KEGG   PATHWAY: cmao03013
Entry
cmao03013                   Pathway                                
Name
Nucleocytoplasmic transport - Colossoma macropomum (tambaqui)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
cmao03013  Nucleocytoplasmic transport
cmao03013

Other DBs
GO: 0050658
Organism
Colossoma macropomum (tambaqui) [GN:cmao]
Gene
118813353  aaas; aladin [KO:K14320]
118812768  nup42; nucleoporin NUP42 [KO:K14321]
118813504  gle1; nucleoporin GLE1 [KO:K18723]
118822845  zgc:193690; ATP-dependent RNA helicase DDX19A [KO:K18655] [EC:5.6.2.7]
118799569  ddx19; ATP-dependent RNA helicase DDX19B [KO:K18655] [EC:5.6.2.7]
118808369  rae1; mRNA export factor isoform X1 [KO:K14298]
118819635  nup98; nuclear pore complex protein Nup98-Nup96 [KO:K14297]
118814839  nup214; nuclear pore complex protein Nup214 [KO:K14317]
118814306  nup88; nucleoporin 88 [KO:K14318]
118801612  ranbp2; RANBP2-like and GRIP domain-containing protein 5/6 isoform X1 [KO:K12172] [EC:2.3.2.-]
118805304  rangap1a; ran GTPase-activating protein 1a [KO:K14319]
118809502  rangap1b; ran GTPase-activating protein 1b [KO:K14319]
118805765  ube2ia; SUMO-conjugating enzyme UBC9-B [KO:K10577]
118822324  ube2ib; SUMO-conjugating enzyme UBC9-A [KO:K10577]
118805371  SUMO-conjugating enzyme UBC9-like [KO:K10577]
118807809  sumo3a; small ubiquitin-related modifier 3-like [KO:K12160]
118807838  sumo1; small ubiquitin-related modifier 1 [KO:K12160]
118808135  sumo2a; small ubiquitin like modifier 2a [KO:K12160]
118805332  sumo2b; small ubiquitin-related modifier 2 [KO:K12160]
118806561  nup160; nuclear pore complex protein Nup160 [KO:K14303]
118805331  nup85; nuclear pore complex protein Nup85 [KO:K14304]
118799784  sec13; protein SEC13 homolog [KO:K14004]
118812325  nup107; nuclear pore complex protein Nup107 [KO:K14301]
118798331  nup133; nuclear pore complex protein Nup133 [KO:K14300]
118805235  seh1l; nucleoporin SEH1 isoform X1 [KO:K14299]
118816214  nup43; nucleoporin Nup43 [KO:K14305]
118812611  nup37; nucleoporin Nup37 [KO:K14302]
118823351  ahctf1; LOW QUALITY PROTEIN: protein ELYS [KO:K25129]
118807347  nup62l; nucleoporin 62 like [KO:K14306]
118798792  nup58; nucleoporin p58/p45 isoform X1 [KO:K14307]
118820299  nup54; nucleoporin p54 isoform X1 [KO:K14308]
118818091  nup205; LOW QUALITY PROTEIN: nuclear pore complex protein Nup205 [KO:K14310]
118820174  nup188; nucleoporin NUP188 homolog isoform X1 [KO:K14311]
118824766  nup155; nuclear pore complex protein Nup155 [KO:K14312]
118818295  nup93; nuclear pore complex protein Nup93 isoform X1 [KO:K14309]
118811914  nup35; nucleoporin NUP35 [KO:K14313]
118804760  ndc1; nucleoporin NDC1 isoform X1 [KO:K14315]
118822571  nup210; nuclear pore membrane glycoprotein 210 [KO:K14314]
118814597  nuclear pore membrane glycoprotein 210-like [KO:K14314]
118824879  pom121; nuclear envelope pore membrane protein POM 121 isoform X1 [KO:K14316]
118807026  tmem33; transmembrane protein 33 [KO:K20724]
118804705  tpra; nucleoprotein TPR [KO:K09291]
118815278  tprb; translocated promoter region b, nuclear basket protein isoform X1 [KO:K09291]
118812405  nup50; nuclear pore complex protein Nup50 isoform X1 [KO:K14295]
118805653  nup153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
118807798  senp2; sentrin-specific protease 2 [KO:K03345] [EC:3.4.22.68]
118799196  kpna1; importin subunit alpha-5 [KO:K23940]
118824790  kpna7; importin subunit alpha-8 [KO:K15043]
118807937  importin subunit alpha-1-like [KO:K15043]
118821129  kpna2; importin subunit alpha-1 [KO:K15043]
118802969  kpna3; importin subunit alpha-4 [KO:K23583]
118796674  kpna4; importin subunit alpha-3 [KO:K23583]
118796825  kpna5; importin subunit alpha-6 isoform X1 [KO:K15042]
118805436  kpna6; importin subunit alpha-7 [KO:K15042]
118805217  kpnb1; importin subunit beta-1 [KO:K14293]
118814376  tnpo1; transportin-1 [KO:K18752]
118798254  transportin-2 [KO:K18727]
118821622  tnpo2; transportin-2 isoform X1 [KO:K18727]
118812087  tnpo3; transportin-3 isoform X1 [KO:K15436]
118804077  ipo4; importin-4 [KO:K20221]
118797882  kpnb3; importin-5 [KO:K20222]
118819508  ipo7; importin-7 [KO:K20223]
118812549  ipo8; importin-8 isoform X1 [KO:K18755]
118799713  ipo9; importin-9 isoform X1 [KO:K20224]
118813030  ipo11; importin-11 [KO:K25201]
118826571  si:ch73-182a11.2; importin-13 [KO:K25202]
118815421  ipo13; importin-13 [KO:K25202]
118811962  snupn; snurportin-1 [KO:K13151]
118798033  xpo1a; exportin-1 [KO:K14290]
118823409  xpo1b; exportin-1 isoform X1 [KO:K14290]
118799675  cse1l; exportin-2 isoform X1 [KO:K18423]
118811984  xpot; exportin-T [KO:K14288]
118799141  xpo4; exportin-4 [KO:K25203]
118816735  exportin-5 [KO:K14289]
118821221  xpo6; exportin-6 [KO:K25204]
118824316  xpo7; exportin-7 isoform X1 [KO:K18460]
118807044  ran; GTP-binding nuclear protein Ran [KO:K07936]
118810488  eef1a1a; elongation factor 1-alpha 1a [KO:K03231]
118822518  eef1a2; elongation factor 1-alpha 2 [KO:K03231]
118798997  si:dkey-37o8.1; elongation factor 1-alpha [KO:K03231]
118804364  eef1a1b; elongation factor 1-alpha 1b [KO:K03231]
118805628  elongation factor 1-alpha [KO:K03231]
118805629  elongation factor 1-alpha-like [KO:K03231]
118825162  phax; phosphorylated adapter RNA export protein [KO:K14291]
118811509  nuclear cap-binding protein subunit 1 [KO:K12882]
118819319  ncbp2; nuclear cap-binding protein subunit 2 [KO:K12883]
118796884  nmd3; 60S ribosomal export protein NMD3 isoform X1 [KO:K07562]
118799037  rbm8a; RNA-binding protein 8A [KO:K12876]
118813739  magoh; protein mago nashi homolog [KO:K12877]
118821241  casc3; protein CASC3 [KO:K14323]
118819154  eif4a3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
118826578  acin1b; LOW QUALITY PROTEIN: apoptotic chromatin condensation inducer 1b [KO:K12875]
118799478  sap18; histone deacetylase complex subunit SAP18 [KO:K14324]
118809545  RNA-binding protein with serine-rich domain 1-like [KO:K14325]
118820994  RNA-binding protein with serine-rich domain 1 [KO:K14325]
118823498  pnn; pinin [KO:K13114]
118821096  alyref; THO complex subunit 4 [KO:K12881]
118796972  upf1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
118811989  upf2; regulator of nonsense transcripts 2 isoform X1 [KO:K14327]
118807161  upf3b; regulator of nonsense transcripts 3B [KO:K14328]
118819953  upf3a; regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
118806908  zgc:153681; nuclear RNA export factor 1 isoform X1 [KO:K14284]
118819801  nxf1; nuclear RNA export factor 1 [KO:K14284]
118806891  nxt2; NTF2-related export protein 2 [KO:K14285]
118805410  ddx39b; DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B [KO:K12812] [EC:5.6.2.7]
118823336  srrm1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
118813432  pym1; partner of Y14 and mago [KO:K14294]
118825626  thoc1; THO complex subunit 1 [KO:K12878]
118807344  thoc2; THO complex subunit 2 [KO:K12879]
118811789  thoc5; THO complex subunit 5 homolog [KO:K13174]
118800537  thoc6; THO complex subunit 6 homolog [KO:K13175]
118799331  thoc7; THO complex subunit 7 homolog [KO:K13176]
118806405  thoc3; THO complex subunit 3 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
cmao03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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