KEGG   PATHWAY: dnx04141
Entry
dnx04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Diuraphis noxia (Russian wheat aphid)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
dnx04141  Protein processing in endoplasmic reticulum
dnx04141

Other DBs
GO: 0030433 0034976
Organism
Diuraphis noxia (Russian wheat aphid) [GN:dnx]
Gene
107173078  protein transport protein Sec61 subunit alpha isoform 2 [KO:K10956]
107170995  protein transport protein Sec61 subunit beta [KO:K09481]
107167267  protein transport protein Sec61 subunit gamma [KO:K07342]
107164786  translocation protein SEC62 [KO:K12275]
107166983  translocation protein SEC63 homolog [KO:K09540]
107168696  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 [KO:K12666]
107167423  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [KO:K12667]
107172907  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
107164794  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
107163007  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
107168201  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
107164275  tumor suppressor candidate 3 [KO:K19478]
107162418  oligosaccharyltransferase complex subunit ostc-A [KO:K26501]
107161901  transmembrane protein 258 [KO:K26502]
107161371  alpha-glucosidase 2 [KO:K01228] [EC:3.2.1.106]
107167232  nucleotide exchange factor SIL1 isoform X1 [KO:K14001]
107163426  hypoxia up-regulated protein 1 [KO:K09486]
107166789  heat shock 70 kDa protein cognate 3 [KO:K09490] [EC:3.6.4.10]
107161364  dnaJ homolog subfamily B member 11 [KO:K09517]
107166128  dnaJ homolog subfamily C member 1 [KO:K09521]
107164696  dnaJ homolog subfamily C member 3-like [KO:K09523]
107173598  endoplasmin homolog [KO:K09487]
107172222  neutral alpha-glucosidase AB [KO:K05546] [EC:3.2.1.207]
107171574  glucosidase 2 subunit beta-like [KO:K08288]
107173933  glucosidase 2 subunit beta-like [KO:K08288]
107169105  glucosidase 2 subunit beta-like [KO:K08288]
107165491  calnexin-like [KO:K08054]
107164732  protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
107173458  calreticulin [KO:K08057]
107168850  mannosyl-oligosaccharide alpha-1,2-mannosidase IA-like [KO:K01230] [EC:3.2.1.113]
107171166  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase [KO:K23741] [EC:3.2.1.209]
107173853  VIP36-like protein [KO:K10082]
107165024  protein ERGIC-53-like [KO:K10080]
107170155  prolactin regulatory element-binding protein [KO:K14003]
107170877  GTP-binding protein SAR1b-like isoform X1 [KO:K07953] [EC:3.6.5.-]
107170514  GTP-binding protein SAR1b-like [KO:K07953] [EC:3.6.5.-]
107163120  protein SEC13 homolog [KO:K14004]
107171497  protein SEC13 homolog [KO:K14004]
107170196  protein transport protein Sec31A [KO:K14005]
107162252  protein transport protein Sec23A [KO:K14006]
107173698  protein transport protein Sec24B-like [KO:K14007]
107173704  protein transport protein Sec24D [KO:K14007]
107168733  UDP-glucose:glycoprotein glucosyltransferase 1 [KO:K11718] [EC:2.4.1.-]
107168053  ER degradation-enhancing alpha-mannosidase-like protein 2 isoform X1 [KO:K10085]
107162878  ER degradation-enhancing alpha-mannosidase-like protein 3 [KO:K10086]
107168637  protein disulfide-isomerase [KO:K09580] [EC:5.3.4.1]
107162468  protein disulfide-isomerase A6 [KO:K09584] [EC:5.3.4.1]
107166346  endoplasmic reticulum resident protein 29 [KO:K09586]
107167620  ero1-like protein [KO:K10950] [EC:1.8.4.-]
107173034  endoplasmic reticulum lectin 1 isoform X1 [KO:K14008]
107163494  translocon-associated protein subunit alpha [KO:K13249]
107171195  translocon-associated protein subunit beta [KO:K13250]
107167405  translocon-associated protein subunit delta [KO:K04571]
107173309  B-cell receptor-associated protein 31 [KO:K14009]
107166692  translocating chain-associated membrane protein 1 [KO:K14010]
107166195  derlin-1 isoform X1 [KO:K11519]
107174078  derlin-2 [KO:K13989]
107168924  UBX domain-containing protein 1 [KO:K24348]
107166390  UBX domain-containing protein 6 [KO:K14011]
107168280  NSFL1 cofactor p47 [KO:K14012]
107163295  uncharacterized protein LOC107163295 isoform X1 [KO:K14014]
107162868  transitional endoplasmic reticulum ATPase TER94 [KO:K13525]
107167161  nuclear protein localization protein 4 homolog isoform X1 [KO:K14015]
107165622  ubiquitin fusion degradation protein 1 homolog [KO:K14016]
107164919  ubiquitin fusion degradation protein 1 homolog [KO:K14016]
107168869  heat shock protein 68-like [KO:K03283]
107167443  heat shock protein 70 B2-like [KO:K03283]
107163650  heat shock protein 70 A1-like [KO:K03283]
107167510  heat shock protein 70 A1-like [KO:K03283]
107169808  heat shock protein 68-like [KO:K03283]
107163583  heat shock 70 kDa protein cognate 4-like [KO:K03283]
107172656  heat shock protein 70 B2-like [KO:K03283]
107163219  heat shock 70 kDa protein cognate 4 [KO:K03283]
107168289  dnaJ homolog subfamily A member 1 [KO:K09502]
107171964  dnaJ protein homolog 1-like [KO:K09507]
107173729  dnaJ homolog subfamily B member 12-like [KO:K09518]
107166880  dnAJ-like protein slr0093 [KO:K09525]
107167047  heat shock protein 83 [KO:K04079]
107165861  heat shock 70 kDa protein 4 [KO:K09485]
107161679  BAG family molecular chaperone regulator 2 [KO:K09556]
107167177  uncharacterized protein LOC107167177 [KO:K09562]
107172057  protein lethal(2)essential for life-like [KO:K09542]
107164980  ubiquitin thioesterase OTU1 [KO:K13719] [EC:3.1.2.-]
107173175  phospholipase A-2-activating protein [KO:K14018]
107172329  UV excision repair protein RAD23 homolog B [KO:K10839]
107164246  ubiquilin-1 [KO:K04523]
107164692  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase [KO:K01456] [EC:3.5.1.52]
107161415  ubiquitin conjugation factor E4 B [KO:K10597] [EC:2.3.2.27]
107173884  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
107161833  activating transcription factor of chaperone [KO:K04374]
107164925  cyclic AMP-dependent transcription factor ATF-6 alpha-like [KO:K09054]
107162103  wolframin [KO:K14020]
107165716  membrane-bound transcription factor site-1 protease [KO:K08653] [EC:3.4.21.112]
107166620  membrane-bound transcription factor site-2 protease [KO:K07765] [EC:3.4.24.85]
107170585  X-box-binding protein 1 [KO:K09027]
107162936  serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
107163715  mitogen-activated protein kinase kinase kinase 15 isoform X1 [KO:K04426] [EC:2.7.11.25]
107167783  dual specificity mitogen-activated protein kinase kinase 7-like [KO:K04431] [EC:2.7.12.2]
107172095  stress-activated protein kinase JNK isoform X1 [KO:K04440] [EC:2.7.11.24]
107161700  E3 ubiquitin-protein ligase MARCH6 [KO:K10661] [EC:2.3.2.27]
107171666  ubiquitin-conjugating enzyme E2 J1-like [KO:K10578] [EC:2.3.2.23]
107173813  ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
107166030  ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
107167307  ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
107163888  E3 ubiquitin-protein ligase synoviolin A-like [KO:K10601] [EC:2.3.2.27]
107172497  E3 ubiquitin-protein ligase RNF185-like isoform X1 [KO:K10666] [EC:2.3.2.27]
107161575  selenoprotein S-like [KO:K14025]
107166720  protein sel-1 homolog 1 [KO:K14026]
107172847  E3 ubiquitin-protein ligase AMFR-like [KO:K10636] [EC:2.3.2.36]
107167348  STIP1 homology and U box-containing protein 1 [KO:K09561] [EC:2.3.2.27]
107165406  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
107171531  E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
107162314  RING-box protein 1A [KO:K03868] [EC:2.3.2.32]
107161275  S-phase kinase-associated protein 1 [KO:K03094]
107162830  F-box only protein 17-like [KO:K10100]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
dnx00510  N-Glycan biosynthesis
dnx03050  Proteasome
dnx03060  Protein export
KO pathway
ko04141   
LinkDB

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