KEGG   PATHWAY: hsa03083
Entry
hsa03083                    Pathway                                
Name
Polycomb repressive complex - Homo sapiens (human)
Class
Genetic Information Processing; Chromosome
Pathway map
hsa03083  Polycomb repressive complex
hsa03083

Drug
D12782  Pociredir (USAN/INN)
Organism
Homo sapiens (human) [GN:hsa]
Gene
2145  EZH1; enhancer of zeste 1 polycomb repressive complex 2 subunit [KO:K17451] [EC:2.1.1.356]
2146  EZH2; enhancer of zeste 2 polycomb repressive complex 2 subunit [KO:K11430] [EC:2.1.1.356]
8726  EED; embryonic ectoderm development [KO:K11462]
23512  SUZ12; SUZ12 polycomb repressive complex 2 subunit [KO:K11463]
5928  RBBP4; RB binding protein 4, chromatin remodeling factor [KO:K10752]
5931  RBBP7; RB binding protein 7, chromatin remodeling factor [KO:K11659]
5252  PHF1; PHD finger protein 1 [KO:K11467]
22823  MTF2; metal response element binding transcription factor 2 [KO:K11485]
26147  PHF19; PHD finger protein 19 [KO:K11486]
100170841  EPOP; elongin BC and polycomb repressive complex 2 associated protein [KO:K26259]
84458  LCOR; ligand dependent nuclear receptor corepressor [KO:K26260]
121536  AEBP2; AE binding protein 2 [KO:K17452]
3720  JARID2; jumonji and AT-rich interaction domain containing 2 [KO:K11478]
8314  BAP1; BRCA1 associated protein 1 [KO:K08588] [EC:3.4.19.12]
171023  ASXL1; ASXL transcriptional regulator 1 [KO:K11471]
55252  ASXL2; ASXL transcriptional regulator 2 [KO:K11471]
80816  ASXL3; ASXL transcriptional regulator 3 [KO:K11471]
8473  OGT; O-linked N-acetylglucosamine (GlcNAc) transferase [KO:K09667] [EC:2.4.1.255]
3054  HCFC1; host cell factor C1 [KO:K14966]
7528  YY1; YY1 transcription factor [KO:K09201]
404281  YY2; YY2 transcription factor [KO:K09201]
55777  MBD5; methyl-CpG binding domain protein 5 [KO:K23219]
114785  MBD6; methyl-CpG binding domain protein 6 [KO:K26585]
3607  FOXK2; forkhead box K2 [KO:K09404]
221937  FOXK1; forkhead box K1 [KO:K09404]
6045  RNF2; ring finger protein 2 [KO:K10695] [EC:2.3.2.27]
6015  RING1; ring finger protein 1 [KO:K10695] [EC:2.3.2.27]
7703  PCGF2; polycomb group ring finger 2 [KO:K11460]
648  BMI1; BMI1 proto-oncogene, polycomb ring finger [KO:K11459]
100532731  COMMD3-BMI1; COMMD3-BMI1 readthrough [KO:K11459]
84733  CBX2; chromobox 2 [KO:K11451]
8535  CBX4; chromobox 4 [KO:K11452] [EC:2.3.2.-]
23466  CBX6; chromobox 6 [KO:K11453]
23492  CBX7; chromobox 7 [KO:K11454]
57332  CBX8; chromobox 8 [KO:K11455]
1911  PHC1; polyhomeotic homolog 1 [KO:K11456]
1912  PHC2; polyhomeotic homolog 2 [KO:K11457]
80012  PHC3; polyhomeotic homolog 3 [KO:K11458]
6322  SCML1; Scm polycomb group protein like 1 [KO:K11464]
10389  SCML2; Scm polycomb group protein like 2 [KO:K11465]
22955  SCMH1; Scm polycomb group protein homolog 1 [KO:K11461]
57713  SFMBT2; Scm like with four mbt domains 2 [KO:K26269]
51460  SFMBT1; Scm like with four mbt domains 1 [KO:K26269]
9212  AURKB; aurora kinase B [KO:K11479] [EC:2.7.11.1]
51619  UBE2D4; ubiquitin conjugating enzyme E2 D4 (putative) [KO:K06689] [EC:2.3.2.23]
7321  UBE2D1; ubiquitin conjugating enzyme E2 D1 [KO:K06689] [EC:2.3.2.23]
7322  UBE2D2; ubiquitin conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
7323  UBE2D3; ubiquitin conjugating enzyme E2 D3 [KO:K06689] [EC:2.3.2.23]
85015  USP45; ubiquitin specific peptidase 45 [KO:K11844] [EC:3.4.19.12]
10600  USP16; ubiquitin specific peptidase 16 [KO:K11844] [EC:3.4.19.12]
23429  RYBP; RING1 and YY1 binding protein [KO:K11469]
10138  YAF2; YY1 associated factor 2 [KO:K11468]
84759  PCGF1; polycomb group ring finger 1 [KO:K11487]
84678  KDM2B; lysine demethylase 2B [KO:K10276] [EC:1.14.11.27]
22992  KDM2A; lysine demethylase 2A [KO:K10276] [EC:1.14.11.27]
54880  BCOR; BCL6 corepressor [KO:K23215]
63035  BCORL1; BCL6 corepressor like 1 [KO:K26199]
6500  SKP1; S-phase kinase associated protein 1 [KO:K03094]
7874  USP7; ubiquitin specific peptidase 7 [KO:K11838] [EC:3.4.19.12]
10336  PCGF3; polycomb group ring finger 3 [KO:K11488]
84333  PCGF5; polycomb group ring finger 5 [KO:K11489]
1460  CSNK2B; casein kinase 2 beta [KO:K03115]
26053  AUTS2; activator of transcription and developmental regulator AUTS2 [KO:K23214]
64319  FBRS; fibrosin [KO:K26253]
57666  FBRSL1; fibrosin like 1 [KO:K26254]
10238  DCAF7; DDB1 and CUL4 associated factor 7 [KO:K11805]
54881  TEX10; testis expressed 10 [KO:K14827]
1387  CREBBP; CREB binding protein [KO:K04498] [EC:2.3.1.48]
2033  EP300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]
84108  PCGF6; polycomb group ring finger 6 [KO:K11470]
1876  E2F6; E2F transcription factor 6 [KO:K09390]
7027  TFDP1; transcription factor Dp-1 [KO:K04683]
4149  MAX; MYC associated factor X [KO:K04453]
23269  MGA; MAX dimerization protein MGA [KO:K23399]
26013  L3MBTL1; L3MBTL histone methyl-lysine binding protein 1 [KO:K24387]
84456  L3MBTL3; L3MBTL histone methyl-lysine binding protein 3 [KO:K24387]
83746  L3MBTL2; L3MBTL histone methyl-lysine binding protein 2 [KO:K24387]
91133  L3MBTL4; L3MBTL histone methyl-lysine binding protein 4 [KO:K24387]
11335  CBX3; chromobox 3 [KO:K11586]
11091  WDR5; WD repeat domain 5 [KO:K14963]
54554  WDR5B; WD repeat domain 5B [KO:K14963]
3065  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
3066  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
Reference
PMID:21881606
  Authors
Richly H, Aloia L, Di Croce L
  Title
Roles of the Polycomb group proteins in stem cells and cancer.
  Journal
Cell Death Dis 2:e204 (2011)
DOI:10.1038/cddis.2011.84
Reference
PMID:28202673
  Authors
Chittock EC, Latwiel S, Miller TC, Muller CW
  Title
Molecular architecture of polycomb repressive complexes.
  Journal
Biochem Soc Trans 45:193-205 (2017)
DOI:10.1042/BST20160173
Reference
PMID:33202645
  Authors
Geng Z, Gao Z
  Title
Mammalian PRC1 Complexes: Compositional Complexity and Diverse Molecular Mechanisms.
  Journal
Int J Mol Sci 21:ijms21228594 (2020)
DOI:10.3390/ijms21228594
Reference
PMID:35681061
  Authors
Kim JJ, Kingston RE
  Title
Context-specific Polycomb mechanisms in development.
  Journal
Nat Rev Genet 23:680-695 (2022)
DOI:10.1038/s41576-022-00499-0
Reference
PMID:36076977
  Authors
Dong GJ, Xu JL, Qi YR, Yuan ZQ, Zhao W
  Title
Critical Roles of Polycomb Repressive Complexes in Transcription and Cancer.
  Journal
Int J Mol Sci 23:ijms23179574 (2022)
DOI:10.3390/ijms23179574
Reference
PMID:37086328
  Authors
Ryan CW, Peirent ER, Regan SL, Guxholli A, Bielas SL
  Title
H2A monoubiquitination: insights from human genetics and animal models.
  Journal
Hum Genet 10.1007/s00439-023-02557-x (2023)
DOI:10.1007/s00439-023-02557-x
KO pathway
ko03083   
LinkDB

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