KEGG   PATHWAY: cvf04218
Entry
cvf04218                    Pathway                                
Name
Cellular senescence - Charadrius vociferus (killdeer)
Description
Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of factors, such as telomere shortening, oncogene activation, irradiation, DNA damage and oxidative stress. It is characterized by enlarged flattened morphology, senescence-associated beta-galactosidase (SA-b-gal) activity, secretion of inflammatory cytokines, growth factors and matrix metalloproteinases, as part of the senescence-associated secretory phenotype (SASP). Cellular senescence is functionally associated with many biological processes including aging, tumor suppression, placental biology, embryonic development, and wound healing.
Class
Cellular Processes; Cell growth and death
Pathway map
cvf04218  Cellular senescence
cvf04218

Other DBs
GO: 0090398
Organism
Charadrius vociferus (killdeer) [GN:cvf]
Gene
104294674  TGFB2; transforming growth factor beta-2 [KO:K13376]
104288206  TGFB3; transforming growth factor beta-3 [KO:K13377]
104295278  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
104283917  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
104288491  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
104291926  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
104288041  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
104289019  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
104287532  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
104294573  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
104289311  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
104281590  RB1; retinoblastoma-associated protein [KO:K06618]
104287603  RBL1; retinoblastoma-like protein 1 [KO:K04681]
104286467  RBL2; retinoblastoma-like protein 2 [KO:K16332]
104292699  E2F1; LOW QUALITY PROTEIN: transcription factor E2F1 [KO:K17454]
104288892  E2F2; transcription factor E2F2 [KO:K09389]
104295986  E2F3; transcription factor E2F3 [KO:K06620]
104292548  E2F5; transcription factor E2F5 [KO:K04682]
104294822  E2F4; transcription factor E2F4 [KO:K04682]
104290469  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
104282648  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
104295548  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104285739  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
104290423  LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
104286266  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
104295401  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
104284073  FOXO1; forkhead box protein O1 [KO:K07201]
104294282  FOXO3; forkhead box protein O3 [KO:K09408]
104292373  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
104281747  cyclin-dependent kinase inhibitor 1-like [KO:K06625]
104292450  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
104294447  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
104292679  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
104281647  KRAS; GTPase KRas isoform X1 [KO:K07827]
104289524  NRAS; GTPase NRas [KO:K07828]
104291693  RRAS2; ras-related protein R-Ras2 [KO:K07830]
104288472  MRAS; ras-related protein M-Ras [KO:K07831]
104290283  HRAS; GTPase HRas [KO:K02833]
104283204  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104285124  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
104294083  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104292814  TSC1; hamartin isoform X1 [KO:K07206]
104294989  TSC2; LOW QUALITY PROTEIN: tuberin [KO:K07207]
104288901  RHEB; GTP-binding protein Rheb [KO:K07208]
104290455  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
104283369  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
104294417  SIRT1; LOW QUALITY PROTEIN: NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
104289457  CCNA1; cyclin-A1 [KO:K06627]
104289006  CCNA2; cyclin-A2 [KO:K06627]
104284977  MYBL2; myb-related protein B [KO:K21769]
104294652  LIN9; protein lin-9 homolog isoform X1 [KO:K21773]
104288250  LIN52; protein lin-52 homolog [KO:K21775]
104288704  LIN54; protein lin-54 homolog isoform X1 [KO:K21776]
104284425  RBBP4; histone-binding protein RBBP4 [KO:K10752]
104294493  FOXM1; LOW QUALITY PROTEIN: forkhead box protein M1 [KO:K09406]
104288920  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
104289342  RASSF5; ras association domain-containing protein 5 [KO:K08015]
104282617  FBXW11; F-box/WD repeat-containing protein 11 [KO:K03362]
104294620  BTRC; F-box/WD repeat-containing protein 1A [KO:K03362]
104289495  HIPK1; homeodomain-interacting protein kinase 1 [KO:K08826] [EC:2.7.11.1]
104293181  HIPK3; homeodomain-interacting protein kinase 3 [KO:K08826] [EC:2.7.11.1]
104288609  HIPK2; homeodomain-interacting protein kinase 2 [KO:K08826] [EC:2.7.11.1]
104285130  HIPK4; homeodomain-interacting protein kinase 4 [KO:K08826] [EC:2.7.11.1]
104292255  serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
104282220  PPP1CC; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
104282547  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
104290771  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
104288536  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104282773  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
104289233  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104291575  ETS1; protein C-ets-1 [KO:K02678]
104290138  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
104295089  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
104292348  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
104292365  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
104285259  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
104285227  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
104287018  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
104290684  CDK1; cyclin-dependent kinase 1 isoform X1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
104285783  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
104287083  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
104283027  MRE11A; double-strand break repair protein MRE11A [KO:K10865]
104291494  RAD50; DNA repair protein RAD50 [KO:K10866] [EC:3.6.-.-]
104292537  NBN; nibrin [KO:K10867]
104291661  ATM; LOW QUALITY PROTEIN: serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
104289437  CHEK2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
104292263  RAD9A; cell cycle checkpoint control protein RAD9A [KO:K10994] [EC:3.1.11.2]
104282217  RAD9B; cell cycle checkpoint control protein RAD9B [KO:K10995]
104295016  RAD1; cell cycle checkpoint protein RAD1 [KO:K02830] [EC:3.1.11.2]
104295318  HUS1; checkpoint protein HUS1 [KO:K10903]
104291170  ATR; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
104287040  CDC25A; M-phase inducer phosphatase 1 [KO:K06645] [EC:3.1.3.48]
104293110  SQSTM1; sequestosome-1 isoform X1 [KO:K14381]
104289059  GATA4; transcription factor GATA-4 [KO:K09183]
104294055  TRAF3IP2; adapter protein CIKS [KO:K21124]
104286863  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
104281556  IL6; interleukin-6 [KO:K05405]
104288018  growth-regulated alpha protein-like [KO:K10030]
104288315  interleukin-8 isoform X1 [KO:K10030]
104288316  interleukin-8-like [KO:K10030]
104288319  interleukin-8-like [KO:K10030]
104295317  IGFBP3; insulin-like growth factor-binding protein 3 [KO:K10138]
104285851  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
104289341  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
104285108  ZFP36L1; zinc finger protein 36, C3H1 type-like 1 [KO:K18753]
104282808  CACNA1D; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
104282297  TRPV4; transient receptor potential cation channel subfamily V member 4 [KO:K04973]
104287460  TRPM7; LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily M member 7 [KO:K04982] [EC:2.7.11.1]
104282327  CAPN11; LOW QUALITY PROTEIN: calpain-11 [KO:K01367] [EC:3.4.22.52]
104290836  CAPN1; LOW QUALITY PROTEIN: calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
104294692  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
104292668  CALML4; calmodulin-like protein 4 [KO:K02183]
104290389  calmodulin-like [KO:K02183]
104282562  CALM2; calmodulin [KO:K02183]
104284618  CALML5; calmodulin-like protein 5 [KO:K02183]
104286947  CALM1; LOW QUALITY PROTEIN: calmodulin [KO:K02183]
104289756  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
104286888  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
104294699  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
104285463  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
104293302  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
104293938  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
104287787  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
104284516  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
104281650  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
104289376  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
104292407  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
104290256  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
104290363  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
104292111  SLC25A31; LOW QUALITY PROTEIN: ADP/ATP translocase 4 [KO:K05863]
104294192  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
104291600  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
104289665  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
104285151  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
104286998  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07909  Sirolimus
C16844  Hydroxyl radical
Reference
PMID:24954210
  Authors
Munoz-Espin D, Serrano M
  Title
Cellular senescence: from physiology to pathology.
  Journal
Nat Rev Mol Cell Biol 15:482-96 (2014)
DOI:10.1038/nrm3823
Reference
PMID:26646499
  Authors
Childs BG, Durik M, Baker DJ, van Deursen JM
  Title
Cellular senescence in aging and age-related disease: from mechanisms to therapy.
  Journal
Nat Med 21:1424-35 (2015)
DOI:10.1038/nm.4000
Reference
PMID:26105537
  Authors
Sharpless NE, Sherr CJ
  Title
Forging a signature of in vivo senescence.
  Journal
Nat Rev Cancer 15:397-408 (2015)
DOI:10.1038/nrc3960
Reference
PMID:26435346
  Authors
Fridlyanskaya I, Alekseenko L, Nikolsky N
  Title
Senescence as a general cellular response to stress: A mini-review.
  Journal
Exp Gerontol 72:124-8 (2015)
DOI:10.1016/j.exger.2015.09.021
Reference
PMID:27417123
  Authors
Lujambio A
  Title
To clear, or not to clear (senescent cells)? That is the question.
  Journal
Bioessays 38 Suppl 1:S56-64 (2016)
DOI:10.1002/bies.201670910
Reference
PMID:26564316
  Authors
Di Mitri D, Alimonti A
  Title
Non-Cell-Autonomous Regulation of Cellular Senescence in Cancer.
  Journal
Trends Cell Biol 26:215-26 (2016)
DOI:10.1016/j.tcb.2015.10.005
Reference
PMID:27574725
  Authors
Francica P, Aebersold DM, Medova M
  Title
Senescence as biologic endpoint following pharmacological targeting of receptor tyrosine kinases in cancer.
  Journal
Biochem Pharmacol 126:1-12 (2017)
DOI:10.1016/j.bcp.2016.08.022
Reference
PMID:23982440
  Authors
Bartling B
  Title
Cellular senescence in normal and premature lung aging.
  Journal
Z Gerontol Geriatr 46:613-22 (2013)
DOI:10.1007/s00391-013-0543-3
Reference
PMID:24238962
  Authors
Munoz-Espin D, Canamero M, Maraver A, Gomez-Lopez G, Contreras J, Murillo-Cuesta S, Rodriguez-Baeza A, Varela-Nieto I, Ruberte J, Collado M, Serrano M
  Title
Programmed cell senescence during mammalian embryonic development.
  Journal
Cell 155:1104-18 (2013)
DOI:10.1016/j.cell.2013.10.019
Reference
PMID:26697828
  Authors
Herranz N, Gallage S, Gil J
  Title
TORn about SASP regulation.
  Journal
Cell Cycle 14:3771-2 (2015)
DOI:10.1080/15384101.2015.1105694
Reference
PMID:28410770
  Authors
Martin N, Bernard D
  Title
Calcium signaling and cellular senescence.
  Journal
Cell Calcium S0143-4160(17)30049-0 (2017)
DOI:10.1016/j.ceca.2017.04.001
Reference
PMID:25764980
  Authors
Farfariello V, Iamshanova O, Germain E, Fliniaux I, Prevarskaya N
  Title
Calcium homeostasis in cancer: A focus on senescence.
  Journal
Biochim Biophys Acta 1853:1974-9 (2015)
DOI:10.1016/j.bbamcr.2015.03.005
Reference
PMID:24062309
  Authors
McCarthy DA, Clark RR, Bartling TR, Trebak M, Melendez JA
  Title
Redox control of the senescence regulator interleukin-1alpha and the secretory phenotype.
  Journal
J Biol Chem 288:32149-59 (2013)
DOI:10.1074/jbc.M113.493841
Reference
PMID:27288568
  Authors
Donninger H, Schmidt ML, Mezzanotte J, Barnoud T, Clark GJ
  Title
Ras signaling through RASSF proteins.
  Journal
Semin Cell Dev Biol 58:86-95 (2016)
DOI:10.1016/j.semcdb.2016.06.007
Reference
PMID:28455242
  Authors
Barnoud T, Schmidt ML, Donninger H, Clark GJ
  Title
The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence.
  Journal
Cancer Lett 400:30-36 (2017)
DOI:10.1016/j.canlet.2017.04.030
Reference
PMID:26404840
  Authors
Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ
  Title
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.
  Journal
Science 349:aaa5612 (2015)
DOI:10.1126/science.aaa5612
Reference
PMID:26777575
  Authors
Cao X, Li M
  Title
A New Pathway for Senescence Regulation.
  Journal
Genomics Proteomics Bioinformatics 13:333-5 (2015)
DOI:10.1016/j.gpb.2015.11.002
Reference
PMID:25564883
  Authors
Gire V, Dulic V
  Title
Senescence from G2 arrest, revisited.
  Journal
Cell Cycle 14:297-304 (2015)
DOI:10.1080/15384101.2014.1000134
Reference
PMID:24981831
  Authors
Mowla SN, Lam EW, Jat PS
  Title
Cellular senescence and aging: the role of B-MYB.
  Journal
Aging Cell 13:773-9 (2014)
DOI:10.1111/acel.12242
Reference
PMID:22546858
  Authors
Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Ronty M, Kinnula VL, Rahman I
  Title
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.
  Journal
J Clin Invest 122:2032-45 (2012)
DOI:10.1172/JCI60132
Reference
PMID:23542362
  Authors
Hwang JW, Yao H, Caito S, Sundar IK, Rahman I
  Title
Redox regulation of SIRT1 in inflammation and cellular senescence.
  Journal
Free Radic Biol Med 61:95-110 (2013)
DOI:10.1016/j.freeradbiomed.2013.03.015
Related
pathway
cvf04020  Calcium signaling pathway
cvf04068  FoxO signaling pathway
cvf04110  Cell cycle
cvf04115  p53 signaling pathway
cvf04150  mTOR signaling pathway
KO pathway
ko04218   
LinkDB

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