferon alpha-1-like [KO:K05414]
116663075  interferon alpha-1-like [KO:K05414]
116663078  interferon alpha-1-like [KO:K05414]
102513411  IFNB1; interferon beta [KO:K05415]
102504614  IFNG; interferon gamma [KO:K04687]
102511862  TLR3; toll-like receptor 3 [KO:K05401]
102522409  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
102520181  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
102516401  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
102503497  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
102508142  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102519782  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
102519409  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
102505905  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
102506204  RELA; transcription factor p65 isoform X1 [KO:K04735]
102510424  TNF; tumor necrosis factor [KO:K03156]
102511430  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
102510552  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1 [KO:K16194] [EC:2.7.11.1]
102517994  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
102523410  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
102508577  EIF2AK4; LOW QUALITY PROTEIN: eIF-2-alpha kinase GCN2 [KO:K16196] [EC:2.7.11.1]
102519027  interferon-induced protein with tetratricopeptide repeats 1 [KO:K14217]
102516301  eukaryotic translation initiation factor 3 subunit E [KO:K03250]
102518617  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
102520228  STAT3; signal transducer and activator of transcription 3 isoform X4 [KO:K04692]
102518913  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
102523764  IFNAR1; LOW QUALITY PROTEIN: interferon alpha/beta receptor 1 [KO:K05130]
102518206  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
102519873  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
102509319  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
102509999  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X4 [KO:K11220]
102510903  STAT2; LOW QUALITY PROTEIN: signal transducer and activator of transcription 2 [KO:K11221]
102520142  IRF9; interferon regulatory factor 9 [KO:K04693]
102508392  LOW QUALITY PROTEIN: interferon-induced GTP-binding protein Mx1 [KO:K14754]
102516300  interferon-induced GTP-binding protein Mx2 [KO:K14754]
116657999  LOW QUALITY PROTEIN: interferon-induced GTP-binding protein Mx1-like [KO:K14754]
116662665  LOW QUALITY PROTEIN: interferon-induced GTP-binding protein Mx2-like [KO:K14754]
102514511  RSAD2; radical S-adenosyl methionine domain-containing protein 2 [KO:K15045]
102505057  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
102509649  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
102517457  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X3 [KO:K04354]
102509034  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
102514622  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X3 [KO:K04354]
106728419  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
102509650  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
102517706  PIAS1; E3 SUMO-protein ligase PIAS1 isoform X1 [KO:K04706] [EC:2.3.2.-]
102523769  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
102504272  EGFR; LOW QUALITY PROTEIN: epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102515306  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
102507247  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102517014  SOS2; son of sevenless homolog 2 [KO:K03099]
102524334  HRAS; GTPase HRas isoform X1 [KO:K02833]
102516372  KRAS; GTPase KRas isoform X1 [KO:K07827]
102509562  NRAS; GTPase NRas [KO:K07828]
102524100  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
102517521  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102506774  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
102509055  YWHAQ; 14-3-3 protein theta [KO:K16197]
102513317  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
102516588  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
102513261  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
102524496  LOW QUALITY PROTEIN: 14-3-3 protein epsilon-like [KO:K06630]
102509328  YWHAG; 14-3-3 protein gamma [KO:K16198]
102518929  YWHAH; LOW QUALITY PROTEIN: 14-3-3 protein eta [KO:K16198]
116661575  14-3-3 protein eta-like [KO:K16198]
102515937  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102511209  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
102517586  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102521659  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102513205  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
102505690  LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
102520923  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
102523502  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102518643  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
102519994  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102503460  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102515350  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102519101  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
106729149  AKT1; LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102504696  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
102508568  CTNNB1; catenin beta-1 [KO:K02105]
102523295  BAD; bcl2-associated agonist of cell death isoform X2 [KO:K02158]
102509404  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X2 [KO:K06625]
102524476  TP53; cellular tumor antigen p53 [KO:K04451]
102504649  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
102522300  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
102520456  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
102516870  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
102517851  E2F1; transcription factor E2F1 [KO:K17454]
102515523  E2F2; transcription factor E2F2 [KO:K09389]
102513737  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
102508884  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
102508761  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
102511649  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
102503604  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102518538  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
102519266  FADD; FAS-associated death domain protein [KO:K02373]
102508224  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
102520133  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
102508474  CFLAR; CASP8 and FADD-like apoptosis regulator isoform X3 [KO:K04724]
102522363  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
102512073  ferritin light chain isoform X1 [KO:K02159]
102513729  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
102524306  cytochrome c [KO:K08738]
116663281  cytochrome c-like [KO:K08738]
116663681  LOW QUALITY PROTEIN: cytochrome c, testis-specific-like [KO:K08738]
102516966  APAF1; apoptotic protease-activating factor 1 isoform X3 [KO:K02084]
102519816  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
102515295  PSME3; proteasome activator complex subunit 3 [KO:K06698]
102524056  LOW QUALITY PROTEIN: proteasome activator complex subunit 3-like [KO:K06698]
116658678  proteasome activator complex subunit 3-like [KO:K06698]
102518674  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
102517671  PPARA; LOW QUALITY PROTEIN: peroxisome proliferator-activated receptor alpha [KO:K07294]
102524294  NR1H3; oxysterols receptor LXR-alpha isoform X1 [KO:K08536]
102518309  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
102511086  MYC; myc proto-oncogene protein [KO:K04377]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20935  2-5A
Reference
PMID:24520529
  Authors
Hassan M, Selimovic D, El-Khattouti A, Ghozlan H, Haikel Y, Abdelkader O
  Title
Hepatitis C virus-host interactions: Etiopathogenesis and therapeutic strategies.
  Journal
World J Exp Med 2:7-25 (2012)
DOI:10.5493/wjem.v2.i2.7
Reference
PMID:23641066
  Authors
Yamauchi Y, Helenius A
  Title
Virus entry at a glance.
  Journal
J Cell Sci 126:1289-95 (2013)
DOI:10.1242/jcs.119685
Reference
PMID:24509809
  Authors
Feneant L, Levy S, Cocquerel L
  Title
CD81 and hepatitis C virus (HCV) infection.
  Journal
Viruses 6:535-72 (2014)
DOI:10.3390/v6020535
Reference
PMID:18081727
  Authors
Dubuisson J, Helle F, Cocquerel L
  Title
Early steps of the hepatitis C virus life cycle.
  Journal
Cell Microbiol 10:821-7 (2008)
DOI:10.1111/j.1462-5822.2007.01107.x
Reference
PMID:23675659
  Authors
Liang TJ, Ghany MG
  Title
Current and future therapies for hepatitis C virus infection.
  Journal
N Engl J Med 368:1907-17 (2013)
DOI:10.1056/NEJMra1213651
Reference
PMID:23836234
  Authors
Scheel TK, Rice CM
  Title
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.
  Journal
Nat Med 19:837-49 (2013)
DOI:10.1038/nm.3248
Reference
PMID:26586968
  Authors
Holmes JA, Thompson AJ
  Title
Interferon-free combination therapies for the treatment of hepatitis C: current insights.
  Journal
Hepat Med 7:51-70 (2015)
DOI:10.2147/HMER.S55864
Reference
PMID:15039538
  Authors
Taguchi T, Nagano-Fujii M, Akutsu M, Kadoya H, Ohgimoto S, Ishido S, Hotta H
  Title
Hepatitis C virus NS5A protein interacts with 2',5'-oligoadenylate synthetase and inhibits antiviral activity of IFN in an IFN sensitivity-determining region-independent manner.
  Journal
J Gen Virol 85:959-69 (2004)
DOI:10.1099/vir.0.19513-0
Reference
PMID:19708811
  Authors
Horner SM, Gale M Jr
  Title
Intracellular innate immune cascades and interferon defenses that control hepatitis C virus.
  Journal
J Interferon Cytokine Res 29:489-98 (2009)
DOI:10.1089/jir.2009.0063
Reference
PMID:20457596
  Authors
Lemon SM
  Title
Induction and evasion of innate antiviral responses by hepatitis C virus.
  Journal
J Biol Chem 285:22741-7 (2010)
DOI:10.1074/jbc.R109.099556
Reference
PMID:23836238
  Authors
Horner SM, Gale M Jr
  Title
Regulation of hepatic innate immunity by hepatitis C virus.
  Journal
Nat Med 19:879-88 (2013)
DOI:10.1038/nm.3253
Reference
PMID:28862649
  Authors
Ortega-Prieto AM, Dorner M
  Title
Immune Evasion Strategies during Chronic Hepatitis B and C Virus Infection.
  Journal
Vaccines (Basel) 5:E24 (2017)
DOI:10.3390/vaccines5030024
Reference
PMID:25852264
  Authors
Yang DR, Zhu HZ
  Title
Hepatitis C virus and antiviral innate immunity: who wins at tug-of-war?
  Journal
World J Gastroenterol 21:3786-800 (2015)
DOI:10.3748/wjg.v21.i13.3786
Reference
PMID:16107833
  Authors
Gale M Jr, Foy EM
  Title
Evasion of intracellular host defence by hepatitis C virus.
  Journal
Nature 436:939-45 (2005)
DOI:10.1038/nature04078
Reference
PMID:17467654
  Authors
Bode JG, Brenndorfer ED, Haussinger D
  Title
Subversion of innate host antiviral strategies by the hepatitis C virus.
  Journal
Arch Biochem Biophys 462:254-65 (2007)
DOI:10.1016/j.abb.2007.03.033
Reference
PMID:12686421
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
PMID:16239065
  Authors
Pang R, Tse E, Poon RT
  Title
Molecular pathways in hepatocellular carcinoma.
  Journal
Cancer Lett 240:157-69 (2006)
DOI:10.1016/j.canlet.2005.08.031
Reference
PMID:15302943
  Authors
Macdonald A, Harris M
  Title
Hepatitis C virus NS5A: tales of a promiscuous protein.
  Journal
J Gen Virol 85:2485-502 (2004)
DOI:10.1099/vir.0.80204-0
Reference
PMID:21250384
  Authors
He Y, Staschke KA, Tan SL
  Title
HCV NS5A: A Multifunctional Regulator of Cellular Pathways and Virus Replication
  Journal
Hepatitis C Viruses: Genomes and Molecular Biology (2006)
Reference
PMID:12101418
  Authors
Lan KH, Sheu ML, Hwang SJ, Yen SH, Chen SY, Wu JC, Wang YJ, Kato N, Omata M, Chang FY, Lee SD
  Title
HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis.
  Journal
Oncogene 21:4801-11 (2002)
DOI:10.1038/sj.onc.1205589
Reference
PMID:11886269
  Authors
Majumder M, Ghosh AK, Steele R, Zhou XY, Phillips NJ, Ray R, Ray RB
  Title
Hepatitis C virus NS5A protein impairs TNF-mediated hepatic apoptosis, but not by an anti-FAS antibody, in transgenic mice.
  Journal
Virology 294:94-105 (2002)
DOI:10.1006/viro.2001.1309
Reference
PMID:15381253
  Authors
Hassan M, Ghozlan H, Abdel-Kader O
  Title
Activation of RB/E2F signaling pathway is required for the modulation of hepatitis C virus core protein-induced cell growth in liver and non-liver cells.
  Journal
Cell Signal 16:1375-85 (2004)
DOI:10.1016/j.cellsig.2004.04.005
Reference
PMID:11514734
  Authors
Kwun HJ, Jung EY, Ahn JY, Lee MN, Jang KL
  Title
p53-dependent transcriptional repression of p21(waf1) by hepatitis C virus NS3.
  Journal
J Gen Virol 82:2235-41 (2001)
DOI:10.1099/0022-1317-82-9-2235
Reference
PMID:12056797
  Authors
Yamanaka T, Uchida M, Doi T
  Title
Innate form of HCV core protein plays an important role in the localization and the function of HCV core protein.
  Journal
Biochem Biophys Res Commun 294:521-7 (2002)
DOI:10.1016/S0006-291X(02)00507-7
Reference
PMID:22611309
  Authors
Lim EJ, Chin R, Angus PW, Torresi J
  Title
Enhanced apoptosis in post-liver transplant hepatitis C: effects of virus and immunosuppressants.
  Journal
World J Gastroenterol 18:2172-9 (2012)
DOI:10.3748/wjg.v18.i18.2172
Reference
PMID:17828818
  Authors
Fischer R, Baumert T, Blum HE
  Title
Hepatitis C virus infection and apoptosis.
  Journal
World J Gastroenterol 13:4865-72 (2007)
DOI:10.3748/wjg.v13.i36.4865
Reference
PMID:16611896
  Authors
Saito K, Meyer K, Warner R, Basu A, Ray RB, Ray R
  Title
Hepatitis C virus core protein inhibits tumor necrosis factor alpha-mediated apoptosis by a protective effect involving cellular FLICE inhibitory protein.
  Journal
J Virol 80:4372-9 (2006)
DOI:10.1128/JVI.80.9.4372-4379.2006
Reference
PMID:19148799
  Authors
Koike K
  Title
Steatosis, liver injury, and hepatocarcinogenesis in hepatitis C viral infection.
  Journal
J Gastroenterol 44 Suppl 19:82-8 (2009)
DOI:10.1007/s00535-008-2276-4
Reference
PMID:17764115
  Authors
Tanaka N, Moriya K, Kiyosawa K, Koike K, Aoyama T
  Title
Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor alpha in transgenic mice: implications for HCV-associated hepatocarcinogenesis.
  Journal
Int J Cancer 122:124-31 (2008)
DOI:10.1002/ijc.23056
Reference
PMID:18251977
  Authors
Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
  Title
Viral hepatocarcinogenesis: from infection to cancer.
  Journal
Liver Int 28:175-88 (2008)
DOI:10.1111/j.1478-3231.2007.01652.x
Related
pathway
cfr03320  PPAR signaling pathway
cfr04010  MAPK signaling pathway
cfr04144  Endocytosis
cfr04210  Apoptosis
cfr04514  Cell adhesion molecules
cfr04620  Toll-like receptor signaling pathway
cfr04622  RIG-I-like receptor signaling pathway
cfr04630  JAK-STAT signaling pathway
cfr04668  TNF signaling pathway
KO pathway
ko05160   
LinkDB

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