KEGG PATHWAY: dsi04392

PATHWAY: dsi04392

Entry

dsi04392                    Pathway

Name

Hippo signaling pathway - multiple species - Drosophila simulans

Description

Hippo signaling pathways control diverse aspects of cell proliferation, survival, and morphogenesis in eukaryotes. The core organization of these networks is conserved over a billion years of evolution, with related forms described in animals and fungi. In Drosophila and mammals, Hippo/MST co-operate with Mats/Mob1 and Salvador/WW45 to activate Warts/LATS, which negatively regulates Yorkie/YAP. Yorkie/YAP interact with Scalloped/TEAD to promote gene transcriptions and control organ size through the balance between cell proliferation and apoptosis. In C. elegans, WTS-1 YAP-1 EGL-44 axis is conserved and regulates thermotolerance and healthy lifespan. In S. cerevisiae, the LATS-related Dbf2 or Dbf20 kinase in complex with Mob1 controls mitotic exit and cytokinesis, and the Hippo/MST family of kinases, STE-20, modulates Tec1, the putative yeast TEAD ortholog.

Class

Environmental Information Processing; Signal transduction

Pathway map

dsi04392

Hippo signaling pathway - multiple species

Other DBs

GO:

0035329

Organism

Drosophila simulans [GN:dsi]

Gene

Dsimw501_GD22944

Dsim_GD22944; uncharacterized protein [KO:K16507]

Dsimw501_GD22718

Dsim_GD22718; uncharacterized protein [KO:K16669]

Dsimw501_GD16644

Dsim_GD16644; uncharacterized protein, isoform C [KO:K08960] [EC:2.7.11.1]

Dsimw501_GD28279

Dsim_GD28279; uncharacterized protein [KO:K16684]

Dsimw501_GD20405

Dsim_GD20405; uncharacterized protein [KO:K16685]

Dsimw501_GD25317

Dsim_GD25317; uncharacterized protein [KO:K04412]

Dsimw501_GD18409

Dsim_GD18409; uncharacterized protein, isoform B [KO:K16686]

Dsimw501_GD16829

Dsim_GD16829; uncharacterized protein [KO:K08791] [EC:2.7.11.1]

Dsimw501_GD20949

Dsim_GD20949; uncharacterized protein [KO:K06685]

Dsimw501_GD27872

Dsim_GD27872; uncharacterized protein [KO:K16682]

Dsimw501_GD24973

Dsim_GD24973; uncharacterized protein, isoform C [KO:K16687]

Dsimw501_GD24822

Dsim_GD24822; uncharacterized protein, isoform P [KO:K09448]

Dsimw501_GD23026

Dsim_GD23026; uncharacterized protein [KO:K16683]

Dsimw501_GD18406

Dsim_GD18406; uncharacterized protein [KO:K09851]

Dsimw501_GD19869

Dsim_GD19869; uncharacterized protein, isoform C [KO:K04409] [EC:2.7.11.1]

Dsimw501_GD20287

Dsim_GD20287; uncharacterized protein [KO:K04409] [EC:2.7.11.1]

Reference

PMID:21415026

Authors

Hilman D, Gat U

Title

The evolutionary history of YAP and the hippo/YAP pathway.

Journal

Mol Biol Evol 28:2403-17 (2011)
DOI:10.1093/molbev/msr065

Reference

PMID:24715453

Authors

Varelas X

Title

The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease.

Journal

Development 141:1614-26 (2014)
DOI:10.1242/dev.102376

Reference

PMID:21808241

Authors

Zhao B, Tumaneng K, Guan KL

Title

The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal.

Journal

Nat Cell Biol 13:877-83 (2011)
DOI:10.1038/ncb2303

Reference

PMID:21138973

Authors

Halder G, Johnson RL

Title

Hippo signaling: growth control and beyond.

Journal

Development 138:9-22 (2011)
DOI:10.1242/dev.045500

Reference

PMID:20951342

Authors

Pan D

Title

The hippo signaling pathway in development and cancer.

Journal

Dev Cell 19:491-505 (2010)
DOI:10.1016/j.devcel.2010.09.011

Reference

PMID:20439427

Authors

Zhao B, Li L, Lei Q, Guan KL

Title

The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version.

Journal

Genes Dev 24:862-74 (2010)
DOI:10.1101/gad.1909210

Reference

PMID:22830020

Authors

Fausti F, Di Agostino S, Sacconi A, Strano S, Blandino G

Title

Hippo and rassf1a Pathways: A Growing Affair.

Journal

Mol Biol Int 2012:307628 (2012)
DOI:10.1155/2012/307628

Reference

PMID:25966461

Authors

Gogl G, Schneider KD, Yeh BJ, Alam N, Nguyen Ba AN, Moses AM, Hetenyi C, Remenyi A, Weiss EL

Title

The Structure of an NDR/LATS Kinase-Mob Complex Reveals a Novel Kinase-Coactivator System and Substrate Docking Mechanism.

Journal

PLoS Biol 13:e1002146 (2015)
DOI:10.1371/journal.pbio.1002146

Reference

PMID:23396260

Authors

Iwasa H, Maimaiti S, Kuroyanagi H, Kawano S, Inami K, Timalsina S, Ikeda M, Nakagawa K, Hata Y

Title

Yes-associated protein homolog, YAP-1, is involved in the thermotolerance and aging in the nematode Caenorhabditis elegans.

Journal

Exp Cell Res 319:931-45 (2013)
DOI:10.1016/j.yexcr.2013.01.020

Reference

PMID:23843471

Authors

Yang Z, Hata Y

Title

What is the Hippo pathway? Is the Hippo pathway conserved in Caenorhabditis elegans?

Journal

J Biochem 154:207-9 (2013)
DOI:10.1093/jb/mvt060

Reference

PMID:24594661

Authors

Hotz M, Barral Y

Title

The Mitotic Exit Network: new turns on old pathways.

Journal

Trends Cell Biol 24:145-52 (2014)
DOI:10.1016/j.tcb.2013.09.010

Reference

PMID:23579499

Authors

Rock JM, Lim D, Stach L, Ogrodowicz RW, Keck JM, Jones MH, Wong CC, Yates JR 3rd, Winey M, Smerdon SJ, Yaffe MB, Amon A

Title

Activation of the yeast Hippo pathway by phosphorylation-dependent assembly of signaling complexes.

Journal

Science 340:871-5 (2013)
DOI:10.1126/science.1235822

Reference

PMID:22525225

Authors

Hergovich A, Hemmings BA

Title

Hippo signalling in the G2/M cell cycle phase: lessons learned from the yeast MEN and SIN pathways.

Journal

Semin Cell Dev Biol 23:794-802 (2012)
DOI:10.1016/j.semcdb.2012.04.001

Reference

PMID:19826484

Authors

Wang Y, Abu Irqeba A, Ayalew M, Suntay K

Title

Sumoylation of transcription factor Tec1 regulates signaling of mitogen-activated protein kinase pathways in yeast.

Journal

PLoS One 4:e7456 (2009)
DOI:10.1371/journal.pone.0007456

Related
pathway

dsi04391

Hippo signaling pathway - fly

KO pathway

ko04392

LinkDB

DBGET integrated database retrieval system