KEGG   PATHWAY: dpo04142
Entry
dpo04142                    Pathway                                
Name
Lysosome - Drosophila pseudoobscura
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
dpo04142  Lysosome
dpo04142

Other DBs
GO: 0005764
Organism
Drosophila pseudoobscura [GN:dpo]
Gene
4804061  V-type proton ATPase 116 kDa subunit a [KO:K02154]
4816825  V-type proton ATPase 116 kDa subunit a [KO:K02154]
4801161  V-type proton ATPase 116 kDa subunit a isoform X3 [KO:K02154]
4801443  V-type proton ATPase 116 kDa subunit a [KO:K02154]
4801449  V-type proton ATPase 116 kDa subunit a [KO:K02154]
4814484  V-type proton ATPase subunit d 1 [KO:K02146]
4801237  probable V-type proton ATPase subunit d 2 [KO:K02146]
4816883  V-type proton ATPase subunit H isoform X1 [KO:K02144]
4804501  V-type proton ATPase subunit S1 [KO:K03662]
4804185  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
4805581  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
6903460  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
6897737  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
6897738  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
117183165  V-type proton ATPase 16 kDa proteolipid subunit-like [KO:K02155]
6897582  V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
4802391  V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
4814631  dmX-like protein 2 isoform X2 [KO:K24155]
4814852  WD repeat-containing protein 7 [KO:K24738]
6897619  oxidation resistance protein 1 isoform X14 [KO:K25442]
4815015  cathepsin B [KO:K01363] [EC:3.4.22.1]
4803632  lysosomal aspartic protease [KO:K01379] [EC:3.4.23.5]
4803883  lysosomal aspartic protease [KO:K01379] [EC:3.4.23.5]
6903379  lysosomal aspartic protease [KO:K01379] [EC:3.4.23.5]
4816769  lysosomal aspartic protease [KO:K01379] [EC:3.4.23.5]
6901404  lysosomal aspartic protease [KO:K01379] [EC:3.4.23.5]
4817634  cathepsin E [KO:K01379] [EC:3.4.23.5]
4817635  lysosomal aspartic protease [KO:K01379] [EC:3.4.23.5]
4817636  aspartic proteinase A3 [KO:K01379] [EC:3.4.23.5]
4817637  aspartic proteinase A1 [KO:K01379] [EC:3.4.23.5]
4801202  lysosomal aspartic protease [KO:K01379] [EC:3.4.23.5]
4801203  pepsin-2B [KO:K01379] [EC:3.4.23.5]
4801204  lysosomal aspartic protease [KO:K01379] [EC:3.4.23.5]
6902149  cathepsin E-B [KO:K01382] [EC:3.4.23.34]
6897624  putative cysteine proteinase CG12163 isoform X1 [KO:K01373] [EC:3.4.22.41]
4805156  zingipain-2 [KO:K01365] [EC:3.4.22.15]
4805308  cathepsin L [KO:K01365] [EC:3.4.22.15]
6900459  cathepsin L1 [KO:K01365] [EC:3.4.22.15]
6900590  cathepsin L [KO:K01365] [EC:3.4.22.15]
6898806  cathepsin L1 [KO:K01365] [EC:3.4.22.15]
6903333  beta-galactosidase [KO:K12309] [EC:3.2.1.23]
4802587  beta-galactosidase isoform X1 [KO:K12309] [EC:3.2.1.23]
6896819  lysosomal acid glucosylceramidase [KO:K01201] [EC:3.2.1.45]
4800570  lysosomal acid glucosylceramidase [KO:K01201] [EC:3.2.1.45]
4817324  alpha-L-iduronidase [KO:K01217] [EC:3.2.1.76]
6903316  alpha-N-acetylgalactosaminidase isoform X1 [KO:K01204] [EC:3.2.1.49]
4818063  alpha-N-acetylglucosaminidase [KO:K01205] [EC:3.2.1.50]
6899124  LOW QUALITY PROTEIN: beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
4805742  beta-glucuronidase isoform X2 [KO:K01195] [EC:3.2.1.31]
6900755  putative alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
4812023  chitooligosaccharidolytic beta-N-acetylglucosaminidase [KO:K12373] [EC:3.2.1.52]
4814710  chitooligosaccharidolytic beta-N-acetylglucosaminidase isoform X2 [KO:K12373] [EC:3.2.1.52]
6901564  chitooligosaccharidolytic beta-N-acetylglucosaminidase [KO:K12373] [EC:3.2.1.52]
4802775  beta-mannosidase [KO:K01192] [EC:3.2.1.25]
6897782  beta-mannosidase [KO:K01192] [EC:3.2.1.25]
26532411  lysosomal alpha-mannosidase isoform X1 [KO:K12311] [EC:3.2.1.24]
6899312  lysosomal alpha-mannosidase [KO:K12311] [EC:3.2.1.24]
6902369  lysosomal alpha-mannosidase [KO:K12311] [EC:3.2.1.24]
6902370  lysosomal alpha-mannosidase [KO:K12311] [EC:3.2.1.24]
6902371  lysosomal alpha-mannosidase [KO:K12311] [EC:3.2.1.24]
117183164  lysosomal alpha-mannosidase [KO:K12311] [EC:3.2.1.24]
4803380  arylsulfatase B [KO:K01135] [EC:3.1.6.12]
6900794  arylsulfatase B [KO:K01135] [EC:3.1.6.12]
6898764  N-acetylglucosamine-6-sulfatase isoform X2 [KO:K01137] [EC:3.1.6.14]
4812223  iduronate 2-sulfatase [KO:K01136] [EC:3.1.6.13]
4801831  N-sulphoglucosamine sulphohydrolase [KO:K01565] [EC:3.10.1.1]
4804008  lipase 3 [KO:K01052] [EC:3.1.1.13]
4805627  lipase 3 [KO:K01052] [EC:3.1.1.13]
6902874  lipase 1 [KO:K01052] [EC:3.1.1.13]
4816673  lipase 3 isoform X1 [KO:K01052] [EC:3.1.1.13]
6904092  lipase 3 isoform X1 [KO:K01052] [EC:3.1.1.13]
4800879  lipase 3 isoform X1 [KO:K01052] [EC:3.1.1.13]
4801270  lipase 3 [KO:K01052] [EC:3.1.1.13]
26534034  lipase 1 [KO:K01052] [EC:3.1.1.13]
4816647  group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
4803163  plancitoxin-1 [KO:K01158] [EC:3.1.22.1]
6896711  prostatic acid phosphatase isoform X2 [KO:K14410] [EC:3.1.3.2]
4800977  lysosomal acid phosphatase [KO:K14410] [EC:3.1.3.2]
4800390  sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
4805622  sphingomyelin phosphodiesterase isoform X1 [KO:K12350] [EC:3.1.4.12]
4800389  sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
4805115  putative N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase GA14866 [KO:K01444] [EC:3.5.1.26]
4805250  L-asparaginase-like protein GA18140 [KO:K01444] [EC:3.5.1.26]
4800324  prosaposin [KO:K12382]
4815256  palmitoyl-protein thioesterase 1 [KO:K01074] [EC:3.1.2.22]
4817466  lysosomal thioesterase PPT2 homolog [KO:K01074] [EC:3.1.2.22]
26534458  uncharacterized protein LOC26534458 isoform X1 [KO:K06497]
4803452  23 kDa integral membrane protein [KO:K06497]
5495518  23 kDa integral membrane protein [KO:K06497]
4803454  CD63 antigen [KO:K06497]
4803455  23 kDa integral membrane protein [KO:K06497]
4803456  23 kDa integral membrane protein [KO:K06497]
4805020  CD63 antigen [KO:K06497]
4816167  CD63 antigen [KO:K06497]
4816582  CD63 antigen [KO:K06497]
4814554  NPC intracellular cholesterol transporter 1 homolog 1b [KO:K12385]
4817531  NPC intracellular cholesterol transporter 2 homolog a [KO:K13443]
4800310  MD-2-related lipid-recognition protein [KO:K13443]
4800771  uncharacterized protein LOC4800771 [KO:K13443]
4800772  mite group 2 allergen Lep d 2 [KO:K13443]
4800773  NPC intracellular cholesterol transporter 2 homolog a [KO:K13443]
4801640  ecdysteroid-regulated 16 kDa protein [KO:K13443]
4801774  NPC intracellular cholesterol transporter 2 isoform X2 [KO:K13443]
6896960  cystinosin homolog isoform X2 [KO:K12386]
4803621  putative inorganic phosphate cotransporter isoform X1 [KO:K12301]
4803737  putative inorganic phosphate cotransporter isoform X1 [KO:K12301]
4803861  putative inorganic phosphate cotransporter [KO:K12301]
4805004  putative inorganic phosphate cotransporter isoform X2 [KO:K12301]
4805685  putative inorganic phosphate cotransporter isoform X2 [KO:K12301]
6897352  putative inorganic phosphate cotransporter isoform X1 [KO:K12301]
6898212  putative inorganic phosphate cotransporter [KO:K12301]
6898660  putative inorganic phosphate cotransporter isoform X1 [KO:K12301]
4814735  putative inorganic phosphate cotransporter [KO:K12301]
4803299  protein Malvolio isoform X1 [KO:K21398]
4805068  uncharacterized protein LOC4805068 isoform X1 [KO:K12387]
4812342  LOW QUALITY PROTEIN: sialomucin core protein 24 [KO:K06546]
4813185  battenin [KO:K12389]
6900083  major facilitator superfamily domain-containing protein 8 isoform X1 [KO:K12307]
4814666  heparan-alpha-glucosaminide N-acetyltransferase [KO:K10532] [EC:2.3.1.78]
6899959  formylglycine-generating enzyme [KO:K13444] [EC:1.8.3.7]
4804592  N-acetylglucosamine-1-phosphotransferase subunits alpha/beta [KO:K08239] [EC:2.7.8.17]
4800748  cation-independent mannose-6-phosphate receptor isoform X2 [KO:K06564]
4811773  clathrin heavy chain [KO:K04646]
6901560  AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
4814861  AP-1 complex subunit beta-1 [KO:K12392]
4802699  AP-1 complex subunit mu-1 [KO:K12393]
4801745  AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
4814676  AP-3 complex subunit delta isoform X1 [KO:K12396]
4815503  AP-3 complex subunit beta-2 [KO:K12397]
4814604  AP-3 complex subunit mu-2 [KO:K12398]
4804283  AP-3 complex subunit sigma-2 [KO:K12399]
4815251  ADP-ribosylation factor-binding protein GGA1 isoform X2 [KO:K12404]
4803831  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
4803832  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
4803833  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
4803834  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
4803835  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
4812167  cell death-inducing p53-target protein 1 [KO:K19363]
6898258  cell death-inducing p53-target protein 1 homolog [KO:K19363]
6898260  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
6898261  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
6898259  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8
Related
pathway
dpo00511  Other glycan degradation
dpo00531  Glycosaminoglycan degradation
dpo04130  SNARE interactions in vesicular transport
dpo04140  Autophagy - animal
dpo04144  Endocytosis
KO pathway
ko04142   
LinkDB

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