KEGG   PATHWAY: cscu00600
Entry
cscu00600                   Pathway                                
Name
Sphingolipid metabolism - Centruroides sculpturatus (bark scorpion)
Class
Metabolism; Lipid metabolism
Pathway map
cscu00600  Sphingolipid metabolism
cscu00600

Module
cscu_M00094  Ceramide biosynthesis [PATH:cscu00600]
cscu_M00099  Sphingosine biosynthesis [PATH:cscu00600]
cscu_M00100  Sphingosine degradation [PATH:cscu00600]
Other DBs
GO: 0006665
Organism
Centruroides sculpturatus (bark scorpion) [GN:cscu]
Gene
111616733  serine palmitoyltransferase 2-like [KO:K00654] [EC:2.3.1.50]
111624623  serine palmitoyltransferase 1-like [KO:K00654] [EC:2.3.1.50]
111632536  serine palmitoyltransferase 2-like isoform X1 [KO:K00654] [EC:2.3.1.50]
111626647  3-ketodihydrosphingosine reductase-like [KO:K04708] [EC:1.1.1.102]
111612809  ceramide synthase 1-like [KO:K04710] [EC:2.3.1.299]
111642175  ceramide synthase 6-like [KO:K23727] [EC:2.3.1.291]
111623012  acid ceramidase-like [KO:K12348] [EC:3.5.1.23]
111629430  neutral ceramidase-like [KO:K12349] [EC:3.5.1.23]
111629431  neutral ceramidase 3-like [KO:K12349] [EC:3.5.1.23]
111636200  alkaline ceramidase-like [KO:K01441] [EC:3.5.1.23]
111626051  alkaline ceramidase 3-like [KO:K04711] [EC:3.5.1.-]
111633137  alkaline ceramidase 3-like [KO:K04711] [EC:3.5.1.-]
111633138  alkaline ceramidase 3-like [KO:K04711] [EC:3.5.1.-]
111625553  sphingolipid delta(4)-desaturase DES1-like isoform X1 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
111631757  phosphatidylcholine:ceramide cholinephosphotransferase 2-like [KO:K04714] [EC:2.7.8.27]
111619305  sphingomyelin phosphodiesterase-like [KO:K12350] [EC:3.1.4.12]
111642092  putative neutral sphingomyelinase isoform X1 [KO:K12351] [EC:3.1.4.12]
111618012  ceramide kinase-like [KO:K04715] [EC:2.7.1.138]
111615420  phospholipid phosphatase 1-like [KO:K01080] [EC:3.1.3.4]
111622500  phospholipid phosphatase 1-like [KO:K01080] [EC:3.1.3.4]
111630393  putative phosphatidate phosphatase [KO:K01080] [EC:3.1.3.4]
111630408  phospholipid phosphatase 3-like [KO:K01080] [EC:3.1.3.4]
111630409  phospholipid phosphatase 1-like [KO:K01080] [EC:3.1.3.4]
111629799  putative phosphatidate phosphatase [KO:K01080] [EC:3.1.3.4]
111627924  sphingosine-1-phosphate phosphatase 1-like [KO:K04716] [EC:3.1.3.-]
111627936  sphingosine-1-phosphate phosphatase 2-like isoform X1 [KO:K04716] [EC:3.1.3.-]
111634940  ceramide phosphoethanolamine synthase-like isoform X1 [KO:K26283] [EC:2.7.8.48]
111642211  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
111630701  sphingosine-1-phosphate lyase-like [KO:K01634] [EC:4.1.2.27]
111634837  glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
111627470  glucosylceramidase-like isoform X1 [KO:K01201] [EC:3.2.1.45]
111627381  glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
111635150  beta-galactosidase-like isoform X1 [KO:K12309] [EC:3.2.1.23]
111635151  beta-galactosidase-like [KO:K12309] [EC:3.2.1.23]
111623789  beta-galactosidase-like [KO:K12309] [EC:3.2.1.23]
111642594  galactose-3-O-sulfotransferase 4-like [KO:K01019] [EC:2.8.2.11]
111637089  beta-hexosaminidase subunit alpha-like [KO:K12373] [EC:3.2.1.52]
111642255  beta-hexosaminidase subunit alpha-like [KO:K12373] [EC:3.2.1.52]
111621946  beta-hexosaminidase subunit beta-like [KO:K12373] [EC:3.2.1.52]
111614332  uncharacterized protein LOC111614332 [KO:K12383]
111631191  ganglioside GM2 activator-like [KO:K12383]
111635705  ganglioside GM2 activator-like [KO:K12383]
111635726  uncharacterized protein LOC111635726 [KO:K12383]
111624530  ganglioside GM2 activator-like [KO:K12383]
111631276  ganglioside GM2 activator-like [KO:K12383]
111635661  ganglioside GM2 activator-like [KO:K12383]
111616655  ganglioside GM2 activator-like [KO:K12383]
111616656  ganglioside GM2 activator-like [KO:K12383]
111631366  ganglioside GM2 activator-like [KO:K12383]
111624529  ganglioside GM2 activator-like [KO:K12383]
111634430  uncharacterized protein LOC111634430 [KO:K12383]
111638116  prosaposin-like [KO:K12382]
111613009  prosaposin-like isoform X1 [KO:K12382]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
cscu00260  Glycine, serine and threonine metabolism
cscu00601  Glycosphingolipid biosynthesis - lacto and neolacto series
cscu00603  Glycosphingolipid biosynthesis - globo and isoglobo series
cscu00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   
LinkDB

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