KEGG   PATHWAY: equ03440
Entry
equ03440                    Pathway                                
Name
Homologous recombination - Enterobacter quasiroggenkampii
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
equ03440  Homologous recombination
equ03440

Other DBs
GO: 0000724
Organism
Enterobacter quasiroggenkampii [GN:equ]
Gene
OM418_18170  recJ; single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
OM418_01545  ssb1; single-stranded DNA-binding protein SSB1 [KO:K03111]
OM418_00015  recF; DNA replication/repair protein RecF [KO:K03629]
OM418_16575  recO; DNA repair protein RecO [KO:K03584]
OM418_05040  recR; recombination mediator RecR [KO:K06187]
OM418_17195  recA; recombinase RecA [KO:K03553]
OM418_22015  polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
OM418_13385  ruvA; Holliday junction branch migration protein RuvA [KO:K03550]
OM418_13380  ruvB; Holliday junction branch migration DNA helicase RuvB [KO:K03551] [EC:5.6.2.4]
OM418_13390  ruvC; crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.21.10]
OM418_00400  recG; ATP-dependent DNA helicase RecG [KO:K03655] [EC:5.6.2.4]
OM418_17730  recB; exodeoxyribonuclease V subunit beta [KO:K03582] [EC:3.1.11.5]
OM418_17740  recC; exodeoxyribonuclease V subunit gamma [KO:K03583] [EC:3.1.11.5]
OM418_17725  recD; exodeoxyribonuclease V subunit alpha [KO:K03581] [EC:3.1.11.5]
OM418_04020  dnaE; DNA polymerase III subunit alpha [KO:K02337] [EC:2.7.7.7]
OM418_00010  dnaN; DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
OM418_05030  dnaX; DNA polymerase III subunit gamma/tau [KO:K02343] [EC:2.7.7.7]
OM418_05870  holA; DNA polymerase III subunit delta [KO:K02340] [EC:2.7.7.7]
OM418_08285  holB; DNA polymerase III subunit delta' [KO:K02341] [EC:2.7.7.7]
OM418_04180  dnaQ; DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
OM418_13300  DNA polymerase III subunit theta [KO:K02345] [EC:2.7.7.7]
OM418_19835  holC; DNA polymerase III subunit chi [KO:K02339] [EC:2.7.7.7]
OM418_03035  DNA polymerase III subunit psi [KO:K02344] [EC:2.7.7.7]
OM418_21710  priA; primosomal protein N' [KO:K04066] [EC:5.6.2.4]
OM418_02155  priB; primosomal replication protein N [KO:K02686]
OM418_05015  priC; primosomal replication protein N'' [KO:K04067]
OM418_02950  dnaT; primosomal protein DnaT [KO:K02317]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   
LinkDB

DBGET integrated database retrieval system