Entry
Name
Spliceosome - Fragaria vesca (woodland strawberry)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
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Pathway map
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Organism
Fragaria vesca (woodland strawberry) [GN:
fve ]
Gene
101313018 small nuclear ribonucleoprotein-associated protein B' [KO:K11086 ]
101309914 DNA-damage-repair/toleration protein DRT111, chloroplastic [KO:K12840 ]
101302671 U4/U6 small nuclear ribonucleoprotein PRP4-like protein [KO:K12662 ]
101304270 U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846 ]
101294012 116 kDa U5 small nuclear ribonucleoprotein component-like [KO:K12852 ]
101304774 stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283 ]
101300979 probable mediator of RNA polymerase II transcription subunit 37e [KO:K03283 ]
101299993 stromal 70 kDa heat shock-related protein, chloroplastic-like [KO:K03283 ]
101313219 probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283 ]
101311491 probable mediator of RNA polymerase II transcription subunit 37e [KO:K03283 ]
101305698 probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283 ]
101299304 glycine-rich RNA-binding protein 2, mitochondrial-like [KO:K12741 ]
101306610 serine/arginine-rich SC35-like splicing factor SCL30A [KO:K12900 ]
101294192 serine/arginine-rich SC35-like splicing factor SCL30A [KO:K12900 ]
Reference
Authors
Wahl MC, Will CL, Luhrmann R
Title
The spliceosome: design principles of a dynamic RNP machine.
Journal
Reference
Authors
Morris DP, Greenleaf AL
Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
Journal
Reference
Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
Journal
Reference
Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
Title
Spliceosome structure: piece by piece.
Journal
KO pathway
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