KEGG   PATHWAY: fve03040
Entry
fve03040                    Pathway                                
Name
Spliceosome - Fragaria vesca (woodland strawberry)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
fve03040  Spliceosome
fve03040

Other DBs
GO: 0005681
Organism
Fragaria vesca (woodland strawberry) [GN:fve]
Gene
101298779  DEAD-box ATP-dependent RNA helicase 42-like [KO:K12811] [EC:5.6.2.7]
101315225  DEAD-box ATP-dependent RNA helicase 42-like [KO:K12811] [EC:5.6.2.7]
101313517  DEAD-box ATP-dependent RNA helicase 42 [KO:K12811] [EC:5.6.2.7]
101311935  DEAD-box ATP-dependent RNA helicase 56 [KO:K12812] [EC:5.6.2.7]
101301987  DEAD-box ATP-dependent RNA helicase 56-like [KO:K12812] [EC:5.6.2.7]
101306750  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [KO:K12813] [EC:5.6.2.6]
101309405  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [KO:K12813] [EC:5.6.2.6]
101293201  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [KO:K12813] [EC:5.6.2.6]
101292001  pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16-like [KO:K12815] [EC:5.6.2.6]
101304062  pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 [KO:K12815] [EC:5.6.2.6]
101309148  pre-mRNA-processing factor 17 [KO:K12816]
101298561  pre-mRNA-splicing factor 18 [KO:K12817]
101308273  probable pre-mRNA-splicing factor ATP-dependent RNA helicase [KO:K12818] [EC:5.6.2.6]
101298073  putative uncharacterized protein At4g01020, chloroplastic [KO:K12818] [EC:5.6.2.6]
101314555  probable pre-mRNA-splicing factor ATP-dependent RNA helicase [KO:K12818] [EC:5.6.2.6]
101307880  putative ATP-dependent RNA helicase DHX33 [KO:K12818] [EC:5.6.2.6]
101302977  probable pre-mRNA-splicing factor ATP-dependent RNA helicase [KO:K12818] [EC:5.6.2.6]
101301748  putative pre-mRNA-splicing factor ATP-dependent RNA helicase PRP1 [KO:K12818] [EC:5.6.2.6]
101310655  pre-mRNA-splicing factor SLU7-A-like [KO:K12819]
101293207  pre-mRNA-splicing factor SLU7-A-like [KO:K12819]
101308806  probable pre-mRNA-splicing factor ATP-dependent RNA helicase [KO:K12820] [EC:5.6.2.6]
101311940  probable pre-mRNA-splicing factor ATP-dependent RNA helicase [KO:K12820] [EC:5.6.2.6]
101313018  small nuclear ribonucleoprotein-associated protein B' [KO:K11086]
101293740  small nuclear ribonucleoprotein Sm D1-like [KO:K11087]
101304384  probable small nuclear ribonucleoprotein Sm D2 [KO:K11096]
101298321  probable small nuclear ribonucleoprotein Sm D2 [KO:K11096]
101312019  small nuclear ribonucleoprotein Sm D3-like [KO:K11088]
101312052  small nuclear ribonucleoprotein E [KO:K11097]
101293407  small nuclear ribonucleoprotein E-like [KO:K11097]
101313167  probable small nuclear ribonucleoprotein F [KO:K11098]
101314090  probable small nuclear ribonucleoprotein F [KO:K11098]
101300834  probable small nuclear ribonucleoprotein G [KO:K11099]
101304805  U1 small nuclear ribonucleoprotein 70 kDa [KO:K11093]
101310568  U1 small nuclear ribonucleoprotein A [KO:K11091]
101308531  U1 small nuclear ribonucleoprotein C [KO:K11095]
101302708  pre-mRNA-processing protein 40A-like [KO:K12821]
101299552  pre-mRNA-processing protein 40A [KO:K12821]
101309725  RNA-binding protein 25-like [KO:K12822]
101300800  DEAD-box ATP-dependent RNA helicase 14-like [KO:K12823] [EC:5.6.2.7]
101310702  DEAD-box ATP-dependent RNA helicase 20 [KO:K12823] [EC:5.6.2.7]
101297138  DEAD-box ATP-dependent RNA helicase 20 [KO:K12823] [EC:5.6.2.7]
101299472  DEAD-box ATP-dependent RNA helicase 40 [KO:K12823] [EC:5.6.2.7]
101299689  DEAD-box ATP-dependent RNA helicase 14 [KO:K12823] [EC:5.6.2.7]
101293860  DEAD-box ATP-dependent RNA helicase 52A-like [KO:K12823] [EC:5.6.2.7]
101296284  pre-mRNA-processing protein 40C [KO:K12824]
101310877  transcription initiation factor TFIID subunit 15b [KO:K13098]
101310792  U2 small nuclear ribonucleoprotein A' [KO:K11092]
101304849  U2 small nuclear ribonucleoprotein B'' [KO:K11094]
101312546  probable splicing factor 3A subunit 1 [KO:K12825]
101315424  probable splicing factor 3A subunit 1 [KO:K12825]
101304789  splicing factor 3A subunit 2 [KO:K12826]
101293340  splicing factor 3A subunit 3-like [KO:K12827]
101302395  splicing factor 3A subunit 3-like [KO:K12827]
101300014  splicing factor 3B subunit 1 [KO:K12828]
101310199  splicing factor 3B subunit 1-like [KO:K12828]
101305920  splicing factor 3B subunit 2 [KO:K12829]
105352418  splicing factor 3B subunit 2-like [KO:K12829]
101302870  splicing factor 3B subunit 3-like [KO:K12830]
101294962  pre-mRNA-splicing factor prp12 [KO:K12830]
101306392  spliceosome-associated protein 49 [KO:K12831]
101310351  splicing factor 3B subunit 4 [KO:K12831]
101301935  uncharacterized LOC101301935 [KO:K12831]
101310875  uncharacterized protein At4g14342 [KO:K12832]
101307711  uncharacterized protein At4g14342-like [KO:K12832]
101311998  uncharacterized protein At4g14342 [KO:K12832]
101311749  splicing factor 3B subunit 6-like protein [KO:K12833]
101307381  PHD finger-like domain-containing protein 5B [KO:K12834]
101295483  PHD finger-like domain-containing protein 5B [KO:K12834]
101308191  PHD finger-like domain-containing protein 5B [KO:K12834]
101305407  DEAD-box ATP-dependent RNA helicase 24 [KO:K12835] [EC:5.6.2.7]
101300701  splicing factor U2af small subunit B-like [KO:K12836]
101309735  splicing factor U2af small subunit B [KO:K12836]
101307705  splicing factor U2af small subunit B-like [KO:K12836]
101309425  splicing factor U2af large subunit B-like [KO:K12837]
101298552  splicing factor U2af large subunit A-like [KO:K12837]
101307480  splicing factor U2af large subunit A [KO:K12837]
101311866  survival of motor neuron-related-splicing factor 30 [KO:K12839]
101309914  DNA-damage-repair/toleration protein DRT111, chloroplastic [KO:K12840]
101301841  U2 snRNP-associated SURP motif-containing protein [KO:K12842]
101310298  sm-like protein LSM2 [KO:K12621]
101296823  sm-like protein LSM3B [KO:K12622]
101304156  probable U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
101297956  sm-like protein LSM5 [KO:K12624]
101298245  sm-like protein LSM36B [KO:K12625]
101304272  sm-like protein LSM6A [KO:K12625]
101292154  sm-like protein LSM7 [KO:K12626]
101295366  sm-like protein LSM8 [KO:K12627]
101310070  U4/U6 small nuclear ribonucleoprotein Prp3 [KO:K12843]
101302671  U4/U6 small nuclear ribonucleoprotein PRP4-like protein [KO:K12662]
101297876  peptidyl-prolyl cis-trans isomerase CYP22 [KO:K09567] [EC:5.2.1.8]
101313550  U4/U6 small nuclear ribonucleoprotein Prp31 [KO:K12844]
101301807  NHP2-like protein 1 [KO:K12845]
101304270  U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846]
101313774  U4/U6.U5 tri-snRNP-associated protein 2-like [KO:K12847]
101308893  U4/U6.U5 tri-snRNP-associated protein 2-like [KO:K12847]
101304094  SART-1 family protein DOT2 [KO:K11984]
101291932  zinc finger matrin-type protein 2 [KO:K12848]
101296496  pre-mRNA-splicing factor 38 [KO:K12849]
101313313  pre-mRNA-splicing factor 38B [KO:K12850]
101294012  116 kDa U5 small nuclear ribonucleoprotein component-like [KO:K12852]
101310223  U5 small nuclear ribonucleoprotein 200 kDa helicase-like [KO:K12854] [EC:5.6.2.6]
101304404  U5 small nuclear ribonucleoprotein 200 kDa helicase-like [KO:K12854] [EC:5.6.2.6]
101290826  protein STABILIZED1-like [KO:K12855]
101293320  pre-mRNA-processing-splicing factor 8 [KO:K12856]
101313272  U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857]
101295385  DEAD-box ATP-dependent RNA helicase 21 [KO:K12858] [EC:5.6.2.7]
105350310  DEAD-box ATP-dependent RNA helicase 21-like [KO:K12858] [EC:5.6.2.7]
101306018  thioredoxin-like protein YLS8 [KO:K12859]
101312821  thioredoxin-like protein YLS8 [KO:K12859]
101314171  pre-mRNA-processing factor 19-like [KO:K10599] [EC:2.3.2.27]
101291540  cell division cycle 5-like protein [KO:K12860]
101313985  pre-mRNA-splicing factor SPF27 homolog [KO:K12861]
101312626  protein pleiotropic regulatory locus 1 [KO:K12862]
105349464  protein pleiotropic regulatory locus 1-like [KO:K12862]
101294868  protein CWC15 homolog [KO:K12863]
101297089  beta-catenin-like protein 1 [KO:K12864]
101304774  stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283]
101300979  probable mediator of RNA polymerase II transcription subunit 37e [KO:K03283]
101306205  heat shock cognate 70 kDa protein-like [KO:K03283]
101306495  heat shock 70 kDa protein II-like [KO:K03283]
101297476  heat shock cognate 70 kDa protein 2-like [KO:K03283]
101294000  heat shock 70 kDa protein [KO:K03283]
101303062  heat shock cognate 70 kDa protein-like [KO:K03283]
101292292  heat shock 70 kDa protein 18-like [KO:K03283]
101299993  stromal 70 kDa heat shock-related protein, chloroplastic-like [KO:K03283]
101313219  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
101312639  heat shock cognate 70 kDa protein-like [KO:K03283]
101312933  heat shock cognate 70 kDa protein-like [KO:K03283]
101311491  probable mediator of RNA polymerase II transcription subunit 37e [KO:K03283]
101305698  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
101314130  heat shock cognate 70 kDa protein-like [KO:K03283]
101295766  heat shock cognate 70 kDa protein-like [KO:K03283]
101314413  heat shock cognate 70 kDa protein-like [KO:K03283]
101296051  heat shock cognate 70 kDa protein-like [KO:K03283]
101314700  heat shock cognate 70 kDa protein-like [KO:K03283]
101296336  heat shock cognate 70 kDa protein-like [KO:K03283]
101296913  heat shock cognate 70 kDa protein-like [KO:K03283]
101296621  heat shock cognate 70 kDa protein-like [KO:K03283]
101297200  heat shock cognate 70 kDa protein-like [KO:K03283]
101297494  heat shock cognate 70 kDa protein-like [KO:K03283]
101298080  heat shock cognate 70 kDa protein-like [KO:K03283]
101315281  heat shock cognate 70 kDa protein-like [KO:K03283]
101314994  heat shock cognate 70 kDa protein-like [KO:K03283]
105349265  heat shock cognate 70 kDa protein-like [KO:K03283]
101298665  heat shock 70 kDa protein II-like [KO:K03283]
101298953  heat shock cognate 70 kDa protein-like [KO:K03283]
101299825  heat shock cognate 70 kDa protein-like [KO:K03283]
101291093  heat shock cognate 70 kDa protein 2 [KO:K03283]
101291669  heat shock cognate 70 kDa protein 2-like [KO:K03283]
101295529  heat shock cognate 70 kDa protein 1-like [KO:K03283]
101310620  heat shock cognate 70 kDa protein-like [KO:K03283]
101297761  heat shock cognate 70 kDa protein-like [KO:K03283]
101310329  heat shock cognate 70 kDa protein-like [KO:K03283]
101294324  polyglutamine-binding protein 1 [KO:K12865]
101292337  SNW/SKI-interacting protein [KO:K06063]
101308548  pre-mRNA-splicing factor SYF1 [KO:K12867]
101313947  pre-mRNA-splicing factor syf2 [KO:K12868]
101291323  crooked neck-like protein 1 [KO:K12869]
101307301  crooked neck-like protein 1 [KO:K12869]
101315138  pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
101295058  peptidyl-prolyl cis-trans isomerase CYP18-2 [KO:K12733] [EC:5.2.1.8]
101309154  coiled-coil domain-containing protein 12 [KO:K12871]
105350766  coiled-coil domain-containing protein 12-like [KO:K12871]
101292690  zinc finger CCCH domain-containing protein 40-like [KO:K12872]
101301118  protein BUD31 homolog 1 [KO:K12873]
101298225  protein BUD31 homolog 2-like [KO:K12873]
101303350  intron-binding protein aquarius [KO:K12874]
101301983  reticulocyte binding protein 2 homolog b [KO:K12875]
101293970  eukaryotic initiation factor 4A-3 [KO:K13025] [EC:5.6.2.7]
105352043  eukaryotic initiation factor 4A-3-like [KO:K13025] [EC:5.6.2.7]
101296481  eukaryotic initiation factor 4A-3-like [KO:K13025] [EC:5.6.2.7]
101313767  RNA-binding protein 8A-B [KO:K12876]
101313154  protein mago nashi homolog [KO:K12877]
101308506  THO complex subunit 1 [KO:K12878]
101312531  THO complex subunit 2 [KO:K12879]
101293567  THO complex subunit 3-like [KO:K12880]
101294154  THO complex subunit 3-like [KO:K12880]
101293924  THO complex subunit 4D [KO:K12881]
101296073  THO complex subunit 4A [KO:K12881]
101310957  nuclear cap-binding protein subunit 1 [KO:K12882]
101310621  nuclear cap-binding protein subunit 2 [KO:K12883]
101295022  UBP1-associated protein 2C [KO:K12741]
101292874  UBP1-associated protein 2C-like [KO:K12741]
101308619  UBP1-associated protein 2B-like [KO:K12741]
101299304  glycine-rich RNA-binding protein 2, mitochondrial-like [KO:K12741]
101312443  glycine-rich RNA-binding protein 3, mitochondrial [KO:K12741]
101306315  heterogeneous nuclear ribonucleoprotein 1 [KO:K12741]
101293328  UBP1-associated protein 2A [KO:K12741]
101294283  UBP1-associated protein 2C-like [KO:K12741]
101312460  RNA-binding protein Musashi homolog 2-like [KO:K12741]
101309651  heterogeneous nuclear ribonucleoprotein 1 [KO:K12741]
101306778  serine/arginine-rich-splicing factor SR34-like [KO:K12890]
101313066  serine/arginine-rich splicing factor SR34A [KO:K12890]
101307222  serine/arginine-rich splicing factor SR30-like [KO:K12890]
101307796  serine/arginine-rich splicing factor SC35-like [KO:K12891]
101310334  serine/arginine-rich splicing factor SC35-like [KO:K12891]
101295270  serine/arginine-rich splicing factor RS41-like [KO:K12893]
101304217  serine/arginine-rich splicing factor RS31-like [KO:K12893]
101302118  serine/arginine-rich splicing factor RS41 [KO:K12893]
101309791  serine/arginine-rich splicing factor RSZ22-like [KO:K12896]
101312341  serine/arginine-rich splicing factor RSZ21 [KO:K12896]
101315447  serine/arginine-rich splicing factor RS2Z33 [KO:K12896]
101290808  serine/arginine-rich splicing factor RS2Z32-like [KO:K12896]
101311858  serine/arginine-rich splicing factor SR45a-like [KO:K12897]
101314648  serine/arginine-rich SC35-like splicing factor SCL28 [KO:K12900]
101306610  serine/arginine-rich SC35-like splicing factor SCL30A [KO:K12900]
101308510  serine/arginine-rich SC35-like splicing factor SCL30 [KO:K12900]
101294192  serine/arginine-rich SC35-like splicing factor SCL30A [KO:K12900]
Reference
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

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