KEGG   PATHWAY: dfa03420
Entry
dfa03420                    Pathway                                
Name
Nucleotide excision repair - Cavenderia fasciculata (cellular slime mold)
Description
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Class
Genetic Information Processing; Replication and repair
Pathway map
dfa03420  Nucleotide excision repair
dfa03420

Other DBs
GO: 0006289
Organism
Cavenderia fasciculata (cellular slime mold) [GN:dfa]
Gene
DFA_07628  polA; mitochondrial DNA polymerase A [KO:K02335] [EC:2.7.7.7]
DFA_00338  culD; cullin [KO:K10609]
DFA_05237  repE; UV-damaged DNA binding protein1 [KO:K10610]
DFA_03564  rad4; DNA repair protein Rad4 family protein [KO:K10838]
DFA_11642  rcbA; repC-binding protein A [KO:K10839]
DFA_07850  ercc8; WD40 repeat-containing protein [KO:K10570]
DFA_07887  ercc6; SNF2-related domain-containing protein [KO:K10841]
DFA_09469  rpb1; RNA polymerase II largest subunit [KO:K03006] [EC:2.7.7.6]
DFA_03939  rpb2; RNA polymerase II core subunit [KO:K03010] [EC:2.7.7.6]
DFA_07782  rpb3; RNA polymerase II core subunit [KO:K03011]
DFA_01521  rpb4; DNA-directed RNA polymerase II subunit 4 [KO:K03012]
DFA_01374  rpb6; RNA polymerase II core subunit [KO:K03014]
DFA_08762  rpb8; RNA polymerase II core subunit [KO:K03016]
DFA_03549  rpb9; RNA polymerase II core subunit [KO:K03017]
DFA_07321  rpb10; RNA polymerase N/8 kDa subunit [KO:K03007]
DFA_02110  rpb12; RNA polymerase [KO:K03009]
DFA_01639  cdk7; p34-cdc2 protein [KO:K02202] [EC:2.7.11.22 2.7.11.23]
DFA_02507  mnat1; CDK-activating kinase assembly factor MAT1 [KO:K10842]
DFA_12137  repB; transcription factor IIH subunit [KO:K10843] [EC:5.6.2.4]
DFA_07199  repD; transcription factor IIH component [KO:K10844] [EC:5.6.2.3]
DFA_02968  gtf2h1; general transcription factor IIH component [KO:K03141]
DFA_04777  gtf2h2; TFIIH subunit [KO:K03142]
DFA_04918  gtf2h3; general transcription factor IIH [KO:K03143]
DFA_01523  gtf2h4; general transcription factor IIH [KO:K03144]
DFA_11908  hypothetical protein [KO:K10846]
DFA_11249  rfa1; putative ssDNA-binding protein [KO:K07466]
DFA_01831  ercc4; DNA excision repair protein 4 [KO:K10848] [EC:3.1.-.-]
DFA_11925  ercc1; DNA excision repair protein 1 [KO:K10849]
DFA_11259  polD1; DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
DFA_00408  polD2; DNA polymerase delta subunit 2 [KO:K02328]
DFA_10336  hypothetical protein [KO:K03504]
DFA_07560  putative DNA polymerase epsilon subunit A [KO:K02324] [EC:2.7.7.7]
DFA_03758  putative DNA polymerase epsilon subunit B [KO:K02325] [EC:2.7.7.7]
DFA_10079  putative histone-like transcription factor [KO:K03506] [EC:2.7.7.7]
DFA_09637  pcna; proliferating cell nuclear antigen [KO:K04802]
DFA_01781  rfc1; replication factor C subunit [KO:K10754]
DFA_10865  rfc2; replication factor C subunit [KO:K10755]
DFA_02273  rfc4; replication factor C subunit [KO:K10755]
DFA_05360  rfc5; replication factor C subunit [KO:K10756]
DFA_09939  rfc3; replication factor C subunit [KO:K10756]
DFA_07246  lig1; DNA ligase I [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
Reference
PMID:11436314
  Authors
Sugasawa K.
  Title
[Molecular mechanism of mammalian nucleotide excision repair]
  Journal
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Reference
PMID:11436316
  Authors
Nakatsu Y.
  Title
[Transcription-coupled repair and Cockayne syndrome]
  Journal
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Reference
PMID:11436323
  Authors
Nakagawa N, Masui R, Kuramitsu S.
  Title
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8]
  Journal
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Reference
PMID:17276014
  Authors
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
  Title
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
  Journal
Neuroscience 145:1388-96 (2007)
DOI:10.1016/j.neuroscience.2006.12.020
Reference
PMID:17884153
  Authors
Saldivar JS, Wu X, Follen M, Gershenson D.
  Title
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
  Journal
Gynecol Oncol 107:S56-71 (2007)
DOI:10.1016/j.ygyno.2007.07.043
Reference
PMID:16922398
  Authors
Sugasawa K.
  Title
[DNA repair pathways involving Cul4A ubiquitin ligases]
  Journal
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Reference
PMID:18018633
  Authors
Ito S, Ando D, Tanaka K.
  Title
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders]
  Journal
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
Related
pathway
dfa03020  RNA polymerase
dfa04120  Ubiquitin mediated proteolysis
KO pathway
ko03420   
LinkDB

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