KEGG   PATHWAY: ctul04150
Entry
ctul04150                   Pathway                                
Name
mTOR signaling pathway - Cyprinodon tularosa (White Sands pupfish)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
ctul04150  mTOR signaling pathway
ctul04150

Organism
Cyprinodon tularosa (White Sands pupfish) [GN:ctul]
Gene
119782194  large neutral amino acids transporter small subunit 1-like [KO:K13780]
119787221  slc7a5; large neutral amino acids transporter small subunit 1 [KO:K13780]
119787813  4F2 cell-surface antigen heavy chain-like [KO:K06519]
119776404  slc3a2a; solute carrier family 3 member 2a [KO:K06519]
119792114  4F2 cell-surface antigen heavy chain [KO:K06519]
119788480  slc38a9; sodium-coupled neutral amino acid transporter 9 [KO:K14995]
119789033  atp6v1ab; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
119778325  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
119779584  atp6v1ba; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
119783577  atp6v1c2; V-type proton ATPase subunit C 1-B [KO:K02148]
119771403  atp6v1c1a; V-type proton ATPase subunit C 1-A [KO:K02148]
119785964  V-type proton ATPase subunit C 1-A-like [KO:K02148]
119799287  atp6v1d; V-type proton ATPase subunit D [KO:K02149]
119776896  atp6v1e1b; V-type proton ATPase subunit E 1 [KO:K02150]
119798466  atp6v1f; V-type proton ATPase subunit F [KO:K02151]
119774488  atp6v1g1; V-type proton ATPase subunit G 1 [KO:K02152]
119781300  atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
119771808  lamtor1; ragulator complex protein LAMTOR1 isoform X1 [KO:K20397]
119776792  lamtor2; ragulator complex protein LAMTOR2 [KO:K20398]
119787034  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
119798467  lamtor4; ragulator complex protein LAMTOR4 [KO:K20399]
119782169  lamtor5; ragulator complex protein LAMTOR5 [KO:K16344]
119782992  flcn; folliculin [KO:K09594]
119797650  fnip1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
119791131  rraga; ras-related GTP-binding protein A [KO:K16185]
119777469  rragca; ras-related GTP binding Ca [KO:K16186]
119772293  ras-related GTP-binding protein C-like [KO:K16186]
119785955  sesn2; sestrin-2 isoform X1 [KO:K20394]
119788920  castor1; cytosolic arginine sensor for mTORC1 subunit 1 [KO:K23080]
119787128  castor2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
119779784  mios; GATOR complex protein MIOS [KO:K20407]
119797260  seh1l; nucleoporin SEH1 [KO:K14299]
119793762  wdr24; GATOR complex protein WDR24 [KO:K20408]
119771452  wdr59; GATOR complex protein WDR59 isoform X1 [KO:K20409]
119797221  sec13; protein SEC13 homolog [KO:K14004]
119782551  depdc5; GATOR complex protein DEPDC5 isoform X1 [KO:K20404]
119780141  nprl2; GATOR complex protein NPRL2 [KO:K20405]
119785349  nprl3; GATOR complex protein NPRL3 isoform X1 [KO:K20406]
119780548  skp2; S-phase kinase-associated protein 2 [KO:K03875]
119796387  rnf152; E3 ubiquitin-protein ligase rnf152 [KO:K15705] [EC:2.3.2.27]
119779336  rptor; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
119791295  akt1s1; uncharacterized protein akt1s1 [KO:K16184]
119786494  mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
119783772  DEP domain-containing mTOR-interacting protein-like isoform X1 [KO:K20402]
119790288  si:dkeyp-97e7.9; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
119775899  mlst8; target of rapamycin complex subunit lst8 [KO:K08266]
119793809  telo2; telomere length regulation protein TEL2 homolog [KO:K11137]
119781561  tti1; TELO2-interacting protein 1 homolog [KO:K20403]
119790155  clip1a; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
119784784  clip1b; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
119777078  grb10b; growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
119792939  growth factor receptor-bound protein 10-like isoform X1 [KO:K20064]
119794275  phosphatidate phosphatase LPIN2-like isoform X1 [KO:K15728] [EC:3.1.3.4]
119794618  lpin1; phosphatidate phosphatase LPIN1 [KO:K15728] [EC:3.1.3.4]
119777593  si:ch73-21k16.1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
119791638  phosphatidate phosphatase LPIN2-like isoform X1 [KO:K15728] [EC:3.1.3.4]
119781294  lpin2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
119776623  ulk1b; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
119790670  ulk1a; serine/threonine-protein kinase ULK1a isoform X1 [KO:K21357] [EC:2.7.11.1]
119796174  ulk2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
119790172  eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205]
119792348  eukaryotic translation initiation factor 4E-binding protein 1-like isoform X1 [KO:K07205]
119788581  eif4e1c; eukaryotic translation initiation factor 4E family member 1c [KO:K03259]
119776335  eif4eb; eukaryotic translation initiation factor 4eb [KO:K03259]
119772616  eif4ea; eukaryotic translation initiation factor 4E-1A [KO:K03259]
119772924  eif4e2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
119782278  ribosomal protein S6 kinase beta-2-like [KO:K04688] [EC:2.7.11.1]
119783834  rps6kb1b; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
119791578  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
119776464  eif4ba; eukaryotic translation initiation factor 4Ba isoform X1 [KO:K03258]
119774746  rps6; 40S ribosomal protein S6 [KO:K02991]
119783425  strada; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
119796988  stradb; STE20-related kinase adapter protein beta [KO:K17532]
119773264  stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
119788080  cab39l1; calcium binding protein 39, like 1 [KO:K08272]
119775250  cab39; calcium-binding protein 39 [KO:K08272]
119777681  cab39l; calcium-binding protein 39-like [KO:K08272]
119772370  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
119798995  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
119776717  tsc1a; TSC complex subunit 1a isoform X1 [KO:K07206]
119772024  tsc1b; TSC complex subunit 1b [KO:K07206]
119774330  tsc2; tuberin isoform X1 [KO:K07207]
119787694  tbc1d7; TBC1 domain family member 7 [KO:K20396]
119776679  rhebl1; ras homolog, mTORC1 binding like 1 [KO:K07208]
119787193  rheb; GTP-binding protein Rheb [KO:K07208]
119774929  ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
119788535  DNA damage-inducible transcript 4 protein-like [KO:K08270]
119785039  wnt1; protein Wnt-1 [KO:K03209]
119794749  protein Wnt-2b-A-like [KO:K00182]
119784981  protein Wnt-2b-A [KO:K00182]
119780420  wnt2; protein Wnt-2 [KO:K00182]
119791048  wnt3; proto-oncogene Wnt-3 [KO:K00312]
119794197  wnt3a; protein Wnt-3a [KO:K00312]
119782986  wnt4b; wingless-type MMTV integration site family, member 4b [KO:K00408]
119779871  wnt4; protein Wnt-4a [KO:K00408]
119784321  wnt5a; protein Wnt-5a [KO:K00444]
119792968  wnt5b; protein Wnt-5b isoform X1 [KO:K00444]
119785174  wnt6b; protein Wnt-6 [KO:K00445]
119774830  protein Wnt-7a [KO:K00572]
119776241  wnt7ba; protein Wnt-7b isoform X1 [KO:K00572]
119777567  wnt7aa; wingless-type MMTV integration site family, member 7Aa isoform X1 [KO:K00572]
119785777  wnt7bb; protein Wnt-7b isoform X1 [KO:K00572]
119788548  wnt8b; protein Wnt-8b [KO:K00714]
119780974  protein Wnt-8-like [KO:K00714]
119780975  protein Wnt-8a-like [KO:K00714]
119778855  wnt9b; protein Wnt-9b [KO:K01064]
119794187  wnt9a; protein Wnt-9a [KO:K01064]
119785038  wnt10b; protein Wnt-10b [KO:K01357]
119785185  wnt10a; protein Wnt-10a [KO:K01357]
119775628  wnt11; protein Wnt-11 [KO:K01384]
119794142  wnt16; protein Wnt-16 [KO:K01558]
119776293  frizzled-7-A-like [KO:K02432]
119776463  fzd1; frizzled-1 [KO:K02432]
119777138  frizzled-7-A-like [KO:K02432]
119777143  frizzled-7-A-like [KO:K02432]
119777482  frizzled-7-A-like [KO:K02432]
119798872  fzd3a; frizzled-3a [KO:K02329]
119787298  frizzled-3-like isoform X1 [KO:K02329]
119771786  fzd4; frizzled-4 [KO:K02354]
119787942  fzd8a; frizzled-8a [KO:K02375]
119791370  fzd5; frizzled-5 [KO:K02375]
119787142  frizzled-8-like [KO:K02375]
119795644  frizzled-6-like [KO:K02376]
119771797  fzd9b; frizzled-9b [KO:K02842]
119792627  fzd10; frizzled-10 isoform X1 [KO:K02842]
119789771  lrp5; LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 5 [KO:K03068]
119790583  lrp6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
119781999  segment polarity protein dishevelled homolog DVL-1-like [KO:K02353]
119789782  dvl2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
119798861  segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
119773983  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
119798510  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
119784060  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
119782197  si:ch211-112c15.8; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
119783104  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
119778144  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
119798134  ins; insulin isoform X1 [KO:K04526]
119776605  igf3; insulin-like growth factor 3 [KO:K05459]
119781054  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
119787886  insra; insulin receptor a [KO:K04527] [EC:2.7.10.1]
119797368  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
119772423  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
119797283  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
119783529  sos2; son of sevenless homolog 2 [KO:K03099]
119785500  son of sevenless homolog 1-like isoform X1 [KO:K03099]
119776860  GTPase HRas [KO:K02833]
119781701  zgc:55558 [KO:K07827]
119793033  kras; GTPase KRas isoform X1 [KO:K07827]
119779101  braf; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
119781396  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
119772490  map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
119792552  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
119781702  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
119777409  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
119796076  rps6ka3b; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
119796661  rps6kal; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
119797613  ribosomal protein S6 kinase alpha-2-like [KO:K04373] [EC:2.7.11.1]
119778784  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
119783405  si:ch73-335l21.1; insulin receptor substrate 1-B [KO:K16172]
119779217  si:ch211-284e13.4; insulin receptor substrate 1-B [KO:K16172]
119794397  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
119788263  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
119782413  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
119782565  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
119776053  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
119790526  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
119782549  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
119789890  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
119796610  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
119797040  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119786919  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119790844  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
119792869  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
119793747  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
119789545  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119790563  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
119771800  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119778657  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119782488  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
119790655  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
119773744  mapkap1; target of rapamycin complex 2 subunit MAPKAP1 [KO:K20410]
119784947  rapamycin-insensitive companion of mTOR-like isoform X1 [KO:K08267]
119786202  proline-rich protein 5-like isoform X1 [KO:K20411]
119793043  prr5a; proline-rich protein 5a [KO:K20411]
119789088  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
119784342  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
119785013  rho-related GTP-binding protein RhoA-D [KO:K04513]
119780031  transforming protein RhoA [KO:K04513]
119799189  rho-related GTP-binding protein RhoA-C [KO:K04513]
119773306  rho-related GTP-binding protein RhoC-like isoform X1 [KO:K04513]
119784438  prkcaa; protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
119798353  si:ch73-374l24.1; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
119783658  protein kinase C beta type-like isoform X1 [KO:K19662] [EC:2.7.11.13]
119780330  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
119782956  prkcg; protein kinase C alpha type isoform X1 [KO:K19663] [EC:2.7.11.13]
119788364  sgk1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
119792609  si:ch211-195b13.1; STKc_SGK domain-containing protein isoform X1 [KO:K13302] [EC:2.7.11.1]
119787276  sgk2b; serine/threonine-protein kinase Sgk2b isoform X1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
ctul00561  Glycerolipid metabolism
ctul04010  MAPK signaling pathway
ctul04140  Autophagy - animal
ctul04810  Regulation of actin cytoskeleton
ctul04910  Insulin signaling pathway
KO pathway
ko04150   
LinkDB

DBGET integrated database retrieval system