Entry
Name
B cell receptor signaling pathway - Carlito syrichta (Philippine tarsier)
Description
B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two immunoglobulin (Ig) heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta. After BCR ligation by antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) are important downstream effectors of BCR signalling. This signalling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes.
Class
Organismal Systems; Immune system
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Carlito syrichta (Philippine tarsier) [GN:
csyr ]
Gene
103273602 CD79A; B-cell antigen receptor complex-associated protein alpha chain isoform X1 [KO:K06506 ]
103250788 CD79B; B-cell antigen receptor complex-associated protein beta chain [KO:K06507 ]
103256042 DAPP1; dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide isoform X1 [KO:K12229 ]
103258883 RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860 ]
103270295 LOW QUALITY PROTEIN: B-cell scaffold protein with ankyrin repeats-like [KO:K26239 ]
103263669 PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
103265906 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
103266637 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
103266669 NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446 ]
103276035 NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
103268196 NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333 ]
103275922 GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364 ]
103272652 LOW QUALITY PROTEIN: ras guanyl-releasing protein 3-like [KO:K12362 ]
103264081 CARD11; caspase recruitment domain-containing protein 11 [KO:K07367 ]
103267615 MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 [KO:K07369 ] [EC:3.4.22.-]
103274648 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
103262537 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649 ]
103272136 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649 ]
103251553 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
103266233 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
103276054 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922 ] [EC:2.7.1.153 ]
103277310 FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b isoform X3 [KO:K12560 ]
103249745 LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily A member 5 [KO:K06512 ]
103260723 leukocyte immunoglobulin-like receptor subfamily B member 5 [KO:K06512 ]
103252845 leukocyte immunoglobulin-like receptor subfamily B member 4 [KO:K06512 ]
103254892 leukocyte immunoglobulin-like receptor subfamily B member 3 [KO:K06512 ]
103255011 LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily A member 4 [KO:K06512 ]
103256344 leukocyte immunoglobulin-like receptor subfamily A member 5 [KO:K06512 ]
103253470 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
103267995 LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily A member 2 [KO:K06512 ]
103276468 LILRB3; leukocyte immunoglobulin-like receptor subfamily B member 3 [KO:K06512 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Niiro H, Clark EA.
Title
Regulation of B-cell fate by antigen-receptor signals.
Journal
Reference
Authors
Kurosaki T.
Title
Genetic analysis of B cell antigen receptor signaling.
Journal
Reference
Authors
Nitschke L.
Title
The role of CD22 and other inhibitory co-receptors in B-cell activation.
Journal
Reference
Authors
Morgan BP, Marchbank KJ, Longhi MP, Harris CL, Gallimore AM.
Title
Complement: central to innate immunity and bridging to adaptive responses.
Journal
Reference
Authors
Kurosaki T.
Title
Regulation of B-cell signal transduction by adaptor proteins.
Journal
Reference
Authors
Nitschke L, Tsubata T.
Title
Molecular interactions regulate BCR signal inhibition by CD22 and CD72.
Journal
Reference
Authors
Jumaa H, Hendriks RW, Reth M.
Title
B cell signaling and tumorigenesis.
Journal
Reference
Authors
Rickert RC.
Title
Regulation of B lymphocyte activation by complement C3 and the B cell coreceptor complex.
Journal
Reference
Authors
Zouali M, Sarmay G
Title
B lymphocyte signaling pathways in systemic autoimmunity: implications for pathogenesis and treatment.
Journal
Reference
Authors
Chiles TC.
Title
Regulation and function of cyclin D2 in B lymphocyte subsets.
Journal
Reference
Authors
Allam A, Marshall AJ
Title
Role of the adaptor proteins Bam32, TAPP1 and TAPP2 in lymphocyte activation.
Journal
Reference
Authors
Gold MR
Title
To make antibodies or not: signaling by the B-cell antigen receptor.
Journal
Reference
Authors
Fu C, Turck CW, Kurosaki T, Chan AC
Title
BLNK: a central linker protein in B cell activation.
Journal
Reference
Authors
Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T
Title
BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation.
Journal
Reference
Authors
Shinohara H, Maeda S, Watarai H, Kurosaki T
Title
IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells.
Journal
Related pathway
csyr04610 Complement and coagulation cascades
KO pathway
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