KEGG   PATHWAY: gaf00564
Entry
gaf00564                    Pathway                                
Name
Glycerophospholipid metabolism - Gambusia affinis (western mosquitofish)
Class
Metabolism; Lipid metabolism
Pathway map
gaf00564  Glycerophospholipid metabolism
gaf00564

Module
gaf_M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:gaf00564]
gaf_M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:gaf00564]
gaf_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:gaf00564]
Other DBs
GO: 0006650
Organism
Gambusia affinis (western mosquitofish) [GN:gaf]
Gene
122827223  glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic-like isoform X1 [KO:K00006] [EC:1.1.1.8]
122839163  LOW QUALITY PROTEIN: glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic-like [KO:K00006] [EC:1.1.1.8]
122834554  gpd1b; glycerol-3-phosphate dehydrogenase 1b [KO:K00006] [EC:1.1.1.8]
122827373  gpd2; glycerol-3-phosphate dehydrogenase, mitochondrial isoform X1 [KO:K00111] [EC:1.1.5.3]
122823233  gpam; glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X1 [KO:K00629] [EC:2.3.1.15]
122826771  gpat2; glycerol-3-phosphate acyltransferase 2, mitochondrial [KO:K00629] [EC:2.3.1.15]
122846938  gpat3; glycerol-3-phosphate acyltransferase 3 [KO:K13506] [EC:2.3.1.15]
122847158  glycerol-3-phosphate acyltransferase 4-like [KO:K13506] [EC:2.3.1.15]
122828052  glycerol-3-phosphate acyltransferase 4-like [KO:K13506] [EC:2.3.1.15]
122828872  agpat9l; glycerol-3-phosphate acyltransferase 3-like [KO:K13506] [EC:2.3.1.15]
122819227  agpat2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta [KO:K13509] [EC:2.3.1.51]
122842184  agpat4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X1 [KO:K13523] [EC:2.3.1.51 2.3.1.-]
122839946  agpat3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma [KO:K13523] [EC:2.3.1.51 2.3.1.-]
122842330  agpat5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [KO:K19007] [EC:2.3.1.51]
122845578  lclat1; lysocardiolipin acyltransferase 1 isoform X1 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
122846363  mboat2a; lysophospholipid acyltransferase 2 isoform X1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
122831320  mboat1; lysophospholipid acyltransferase 1 isoform X1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
122825639  mboat2b; lysophospholipid acyltransferase 2b [KO:K13517] [EC:2.3.1.51 2.3.1.-]
122824951  gnpat2; dihydroxyacetone phosphate acyltransferase isoform X1 [KO:K00649] [EC:2.3.1.42]
122825092  gnpat; dihydroxyacetone phosphate acyltransferase isoform X1 [KO:K00649] [EC:2.3.1.42]
122823157  adprm; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
122846250  plpp2a; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
122846840  plpp1a; phospholipid phosphatase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
122841467  phospholipid phosphatase 3-like isoform X1 [KO:K01080] [EC:3.1.3.4]
122827650  phospholipid phosphatase 1-like isoform X1 [KO:K01080] [EC:3.1.3.4]
122839066  plpp2b; phospholipid phosphatase 2b [KO:K01080] [EC:3.1.3.4]
122839200  plpp3; phospholipid phosphatase 3 isoform X1 [KO:K01080] [EC:3.1.3.4]
122821597  ppap2d; phosphatidic acid phosphatase type 2D [KO:K01080] [EC:3.1.3.4]
122829715  phospholipid phosphatase 3-like [KO:K01080] [EC:3.1.3.4]
122843958  lpin1a; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
122841851  lpin2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
122824296  phosphatidate phosphatase LPIN2-like [KO:K15728] [EC:3.1.3.4]
122825469  lpin1b; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
122833781  zgc:123305 isoform X1 [KO:K15728] [EC:3.1.3.4]
122842233  plpp4; phospholipid phosphatase 4 isoform X1 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
122826616  plpp5; phospholipid phosphatase 5 isoform X1 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
122830151  dgke; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
122837112  diacylglycerol kinase theta-like isoform X1 [KO:K00901] [EC:2.7.1.107]
122831238  dgkb; diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
122832159  dgkaa; diacylglycerol kinase, alpha a [KO:K00901] [EC:2.7.1.107]
122826214  dgki; diacylglycerol kinase iota isoform X1 [KO:K00901] [EC:2.7.1.107]
122832818  diacylglycerol kinase delta-like isoform X1 [KO:K00901] [EC:2.7.1.107]
122819926  si:dkey-172j4.3; diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
122834650  dgkab; diacylglycerol kinase, alpha b [KO:K00901] [EC:2.7.1.107]
122839488  diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
122839610  dgkh; diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
122836176  dgkzb; diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
122826200  chpt1; cholinephosphotransferase 1 [KO:K00994] [EC:2.7.8.2]
122834012  cept1b; choline/ethanolaminephosphotransferase 1b isoform X1 [KO:K13644] [EC:2.7.8.1 2.7.8.2]
122845683  pld1a; phospholipase D1a [KO:K01115] [EC:3.1.4.4]
122824383  phospholipase D1-like [KO:K01115] [EC:3.1.4.4]
122845191  pld2; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
122846224  5'-3' exonuclease PLD4 isoform X1 [KO:K16860] [EC:3.1.4.4]
122837211  pld7; 5'-3' exonuclease PLD3 isoform X1 [KO:K16860] [EC:3.1.4.4]
122832884  pld3; 5'-3' exonuclease PLD3 [KO:K16860] [EC:3.1.4.4]
122835881  lcat; phosphatidylcholine-sterol acyltransferase [KO:K00650] [EC:2.3.1.43]
122833061  proca1; uncharacterized protein proca1 [KO:K01047] [EC:3.1.1.4]
122819596  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
122819710  pla2g3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
122827867  group 3 secretory phospholipase A2-like isoform X1 [KO:K01047] [EC:3.1.1.4]
122821499  pla2g10; group 10 secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
122828290  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
122828291  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
122842916  pla2g12b; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
122829058  group XIIB secretory phospholipase A2-like protein [KO:K01047] [EC:3.1.1.4]
122829097  pla2g12a; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
122838744  pla2g4ab; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
122821315  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
122829972  pla2g6; LOW QUALITY PROTEIN: 85/88 kDa calcium-independent phospholipase A2 [KO:K16343] [EC:3.1.1.4]
122846558  plb1; phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]
122825857  phospholipase B1, membrane-associated-like [KO:K14621] [EC:3.1.1.4 3.1.1.5]
122846165  phospholipase A and acyltransferase 4-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
122836962  phospholipase A and acyltransferase 3-like isoform X1 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
122826947  plaat1l; phospholipase A and acyltransferase 1 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
122827777  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
122831141  lysophosphatidylcholine acyltransferase 1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
122840694  lpcat2; lysophosphatidylcholine acyltransferase 2 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
122843627  lpcat1; lysophosphatidylcholine acyltransferase 1 isoform X1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
122819906  lpcat4; lysophospholipid acyltransferase LPCAT4 [KO:K13512] [EC:2.3.1.23 2.3.1.-]
122830991  lpcat3; lysophospholipid acyltransferase 5 isoform X1 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
122824073  lypla1; acyl-protein thioesterase 1 [KO:K06128] [EC:3.1.1.5]
122835882  pla2g15; group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
122843143  lypla2; acyl-protein thioesterase 2 isoform X1 [KO:K06130] [EC:3.1.1.5]
122819243  pnpla7a; patatin-like phospholipase domain-containing protein 7a isoform X1 [KO:K14676] [EC:3.1.1.5]
122827737  pnpla7b; patatin-like phospholipase domain-containing protein 7 [KO:K14676] [EC:3.1.1.5]
122829761  pnpla6; patatin-like phospholipase domain-containing protein 6 isoform X1 [KO:K14676] [EC:3.1.1.5]
122825015  gpcpd1; glycerophosphocholine phosphodiesterase GPCPD1 isoform X1 [KO:K18695] [EC:3.1.4.2]
122823272  choline O-acetyltransferase-like [KO:K00623] [EC:2.3.1.6]
122843031  chata; choline O-acetyltransferase isoform X1 [KO:K00623] [EC:2.3.1.6]
122820465  ache; acetylcholinesterase [KO:K01049] [EC:3.1.1.7]
122826672  cAMP-regulated D2 protein [KO:K01049] [EC:3.1.1.7]
122834960  chka; choline kinase alpha isoform X1 [KO:K14156] [EC:2.7.1.32 2.7.1.82]
122835704  chkb; choline/ethanolamine kinase isoform X1 [KO:K14156] [EC:2.7.1.32 2.7.1.82]
122823649  probable phosphatase phospho1 [KO:K06124] [EC:3.1.3.75]
122822549  phospho1; probable phosphatase phospho1 isoform X1 [KO:K06124] [EC:3.1.3.75]
122841559  pcyt1aa; choline-phosphate cytidylyltransferase A [KO:K00968] [EC:2.7.7.15]
122844463  pcyt1bb; phosphate cytidylyltransferase 1B, choline b [KO:K00968] [EC:2.7.7.15]
122823899  choline-phosphate cytidylyltransferase B-like isoform X1 [KO:K00968] [EC:2.7.7.15]
122825248  selenoi; ethanolaminephosphotransferase 1 [KO:K00993] [EC:2.7.8.1]
122826694  etnk1; ethanolamine kinase 1 [KO:K00894] [EC:2.7.1.82]
122834166  etnk2; ethanolamine kinase 2 [KO:K00894] [EC:2.7.1.82]
122835675  ethanolamine kinase 2-like isoform X1 [KO:K00894] [EC:2.7.1.82]
122829662  pcyt2; LOW QUALITY PROTEIN: ethanolamine-phosphate cytidylyltransferase [KO:K00967] [EC:2.7.7.14]
122821797  ethanolamine-phosphate cytidylyltransferase-like [KO:K00967] [EC:2.7.7.14]
122836935  pmt; phosphoethanolamine methyltransferase isoform X1 [KO:K05929] [EC:2.1.1.103]
122820618  etnppl; ethanolamine-phosphate phospho-lyase isoform X1 [KO:K14286] [EC:4.2.3.2]
122823227  pemt; phosphatidylethanolamine N-methyltransferase [KO:K00551] [EC:2.1.1.17 2.1.1.71]
122828185  cds1; phosphatidate cytidylyltransferase 1 [KO:K00981] [EC:2.7.7.41]
122828449  cds2; phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
122839769  pla1a; phospholipase A1 member A isoform X1 [KO:K13618] [EC:3.1.1.111]
122831457  ptdss1a; phosphatidylserine synthase 1 [KO:K08729] [EC:2.7.8.-]
122843289  ptdss1b; phosphatidylserine synthase 1 [KO:K08729] [EC:2.7.8.-]
122835925  ptdss2; phosphatidylserine synthase 2 [KO:K08730] [EC:2.7.8.29]
122846758  pisd; phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X1 [KO:K01613] [EC:4.1.1.65]
122822705  CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial isoform X1 [KO:K00995] [EC:2.7.8.5]
122830691  tafazzin; tafazzin isoform X1 [KO:K13511] [EC:2.3.1.-]
122825746  lpgat1; acyl-CoA:lysophosphatidylglycerol acyltransferase 1 [KO:K13514] [EC:2.3.1.-]
122821647  cdipt; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
122830546  mboat7; lysophospholipid acyltransferase 7 [KO:K13516] [EC:2.3.1.-]
Compound
C00040  Acyl-CoA
C00065  L-Serine
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340  Heptaprenylglyceryl phosphate
C22341  Heptaprenylglycerol
C22342  Diacetylheptaprenylglycerol
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
PMID:10092508
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
PMID:10542045
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
PMID:12431977
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
PMID:14663079
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
PMID:15522832
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
PMID:10938271
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
gaf00010  Glycolysis / Gluconeogenesis
gaf00260  Glycine, serine and threonine metabolism
gaf00561  Glycerolipid metabolism
gaf00562  Inositol phosphate metabolism
gaf00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
gaf00565  Ether lipid metabolism
gaf00620  Pyruvate metabolism
KO pathway
ko00564   
LinkDB

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