Entry
Name
Allograft rejection - Equus caballus (horse)
Description
Allograft rejection is the consequence of the recipient's alloimmune response to nonself antigens expressed by donor tissues. After transplantation of organ allografts, there are two pathways of antigen presentation. In the direct pathway, recipient T cells react to intact allogeneic MHC molecules expressed on the surface of donor cells. This pathway would activate host CD4 or CD8 T cells. In contrast, donor MHC molecules (and all other proteins) shed from the graft can be taken up by host APCs and presented to recipient T cells in the context of self-MHC molecules - the indirect pathway. Such presentation activates predominantly CD4 T cells. A direct cytotoxic T-cell attack on graft cells can be made only by T cells that recognize the graft MHC molecules directly. Nontheless, T cells with indirect allospecificity can contribute to graft rejection by activating macrophages, which cause tissue injury and fibrosis, and are also likely to be important in the development of an alloantibody response to graft.
Class
Human Diseases; Immune disease
BRITE hierarchy
Pathway map
Ortholog table
Organism
Equus caballus (horse) [GN:
ecb ]
Gene
100054114 HLA class I histocompatibility antigen, alpha chain G isoform X1 [KO:K06751 ]
100051657 7-51 putative nonclassical MHC class I antigen precursor [KO:K06751 ]
100057920 HLA class I histocompatibility antigen, Cw-12 alpha chain isoform X2 [KO:K06751 ]
100056182 HLA class I histocompatibility antigen, B-40 alpha chain isoform X1 [KO:K06751 ]
100049798 class I histocompatibility antigen, Gogo-OKO alpha chain isoform X12 [KO:K06751 ]
100050473 class I histocompatibility antigen, Gogo-B*0103 alpha chain isoform X1 [KO:K06751 ]
100050706 saoe class I histocompatibility antigen, A alpha chain isoform X1 [KO:K06751 ]
100053918 HLA class I histocompatibility antigen, B-46 alpha chain isoform X2 [KO:K06751 ]
100054397 saoe class I histocompatibility antigen, A alpha chain [KO:K06751 ]
100054448 HLA class I histocompatibility antigen, alpha chain G isoform X3 [KO:K06751 ]
100056309 HLA class I histocompatibility antigen, B-15 alpha chain-like [KO:K06751 ]
100056099 HLA class I histocompatibility antigen, alpha chain G isoform X1 [KO:K06751 ]
100056231 saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751 ]
100059994 HLA class I histocompatibility antigen, B-15 alpha chain isoform X1 [KO:K06751 ]
100060096 H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751 ]
100060767 CD86; T-lymphocyte activation antigen CD86 isoform X5 [KO:K05413 ]
100052326 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
100071639 FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390 ]
100061035 HLA class II histocompatibility antigen, DM alpha chain-like precursor [KO:K06752 ]
100060770 HLA class II histocompatibility antigen, DO beta chain isoform X1 [KO:K06752 ]
100061127 HLA class II histocompatibility antigen, DO alpha chain [KO:K06752 ]
100060996 HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752 ]
100060531 HLA class II histocompatibility antigen, DQ beta 2 chain isoform X1 [KO:K06752 ]
111767457 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
100060697 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
100034049 CD40; tumor necrosis factor receptor superfamily member 5 precursor [KO:K03160 ]
Compound
Reference
Authors
Arakelov A, Lakkis FG.
Title
The alloimmune response and effector mechanisms of allograft rejection.
Journal
Semin Nephrol 20:95-102 (2000)
Reference
Authors
Le Moine A, Goldman M, Abramowicz D.
Title
Multiple pathways to allograft rejection.
Journal
Reference
Authors
Trivedi HL.
Title
Immunobiology of rejection and adaptation.
Journal
Reference
Authors
Pietra BA.
Title
Transplantation immunology 2003: simplified approach.
Journal
Reference
Authors
Oka T, Yoshimura N.
Title
Immunosuppression in organ transplantation.
Journal
Reference
Authors
Sayegh MH.
Title
Why do we reject a graft? Role of indirect allorecognition in graft rejection.
Journal
Reference
Authors
Benichou G.
Title
Direct and indirect antigen recognition: the pathways to allograft immune rejection.
Journal
Reference
Authors
Turvey SE, Wood KJ.
Title
Immunobiology of solid organ transplantation.
Journal
Int Surg 84:279-90 (1999)
Reference
Authors
Janeway CA, Travers P, Walport M, Shlomchik MJ.
Title
Immunobiology 6th edition
Journal
Garland Science Publishing (2005)
Reference
Authors
Game DS, Lechler RI.
Title
Pathways of allorecognition: implications for transplantation tolerance.
Journal
Reference
Authors
Lechler RI, Garden OA, Turka LA.
Title
The complementary roles of deletion and regulation in transplantation tolerance.
Journal
Related pathway
ecb04610 Complement and coagulation cascades
ecb04612 Antigen processing and presentation
ecb04660 T cell receptor signaling pathway
ecb04662 B cell receptor signaling pathway
KO pathway
LinkDB
All DBs